公开(公告)号：US10251904B2

公开(公告)日：2019-04-09

申请号：US15267433

申请日：2016-09-16

Applicant: Gilead Sciences, Inc.

Inventor： Michael O'Neil Hanrahan Clarke ,  Joy Yang Feng ,  Robert Jordan ,  Richard L. Mackman ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/706 ,  A61K31/7056

Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.

公开(公告)号：US10065958B2

公开(公告)日：2018-09-04

申请号：US14613719

申请日：2015-02-04

Applicant: Gilead Sciences, Inc.

Inventor： Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dorothy Agnes Theodore

IPC: C07D487/04 ,  C07F9/6561 ,  C07H19/04 ,  A61K9/00 ,  A61K31/706 ,  A61K45/06 ,  C07H7/06

CPC classification number: C07D487/04 ,  A61K9/0078 ,  A61K31/706 ,  A61K45/06 ,  C07F9/6561 ,  C07H7/06 ,  C07H19/04

Abstract: Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections.

公开(公告)号：US09957275B2

公开(公告)日：2018-05-01

申请号：US15639970

申请日：2017-06-30

Applicant: Gilead Sciences, Inc.

Inventor： Kerim Babaoglu ,  Constantine G. Boojamra ,  Eugene J. Eisenberg ,  Hon Chung Hui ,  Richard L. Mackman ,  Jay P. Parrish ,  Michael Sangi ,  Oliver L. Saunders ,  Dustin Siegel ,  David Sperandio ,  Hai Yang

IPC: C07D487/04 ,  C07D487/08 ,  C07D495/04 ,  C07D513/04 ,  A61K31/519 ,  A61K45/06 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/551 ,  A61K31/675 ,  C07F9/6561 ,  C07D519/00

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/551 ,  A61K31/675 ,  A61K45/06 ,  C07D495/04 ,  C07D513/04 ,  C07D519/00 ,  C07F9/65616

Abstract: The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

公开(公告)号：US09873716B2

公开(公告)日：2018-01-23

申请号：US14740680

申请日：2015-06-16

Applicant: Gilead Sciences, Inc. ,  Cypralis Limited

Inventor： Caroline Aciro ,  David Kenneth Dean ,  Neil Andrew Dunbar ,  Adrian John Highton ,  Petr Jansa ,  Kapil Kumar Karki ,  Andrew J. Keats ,  Linos Lazarides ,  Richard L. Mackman ,  Simon N. Pettit ,  Karine G. Poullennec ,  Adam James Schrier ,  Dustin Siegel ,  Victoria Alexandra Steadman

IPC: A61K38/21 ,  C07K5/062 ,  C07D487/08 ,  C07D498/08 ,  C07D498/18 ,  A61K38/12 ,  A61K39/29 ,  A61K45/06 ,  C07K5/02 ,  C07D471/18 ,  C07D498/22 ,  A61K38/55 ,  A61K31/403 ,  A61K31/497 ,  A61K31/504 ,  A61K31/7056 ,  A61K31/7072 ,  C07K5/078 ,  C07K5/065 ,  A61K38/15 ,  A61K38/00

CPC classification number: C07K5/06034 ,  A61K31/403 ,  A61K31/497 ,  A61K31/504 ,  A61K31/7056 ,  A61K31/7072 ,  A61K38/00 ,  A61K38/05 ,  A61K38/12 ,  A61K38/15 ,  A61K38/21 ,  A61K38/55 ,  A61K39/29 ,  A61K45/06 ,  C07D471/18 ,  C07D487/08 ,  C07D498/08 ,  C07D498/18 ,  C07D498/22 ,  C07K5/02 ,  C07K5/06052 ,  C07K5/0606 ,  C07K5/06078 ,  C07K5/06086 ,  C07K5/06139 ,  C07K5/06191 ,  C07K19/00 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/389 ,  Y02A50/391 ,  Y02A50/395 ,  A61K2300/00

Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.

公开(公告)号：US20180016280A1

公开(公告)日：2018-01-18

申请号：US15610104

申请日：2017-05-31

Applicant: Gilead Sciences, Inc.

Inventor： Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Richard L. Mackman ,  Dustin Siegel

IPC: C07D487/04 ,  C07F9/6561 ,  C07D405/14 ,  C07H7/06 ,  C07D405/04

CPC classification number: C07D487/04 ,  C07D405/04 ,  C07D405/14 ,  C07F9/6561 ,  C07H7/06

Abstract: Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds.

公开(公告)号：US09701677B2

公开(公告)日：2017-07-11

申请号：US14998074

申请日：2015-12-23

Applicant: Gilead Sciences, Inc. ,  Institute of Organic Chemistry and Biochemistry of the AS CR, v.v.i.

Inventor： Petr Jansa ,  Miroslav Kvasnica ,  Richard L. Mackman

IPC: C07D471/04 ,  C07D487/04 ,  A61K31/519 ,  A61P31/18 ,  A61K45/06

CPC classification number: C07D471/04 ,  A61K31/519 ,  A61K45/06

Abstract: Described herein are compounds of Formula (I) and tautomers and pharmaceutical salts thereof, compositions and formulations containing such compounds, and methods of using and making such compounds.

公开(公告)号：US20170190737A1

公开(公告)日：2017-07-06

申请号：US15465492

申请日：2017-03-21

Applicant: Gilead Sciences, Inc. ,  Selcia Limited

Inventor： Caroline Aciro ,  David Kenneth Dean ,  Neil Andrew Dunbar ,  Adrian John Highton ,  Petr Jansa ,  Kapil Kumar Karki ,  Andrew John Keats ,  Linos Lazarides ,  Richard L. Mackman ,  Simon N. Pettit ,  Karine G. Poullennec ,  Adam James Schrier ,  Dustin Siegel ,  Victoria Alexandra Steadman

IPC: C07K5/062 ,  C07K5/078 ,  A61K45/06 ,  C07K5/06 ,  C07K19/00 ,  A61K38/05 ,  C07K5/065 ,  C07K5/068

CPC classification number: C07K5/06034 ,  A61K31/403 ,  A61K31/497 ,  A61K31/504 ,  A61K31/7056 ,  A61K31/7072 ,  A61K38/00 ,  A61K38/05 ,  A61K38/12 ,  A61K38/15 ,  A61K38/21 ,  A61K38/55 ,  A61K39/29 ,  A61K45/06 ,  C07D471/18 ,  C07D487/08 ,  C07D498/08 ,  C07D498/18 ,  C07D498/22 ,  C07K5/02 ,  C07K5/06052 ,  C07K5/0606 ,  C07K5/06078 ,  C07K5/06086 ,  C07K5/06139 ,  C07K5/06191 ,  C07K19/00 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/389 ,  Y02A50/391 ,  Y02A50/395 ,  A61K2300/00

Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.

公开(公告)号：US20160235748A1

公开(公告)日：2016-08-18

申请号：US15000821

申请日：2016-01-19

Applicant: Gilead Sciences, Inc.

Inventor： Constantine G. Boojamra ,  Hon Chung Hui ,  Petr Jansa ,  Richard L. Mackman ,  Jay P. Parrish ,  Michael Sangi ,  Dustin Siegel ,  David Sperandio ,  Hai Yang

IPC: A61K31/5025 ,  C07D487/04 ,  A61K31/5377 ,  C07F9/6561 ,  A61K31/675 ,  A61K45/06 ,  C07D519/00

CPC classification number: A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/675 ,  A61K45/06 ,  C07D487/04 ,  C07D487/08 ,  C07D519/00 ,  C07F9/6561

Abstract: The invention provides compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections. The compounds and compositions are useful for treating Pneumovirinae virus infection including Human respiratory syncytial virus infections.

公开(公告)号：US20160122374A1

公开(公告)日：2016-05-05

申请号：US14926062

申请日：2015-10-29

Applicant: Gilead Sciences, Inc.

Inventor： Byoung Kwon Chun ,  Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: C07F9/6561 ,  A61K31/675 ,  A61K45/06 ,  A61K31/685

CPC classification number: A61K31/685 ,  A61K31/00 ,  A61K31/53 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/675 ,  A61K31/683 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00 ,  C07F9/2429 ,  C07F9/65616 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K2300/00

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

Abstract translation: 本发明提供了通过给予式IV的核糖苷，核苷磷酸酯及其前体药物治疗丝状病毒感染的化合物，方法和药物组合物：所提供的化合物，组合物和方法特别可用于治疗马尔堡病毒，埃博拉病毒和Cueva 病毒感染。

公开(公告)号：US20160024107A1

公开(公告)日：2016-01-28

申请号：US14806227

申请日：2015-07-22

Applicant: Gilead Sciences, Inc.

Inventor： Michael O'Neil Hanrahan Clarke ,  Richard L. Mackman ,  Dustin Siegel

IPC: C07D495/04

CPC classification number: C07D495/04 ,  C07H7/06 ,  C07H11/04

Abstract: Provided herein are formulations, methods and substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds.

Abstract translation: 本文提供了用于治疗肺炎链球菌病毒感染的制剂，方法和取代的噻吩并[3,2-d]嘧啶，呋喃并[3,2-d]嘧啶和式（I）的吡咯并[3,2-d]嘧啶化合物， 包括呼吸道合胞病毒感染，以及合成取代噻吩并[3,2-d]嘧啶，呋喃并[3,2-d]嘧啶和吡咯并[3,2-d]嘧啶化合物的方法和中间体。