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41.发明申请HEPATOCYTE GROWTH FACTOR RECEPTOR SPLICE VARIANTS AND METHODS OF USING SAME 审中-公开肝细胞生长因子受体拮抗剂变异体及其使用方法公开(公告)号：US20100183573A1
公开(公告)日：2010-07-22
申请号：US12709269
申请日：2010-02-19
申请人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran , Dvir Dahary , Liat Mintz , Hanqing Xie
发明人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran , Dvir Dahary , Liat Mintz , Hanqing Xie
IPC分类号： A61K38/16 , C07K14/00 , C07H21/04 , C12N15/63 , C12N1/21 , A61K31/7088 , A61K35/74 , A61K35/66 , C12N1/19 , C12N5/10 , A61K35/64 , A61K35/12 , A61P35/02 , A61P9/10 , A61P37/00
CPC分类号： C07K14/71 , A61K38/00 , C07K16/248 , C07K2317/34 , C07K2317/55 , C07K2317/73
摘要： Novel polypeptides that are splice variants of c-Met, the receptor for hepatocyte growth factor and polynucleotides encoding same are provided. Methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention, are also provided.
摘要翻译： 提供了作为c-Met的剪接变体，肝细胞生长因子的受体和编码其的多核苷酸的新型多肽。 还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。
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42.发明申请HEPATOCYTE GROWTH FACTOR RECEPTOR SPLICE VARIANTS AND METHODS OF USING SAME 有权肝细胞生长因子受体拮抗剂变异体及其使用方法公开(公告)号：US20080159992A1
公开(公告)日：2008-07-03
申请号：US11781905
申请日：2007-07-23
申请人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran , Dvir Dahary , Liat Mintz , Hanqing Xie
发明人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran , Dvir Dahary , Liat Mintz , Hanqing Xie
摘要： Novel polypeptides that are splice variants of c-Met, the receptor for hepatocyte growth factor and polynucleotides encoding same are provided. Methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention, are also provided.
摘要翻译： 提供了作为c-Met的剪接变体，肝细胞生长因子的受体和编码其的多核苷酸的新型多肽。 还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。
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43.发明申请ATRIAL NATRIURETIC PEPTIDE (ANP) SPLICE VARIANTS AND METHODS OF USING SAME 审中-公开ATRIAL NATRIURETIC PEPTIDE（ANP）SPLICE VARIANTS AND METHODS OF USAME公开(公告)号：US20090035287A1
公开(公告)日：2009-02-05
申请号：US12088132
申请日：2006-09-26
IPC分类号： A61K35/12 , C12N15/11 , C07K14/00 , C12N15/00 , A61K38/00 , A61P9/00 , C12N5/06 , C12P21/04 , A61K31/7088
CPC分类号： C07K14/58
摘要： Novel ANP polypeptides and polynucleotides encoding same are provided. Also provided are methods and pharmaceutical compositions which can be used to treat ANP-related diseases and disorders including cardiovascular disorders using the polypeptides and polynucleotides of the present invention.
摘要翻译： 提供了新的ANP多肽和编码相同的多核苷酸。 还提供了可使用本发明的多肽和多核苷酸治疗ANP相关疾病和病症（包括心血管疾病）的方法和药物组合物。
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44.发明授权公开(公告)号：US07758862B2
公开(公告)日：2010-07-20
申请号：US12088210
申请日：2006-10-03
申请人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran
发明人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/20 , C07K2319/30
摘要： Novel polypeptides that are splice variants of c-Met, the receptor for hepatocyte growth factor and polynucleotides encoding same are provided. Methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention, are also provided.
摘要翻译： 提供了作为c-Met的剪接变体，肝细胞生长因子的受体和编码其的多核苷酸的新型多肽。 还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。
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公开(公告)号：US20100166733A1
公开(公告)日：2010-07-01
申请号：US12305953
申请日：2006-06-21
申请人： Zurit Levin , Amir Toporik , Michal Ayalon-Soffer , Iris Hecht , Merav Beiman , Dani Eshel , Tali Handelsman
发明人： Zurit Levin , Amir Toporik , Michal Ayalon-Soffer , Iris Hecht , Merav Beiman , Dani Eshel , Tali Handelsman
IPC分类号： A61K39/395 , C07H21/00 , C07K16/00 , C12N15/74 , C12N5/10 , C12P21/00 , A61K31/7088 , A61K45/00 , A61P3/10 , A61P11/06 , A61P11/08 , A61P9/10 , A61P21/00 , A61P37/02
CPC分类号： C07K14/523 , A61K38/00
摘要： Novel MCP-1 splice variant polypeptides and polynucleotides encoding same are provided. Also provided are pharmaceutical compositions comprising the splice variant polypeptides and polynucleotides, vectors and host cells comprising same. The compositions of the present invention are useful to treat various MCP-1 related disorders as well as for diagnosing, determining predisposition and/or prognosis of various disorders.
摘要翻译： 提供了新的MCP-1剪接变体多肽和编码它们的多核苷酸。 还提供了包含剪接变体多肽和多核苷酸，载体和包含其的宿主细胞的药物组合物。 本发明的组合物可用于治疗各种MCP-1相关疾病以及用于诊断，确定各种疾病的倾向和/或预后。
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46.发明申请HEPATOCYTE GROWTH FACTOR RECEPTOR SPLICE VARIANTS AND METHODS OF USING SAME 失效肝细胞生长因子受体拮抗剂变异体及其使用方法公开(公告)号：US20090036374A1
公开(公告)日：2009-02-05
申请号：US12088210
申请日：2006-10-03
申请人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran
发明人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran
IPC分类号： C07K14/435 , C12N15/62 , C12N15/85 , C12N5/10 , A61K38/17 , A61K31/7088 , A61P35/00 , A61P29/00 , A61P37/00
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/20 , C07K2319/30
摘要： Novel polypeptides that are splice variants of c-Met, the receptor for hepatocyte growth factor and polynucleotides encoding same are provided. Methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention, are also provided.
摘要翻译： 提供了作为c-Met的剪接变体，肝细胞生长因子的受体和编码其的多核苷酸的新型多肽。 还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。
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