公开(公告)号：US07184824B2

公开(公告)日：2007-02-27

申请号：US10965752

申请日：2004-10-18

Applicant: Dan Hashimshony

Inventor： Dan Hashimshony

IPC: A61B5/05

CPC classification number: A61B5/415 ,  A61B5/0507 ,  A61B5/053 ,  A61B5/418

Abstract: A probe, method and system for examining tissue in order to differentiate it from other tissue according to the dielectric properties of the examined tissue are provided. The probe includes an inner conductor, having a plurality of sharp, thin, conductive spikes, at a proximal end with respect to a tissue for examination, the plurality of sharp, thin, conductive spikes being operative to enhance the electrical fringe fields, where interaction with the tissue for examination occurs. The method includes: applying the probe to the tissue to be examined, such that the probe generates an electrical fringe field in the zone of the examined tissue and produces a reflected pulse therefrom with negligible radiation penetrating into the tissue itself; detecting the reflected electrical pulse; and comparing electrical characteristics of the reflected electrical pulse with respect to the applied electrical pulse to provide an indication of the dielectric properties of the examined tissue.

Abstract translation: 提供了用于检查组织以便根据被检查组织的介电性质将其与其他组织区分开的探针，方法和系统。 所述探针包括内导体，所述内导体具有相对于组织进行检查的近端处的多个尖锐，薄的导电尖峰，所述多个尖锐的，薄的导电尖钉可操作以增强电边缘场，其中相互作用 随着组织进行检查。 该方法包括：将探针施加到待检查的组织，使得探针在被检查组织的区域中产生电气边缘场，并从其中产生可忽略的辐射穿透到组织本身中的反射脉冲; 检测反射电脉冲; 并且将反射电脉冲的电特性相对于所施加的电脉冲进行比较，以提供被检查组织的介电性质的指示。

公开(公告)号：US07505811B2

公开(公告)日：2009-03-17

申请号：US10298196

申请日：2002-11-18

Applicant: Dan Hashimshony

Inventor： Dan Hashimshony

IPC: A61B5/05 ,  A61B6/00

CPC classification number: A61K49/00 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/0538 ,  A61B5/065 ,  A61B5/411 ,  A61B5/416 ,  Y10S607/901

Abstract: A method, apparatus and probe for examining tissue for the presence of target cells, particularly cancerous cells, by subjecting the tissue to be examined to a contrast agent containing small particles of a physical element conjugated with a biological carrier selectively bindable to the target cells. Energy pulses are applied to the examined tissue. The changes in impedance and/or optical characteristics of the examined tissue produced by the applied energy pulses are detected and utilized for determining the presence of the target cells in the examined tissue. In a described preferred embodiment, the applied energy pulses include laser pulses, and the physical element conjugated with a biological carrier is a light-sensitive semiconductor having an impedance which substantially decreases in the presence of light. The same probe used for detecting the targeted cells may also be used for destroying the cells so targeted.

Abstract translation: 一种用于通过使检查组织对包含与选择性地与靶细胞结合的生物载体结合的物理元素的小颗粒的造影剂来检查组织是否存在靶细胞特别是癌细胞的方法，装置和探针。 能量脉冲被施加到被检查的组织。 检测由所施加的能量脉冲产生的被检查组织的阻抗和/或光学特性的变化并用于确定所检查组织中靶细胞的存在。 在所描述的优选实施例中，所施加的能量脉冲包括激光脉冲，并且与生物载体共轭的物理元件是具有在存在光时显着降低的阻抗的光敏半导体。 用于检测靶细胞的相同探针也可用于破坏如此靶向的细胞。

公开(公告)号：US20070260156A1

公开(公告)日：2007-11-08

申请号：US11743027

申请日：2007-05-01

Applicant: Dan Hashimshony

Inventor： Dan Hashimshony

IPC: A61B5/053

CPC classification number: A61K49/00 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/0538 ,  A61B5/065 ,  A61B5/411 ,  A61B5/416 ,  Y10S607/901

Abstract: A method, apparatus and probe for examining tissue for the presence of target cells, particularly cancerous cells, by subjecting the tissue to be examined to a contrast agent containing small particles of a physical element conjugated with a biological carrier selectively bindable to the target cells. Energy pulses are applied to the examined tissue. The changes in impedance and/or optical characteristics of the examined tissue produced by the applied energy pulses are detected and utilized for determining the presence of the target cells in the examined tissue. In a described preferred embodiment, the applied energy pulses include laser pulses, and the physical element conjugated with a biological carrier is a light-sensitive semiconductor having an impedance which substantially decreases in the presence of light. The same probe used for detecting the targeted cells may also be used for destroying the cells so targeted.

Abstract translation: 一种用于通过使检查组织对包含与选择性地与靶细胞结合的生物载体结合的物理元素的小颗粒的造影剂来检查组织是否存在靶细胞特别是癌细胞的方法，装置和探针。 能量脉冲被施加到被检查的组织。 检测由所施加的能量脉冲产生的被检查组织的阻抗和/或光学特性的变化并用于确定所检查组织中靶细胞的存在。 在所描述的优选实施例中，所施加的能量脉冲包括激光脉冲，并且与生物载体共轭的物理元件是具有在存在光时显着降低的阻抗的光敏半导体。 用于检测靶细胞的相同探针也可用于破坏如此靶向的细胞。

公开(公告)号：US06463124B1

公开(公告)日：2002-10-08

申请号：US09596530

申请日：2000-06-19

Applicant: Effraim Weisman ,  Nathan Sela ,  Dan Hashimshony ,  Uriel Halavee ,  Guy Shinar ,  Gilad Marcus

Inventor： Effraim Weisman ,  Nathan Sela ,  Dan Hashimshony ,  Uriel Halavee ,  Guy Shinar ,  Gilad Marcus

IPC: H01J3506

CPC classification number: A61N5/1001 ,  A61N5/1002 ,  H01J35/065 ,  H01J35/32 ,  H01J2201/342 ,  H01J2235/06 ,  H01J2235/164

Abstract: An apparatus provides in-situ radiation treating utilizing a miniature energy transducer to produce x-rays, wherein the energy transducer includes a Schottky cathode tip. More specifically, the energy transducer includes a transducer body, an anode provided at a first end of the transducer body, and a cathode provided at a second end of the transducer body opposite the anode. The energy transducer is coupled to an energy source by a flexible insertion device. The energy source provides electrical and/or light signals to the energy transducer via the flexible insertion device. Light transmitted from the energy source to the energy transducer by the flexible insertion device is focused on a Schottky cathode tip of the cathode by the optical fiber provided in the hollow core of the anode. The application of the light signal to the cathode tip results in heating of the tip and along with the electric field generated by the acceleration voltage it leads to electron Schottky emission and electron acceleration towards the anode. In another preferred embodiment, an electrical current, transmitted from the energy source to the energy transducer by the flexible insertion device, is applied to the Schottky cathode tip of the cathode, causing thermo-emission. The electrons generated due to this process are accelerated towards the anode across a voltage difference between the anode and the cathode.

Abstract translation: 一种装置利用微型能量换能器提供原位辐射处理以产生X射线，其中能量换能器包括肖特基阴极尖端。 更具体地，能量换能器包括换能器主体，设置在换能器主体的第一端的阳极和设置在换能器本体的与阳极相对的第二端的阴极。 能量传感器通过柔性插入装置耦合到能量源。 能量源通过柔性插入装置向能量换能器提供电和/或光信号。 通过柔性插入装置从能量源传递到能量换能器的光通过设置在阳极中空芯中的光纤聚焦在阴极的肖特基阴极尖端上。 将光信号施加到阴极尖端导致尖端的加热以及由加速电压产生的电场，从而导致电子肖特基发射和朝向阳极的电子加速。 在另一个优选实施例中，通过柔性插入装置从能量源传递到能量换能器的电流被施加到阴极的肖特基阴极尖端，引起热发射。 由于该过程产生的电子在阳极和阴极之间的电压差上被朝向阳极加速。

公开(公告)号：US09226979B2

公开(公告)日：2016-01-05

申请号：US13485412

申请日：2012-05-31

Applicant: Dan Hashimshony

Inventor： Dan Hashimshony

IPC: A61B5/00 ,  A61K49/00 ,  A61B5/053 ,  A61B5/06

CPC classification number: A61K49/00 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/0538 ,  A61B5/065 ,  A61B5/411 ,  A61B5/416 ,  Y10S607/901

Abstract: A method, apparatus and probe for examining tissue for the presence of target cells, particularly cancerous cells, by subjecting the tissue to be examined to a contrast agent containing small particles of a physical element conjugated with a biological carrier selectively bindable to the target cells. Energy pulses are applied to the examined tissue. The changes in impedance and/or optical characteristics of the examined tissue produced by the applied energy pulses are detected and utilized for determining the presence of the target cells in the examined tissue. In a described preferred embodiment, the applied energy pulses include laser pulses, and the physical element conjugated with a biological carrier is a light-sensitive semiconductor having an impedance which substantially decreases in the presence of light. The same probe used for detecting the targeted cells may also be used for destroying the cells so targeted.

公开(公告)号：US20080154090A1

公开(公告)日：2008-06-26

申请号：US10567581

申请日：2006-01-04

Applicant: Dan Hashimshony

Inventor： Dan Hashimshony

IPC: A61B1/018 ,  A61M25/09

CPC classification number: A61B1/018

Abstract: An endoscopic system for in-vivo tissue characterization, using a nonirradiative electromagnetic sensor, is described. The endoscopic system is further configured to employ several follow-up procedures, for example, biopsy sampling, localized surgery, dispensing a medicament, and the like, so that on the whole, the endoscopic system provides for the early detection of cancerous and pre-cancerous tissue, in vivo, and for the application of immediate follow-up procedures to any such tissue.

Abstract translation: 描述了使用非辐射电磁传感器进行体内组织表征的内窥镜系统。 内窥镜系统还被配置为采用几个后续程序，例如活组织检查取样，局部手术，分配药物等，使得整体上，内窥镜系统提供癌症和预先检测的早期检测， 癌组织，体内，以及对任何这样的组织应用立即随访。

公开(公告)号：US06486685B1

公开(公告)日：2002-11-26

申请号：US09554915

申请日：2000-09-08

Applicant: Dan Hashimshony

Inventor： Dan Hashimshony

IPC: G01R3126

CPC classification number: G01R27/06 ,  G01R31/308

Abstract: Apparatus and method for measuring surface resistivity of a wafer (12). A source of high frequency radiation (6, 41) emits an incident wave burst that impinges the wafer at a desired spot location. A reflected wave burst is detected at an appropriate time window by a receiver (8, 42). The relationship between incident and reflected energies is a function of the surface resistivity of the wafer.

Abstract translation: 用于测量晶片（12）的表面电阻率的装置和方法。 高频辐射源（6,41）发射入射波纹，其将晶片撞击到期望的光点位置。 在适当的时间窗口处由接收器（8,42）检测到反射波阵发。 入射和反射能量之间的关系是晶片的表面电阻率的函数。

公开(公告)号：US20050107718A1

公开(公告)日：2005-05-19

申请号：US10965752

申请日：2004-10-18

Applicant: Dan Hashimshony

Inventor： Dan Hashimshony

IPC: G01N22/00 ,  A61B5/05 ,  A61B5/053 ,  A61B10/00

CPC classification number: A61B5/415 ,  A61B5/0507 ,  A61B5/053 ,  A61B5/418

Abstract: A method and system for examining tissue in order to differentiate it from other tissue according to the dielectric properties of the examined tissue, by: applying a probe to the tissue to be examined, such that the probe generates an electrical fringe field in the zone of the examined tissue and produces a reflected pulse therefrom with negligible radiation penetrating into the tissue itself; detecting the reflected electrical pulse; and comparing electrical characteristics of the reflected electrical pulse with respect to the applied electrical pulse to provide an indication of the dielectric properties of the examined tissue.

Abstract translation: 一种用于根据所检查组织的介电特性来检查组织以便将其与其他组织区分开的方法和系统，方法是：将探针施加到待检查的组织上，使得所述探针在所述检测组织的区域中产生电气边缘区域 所检查的组织并且从其中产生可忽略的辐射穿过组织本身的反射脉冲; 检测反射电脉冲; 并且将反射电脉冲的电特性相对于所施加的电脉冲进行比较，以提供被检查组织的介电性质的指示。

公开(公告)号：US06813515B2

公开(公告)日：2004-11-02

申请号：US10035428

申请日：2002-01-04

Applicant: Dan Hashimshony

Inventor： Dan Hashimshony

IPC: A61B505

CPC classification number: A61B5/415 ,  A61B5/0507 ,  A61B5/053 ,  A61B5/418

Abstract: A method and system for examining tissue in order to differentiate it from other tissue according to the dielectric properties of the examined tissue, by: applying a probe to the tissue to be examined, such that the probe generates an electrical fringe field in the zone of the examined tissue and produces a reflected pulse therefrom with negligible radiation penetrating into the tissue itself; detecting the reflected electrical pulse; and comparing electrical characteristics of the reflected electrical pulse with respect to the applied electrical pulse to provide an indication of the dielectric properties of the examined tissue.

Abstract translation: 一种用于根据所检查组织的介电特性来检查组织以便将其与其他组织区分开的方法和系统，方法是：将探针施加到待检查的组织上，使得所述探针在所述检测组织的区域中产生电气边缘区域 所检查的组织并且从其中产生可忽略的辐射穿过组织本身的反射脉冲; 检测反射电脉冲; 并且将反射电脉冲的电特性相对于所施加的电脉冲进行比较，以提供被检查组织的介电性质的指示。