公开(公告)号：US20110146122A1

公开(公告)日：2011-06-23

申请号：US13036867

申请日：2011-02-28

Applicant: Sherif Ali ,  Kim Canchola ,  Russell Smith ,  Tracy Tenpenny ,  Jeffrey Kerlin ,  James Brown ,  Mike Erwin

Inventor： Sherif Ali ,  Kim Canchola ,  Russell Smith ,  Tracy Tenpenny ,  Jeffrey Kerlin ,  James Brown ,  Mike Erwin

IPC: A44C5/00 ,  A61B5/117

CPC classification number: G09F3/005

Abstract: A closure mechanism receiving aperture presents a substantially contiguous, uninterrupted planar surface on a flexible medium, primarily for use with identification devices, i.e., wristbands. The aperture does not interrupt the printable area so that printer ink may be printed over the aperture without passing through. The inventive aperture also does not produce waster material or chads which can jam or foul-up a printer. An inventive wristband includes both snap closure and adhesive closure mechanisms that can be used at the same time.

Abstract translation: 闭合机构接收孔在柔性介质上呈现基本连续的不间断平面，主要用于识别装置即腕带。 光圈不会打印可打印区域，因此打印机墨水可能会打印在光圈上而不通过。 本发明的孔径也不会产生可能堵塞或弄脏打印机的废物或绷带。 本发明的腕带包括可以同时使用的卡扣闭合和粘合剂封闭机构。

公开(公告)号：US20110118250A1

公开(公告)日：2011-05-19

申请号：US12909566

申请日：2010-10-21

Applicant: Brian K. Albrecht ,  Denise Lyn Andersen ,  Michael Bartberger ,  James Brown ,  Ryan Brown ,  Stuart C. Chaffee ,  Yuan Cheng ,  Michael Croghan ,  Russell Graceffa ,  Scott Harried ,  Stephen Hitchcock ,  Randall Hungate ,  Ted Judd ,  Matthew Kaller ,  Charles Kreiman ,  Daniel La ,  Patricia Lopez ,  Craig Masse ,  Holger Monenschein ,  Thomas Nguyen ,  Thomas Nixey ,  Vinod F. Patel ,  Lewis Pennington ,  Matthew Weiss ,  Qiufen Xue ,  Bryant Yang ,  Wenge Zhong

Inventor： Brian K. Albrecht ,  Denise Lyn Andersen ,  Michael Bartberger ,  James Brown ,  Ryan Brown ,  Stuart C. Chaffee ,  Yuan Cheng ,  Michael Croghan ,  Russell Graceffa ,  Scott Harried ,  Stephen Hitchcock ,  Randall Hungate ,  Ted Judd ,  Matthew Kaller ,  Charles Kreiman ,  Daniel La ,  Patricia Lopez ,  Craig Masse ,  Holger Monenschein ,  Thomas Nguyen ,  Thomas Nixey ,  Vinod F. Patel ,  Lewis Pennington ,  Matthew Weiss ,  Qiufen Xue ,  Bryant Yang ,  Wenge Zhong

IPC: A61K31/538 ,  C07D405/12 ,  A61K31/4433 ,  A61K31/444 ,  C07D405/14 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/497 ,  C07D413/12 ,  A61K31/5377 ,  A61K31/4178 ,  A61K31/4545 ,  A61K31/453 ,  C07D311/96 ,  A61K31/352 ,  C07D407/12 ,  A61K31/4709 ,  C07D401/12 ,  C07D409/12 ,  A61K31/422 ,  A61K31/4025 ,  C07D471/04 ,  A61K31/501 ,  A61P25/28 ,  A61P25/00 ,  A61P25/16

CPC classification number: C07D405/12 ,  C07D413/12

Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

Abstract translation: 本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默氏病（AD））和相关病症的新一类化合物。 在一个实施方案中，化合物具有通式I，其中A，B，R 3，R 4，R 5，i和j在本文中定义。 本发明还包括药物组合物，其包括一种或多种式I化合物，这些化合物的使用方法，包括治疗AD和相关疾病，通过给受试者施用式I化合物或包含它们的组合物。 本发明还包括式II和III的其它实施方案，可用于制备本发明化合物的中间体和方法。

公开(公告)号：US07784478B2

公开(公告)日：2010-08-31

申请号：US11625556

申请日：2007-01-22

Applicant: Pejman Fani ,  Mark Rouillard ,  John Korbler ,  James Brown ,  Chad Hosack

Inventor： Pejman Fani ,  Mark Rouillard ,  John Korbler ,  James Brown ,  Chad Hosack

IPC: B08B3/12

CPC classification number: H01L21/02057 ,  B08B3/04 ,  B08B3/10 ,  B08B3/12 ,  H01L21/67051

Abstract: A system, apparatus and method for processing flat articles, such as semiconductor wafers, with acoustical energy. In a cleaning process, the inventive system, apparatus and method can remove particles from both sides of a wafer more efficiently and effectively. In one aspect, the invention is a system for processing flat articles comprising: a first dispenser for applying a liquid to a first surface of a flat article; a second dispenser for applying liquid to a second surface of a flat article; a first transducer assembly positioned so as to transmit acoustical energy to the first surface of the flat article; and a second transducer assembly positioned so as to transmit acoustical energy to the second surface of the flat article.

Abstract translation: 用于处理具有声能的扁平制品（例如半导体晶片）的系统，装置和方法。 在清洁过程中，本发明的系统，装置和方法可以更有效和更有效地从晶片的两侧去除颗粒。 一方面，本发明是一种用于处理扁平制品的系统，包括：用于将液体施加到平坦物品的第一表面的第一分配器; 用于将液体施加到平坦物品的第二表面的第二分配器; 第一换能器组件被定位成将声能传递到平坦物品的第一表面; 以及第二换能器组件，其定位成将声能传递到平坦物品的第二表面。

公开(公告)号：US20100078411A1

公开(公告)日：2010-04-01

申请号：US12241438

申请日：2008-09-30

Applicant: Thomas Malcolm Hughes ,  James Brown ,  Vincent Papotto ,  Phil Roark

Inventor： Thomas Malcolm Hughes ,  James Brown ,  Vincent Papotto ,  Phil Roark

IPC: B23K26/00

CPC classification number: G01F13/005 ,  B23K26/144 ,  B23K26/147 ,  B23K26/702

Abstract: Powder feed cylinder assemblies and powder feeders are provided. A powder feed cylinder assembly includes a cylinder, a bit, and bushings. The cylinder has a main passage, a first feed channel, and a second feed channel, each feed channel at two axial locations between the cylinder's two ends. The bit extends through the main passage and has an outer surface including a helical channel formed thereon. A center bushing is disposed in the main passage between the two axial locations and has a first axially-extending passage through which the bit extends. The first end bushing is disposed in the main passage on one side of the center bushing and has a second axially-extending passage through which the bit extends. The second end bushing is disposed in the cylinder on the other side of the center bushing and has a third axially-extending passage through which the bit extends.

Abstract translation: 提供粉末进料缸组件和粉末进料器。 粉末进料缸组件包括气缸，钻头和衬套。 气缸具有主通道，第一进料通道和第二进料通道，每个进料通道在气缸两端之间的两个轴向位置。 钻头延伸穿过主通道并且具有包括形成在其上的螺旋通道的外表面。 中心衬套设置在两个轴向位置之间的主通道中，并且具有第一轴向延伸的通道，钻头通过该通道延伸。 第一端衬套设置在中间衬套的一侧的主通道中，并且具有第二轴向延伸的通道，钻头通过该通道延伸。 第二端衬套设置在中心衬套的另一侧的气缸中，并且具有第三轴向延伸的通道，钻头通过该通道延伸。

公开(公告)号：US07614811B2

公开(公告)日：2009-11-10

申请号：US11138142

申请日：2005-05-26

Applicant: Jack W. Kaufman ,  James Brown

Inventor： Jack W. Kaufman ,  James Brown

IPC: B43K5/14

CPC classification number: A61M35/006 ,  A61M35/003 ,  A61M2210/04 ,  B43M11/06

Abstract: The present invention relates to a hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region therebetween. Preferably, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose.

Abstract translation: 本发明涉及包括流体源，连接到流体源的易碎施用器尖端和连接到易碎施用器尖端的吸收构件的手持分配施用器。 当易碎的施用器尖端破裂时，流体从源流向吸收构件，由此将流体施加并扩散在表面上。 优选地，易碎施用器尖端包括永久地连接到流体源的支撑元件，从支撑元件向外延伸的相对刚性的舌元件以及它们之间的易碎区域。 优选地，舌元件包括用于加强舌元件以防止易碎区域的无意破坏的肋。 更优选地，施用器末端包括设置在易碎区域周围的半透性或不可渗透的盖，以控制吸收构件中的流体分散体的速度和方向。 自适应实施例允许生成适用于特定医疗目的的设计。

公开(公告)号：US20070290941A1

公开(公告)日：2007-12-20

申请号：US11763570

申请日：2007-06-15

Applicant: James Brown ,  Christopher Lawrence

Inventor： James Brown ,  Christopher Lawrence

IPC: H01Q7/04 ,  G08B13/14 ,  H01Q1/52

CPC classification number: H01Q9/04 ,  G01V15/00 ,  G06K19/07749 ,  G06K19/07771 ,  H01P7/065 ,  H01Q1/2225 ,  H01Q1/38 ,  H01Q1/52 ,  H01Q13/08 ,  H05K9/00

Abstract: Apparatus and methods for providing a substantially surface independent tagging system are disclosed. A resonant dielectric cavity is defined between upper and lower conducting layers, and closed at one end by a conducting base portion. Incident radiation couples into the cavity and is resonantly enhanced. An electronic device or tag paced at the edge of the cavity experiences a high electric field strength on account of this enhancement and is driven into operation.

Abstract translation: 公开了用于提供基本上表面独立的标签系统的装置和方法。 谐振介电腔被限定在上导电层和下导电层之间，并且在一端由导电基底部封闭。 入射辐射耦合到空腔中并且共振地增强。 考虑到这种增强，位于空腔边缘的电子设备或标签经历高电场强度并被驱动进行操作。

公开(公告)号：US20070286668A1

公开(公告)日：2007-12-13

申请号：US11740910

申请日：2007-04-26

Applicant: JACK KAUFMAN ,  James Brown

Inventor： JACK KAUFMAN ,  James Brown

IPC: B43K5/14

CPC classification number: A61M35/006 ,  A61M35/003 ,  B43M11/06

Abstract: The present invention relates to a hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region there between. Preferably, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose.

Abstract translation: 本发明涉及包括流体源，连接到流体源的易碎施用器尖端和连接到易碎施用器尖端的吸收构件的手持分配施用器。 当易碎的施用器尖端破裂时，流体从源流向吸收构件，由此将流体施加并扩散在表面上。 优选地，易碎的施用器尖端包括永久地连接到流体源的支撑元件，从支撑元件向外延伸的相对刚性的舌元件以及其间的易碎区域。 优选地，舌元件包括用于加强舌元件以防止易碎区域的无意破坏的肋。 更优选地，施用器末端包括设置在易碎区域周围的半透性或不可渗透的盖，以控制吸收构件中的流体分散体的速度和方向。 自适应实施例允许生成适用于特定医疗目的的设计。

公开(公告)号：US20070138228A1

公开(公告)日：2007-06-21

申请号：US11305386

申请日：2005-12-16

Applicant: James Brown ,  Charles Darcangelo ,  Yawei Sun ,  Ljerka Ukrainczyk

Inventor： James Brown ,  Charles Darcangelo ,  Yawei Sun ,  Ljerka Ukrainczyk

IPC: B65H20/00

CPC classification number: B24B9/10 ,  B24B41/06

Abstract: An apparatus for finishing a glass sheet comprising a pair of fluid bearings having bearing surfaces in opposing relation, the bearing surfaces spaced apart to define a channel for receiving the glass sheet, each bearing surface having a plurality of pores through which jets are introduced into the channel, the pores positioned on the bearing surface such that the jets produce a uniform fluid pressure across the bearing surface.

Abstract translation: 一种用于整理玻璃板的装置，包括一对具有相对关系的轴承表面的流体轴承，所述轴承表面间隔开以限定用于接收玻璃板的通道，每个轴承表面具有多个孔，通过该孔 通道，孔位于支承表面上，使得喷嘴在轴承表面上产生均匀的流体压力。

公开(公告)号：US20070100842A1

公开(公告)日：2007-05-03

申请号：US11163877

申请日：2005-11-02

Applicant: Nathan Wykes ,  Kevin Brackney ,  John McGinn ,  Brian Doyle ,  Jeff Wang ,  James Brown ,  James Harman

Inventor： Nathan Wykes ,  Kevin Brackney ,  John McGinn ,  Brian Doyle ,  Jeff Wang ,  James Brown ,  James Harman

IPC: G06F7/00

CPC classification number: G06Q30/0603 ,  Y10S707/948 ,  Y10S707/962

Abstract: An electronic catalog is provided that stores items and attributes associated with the items. One or more of the attributes may have more than one value. Items are stored in an item table with different attributes for items stored in different rows in an attribute table. Additional items may be added to a catalog by adding additional rows to the item table, with attributes related to the additional items added as rows into the attribute table. Particular attributes may have multiple values, and attributes with multiple values are associated with sub-items that correspond to different attribute trees or attribute sets associated with the item. Searching can be performed for attribute values and search results returned indicating all items and sub-items that satisfy the search criteria.

Abstract translation: 提供了一个电子目录，用于存储与项目相关的项目和属性。 一个或多个属性可能有多个值。 项目存储在具有属性表中存储在不同行中的项目的不同属性的项目表中。 可以通过向项目表添加附加行将附加项目添加到目录中，其中与作为行添加到属性表中的附加项目相关联的属性。 特定属性可以具有多个值，并且具有多个值的属性与对应于与该项相关联的不同属性树或属性集的子项相关联。 可以对属性值和返回的搜索结果执行搜索，指示满足搜索条件的所有项目和子项目。

公开(公告)号：US20070087058A1

公开(公告)日：2007-04-19

申请号：US11636743

申请日：2006-12-11

Applicant: John Peery ,  Scott Gilbert ,  James Brown

Inventor： John Peery ,  Scott Gilbert ,  James Brown

IPC: A61K9/24 ,  A61K9/22

CPC classification number: A61K9/0004

Abstract: An osmotic delivery system for controlled delivery of a beneficial agent includes an implantable capsule containing a beneficial agent and an osmotic engine that swells on contact with water, thereby causing the release of the beneficial agent over time. The osmotic delivery system has a membrane material that allows a controlled amount of fluid to enter from an exterior of the capsule, while preventing the compositions within the capsule from passing out of the capsule. The osmotic delivery system is designed to meet at least the operating pressures of 1000 psi. The membrane material is cast, calendered or extruded followed by machining (i.e., die-cutting, stamping or otherwise cutting to shape) to provide a uniform nonribbed membrane material. The capsule also includes a membrane material-retaining means that is positioned at a fluid uptake end to retain the membrane material within the capsule, even under periods of high pressure.