Abstract:
A method for delivering a drug into tissue includes the steps of: providing a drug delivery device having at least one nozzle and a drug contained in a portion of the device; identifying a site for delivery of the drug in or on tissue; placing a portion of the device on or near the site; and delivering the drug into the tissue at the site through at least one nozzle of the device under microjet propulsion.
Abstract:
A device for delivering a drug includes a delivery tube wherein the delivery tube has a pressure chamber therein and at least one nozzle at a distal end of the delivery tube and in fluid communication with the pressure chamber. A source of drug is adjacent the at least one nozzle and a handle is located at a proximal end of the delivery tube. An energy source is located in the handle for providing a driving pressure of up to about 2,000 psi within the delivery tube for driving the drug through the at least one nozzle and out of the delivery tube. The delivery device is particularly useful for delivering drug under microjet propulsion to the mouth, ear and other areas of the body that are difficult to access.
Abstract:
A device includes a substrate. The substrate further includes a first major surface including a plurality of lands, and a second major surface. At least one component is attached to at least some of the plurality of pads on the first major surface. At least one sacrificial component is attached to the first major surface. The at least one component has a first height with respect to the first major surface, and the at least one sacrificial component has a second height with respect to the first major surface. The second height is greater than the first height. The sacrificial component includes a fuse.
Abstract:
A method and apparatus for generating views of an environment with proper perspective and parallax. This invention captures panoramic views at many points in the environment, preferably by using fisheye lenses with subhemispherical fields of views to yield overlapping fisheye images that are seemed together, and stores them as planar polygons, which have been extended to include imagery occluded at their viewing position but visible at nearby points. Three-dimensional information on the environmental source of these polygons is determined and stored, enabling the playback system to simulate parallax as well as to produce stereographic images. Given a location and orientation in the environment, the playback system finds a nearby capture point and translates the polygons at that point to the specified location, producing an image. It then rotates that image to the desired orientation which it then displays.
Abstract:
A novel expression system using the heat-inducible bovine hsp70A promoter and associated cis-acting elements is disclosed. The system provides for the continuous production of a highly pure, authentic protein, substantially free of infectious viral and cellular protein contaminants.
Abstract:
A method for making a jet injection drug delivery device wherein the drug delivery device has at least one drug reservoir and at least one injection nozzle includes the steps of: identifying a drug desired to be delivered; identifying a volume of the drug desired to be delivered; establishing a reservoir diameter for the at least one drug reservoir; establishing a nozzle diameter for the at least one injection nozzle; identifying a tissue model for delivery of the drug; identifying a penetration depth in the tissue model for the delivery of the drug; and injecting the drug into the tissue model under variable pressure until the desired penetration depth is achieved. The method also includes identifying an optimal pressure range for the drug delivery device that achieves the desired penetration depth.
Abstract:
A method and apparatus for generating views of an environment with proper perspective and parallax. This invention captures panoramic views at many points in the environment, preferably by using fisheye lenses with subhemispherical fields of views to yield overlapping fisheye images that are seemed together, and stores them as planar polygons, which have been extended to include imagery occluded at their viewing position but visible at nearby points. Three-dimensional information on the environmental source of these polygons is determined and stored, enabling the playback system to simulate parallax as well as to produce stereographic images. Given a location and orientation in the environment, the playback system finds a nearby capture point and translates the polygons at that point to the specified location, producing an image. It then rotates that image to the desired orientation which it then displays.