摘要:
A nuclear fuel assembly for boiling water reactor is provided. The nuclear fuel assembly includes a base, a head, a bundle of fuel rods extending longitudinally between the base and the head, a tubular fuel channel encasing the bundle of fuel rods, and at least one fuel channel spacer for transversely spacing the fuel assembly from an adjacent element. The or each fuel channel spacer includes a support having at least one plate and at least one corresponding leaf spring supported by the corresponding plate, the or each plate being fixed to a corresponding sidewall of the fuel channel.
摘要:
The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
摘要:
The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
摘要:
Compositions and methods are provided for prognostic classification of inflammatory diseases, e.g. inflammatory demyelinating disease, patients into subtypes, which subtypes are informative of the patient's need for therapy and responsiveness to a therapy of interest. The patterns of cytokines provides for a signature pattern that can identify patients likely to benefit from therapeutic intervention as well as discriminate patients that have a high probability of responsiveness to a therapy from those that have a low probability of responsiveness. Assessment of this signature pattern thus allows improved methods of care. In one embodiment of the invention, the autoimmune disease is multiple sclerosis or neuromyelitis optica.
摘要:
Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要:
A request is received with a first operation identifier to lock a first resource. The first resource is locked with the first operation identifier. It is determined whether a second resource should be locked with the first operation identifier or with a second operation identifier based on whether an operation to be performed for the request may complete after the request is processed. Additional embodiments are described and claimed.
摘要:
Disclosed is a method, system, and program for locking management. A command is received that specifies an operation identifier. It is determined whether the command is associated with a transaction using the operation identifier. If it is determined that the command is associated with a transaction, operating at a transaction level of locking. Further disclosed is a method, system, and program for lock management. Under control of a lock manager, lock request queuing is performed, heartbeat functions are performed, and state information is maintained.