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公开(公告)号：US20120046729A1
公开(公告)日：2012-02-23
申请号：US13087341
申请日：2011-04-14
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2/2475 , A61F2/88 , A61F2/958 , A61F2002/825 , A61F2002/8483 , A61F2002/91558 , A61F2002/91566 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0054 , A61F2230/0076 , A61F2230/0078
摘要： Devices and methods for treating veins and venous conditions, such as chronic cerebrospinal venous insufficiency, are provided. In one aspect, the disclosed subject matter provides an intraluminal scaffold having a generally tubular body with a lumen defined therethrough, the tubular body having a compressed condition for delivery and an expanded condition for implant within a vessel having a distended portion, at least a length of the tubular body configured to form an enlarged portion in the expanded condition to engage a wall of the distended portion of the vessel. Methods for fabricating and using the scaffold, methods for remodeling a vein, and methods of deploying a medical device in a vessel without negatively impacting the function of a valve of the vessel, are also provided.
摘要翻译： 提供了用于治疗静脉和静脉疾病如慢性脑脊髓静脉功能不全的装置和方法。 在一个方面，所公开的主题提供了一种管腔内支架，其具有通过其限定的内腔的大体管状体，该管状体具有用于输送的压缩状态和用于植入物的膨胀状态，该容器具有扩张部分，至少长度 所述管体被构造成在膨胀状态下形成扩大部分以接合容器的扩张部分的壁。 还提供了制造和使用支架的方法，用于重建静脉的方法，以及在容器中部署医疗装置的方法，而不会不利地影响容器的阀的功能。
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公开(公告)号：US08057813B2
公开(公告)日：2011-11-15
申请号：US11084172
申请日：2005-03-18
IPC分类号： A61F13/00
CPC分类号： A61F2/91 , A61F2/86 , A61F2/915 , A61F2/958 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2002/91591 , A61F2250/0067 , A61F2310/0097 , A61K47/6957 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00
摘要： Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.
摘要翻译： 公开了用于从血管成形术球囊和诸如腔内支架之类的假体递送治疗剂的介入装置。 本发明还涉及将有益试剂装载到球囊和装置上的方法以及将试剂从分开的表面递送的方法。 本发明还涉及具有装载有第一有益试剂的假体表面的介入装置和装载有第二有益试剂的气囊表面。 本发明还涉及一种将多种有益试剂装载到假体表面和球囊表面上的方法，以及制造用于从单独表面递送第一有益试剂和第二有益试剂的介入装置的方法。
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公开(公告)号：US07771459B2
公开(公告)日：2010-08-10
申请号：US11145692
申请日：2005-06-06
申请人： Randolf von Oepen
发明人： Randolf von Oepen
CPC分类号： A61B17/888 , A61B17/8615 , A61B17/864 , A61B2017/00004
摘要： Disclosed is a medical fastener that can be mounted to a bone of a patient. The medical fastener can include a head portion comprising a recess having a first portion, a second tapered portion extending from the first portion, and a third cylindrical portion extending from the second tapered portion. A threaded body portion can extend from the head portion. The first portion and the second portion can have a Torx geometry or star-shaped configuration. Also disclosed is a driver usable to mount the medical fastener to the bone. The driver can include a tip that is complementary to the recess and an end that enables the driver to mount to a drill or other device that can rotate the driver.
摘要翻译： 公开了可以安装到患者的骨骼上的医疗紧固件。 医疗紧固件可以包括头部，头部包括具有第一部分的凹部，从第一部分延伸的第二锥形部分和从第二锥形部分延伸的第三圆柱形部分。 螺纹体部分可以从头部延伸。 第一部分和第二部分可以具有Torx几何形状或星形配置。 还公开了可用于将医疗紧固件安装到骨头的驱动器。 驱动器可以包括与凹部互补的尖端和使得驱动器能够安装到能够旋转驱动器的钻孔或其他装置的端部。
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44.发明申请Expandable Member Formed Of A Fibrous Matrix Having Hydrogel Polymer For Intraluminal Drug Delivery 有权具有用于腔内药物递送的水凝胶聚合物的纤维基质的可膨胀构件公开(公告)号：US20100076377A1
公开(公告)日：2010-03-25
申请号：US12238026
申请日：2008-09-25
CPC分类号： A61M25/1029 , A61L29/085 , A61L29/16 , A61L2300/606 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1088
摘要： An intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member including a hydrogel polymer having a therapeutic agent incorporated therein. The hydrogel polymer can be coated on the fiber elements in a co-axial configuration. The fiber elements may also have a second coating including a protective substance surrounding the hydrogel polymer having a therapeutic agent therein. The matrix of fiber elements can be formed by electrospinning. A process of delivering a therapeutic agent to a target site includes providing an intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member including a hydrogel polymer having a therapeutic agent dispersed therein, and advancing the catheter device at a desired treatment site. Once at the desired treatment site, fluid is introduced into the inflation lumen to expand the expandable member from a first profile to a second profile, and the therapeutic agent is released from the hydrogel polymer and delivered to the desired treatment site.
摘要翻译： 一种管腔内导管装置，其具有由纤维元件基质形成的可膨胀构件，所述可扩张构件包括其中结合有治疗剂的水凝胶聚合物。 水凝胶聚合物可以以同轴构型涂覆在纤维元件上。 纤维元件还可以具有包含围绕水凝胶聚合物的保护性物质的第二涂层，其中具有治疗剂。 纤维元素的基质可以通过静电纺丝形成。 将治疗剂递送到靶位置的过程包括提供具有由纤维元件基质形成的可扩张构件的管腔内导管装置，所述可扩张构件包括其中分散有治疗剂的水凝胶聚合物，并将导管装置推进到 所需治疗部位。 一旦在期望的治疗部位，将流体引入充气腔，以将可膨胀构件从第一轮廓扩张到第二轮廓，并且将治疗剂从水凝胶聚合物释放并递送到所需的治疗部位。
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公开(公告)号：US06533809B2
公开(公告)日：2003-03-18
申请号：US09774595
申请日：2001-02-01
申请人： Randolf von Oepen
发明人： Randolf von Oepen
IPC分类号： A61F206
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91541 , A61F2002/91558 , A61F2230/0054
摘要： A stent has a tubular flexible body with a wall having a web structure. The web structure has several adjoining cells. The cells are surrounded by webs of the web structure. Each cell has at least one spring element.
摘要翻译： 支架具有管状柔性体，其壁具有腹板结构。 网状结构具有几个邻接的单元。 细胞被网状结构的腹板包围。 每个单元具有至少一个弹簧元件。
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公开(公告)号：US20180028787A1
公开(公告)日：2018-02-01
申请号：US15662013
申请日：2017-07-27
摘要： A steerable catheter has a body with an outer surface and an inner surface defining a central lumen. The outer surface and inner surface define a wall of the body, which has a plurality of steering lumen and control lumen extending longitudinally therethrough. The body includes a body material. The steering lumen and control lumen have a control lumen lining and steering lumen lining, respectively, with a higher durometer than the body material. A steering wire is positioned within the steering lumen and a control wire is positioned within the control lumen.
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公开(公告)号：US20130138145A1
公开(公告)日：2013-05-30
申请号：US13308240
申请日：2011-11-30
申请人： Randolf von Oepen
发明人： Randolf von Oepen
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B2017/00349 , A61B2017/00637 , A61B2017/00676 , A61B2017/22038 , A61B2017/2215 , A61B2017/2845 , A61B2090/036
摘要： A tissue closure device includes a main body, a sheath, and a biasing member. The main body has a plurality of resilient arms that each extend from a proximal end to a distal tip. The resilient arms are movable between an open configuration in which the distal tips are radially spaced apart from the longitudinal axis of the main body and from each other and a closed configuration in which the distal tips abut one another at or near the longitudinal axis. The sheath is longitudinally slideable on the main body to move the arms between the open and closed configurations. The biasing member causes the sheath to bias the arms toward the closed configuration.
摘要翻译： 组织封闭装置包括主体，护套和偏置构件。 主体具有多个弹性臂，每个弹性臂从近端延伸到远端。 弹性臂可以在其中远侧末端与主体的纵向轴线径向间隔开并且彼此之间的打开构造可移动，并且闭合构型，其中远侧末端在纵向轴线处或附近彼此抵接。 护套可以在主体上纵向滑动，以在打开和关闭构型之间移动臂。 偏置构件使护套将臂朝向闭合构型偏置。
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公开(公告)号：US20120285836A1
公开(公告)日：2012-11-15
申请号：US13107216
申请日：2011-05-13
申请人： Randolf von Oepen
发明人： Randolf von Oepen
IPC分类号： C25F3/16
摘要： An apparatus and method for electrochemically treating the struts of an intravascular stent is disclosed. An intravascular stent is mounted in a chamber and is electrochemically treated in order to remove a portion of the stent struts in order to form an airfoil shape. The airfoil-shaped stent struts will reduce turbulent blood flow in the vasculature in which the stent is implanted thereby improving clinical outcome.
摘要翻译： 公开了一种用于电化学处理血管内支架的支柱的装置和方法。 将血管内支架安装在腔室中并进行电化学处理以便去除支架支架的一部分以形成翼型形状。 翼型支架支架将减少植入支架植入的脉管系统中的湍流血流，从而改善临床结果。
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公开(公告)号：US08246574B2
公开(公告)日：2012-08-21
申请号：US11738368
申请日：2007-04-20
CPC分类号： A61M25/0045 , A61M25/0053
摘要： A support catheter that can be used to aid positioning of a guidewire and other medical devices. The support catheter includes a catheter body having a length, and a supporting structure formed or disposed in or on the catheter body. The catheter support structure, whether alone or in combination with the other portions of the support catheter, provides flexibility, stiffness, and torqueability to the support catheter.
摘要翻译： 可用于辅助导丝和其他医疗装置的定位的支撑导管。 支撑导管包括具有长度的导管主体和形成或设置在导管主体中或导管本体上的支撑结构。 导管支撑结构，无论是单独还是与支撑导管的其他部分组合，都为支撑导管提供了灵活性，刚度和可逆性。
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50.发明授权Expandable member formed of a fibrous matrix for intraluminal drug delivery 有权由用于管腔内药物递送的纤维基质形成的可膨胀构件公开(公告)号：US08076529B2
公开(公告)日：2011-12-13
申请号：US12238627
申请日：2008-09-26
CPC分类号： A61M25/104 , A61L29/16 , A61L2300/606 , A61M25/10 , A61M25/1029 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , D01D5/0076
摘要： An intraluminal catheter device having an expandable member formed of a matrix of fiber elements with a therapeutic agent incorporated therein. The therapeutic agent can be coated on the fiber elements in a co-axial configuration. The fiber elements may also have a second coating including a protective substance surrounding the therapeutic agent. The matrix of fiber elements can be formed by electrospinning. A process of delivering a therapeutic agent to a target site includes providing an intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member having a therapeutic agent dispersed therein, and advancing the catheter device at a desired treatment site. Once at the desired treatment site, fluid is introduced into the inflation lumen to expand the expandable member from a first profile to a second profile, and the therapeutic agent is delivered to the desired treatment site.
摘要翻译： 一种管腔内导管装置，其具有由其中结合有治疗剂的纤维元件基质形成的可扩张构件。 治疗剂可以以同轴构型涂覆在纤维元件上。 纤维元件还可以具有包含围绕治疗剂的保护性物质的第二涂层。 纤维元素的基质可以通过静电纺丝形成。 将治疗剂递送到靶位置的过程包括提供具有由纤维元件基质形成的可扩张构件的管腔内导管装置，所述可扩张构件具有分散在其中的治疗剂，并且将导管装置推进到期望的治疗部位。 一旦在所需的治疗部位，将流体引入充气腔，以将可膨胀构件从第一轮廓扩张到第二轮廓，并将治疗剂递送到所需的治疗部位。
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