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62 条记录 (耗时 0.058 秒)

    UV absorbing polymer
    41.
    发明授权
    UV absorbing polymer 有权
    紫外线吸收聚合物

    公开(公告)号：US06252032B1

    公开(公告)日：2001-06-26

    申请号：US09349270

    申请日：1999-07-07

    申请人： William P. Van Antwerp ,  Li Yao

    发明人： William P. Van Antwerp ,  Li Yao

    IPC分类号： C08G1830

    CPC分类号： C08G18/3842 ,  Y10S522/904 ,  Y10S522/905

    摘要： An ultraviolet-absorbing polymer is formed from a reaction mixture including a diisocyanate, at least one selected from the group consisting of a diol, a diamine and mixtures thereof, and a polyfunctional UV-absorbing monomer.

    摘要翻译： 紫外线吸收聚合物由包括二异氰酸酯，选自二醇，二胺及其混合物中的至少一种的二异氰酸酯和多官能UV吸收单体的反应混合物形成。

    Method of fabricating thin film sensors
    42.
    发明授权
    Method of fabricating thin film sensors 失效
    制造薄膜传感器的方法

    公开(公告)号：US5391250A

    公开(公告)日：1995-02-21

    申请号：US212961

    申请日：1994-03-15

    申请人： Paul S. Cheney, II ,  William P. Van Antwerp

    发明人： Paul S. Cheney, II ,  William P. Van Antwerp

    IPC分类号： G01N33/50 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1477 ,  A61B5/1486 ,  B32B38/10 ,  G01N27/28 ,  G01N27/403 ,  B29C65/00 ,  B32B31/00

    CPC分类号： B32B38/10 ,  G01N27/3272 ,  B32B2310/0843 ,  B32B2457/00 ,  Y10T156/1082

    摘要： An improved method is provided for making thin film electrochemical sensors, such as subcutaneous glucose sensors used to monitor blood glucose levels in a diabetic patient. The fabrication method comprises placing a thin film base layer of insulative material onto a rigid flat substrate, with a curable adhesive interposed between the perimeter of the base layer and substrate to define a shallow cavity underlying a central portion of the base layer. The subassembly is subjected to heat and pressure to cure the adhesive, resulting in air expulsion from the cavity such that the central portion of the base layer is drawn into intimate contact with the substrate. Appropriate conductor elements for one or more sensors are formed on the base layer as by conventional contact mask photolithography, and a thin film cover layer of insulative material is applied thereover with apertures in the cover layer exposing distal end sensor electrodes and proximal end contact pads. The insulative cover and base layers are then cut along a line surrounding each finished sensor which is lifted and separated easily from the substrate.

    摘要翻译： 提供了一种改进的方法来制造薄膜电化学传感器，例如用于监测糖尿病患者血糖水平的皮下葡萄糖传感器。 该制造方法包括将绝缘材料的薄膜基底层放置在刚性平坦基底上，其中可固化粘合剂插入在基底层的周边和基底之间，以限定在基底层的中心部分下面的浅腔。 将该组件经受热和压力以使粘合剂固化，导致空气从空腔排出，使得基层的中心部分被拉伸成与基底紧密接触。 通过常规的接触掩模光刻法，在基底层上形成用于一个或多个传感器的适当的导体元件，并且在其上施加绝缘材料的薄膜覆盖层，覆盖层中的孔露出远端传感器电极和近端接触焊盘。 然后，沿着围绕每个成品传感器的线切割绝缘盖和基层，所述传感器被提起并容易地从基板分离。

    Precious metal recovery using ozone
    43.
    发明授权
    Precious metal recovery using ozone 失效
    使用臭氧的贵金属回收

    公开(公告)号：US4752412A

    公开(公告)日：1988-06-21

    申请号：US11370

    申请日：1987-02-06

    申请人： William P. Van Antwerp ,  Phillip A. Lincoln

    发明人： William P. Van Antwerp ,  Phillip A. Lincoln

    IPC分类号： C01B15/01 ,  C22B3/44

    CPC分类号： C22B3/44 ,  C22B11/04 ,  Y02P10/234

    摘要： A method for recovering precious metals from ore is disclosed. Ore is treated in an acidic slurry with an activated oxygen mixture obtained from an ultraviolet light ozone generator. The activated oxygen frees chemically bonded precious metals creating an expanded, hydrated ore so that the metals may be oxidized and leached out using standard leaching techniques. In addition, the activated oxygen aids in the leaching process. Substantial increases in the amount of precious metal recovered from a given amount of ore result.

    摘要翻译： 公开了一种从矿石中回收贵金属的方法。 用酸性浆液处理矿石，并用紫外光臭氧发生器得到活性氧混合物。 活性氧释放化学键合的贵金属，产生膨胀的水合矿石，使得金属可以使用标准浸出技术被氧化和浸出。 此外，活性氧有助于浸出过程。 从一定量的矿石中回收的贵金属的量大幅度增加。

    Osmotic pump apparatus and associated methods
    46.
    发明申请
    Osmotic pump apparatus and associated methods 审中-公开
    渗透泵装置及相关方法

    公开(公告)号：US20080102119A1

    公开(公告)日：2008-05-01

    申请号：US11591374

    申请日：2006-11-01

    申请人： Eric A. Grovender ,  Ashok V. Joshi ,  John Howard Gordon ,  Sai Bhavaraju ,  William P. Van Antwerp

    发明人： Eric A. Grovender ,  Ashok V. Joshi ,  John Howard Gordon ,  Sai Bhavaraju ,  William P. Van Antwerp

    IPC分类号： A61K9/24 ,  A61K9/22

    CPC分类号： A61K9/0024 ,  A61K9/0004 ,  A61M5/14276 ,  A61M5/14526 ,  A61M5/14593 ,  A61M5/172 ,  A61M2005/14513 ,  A61M2039/242

    摘要： Apparatuses and methods for pumping fluids such as fluid medications are disclosed. Embodiments of the invention provide an osmotic pump fluid delivery apparatus including elements designed to control the fluid delivery rate. Typical embodiments of the invention include an arrangement of elements such as solute reservoirs that can manipulate the solute concentrations within an inner osmotic compartment or compartments of an osmotic pump so as to control fluid delivery from the pump. Other embodiments include sealed electro-osmotic pumps that do not discharge ions into the surroundings or require water from an external source. These embodiments of the invention provide new ways to control fluid delivery in apparatuses that employ osmotic processes to function.

    摘要翻译： 公开了用于泵送液体如液体药物的装置和方法。 本发明的实施例提供一种渗透泵流体输送装置，其包括设计成控制流体输送速率的元件。 本发明的典型实施例包括可以操纵渗透室的内部渗透室或渗透泵的隔室内的溶质浓度以便控制从泵输送流体的溶质储存器等元件的排列。 其他实施例包括不将离子排放到周围环境或者需要来自外部源的水的密封电渗透泵。 本发明的这些实施例提供了在使用渗透过程起作用的装置中控制流体递送的新方式。

    Multiple agent diabetes therapy
    47.
    发明授权
    Multiple agent diabetes therapy 有权
    多剂糖尿病治疗

    公开(公告)号：US07323543B2

    公开(公告)日：2008-01-29

    申请号：US11166390

    申请日：2005-06-24

    申请人： William P. Van Antwerp ,  Andreas H. R. Pfuetzner

    发明人： William P. Van Antwerp ,  Andreas H. R. Pfuetzner

    IPC分类号： C07K14/605

    CPC分类号： A61K38/28 ,  A61K38/30 ,  A61K2300/00

    摘要： A pharmaceutical composition includes at least two of agents I)-iii), wherein agent i) is selected from the group consisting of an insulin, an insulin analog, a physiologically active fragment of said insulin and a physiologically active fragment of said insulin analog, agent ii) is selected from the group consisting of an insulin-related peptide, an insulin-related peptide analog, a physiologically active insulin-related peptide fragment and a physiologically active insulin-related peptide analog fragment, and agent iii) is an insulin sensitizer.

    摘要翻译： 药物组合物包含至少两种试剂I）-iii），其中试剂i）选自胰岛素，胰岛素类似物，所述胰岛素的生理活性片段和所述胰岛素类似物的生理活性片段， 药剂ii）选自胰岛素相关肽，胰岛素相关肽类似物，生理活性胰岛素相关肽片段和生理活性胰岛素相关肽类似物片段，以及药剂iii）是胰岛素敏化剂 。

    Analyte sensing via acridine-based boronate biosensors
    48.
    发明授权
    Analyte sensing via acridine-based boronate biosensors 失效
    通过基于吖啶的硼酸盐生物传感器进行分析物检测

    公开(公告)号：US07045361B2

    公开(公告)日：2006-05-16

    申请号：US09952563

    申请日：2001-09-12

    申请人： Aaron M. Heiss ,  Joseph C. Walsh ,  David J. Vachon ,  Glenn Noronha ,  Jonathan Reilly ,  Bill C. Ponder ,  William P. Van Antwerp

    发明人： Aaron M. Heiss ,  Joseph C. Walsh ,  David J. Vachon ,  Glenn Noronha ,  Jonathan Reilly ,  Bill C. Ponder ,  William P. Van Antwerp

    IPC分类号： G01N21/64 ,  G01N33/58 ,  G01N33/66

    CPC分类号： G01N33/66 ,  C12Q1/54 ,  Y10T436/144444

    摘要： Fluorescent biosensor molecules, fluorescent biosensors and systems, as well as methods of making and using these biosensor molecules and systems are described. These biosensor molecules address the problem of obtaining fluorescence emission at wavelengths greater than about 500 nm. Biosensor molecules generally include an (1) an acridine-based fluorophore, (2) a linker moiety and (3) a boronate substrate recognition/binding moiety, which binds polyhydroxylate analytes, such as glucose. These biosensor molecules further include a “switch” element that is drawn from the electronic interactions among these submolecular components. This fluorescent switch is generally “off” in the absence of bound polyhydroxylate analyte and is generally “on” in the presence of bound polyhydroxylate analyte. Thus, the reversible binding of a polyhydroxylate analyte essentially turns the fluorescent switch “on” and “off”. This property of the biosensor molecules, as well as their ability to emit fluorescent light at greater than about 500 nm, renders these biosensor molecules particularly well-suited for detecting and measuring in-vivo glucose concentrations.

    摘要翻译： 描述荧光生物传感器分子，荧光生物传感器和系统，以及制造和使用这些生物传感器分子和系统的方法。 这些生物传感器分子解决了在大于约500nm的波长处获得荧光发射的问题。 生物传感器分子通常包括（1）基于吖啶的荧光团，（2）接头部分和（3）结合多羟基化合物分析物如葡萄糖的硼酸酯底物识别/结合部分。 这些生物传感器分子还包括从这些亚分子组分之间的电子相互作用中抽出的“开关”元件。 在不存在结合的多羟基甲酸盐分析物的情况下，该荧光开关通常是“关闭”的，并且在结合的多羟基化合物分析物的存在下通常是“开”的。 因此，多羟基化合物分析物的可逆结合基本上使得荧光开关“开”和“关”。 生物传感器分子的这种性质以及它们在大于约500nm处发射荧光的能力使得这些生物传感器分子特别适用于检测和测量体内葡萄糖浓度。

    Leak detection system and method of using the same
    49.
    发明授权
    Leak detection system and method of using the same 有权
    泄漏检测系统及其使用方法

    公开(公告)号：US06752785B2

    公开(公告)日：2004-06-22

    申请号：US10190168

    申请日：2002-07-03

    申请人： William P. Van Antwerp ,  Sheldon B. Moberg ,  Cary D. Talbot

    发明人： William P. Van Antwerp ,  Sheldon B. Moberg ,  Cary D. Talbot

    IPC分类号： A61M500

    CPC分类号： A61M5/16836 ,  A61M5/14248 ,  A61M2205/3306 ,  A61M2209/045

    摘要： In a fluid delivery system for delivering a fluid into an individual's body, a leak detection system indicates that the fluid has leaked outside a normal fluid path of the fluid delivery system, such as near an infusion site or a fluid-filled reservoir. Preferably, the leak detection system includes a chemical positioned near the infusion site that reacts with preservatives in the leaking fluid to generate a highly visible, brightly colored, chemical complex. Alternatively, mechanical, electro-optical, electrochemical, electrical or other chemical systems may be used to detect the presence of fluid that is leaking near the infusion site. Further, the leak detection systems may be used to detect the presence of fluid that is leaking from or near other locations within the fluid delivery system, such as on or near a fluid-filled reservoir, or a flexible tube coupled between the reservoir and the infusion site.

    摘要翻译： 在用于将流体输送到个体的流体输送系统中，泄漏检测系统指示流体已经泄漏在流体输送系统的正常流体路径外部，诸如在输注部位附近或流体填充的储存器附近。 优选地，泄漏检测系统包括位于输注部位附近的化学物质，其与泄漏流体中的防腐剂反应以产生高度可见，明亮的化学复合物。 或者，可以使用机械，电光学，电化学，电气或其它化学系统来检测在输注部位附近泄漏的流体的存在。 此外，泄漏检测系统可以用于检测在流体输送系统内或其附近的流体输送系统中的其他位置泄漏的流体的存在，例如在流体填充的储存器上或附近，或者联接在储存器和储存器之间的柔性管 输液部位。