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公开(公告)号：US08048001B2
公开(公告)日：2011-11-01
申请号：US11558967
申请日：2006-11-13
IPC分类号： A61B5/0225 , A61B5/021
CPC分类号： A61B5/02028 , A61B7/00 , A61N1/36514 , A61N1/36528
摘要： A cardiac rhythm management system provides for ambulatory monitoring of hemodynamic performance based on quantitative measurements of heart sound related parameters for diagnostic and therapeutic purposes. Monitoring of such heart sound related parameters allows the cardiac rhythm management system to determine a need for delivering a therapy and/or therapy parameter adjustments based on conditions of a heart. This monitoring also allows a physician to observe or assess the hemodynamic performance for diagnosing and making therapeutic decisions. Because the conditions of the heart may fluctuate and may deteriorate significantly between physician visits, the ambulatory monitoring, performed on a continuous or periodic basis, ensures a prompt response by the cardiac rhythm management system that may save a life, prevent hospitalization, or prevent further deterioration of the heart.
摘要翻译： 心律管理系统基于用于诊断和治疗目的的心音相关参数的定量测量，提供对血液动力学性能的动态监测。 监测这种心脏声音相关参数允许心律管理系统基于心脏的情况来确定递送治疗和/或治疗参数调整的需要。 该监测还允许医师观察或评估用于诊断和作出治疗决定的血液动力学性能。 由于心脏的状况可能波动，并且可能在医师访问之间显着恶化，所以在连续或周期性的基础上进行的动态监测可确保心律管理系统能够节省生命，预防住院或进一步防止心律失常的迅速反应 心脏恶化
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公开(公告)号：US08012098B2
公开(公告)日：2011-09-06
申请号：US12484108
申请日：2009-06-12
IPC分类号： A61B5/02
CPC分类号： A61N1/36542 , A61B7/00 , A61N1/36535 , A61N1/36578
摘要： A system for determining a patient's posture by monitoring heart sounds. The system comprises an implantable medical device that includes a sensor operable to produce an electrical signal representative of heart sounds, a sensor interface circuit coupled to the sensor to produce a heart sound signal, and a controller circuit coupled to the sensor interface circuit. The heart sounds are associated with mechanical activity of a patient's heart and the controller circuit is operable to detect a posture of the patient from a heart sound signal.
摘要翻译： 通过监测心脏声音来确定患者姿势的系统。 该系统包括可植入医疗装置，其包括可操作以产生表示心脏声音的电信号的传感器，耦合到传感器以产生心音信号的传感器接口电路，以及耦合到传感器接口电路的控制器电路。 心脏声音与患者心脏的机械活动相关联，并且控制器电路可操作以从心脏声音信号检测患者的姿势。
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公开(公告)号：US08005543B2
公开(公告)日：2011-08-23
申请号：US11382128
申请日：2006-05-08
IPC分类号： A61N1/362
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/0215 , A61B5/02158 , A61B5/0402 , A61B5/0488 , A61N1/36114 , A61N1/36117 , A61N1/36128 , A61N1/36139 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/36592 , A61N1/372 , A61N1/37288
摘要： Various system embodiments comprise a stimulator adapted to deliver a stimulation signal for a heart failure therapy, a number of sensors adapted to provide at least a first measurement of a heart failure status and a second measurement of the heart failure status, and a controller. The controller is connected to the stimulator and to the number of sensors. The controller is adapted to use the first and second measurements to create a heart failure status index, and control the stimulator to modulate the signal using the index. Other aspects and embodiments are provided herein.
摘要翻译： 各种系统实施例包括适于递送用于心力衰竭治疗的刺激信号的刺激器，适于提供心力衰竭状态的至少第一测量和心力衰竭状态的第二测量的多个传感器以及控制器。 控制器连接到刺激器和传感器的数量。 控制器适于使用第一和第二测量来创建心力衰竭状态指数，并且使用该索引来控制刺激器来调制信号。 本文提供了其它方面和实施例。
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公开(公告)号：US07951087B2
公开(公告)日：2011-05-31
申请号：US12645906
申请日：2009-12-23
IPC分类号： A61B5/02
CPC分类号： A61B7/04 , A61B5/1116 , A61B8/0883 , A61N1/3627 , A61N1/36535 , A61N1/36578 , A61N1/36585
摘要： A system to monitor heart sounds. The system comprises an implantable heart sound sensor configured to produce an electrical signal representative of at least one heart sound, an implantable posture sensor operable to produce an electrical signal representative of a patient's posture, and a controller circuit. The controller circuit is configured to determine a patient posture, measure at least one heart sound in correspondence with at least one corresponding patient posture, adjust the heart sound measurement by using the corresponding determined patient posture to reduce or remove variation in the heart sound measurement due to patient posture, detect a change in the adjusted heart sound measurement, and provide an indication of congestive heart failure to a user or an automated process in response to the detected change.
摘要翻译： 监听心音的系统 该系统包括被配置为产生表示至少一个心音的电信号的可植入心音传感器，可操作以产生表示患者姿势的电信号的可植入姿态传感器和控制器电路。 控制器电路被配置为确定患者姿势，测量与至少一个对应的患者姿势相对应的至少一个心音，通过使用相应的确定的患者姿势来调整心脏声音测量，以减少或消除心音测量中的变化 到患者姿势，检测调整后的心音测量的变化，并响应于检测到的变化向用户或自动化过程提供充血性心力衰竭的指示。
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公开(公告)号：US20110098588A1
公开(公告)日：2011-04-28
申请号：US12985055
申请日：2011-01-05
IPC分类号： A61B5/02
CPC分类号： A61B5/02028 , A61B7/00 , A61N1/36514 , A61N1/36528
摘要： A cardiac rhythm management system provides for ambulatory monitoring of hemodynamic performance based on quantitative measurements of heart sound related parameters for diagnostic and therapeutic purposes. Monitoring of such heart sound related parameters allows the cardiac rhythm management system to determine a need for delivering a therapy and/or therapy parameter adjustments based on conditions of a heart. This monitoring also allows a physician to observe or assess the hemodynamic performance for diagnosing and making therapeutic decisions. Because the conditions of the heart may fluctuate and may deteriorate significantly between physician visits, the ambulatory monitoring, performed on a continuous or periodic basis, ensures a prompt response by the cardiac rhythm management system that may save a life, prevent hospitalization, or prevent further deterioration of the heart.
摘要翻译： 心律管理系统基于用于诊断和治疗目的的心音相关参数的定量测量，提供对血液动力学性能的动态监测。 监测这种心脏声音相关参数允许心律管理系统基于心脏的情况来确定递送治疗和/或治疗参数调整的需要。 该监测还允许医师观察或评估用于诊断和作出治疗决定的血液动力学性能。 由于心脏的状况可能波动，并且可能在医师访问之间显着恶化，所以在连续或周期性的基础上进行的动态监测可确保心律管理系统能够节省生命，预防住院或进一步防止心律失常的迅速反应 心脏恶化
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46.发明申请SENSING RATE OF CHANGE OF PRESSURE IN THE LEFT VENTRICLE WITH AN IMPLANTED DEVICE 有权在具有嵌入式装置的左心室中的压力变化率的感测率公开(公告)号：US20100145403A1
公开(公告)日：2010-06-10
申请号：US12703533
申请日：2010-02-10
CPC分类号： A61B5/021 , A61N1/36564 , A61N1/36578 , A61N1/375
摘要： An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.
摘要翻译： 一种用远程位置加速度计监测S1心音的可植入装置和方法。 该装置包括将心音转换为电信号的换能器。 控制电路耦合到换能器。 控制电路被配置为接收电信号，识别S1心音，并将S1心音转换为电信息。 控制电路还从电信息生成形态数据。 形态学数据涉及血流动力学指标，如左心室收缩力。 壳体可以包围控制电路。 壳体限定与壳体的外表面共同延伸的体积。 传感器位于由外壳限定的体积中。
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47.发明申请SYSTEM AND METHOD FOR DETECTION OF HF DECOMPENSATION BASED ON SIGNS AND SYMPTOMS 有权基于标志和症状检测HF分解的系统和方法公开(公告)号：US20100073170A1
公开(公告)日：2010-03-25
申请号：US12563882
申请日：2009-09-21
CPC分类号： A61B5/0205 , A61B5/0002 , A61B5/7264 , G06F19/00
摘要： In an example, physiologic information about a patient can be obtained and mapped to a first set of fuzzy logic membership functions, and a symptom status can be derived from the mapping of the physiologic information using a first fuzzy logic inference. In an example, the symptom status can be mapped to a second set of fuzzy logic membership functions, and a disease status can be derived from the mapping of the symptom status to the second set of fuzzy logic membership functions using a second fuzzy logic inference.
摘要翻译： 在一个示例中，可以获得关于患者的生理信息并将其映射到第一组模糊逻辑隶属函数，并且可以使用第一模糊逻辑推断从生理信息的映射导出症状状态。 在一个示例中，症状状态可被映射到第二组模糊逻辑隶属函数，并且可以使用第二模糊逻辑推理从症状状态与第二组模糊逻辑隶属函数的映射导出疾病状态。
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公开(公告)号：US20080177156A1
公开(公告)日：2008-07-24
申请号：US11624974
申请日：2007-01-19
IPC分类号： A61B5/0205 , A61B5/0215
CPC分类号： A61B5/0215 , A61B5/02028 , A61B5/0205 , A61B5/145
摘要： This document discusses, among other things, a system and method for sensing a pulmonary artery pressure (“PAP”) signal of a pulmonary artery (“PA”) and computing an indication of a reduction of blood supply to at least a portion of a heart using information from the PAP signal. The reduction of blood supply to at least a portion of the heart can be detected using a PAP signal characteristic or measurement, using a change in the PAP, using an interval between multiple PAP signal features, using a mitral valve performance, or using information from the PAP and information from a different physiological signal, including a cardiac signal, a heart sound signal, right ventricular pressure signal, a left ventricular pressure signal, a blood pressure signal, and an oxygen saturation signal.
摘要翻译： 本文件尤其涉及用于感测肺动脉（“PA”）的肺动脉压（“PAP”）信号的系统和方法，并且计算将血液供应减少到至少一部分 心脏使用来自PAP信号的信息。 使用PAP信号特征或测量可以使用PAP信号特征或多个PAP信号特征之间的间隔，使用二尖瓣性能来使用PAP信号特征或测量来检测对心脏的至少一部分的血液供应，或使用来自 PAP和来自不同生理信号的信息，包括心脏信号，心音信号，右心室压力信号，左心室压力信号，血压信号和氧饱和度信号。
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公开(公告)号：US20080125820A1
公开(公告)日：2008-05-29
申请号：US11564637
申请日：2006-11-29
申请人： Jeffrey E. Stahmann , Krzysztof Z. Siejko , Carlos Haro , Abhilash Patangay , Gerrard M. Carlson , Andres Belalcazar
发明人： Jeffrey E. Stahmann , Krzysztof Z. Siejko , Carlos Haro , Abhilash Patangay , Gerrard M. Carlson , Andres Belalcazar
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61B5/0031 , A61B5/021 , A61B5/024 , A61B5/053 , A61B5/08 , A61B5/0816 , A61B5/1116 , A61B5/4806 , A61B5/686 , A61B5/7275 , A61B7/04 , A61N1/36578
摘要： A system and method to sense heart sounds with one or more implantable medical devices according to one or more parameters. The system alters one or more of the parameters as a function of one or more triggering events. The system then senses heart sounds with the one or more implantable medical devices according to at least the one or more altered parameters.
摘要翻译： 根据一个或多个参数用一个或多个可植入医疗装置感测心脏声音的系统和方法。 系统根据一个或多个触发事件改变一个或多个参数。 该系统然后根据至少一个或多个改变的参数用一个或多个可植入医疗装置感测心脏声音。
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50.发明授权Between-patient comparisons for risk stratification of future heart failure decompensation 有权患者对未来心力衰竭代偿失调风险分层的比较公开(公告)号：US08768718B2
公开(公告)日：2014-07-01
申请号：US11616430
申请日：2006-12-27
申请人： Shelley Cazares , Jon Peterson , Haresh G. Sachanandani , Kevin J. Stalsberg , Robert J. Sweeney , Krzysztof Z. Siejko , Gerrard M. Carlson
发明人： Shelley Cazares , Jon Peterson , Haresh G. Sachanandani , Kevin J. Stalsberg , Robert J. Sweeney , Krzysztof Z. Siejko , Gerrard M. Carlson
CPC分类号： G06Q50/22 , A61B5/0031 , A61N1/37282 , G06F19/00 , G16H50/20 , G16H50/30 , G16H50/50 , G16H50/70
摘要： This document discusses, among other things, systems and methods for using between-patient comparisons for risk stratification of future heart failure decompensation. A method comprises receiving patient data of a current patient, the patient data collected by a patient monitoring device; determining a reference group related to the patient; determining a reference group dataset selected from the reference group, wherein the dataset includes patient data that is of a similar type received from the patient monitoring device; generating a model of the reference group dataset; and automatically comparing the received physiological data to a model to derive an index for the patient.
摘要翻译： 本文件除了其他内容之外还讨论了使用患者间比较以预测未来心力衰竭代偿失调的风险分层的系统和方法。 一种方法包括接收当前患者的患者数据，由患者监测装置收集的患者数据; 确定与患者相关的参考组; 确定从所述参考组中选择的参考组数据集，其中所述数据集包括从所述患者监视装置接收到的类似类型的患者数据; 生成参考组数据集的模型; 并且将接收到的生理数据自动地与模型进行比较以导出患者的指标。
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