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    Promotable transactions with promotable single phase enlistments
    41.
    发明申请
    Promotable transactions with promotable single phase enlistments 有权
    可升级的单阶段征募活动

    公开(公告)号：US20050289146A1

    公开(公告)日：2005-12-29

    申请号：US10898624

    申请日：2004-07-23

    申请人： Joe Long ,  James Johnson ,  Michael Clark ,  Egidio Sburlino ,  Gert Drapers ,  Jagan Peri ,  Dax Hawkins

    发明人： Joe Long ,  James Johnson ,  Michael Clark ,  Egidio Sburlino ,  Gert Drapers ,  Jagan Peri ,  Dax Hawkins

    IPC分类号： G06F17/30

    CPC分类号： G06Q30/0241 ,  G06F17/30371 ,  Y10S707/955

    摘要： A transaction protocol is described that allows a database transaction to begin as a local, lightweight transaction without involving a distributed transaction coordinator and then be promoted to a distributed transaction only when required, e.g. when more than one database connection is required. A promotable enlistment allows a first resource to begin processing a promotable transaction. If the resource is notified that the transaction is being promoted to a distributed transaction, the resource is configured to promote the enlistment to a distributed transaction coordinator which coordinates processing of the transaction between the first resource and at least a second resource.

    摘要翻译： 描述了允许数据库事务作为本地轻量级事务开始而不涉及分布式事务协调器的事务协议，然后仅在需要时被提升为分布式事务。 当需要多个数据库连接时。 可升级的招募允许第一个资源开始处理可升级的交易。 如果资源被通知事务正被提升为分布式事务，则资源被配置为促进向分配的事务协调器的登记，该分配事务协调器协调第一资源和至少第二资源之间的事务的处理。

    Polypeptides including modified constant regions
    42.
    发明申请
    Polypeptides including modified constant regions 审中-公开
    多肽包括修饰的恒定区

    公开(公告)号：US20050215768A1

    公开(公告)日：2005-09-29

    申请号：US10959318

    申请日：2004-10-07

    申请人： Kathryn Armour ,  Michael Clark

    发明人： Kathryn Armour ,  Michael Clark

    IPC分类号： C07K16/00 ,  C07K16/34 ,  C07K16/44

    CPC分类号： C07K16/34 ,  C07K16/00 ,  C07K2317/52 ,  C07K2317/732

    摘要： Disclosed are processes for producing a variant polypeptide (e.g. antibodies) having increased binding affinity for an FcγR, which processes comprise modifying the polypeptides by substitution of the amino acid at position 268 of a human IgG CH2 region for a non-native polar or charged amino acid e.g. Gln, Asn, Glu, or Asp. also provided are corresponding polypeptides, nucleic acids, and methods of use of the same e.g. in improved lytic therapies.

    摘要翻译： 公开了用于产生具有增加的对FcgammaR的结合亲和力的变体多肽（例如抗体）的方法，该方法包括通过用人IgG CH2区域268位氨基酸取代非天然极性或带电荷氨基来修饰多肽 酸例如 Gln，Asn，Glu或Asp。 还提供了相应的多肽，核酸和其使用方法。 改善溶解疗法。

    Method and measuring changes in microvascular capillary blood flow
    43.
    发明申请
    Method and measuring changes in microvascular capillary blood flow 审中-公开
    方法和测量微血管毛细血管血流量的变化

    公开(公告)号：US20050049507A1

    公开(公告)日：2005-03-03

    申请号：US10480438

    申请日：2002-06-11

    申请人： Michael Clark ,  Stephen Rattigan ,  Eugene Barret ,  Jonathan Lindner ,  Sanjiv Kaul

    发明人： Michael Clark ,  Stephen Rattigan ,  Eugene Barret ,  Jonathan Lindner ,  Sanjiv Kaul

    IPC分类号： A61B8/00 ,  A61B8/06 ,  A61K49/22 ,  A61B8/14

    CPC分类号： A61B8/481 ,  A61B5/02007 ,  A61B8/06 ,  A61K49/223

    摘要： A method of measuring changes in microvascular capillary flow in a predetermined region in a subject comprising: (a) administering an ultrasound contrast medium to said subject such that said contrast medium reaches the microvascular capillaries in said predetermined region; (b) measuring microvascular capillary blood flow volume and/or microvascular flow index of said capillaries; (c) applying a defined signal to said subject; and, (d) measuring changes in said microvascular capillary flow.

    摘要翻译： 一种测量受试者的预定区域中的微血管毛细管流动变化的方法，包括：（a）向所述受试者施用超声波造影剂，使得所述造影剂到达所述预定区域中的微血管毛细血管; （b）测量所述毛细血管的微血管毛细血管血流量和/或微血管流动指数; （c）将定义的信号应用于所述受试者; 和（d）测量所述微血管毛细血管流量的变化。

    Synchronization of subsets of data including support for varying set membership
    45.
    发明授权
    Synchronization of subsets of data including support for varying set membership 有权
    数据子集的同步，包括对不同集合成员资格的支持

    公开(公告)号：US08805783B2

    公开(公告)日：2014-08-12

    申请号：US12915795

    申请日：2010-10-29

    申请人： Siva Muhunthan ,  Lev Novik ,  Michael Clark ,  Andrei Maksimenka

    发明人： Siva Muhunthan ,  Lev Novik ,  Michael Clark ,  Andrei Maksimenka

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30575

    摘要： An efficient way and general mechanism is provided to represent and exchange knowledge and/or partial knowledge across nodes when synchronizing between any two nodes including custom or move filters where set membership can change over time at a device as data items come in and out of filter scope. A first node sends a second node its knowledge and/or partial knowledge, including objects and versions of those objects. The second node compares its knowledge and/or partial knowledge with the knowledge and/or partial knowledge of the first node, and then sends the first node any latest versions of objects of which the first node is unaware. In addition, the second node sends its knowledge and/or partial knowledge to the first node. The first node then performs a similar object-by-object version comparison to determine any conflicts due to independent evolution of objects and any changes that can be sent to the second node in order to bring the objects of the second node up to date with the knowledge and/or partial knowledge of the first node. Replicas can track filters to efficiently support synchronizing with filtered replicas. Filter forgotten knowledge is also used to represent how recently a replica can guarantee to know which items have been in the filter. Ghosts can be used to represent items that have been in the filter recently but have currently moved out. Filter forgotten knowledge concept allows both new filters to be tracked when they are introduced into the community, as well as periodically cleaning up of tombstones and ghosts.

    摘要翻译： 提供了一种有效的方法和一般机制，用于在任何两个节点之间进行同步时，在包括自定义或移动过滤器在内的任何两个节点之间进行表示和交换知识和/或部分知识，其中，随着数据项进入和退出过滤器 范围。 第一节点向第二节点发送其知识和/或部分知识，包括这些对象的对象和版本。 第二节点将其知识和/或部分知识与第一节点的知识和/或部分知识进行比较，然后向第一节点发送第一节点不知道的对象的最新版本。 另外，第二节点将其知识和/或部分知识发送到第一节点。 然后，第一个节点执行类似的逐个对象版本比较，以确定由于对象的独立演化而导致的任何冲突以及可以发送到第二个节点的任何更改，以使第二个节点的对象与 第一个节点的知识和/或部分知识。 副本可以跟踪过滤器以有效地支持与过滤的副本同步。 过滤器被遗忘的知识也用于表示副本最近可以如何保证知道哪些项目已经在过滤器中。 Ghosts可以用来表示最近已经在过滤器中但目前移出的项目。 过滤器被遗忘的知识概念允许在引入社区时跟踪新的过滤器，并定期清理墓碑和鬼魂。

    SYNCHRONIZATION OF SUBSETS OF DATA INCLUDING SUPPORT FOR VARYING SET MEMBERSHIP
    47.
    发明申请
    SYNCHRONIZATION OF SUBSETS OF DATA INCLUDING SUPPORT FOR VARYING SET MEMBERSHIP 有权
    包括支持变更设置成员资料的数据同步

    公开(公告)号：US20110295796A1

    公开(公告)日：2011-12-01

    申请号：US12915795

    申请日：2010-10-29

    申请人： Siva Muhunthan ,  Lev Novik ,  Michael Clark ,  Andrei Maksimenka

    发明人： Siva Muhunthan ,  Lev Novik ,  Michael Clark ,  Andrei Maksimenka

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30575

    摘要： An efficient way and general mechanism is provided to represent and exchange knowledge and/or partial knowledge across nodes when synchronizing between any two nodes including custom or move filters where set membership can change over time at a device as data items come in and out of filter scope. A first node sends a second node its knowledge and/or partial knowledge, including objects and versions of those objects. The second node compares its knowledge and/or partial knowledge with the knowledge and/or partial knowledge of the first node, and then sends the first node any latest versions of objects of which the first node is unaware. In addition, the second node sends its knowledge and/or partial knowledge to the first node. The first node then performs a similar object-by-object version comparison to determine any conflicts due to independent evolution of objects and any changes that can be sent to the second node in order to bring the objects of the second node up to date with the knowledge and/or partial knowledge of the first node. Replicas can track filters to efficiently support synchronizing with filtered replicas. Filter forgotten knowledge is also used to represent how recently a replica can guarantee to know which items have been in the filter. Ghosts can be used to represent items that have been in the filter recently but have currently moved out. Filter forgotten knowledge concept allows both new filters to be tracked when they are introduced into the community, as well as periodically cleaning up of tombstones and ghosts.

    摘要翻译： 提供了一种有效的方法和一般机制，用于在任何两个节点之间进行同步时，在包括自定义或移动过滤器在内的任何两个节点之间进行表示和交换知识和/或部分知识，其中，随着数据项进入和退出过滤器 范围。 第一节点向第二节点发送其知识和/或部分知识，包括这些对象的对象和版本。 第二节点将其知识和/或部分知识与第一节点的知识和/或部分知识进行比较，然后向第一节点发送第一节点不知道的对象的最新版本。 另外，第二节点将其知识和/或部分知识发送到第一节点。 然后，第一个节点执行类似的逐个对象版本比较，以确定由于对象的独立演化而导致的任何冲突以及可以发送到第二个节点的任何更改，以使第二个节点的对象与 第一个节点的知识和/或部分知识。 副本可以跟踪过滤器以有效地支持与过滤的副本同步。 过滤器被遗忘的知识也用于表示副本最近可以如何保证知道哪些项目已经在过滤器中。 Ghosts可以用来表示最近已经在过滤器中但目前移出的项目。 过滤器被遗忘的知识概念允许在引入社区时跟踪新的过滤器，并定期清理墓碑和鬼魂。

    Framework for database transactions
    50.
    发明申请
    Framework for database transactions 有权
    数据库事务框架

    公开(公告)号：US20070198455A1

    公开(公告)日：2007-08-23

    申请号：US11326947

    申请日：2006-01-06

    申请人： Alazel Acheson ,  Christian Kleinerman ,  Michael Clark ,  Pablo Castro ,  Stephen Starck

    发明人： Alazel Acheson ,  Christian Kleinerman ,  Michael Clark ,  Pablo Castro ,  Stephen Starck

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30348

    摘要： Various mechanisms are presented that allow for the coordination of transactions in a managed runtime environment. In one aspect, a runtime environment that is hosted in a database system, includes an application programming interface (API). The API can surface the database transactions as ambient transactions, and present them to some user code. When the user code connects to some remote resource, the ambient transaction can be implicitly propagated to the remoter resource, resulting in coordination of the database transaction with any given transaction running in the remote resource.

    摘要翻译： 提出了允许在受管运行时环境中协调事务的各种机制。 一方面，托管在数据库系统中的运行时环境包括应用程序编程接口（API）。 API可以将数据库事务表示为环境事务，并将其呈现给某些用户代码。 当用户代码连接到一些远程资源时，环境事务可以隐式传播到远程资源，导致数据库事务与在远程资源中运行的任何给定事务协调。