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公开(公告)号：US06503750B1
公开(公告)日：2003-01-07
申请号：US09200309
申请日：1998-11-25
IPC分类号： C12M134
CPC分类号： B01L7/52 , B01J19/0093 , B01J2219/00788 , B01J2219/0081 , B01J2219/00828 , B01J2219/00873 , B01J2219/00961 , B01L3/5027 , B01L2300/1827 , B01L2300/1838
摘要： A sleeve-type silicon polymerase chain reaction (PCR) chamber or thermocycler having improved thermal performance. The silicon sleeve reaction chamber is improved in thermal performance by etched features therein that reduce thermal mass and increase the surface area of the sleeve for cooling. This improved thermal performance of the thermocycler enables an increase in speed and efficiency of the reaction chamber. The improvement is accomplished by providing grooves in the faces of the sleeve and a series of grooves on the interior surfaces that connect with grooves on the faces of the sleeve. The grooves can be anisotropically etched in the silicon sleeve simultaneously with formation of the chamber.
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公开(公告)号：US6056331A
公开(公告)日：2000-05-02
申请号：US711841
申请日：1996-09-12
申请人： William J. Benett , James A. Folta
发明人： William J. Benett , James A. Folta
CPC分类号： F16L19/02 , Y10S285/911 , Y10T29/49872
摘要： A method and apparatus for connecting a tube to a surface that creates a dead volume seal. The apparatus is composed of three components, a body, a ferrule, and a threaded fitting. The ferrule is compressed onto a tube and a seal is formed between the tube and a device retained in the body by threading the fitting into the body which provides pressure that seals the face of the ferrule to a mating surface on the device. This seal can be used at elevated temperatures depending on the materials used. While the invention has been developed for use with micro-machined silicon wafers used in Capillary Gas Chromatograph (GC), it can be utilized anywhere for making a gas or fluid face seal to the surface of a device that has near zero dead volume.
摘要翻译： 一种将管连接到产生死体积密封的表面的方法和装置。 该装置由三个部件组成，一个主体，一个套圈和一个螺纹接头。 套圈被压缩到管上，并且通过将配件穿入主体中而将管和保持在主体中的装置之间形成密封，该压力提供将套圈的表面密封到装置上的配合表面的压力。 根据所使用的材料，该密封可以在高温下使用。 虽然本发明已被开发用于毛细管气相色谱（GC）中使用的微加工硅晶片，但是其可用于在具有接近零死体积的器件的表面形成气体或流体表面密封件的任何地方。
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公开(公告)号：US5548605A
公开(公告)日：1996-08-20
申请号：US440595
申请日：1995-05-15
CPC分类号： H01S5/02423 , H01S5/4025
摘要： A silicon wafer has slots sawn in it that allow diode laser bars to be mounted in contact with the silicon. Microchannels are etched into the back of the wafer to provide cooling of the diode bars. To facilitate getting the channels close to the diode bars, the channels are rotated from an angle perpendicular to the diode bars which allows increased penetration between the mounted diode bars. This invention enables the fabrication of monolithic silicon microchannel heatsinks for laser diodes. The heatsinks have low thermal resistance because of the close proximity of the microchannels to the laser diode being cooled. This allows high average power operation of two-dimensional laser diode arrays that have a high density of laser diode bars and therefore high optical power density.
摘要翻译： 一个硅晶片上有一个锯槽，可以使二极管激光棒安装成与硅接触。 将微通道蚀刻到晶片的背面以提供二极管条的冷却。 为了使通道靠近二极管条，通道从垂直于二极管条的角度旋转，这允许在安装的二极管条之间增加穿透。 本发明能够制造用于激光二极管的单片硅微通道散热器。 由于微通道与被冷却的激光二极管的紧密接近，散热器具有低热阻。 这允许具有高密度激光二极管条并因此具有高光功率密度的二维激光二极管阵列的高平均功率操作。
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44.发明授权
公开(公告)号：US5105430A
公开(公告)日：1992-04-14
申请号：US682770
申请日：1991-04-09
IPC分类号： H01L23/473 , H01S5/00 , H01S5/024 , H01S5/40
CPC分类号： H01S5/02423 , H01S5/4031 , H01L2224/45144 , H01L2224/48091 , H01S5/02236 , H01S5/02272
摘要： A laser diode array is disclosed that includes a plurality of planar assemblies and active cooling of each assembly. The laser diode array may be operated in a long duty cycle, or in continuous operation. A laser diode bar and a microchannel heat sink are thermally coupled in a compact, thin planar assembly having the laser diode bar located proximate to one edge. In an array, a number of such thin planar assemblies are secured together in a stacked configuration, in close proximity so that the laser diodes are spaced closely. The cooling means includes a microchannel heat sink proximate to the laser diode bar to absorb heat generated by laser operation. To provide the coolant to the microchannels, each thin planar assembly comprises passageways that connect the microchannels to inlet and outlet corridors. Each inlet passageway may comprise a narrow slot that directs coolant into the microchannels and increases the velocity of flow therethrough. The corridors comprises holes extending through each of the assemblies in the array. The inlet and outlet corridors are connected to a conventional coolant circulation system. The laser diode array with active cooling has applications as an optical pump for high power solid state lasers, or by mating the diodes with fiber optic lenses. Further, the arrays can be useful in applications having space constraints and energy limitations, and in military and space applications. The arrays can be incorporated in equipment such as communications devices and active sensors.
摘要翻译： 公开了一种激光二极管阵列，其包括多个平面组件和每个组件的主动冷却。 激光二极管阵列可以在长占空比或连续操作中操作。 激光二极管条和微通道散热器热耦合在紧凑的薄平面组件中，其具有位于一个边缘附近的激光二极管条。 在阵列中，许多这样的薄平面组件以堆叠的形式紧密地固定在一起，使得激光二极管紧密地间隔开。 冷却装置包括靠近激光二极管条的微通道散热器，以吸收由激光操作产生的热量。 为了将冷却剂提供给微通道，每个薄平面组件包括将微通道连接到入口和出口走廊的通道。 每个入口通道可以包括狭窄的狭槽，其将冷却剂引导到微通道中并增加流过其中的流速。 走廊包括延伸穿过阵列中每个组件的孔。 入口和出口走廊连接到常规的冷却剂循环系统。 具有主动冷却的激光二极管阵列可用作高功率固体激光器的光泵，或通过将二极管与光纤透镜配合使用。 此外，阵列可以在具有空间限制和能量限制的应用中以及在军事和空间应用中是有用的。 阵列可以并入设备，如通信设备和有源传感器。
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公开(公告)号：US11975321B2
公开(公告)日：2024-05-07
申请号：US16367125
申请日：2019-03-27
CPC分类号： B01L3/502715 , G01N21/76 , B01L2200/10
摘要： A multi-channel optical detection system includes a base unit adapted to receive a multi-chamber assay cartridge having a plurality of reaction chambers loaded with a sample and an optical detection reagent, and an optical detection unit having a multi-channel optical block having a plurality of detection channels each with an associated light source, and an optic sensor. The optical detection unit is connectable to the base unit so that interrogation ports of the detection channels are optically aligned with optically transparent windows of the reaction chambers of a loaded cartridge, so that upon initialization, light sources are activated to interrogate reaction products in the reaction chambers and detect the optical responses therefrom.
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公开(公告)号：US07901623B2
公开(公告)日：2011-03-08
申请号：US11528286
申请日：2006-09-26
申请人： Robin R. Miles , William J. Benett , Matthew A. Coleman , Francesca S. Pearson , Shanavaz L. Nasarabadi
发明人： Robin R. Miles , William J. Benett , Matthew A. Coleman , Francesca S. Pearson , Shanavaz L. Nasarabadi
IPC分类号： G01N33/00
CPC分类号： G01N33/558
摘要： A lateral flow strip assay apparatus comprising a housing; a lateral flow strip in the housing, the lateral flow strip having a receiving portion; a sample collection unit; and a reagent reservoir. Saliva and/or buccal cells are collected from an individual using the sample collection unit. The sample collection unit is immersed in the reagent reservoir. The tip of the lateral flow strip is immersed in the reservoir and the reagent/sample mixture wicks up into the lateral flow strip to perform the assay.
摘要翻译： 一种侧流条测定装置，包括壳体; 所述外壳中的横向流动条，所述横向流动带具有接收部分; 样本收集单元; 和试剂储存器。 使用样品收集单元从个体收集唾液和/或颊细胞。 样品收集单元浸入试剂容器中。 横向流动条的尖端浸入储存器中，并将试剂/样品混合物吸入侧流条中以进行测定。
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公开(公告)号：US20100139368A1
公开(公告)日：2010-06-10
申请号：US12628952
申请日：2009-12-01
CPC分类号： G01N21/1702 , G01N33/0016 , G01N2021/1704
摘要： All-optical photoacoustic spectrometer sensing systems (PASS system) and methods include all the hardware needed to analyze the presence of a large variety of materials (solid, liquid and gas). Some of the all-optical PASS systems require only two optical-fibers to communicate with the opto-electronic power and readout systems that exist outside of the material environment. Methods for improving the signal-to-noise are provided and enable mirco-scale systems and methods for operating such systems.
摘要翻译： 全光学光声光谱仪传感系统（PASS系统）和方法包括分析各种材料（固体，液体和气体）的存在所需的所有硬件。 全光学PASS系统中的一些只需要两根光纤与存在于材料环境之外的光电和读出系统进行通信。 提供了改善信噪比的方法，并且实现了用于操作这种系统的微小规模系统和方法。
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公开(公告)号：US20080025871A1
公开(公告)日：2008-01-31
申请号：US11495952
申请日：2006-07-27
申请人： John M. Dzenitis , Benjamin J. Hindson , Anthony J. Makarewicz , William J. Benett , Aaron M. Mason , Paul B. Haigh
发明人： John M. Dzenitis , Benjamin J. Hindson , Anthony J. Makarewicz , William J. Benett , Aaron M. Mason , Paul B. Haigh
CPC分类号： B01F11/0022 , B01F11/0065 , B01F11/0071 , B01F11/0074 , B01F15/00831 , B01F15/0085 , G01N35/1002
摘要： A system for maintaining a liquid slurry of microbeads for use in biological or chemical analysis comprising providing a flexible bag and filling the flexible bag with a slurry of a liquid and microbeads. One embodiment is an apparatus for maintaining liquid slurries of particles for use in biological or chemical analysis comprising a bag, a liquid contained within the bag, and particles contained within the liquid in the bag.
摘要翻译： 一种用于维持用于生物或化学分析的微珠的液体浆料的系统，包括提供柔性袋，并用液体和微珠的浆液填充柔性袋。 一个实施方案是一种用于维持用于生物或化学分析的液体浆液的装置，其包括袋，包含在袋内的液体和包含在袋中的液体中的颗粒。
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公开(公告)号：US06893863B2
公开(公告)日：2005-05-17
申请号：US10260120
申请日：2002-09-27
CPC分类号： B01L7/52 , B01J19/0093 , B01J2219/00788 , B01J2219/0081 , B01J2219/00828 , B01J2219/00873 , B01J2219/00961 , B01L3/5027 , B01L2300/1827 , B01L2300/1838
摘要： A sleeve-type silicon polymerase chain reaction (PCR) chamber or thermocycler having improved thermal performance. The silicon sleeve reaction chamber is improved in thermal performance by etched features therein that reduce thermal mass and increase the surface area of the sleeve for cooling. This improved thermal performance of the thermocycler enables an increase in speed and efficiency of the reaction chamber. The improvement is accomplished by providing grooves in the faces of the sleeve and a series of grooves on the interior surfaces that connect with grooves on the faces of the sleeve. The grooves can be anisotropically etched in the silicon sleeve simultaneously with formation of the chamber.
摘要翻译： 具有改进的热性能的套筒型硅聚合酶链反应（PCR）室或热循环仪。 通过其中的蚀刻特征，硅套筒反应室的热性能得到改善，其降低热质量并增加用于冷却的套筒的表面积。 热循环仪的这种改进的热性能使得能够提高反应室的速度和效率。 通过在套筒的表面上设置凹槽和在内表面上与套筒表面上的凹槽连接的一系列凹槽来实现改进。 在形成腔室的同时，可以在硅套管中各向异性地蚀刻凹槽。
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公开(公告)号：US06746503B1
公开(公告)日：2004-06-08
申请号：US10355785
申请日：2003-01-30
IPC分类号： B01D4504
CPC分类号： B01D45/08 , Y10S55/05 , Y10S264/48
摘要： A system for separating particles entrained in a fluid includes a base with a first channel and a second channel. A precision gap connects the first channel and the second channel. The precision gap is of a size that allows small particles to pass from the first channel into the second channel and prevents large particles from the first channel into the second channel. A cover is positioned over the base unit, the first channel, the precision gap, and the second channel. An port directs the fluid containing the entrained particles into the first channel. An output port directs the large particles out of the first channel. A port connected to the second channel directs the small particles out of the second channel.
摘要翻译： 用于分离夹带在流体中的颗粒的系统包括具有第一通道和第二通道的底座。 精密间隙连接第一通道和第二通道。 精密间隙具有允许小颗粒从第一通道进入第二通道并防止大颗粒从第一通道进入第二通道的尺寸。 盖子位于基座单元上，第一通道，精密间隙和第二通道上。 端口将含有夹带的颗粒的流体引导到第一通道中。 输出端口将大颗粒引导出第一个通道。 连接到第二通道的端口将小颗粒引导出第二通道。
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