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58 条记录 (耗时 0.03 秒)

    Laser and acoustic lens for lithotripsy
    5.
    发明授权
    Laser and acoustic lens for lithotripsy 失效
    激光和声透镜用于碎石术

    公开(公告)号：US06491685B2

    公开(公告)日：2002-12-10

    申请号：US09516999

    申请日：2000-03-01

    申请人： Steven R. Visuri ,  Anthony J. Makarewicz ,  Richard A. London ,  William J. Benett ,  Peter Krulevitch ,  Luiz B. Da Silva

    发明人： Steven R. Visuri ,  Anthony J. Makarewicz ,  Richard A. London ,  William J. Benett ,  Peter Krulevitch ,  Luiz B. Da Silva

    IPC分类号： A61B1722

    CPC分类号： A61B18/26 ,  A61B2018/263

    摘要： An acoustic focusing device whose acoustic waves are generated by laser radiation through an optical fiber. The acoustic energy is capable of efficient destruction of renal and biliary calculi and deliverable to the site of the calculi via an endoscopic procedure. The device includes a transducer tip attached to the distal end of an optical fiber through which laser energy is directed. The transducer tip encapsulates an exogenous absorbing dye. Under proper irradiation conditions (high absorbed energy density, short pulse duration) a stress wave is produced via thermoelastic expansion of the absorber for the destruction of the calculi. The transducer tip can be configured into an acoustic lens such that the transmitted acoustic wave is shaped or focused. Also, compressive stress waves can be reflected off a high density/low density interface to invert the compressive wave into a tensile stress wave, and tensile stresses may be more effective in some instances in disrupting material as most materials are weaker in tension than compression. Estimations indicate that stress amplitudes provided by this device can be magnified more than 100 times, greatly improving the efficiency of optical energy for targeted material destruction.

    摘要翻译： 声波聚焦装置，其声波通过激光辐射通过光纤产生。 声能能够有效地破坏肾脏和胆汁结石，并可通过内窥镜手术递送至结石部位。 该装置包括附接到光纤的远端的换能器尖端，通过激光能量被引导。 换能器尖端封装外源吸收染料。 在适当的照射条件（高吸收能量密度，短脉冲持续时间）下，通过吸收器的热弹性膨胀产生应力波，以破坏结石。 换能器尖端可以被配置成声透镜，使得发射的声波成形或聚焦。 此外，压应力波可以从高密度/低密度界面反射，以将压缩波反转成拉伸应力波，并且拉伸应力在某些情况下在破坏材料中可能更有效，因为大多数材料的张力比压缩弱。 估计表明，该装置提供的应力幅度可以放大100倍以上，大大提高了光能量对目标材料的破坏效率。

    Thermal Cycler
    6.
    发明申请
    Thermal Cycler 审中-公开
    热循环仪

    公开(公告)号：US20090209030A1

    公开(公告)日：2009-08-20

    申请号：US12415623

    申请日：2009-03-31

    申请人： William J. Benett ,  James B. Richards ,  Paul L. Stratton ,  Elizabeth K. Wheeler ,  Peter Krulevitch ,  Steve Visuri ,  John M. Dzenitis

    发明人： William J. Benett ,  James B. Richards ,  Paul L. Stratton ,  Elizabeth K. Wheeler ,  Peter Krulevitch ,  Steve Visuri ,  John M. Dzenitis

    IPC分类号： C12M1/02 ,  H05K3/00

    CPC分类号： B01L7/52 ,  B01L3/5082 ,  B01L2200/12 ,  B01L2300/123 ,  B01L2300/1827 ,  B01L2300/1844 ,  Y10T29/49124

    摘要： A thermalcycler is constructing with a first thermalcycler body section of a flexible circuit material or a circuit board material. The first thermalcycler body section has a first face. A first cavity portion is formed in the first face. A second thermalcycler body section is constructed of a flexible circuit material or a circuit board material. The second thermalcycler body section has a second face. A second cavity portion is formed in the second face. When the first cavity portion and the second cavity portion are positioned together they form a cavity. A thermalcycler unit is positioned in the cavity. The first thermalcycler body section and the second thermalcycler body section are connected together with the first face and the face opposed to each other and the thermalcycler unit operatively connected to the first cavity portion and the second cavity portion.

    摘要翻译： 热循环器正在构造具有柔性电路材料或电路板材料的第一热循环体主体部分。 第一热循环体主体部分具有第一面。 第一空腔部分形成在第一面中。 第二个热循环器主体部分由柔性电路材料或电路板材料构成。 第二热循环器本体部分具有第二面。 第二空腔部分形成在第二面中。 当第一空腔部分和第二空腔部分位于一起时，它们形成空腔。 热循环器单元位于空腔中。 第一热循环器主体部分和第二热循环器主体部分与第一面和彼此相对的面连接在一起，并且热循环器单元可操作地连接到第一腔部分和第二腔部分。

    Methods and compositions for rapid thermal cycling
    7.
    发明授权
    Methods and compositions for rapid thermal cycling 有权
    快速热循环的方法和组成

    公开(公告)号：US09170028B1

    公开(公告)日：2015-10-27

    申请号：US13267767

    申请日：2011-10-06

    申请人： Neil Reginald Beer ,  William J. Benett ,  James M. Frank ,  Joshua R. Deotte ,  Christopher Spadaccini

    发明人： Neil Reginald Beer ,  William J. Benett ,  James M. Frank ,  Joshua R. Deotte ,  Christopher Spadaccini

    IPC分类号： F24H1/00 ,  F24H1/10 ,  H05B3/78

    CPC分类号： F24H1/00 ,  B01L7/52 ,  B01L7/54 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2300/1822 ,  B01L2300/1827 ,  C12M29/00 ,  C12M41/12 ,  C12M41/18 ,  C12M41/48 ,  F24H1/10

    摘要： The rapid thermal cycling of a material is targeted. A microfluidic heat exchanger with an internal porous medium is coupled to tanks containing cold fluid and hot fluid. Fluid flows alternately from the cold tank and the hot tank into the porous medium, cooling and heating samples contained in the microfluidic heat exchanger's sample wells. A valve may be coupled to the tanks and a pump, and switching the position of the valve may switch the source and direction of fluid flowing through the porous medium. A controller may control the switching of valve positions based on the temperature of the samples and determined temperature thresholds. A sample tray for containing samples to be thermally cycled may be used in conjunction with the thermal cycling system. A surface or internal electrical heater may aid in heating the samples, or may replace the necessity for the hot tank.

    摘要翻译： 材料的快速热循环是目标。 具有内部多孔介质的微流体热交换器耦合到容纳冷流体和热流体的罐。 流体从冷箱和热罐交替地流入多孔介质，冷却和加热微流体换热器样品孔中包含的样品。 阀可以联接到罐和泵，并且切换阀的位置可以切换流过多孔介质的流体的源和方向。 控制器可以基于样品的温度和确定的温度阈值来控制阀位置的切换。 用于包含热循环样品的样品盘可以与热循环系统一起使用。 表面或内部电加热器可能有助于加热样品，也可能取代热水箱的必要性。