公开(公告)号：US12062457B2

公开(公告)日：2024-08-13

申请号：US17359479

申请日：2021-06-25

Applicant: Meso Scale Technologies, LLC.

Inventor： Jacob N. Wohlstadter ,  Michael Vock ,  Charles M. Clinton ,  George Sigal

IPC: G16H50/80 ,  G01N21/76 ,  G06Q50/40 ,  G16H10/40 ,  G16H40/20 ,  G16H40/67 ,  G16H50/20

CPC classification number: G16H50/80 ,  G01N21/76 ,  G06Q50/40 ,  G16H10/40 ,  G16H40/20 ,  G16H40/67 ,  G16H50/20

Abstract: Provided herein are systems, methods, and apparatuses for providing a real-time global bio-surveillance and response solution. The systems and apparatuses may include one or more sentinel subsystems and one or more surge subsystems that each include a real-time, cloud-based, distributed, interconnected set of hardware, software, and/or firmware for comprehensive surveillance, complete detection, and immediate response various to biological, chemical, and/or bio-chemical anomalies, for example, a new or emerging pathogen or other health condition.

公开(公告)号：US11940385B2

公开(公告)日：2024-03-26

申请号：US16270062

申请日：2019-02-07

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Charles M. Clinton ,  Eli N. Glezer ,  Sharon West ,  George Sigal ,  Carl Stevens ,  Michael L. Vock

IPC: G01N35/00 ,  G01N21/69 ,  G01N21/76 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

CPC classification number: G01N21/76 ,  G01N21/69 ,  G01N35/0092 ,  G01N35/028 ,  G01N2035/00524 ,  G01N2035/0425 ,  G01N35/1079 ,  Y10T436/114165

Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

公开(公告)号：US20230358764A1

公开(公告)日：2023-11-09

申请号：US18118432

申请日：2023-03-07

Applicant: Meso Scale Technologies, LLC.

Inventor： George Sigal

IPC: G01N33/576 ,  G01N33/68

CPC classification number: G01N33/6893 ,  G01N33/576 ,  G01N2800/085 ,  Y02A50/30

Abstract: The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or regimen. The invention also relates to assay kits used in connection with the diagnostic methods described herein.

公开(公告)号：US11600373B2

公开(公告)日：2023-03-07

申请号：US16555271

申请日：2019-08-29

Applicant: MESO SCALE TECHNOLOGIES, LLC ,  THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

Inventor： William F. Blakely ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Anu Mathew ,  Natalia I. Ossetrova ,  George Sigal

IPC: G01N33/566 ,  G01N33/569 ,  G01N33/68 ,  G16H20/40 ,  G01T1/02 ,  G01T1/00 ,  G01N27/327 ,  G01N35/00

Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

公开(公告)号：US11525825B2

公开(公告)日：2022-12-13

申请号：US16564208

申请日：2019-09-09

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  George Sigal ,  Martin Stengelin ,  David Routenberg

IPC: C12Q1/6832 ,  C12Q1/6837 ,  C12Q1/6844 ,  G01N33/543

Abstract: The present invention is directed to kits for improving assay specificity and performance in binding assays.

公开(公告)号：US20220252590A1

公开(公告)日：2022-08-11

申请号：US17553441

申请日：2021-12-16

Applicant: Meso Scale Technologies, LLC.

Inventor： Sudeep Kumar ,  George Sigal ,  Michael Tsionsky

IPC: G01N33/543 ,  G01N33/53 ,  C12Q1/6823 ,  C12Q1/6832 ,  C12Q1/6834

Abstract: The invention relates to methods for conducting binding assays in an assay device that includes one or more storage and use zone. The storage zones of the assay device are configured to house one or more reagents used in an assay conducted in the use zone of the device.

公开(公告)号：US20220196638A1

公开(公告)日：2022-06-23

申请号：US17563249

申请日：2021-12-28

Applicant: Meso Scale Technologies, LLC.

Inventor： Ian Chamberlin ,  Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Manish Kochar ,  Sandor Kovacs ,  DT Le ,  Aaron Leimkuehler ,  Greg Pinckney ,  Kristian Roth ,  George Sigal ,  Fei Yin

IPC: G01N33/53 ,  B01L3/00 ,  G01N21/64 ,  G01N33/543 ,  G01N33/569

Abstract: We describe apparatuses, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of liquid samples in a clinical point of care setting.

公开(公告)号：US11300571B2

公开(公告)日：2022-04-12

申请号：US16420724

申请日：2019-05-23

Applicant: Meso Scale Technologies, LLC

Inventor： Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Sandor L. Kovacs ,  Sudeep M. Kumar ,  George Sigal ,  Carl Stevens ,  Michael Vock

IPC: B01L3/00 ,  G01N35/02 ,  G01N33/58 ,  B67B7/00 ,  G01N35/10 ,  G01N21/64 ,  G01N21/66 ,  G01N33/53 ,  G01N35/04

Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

公开(公告)号：US20210402390A1

公开(公告)日：2021-12-30

申请号：US17476880

申请日：2021-09-16

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Sudeep Kumar ,  Pankaj Oberoi ,  George Sigal ,  Michael Tsionsky

IPC: B01L3/00 ,  C12Q1/6876 ,  G01N33/543 ,  C12Q1/6816 ,  C12Q1/6804 ,  G01N33/68

Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

公开(公告)号：US11059046B2

公开(公告)日：2021-07-13

申请号：US16227081

申请日：2018-12-20

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Sudeep Kumar ,  Pankaj Oberoi ,  George Sigal ,  Michael Tsionsky

IPC: C12Q1/6804 ,  G01N33/68 ,  G01N33/543 ,  C12Q1/6816 ,  C12Q1/6876 ,  B01L3/00

Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.