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    Ordered molecular presentation of antigens, method of preparation and use
    42.
    发明授权
    Ordered molecular presentation of antigens, method of preparation and use 失效
    有序分子表达的抗原，制备和使用方法

    公开(公告)号：US07229624B2

    公开(公告)日：2007-06-12

    申请号：US10733582

    申请日：2003-12-12

    Applicant: Wolfgang A. Renner ,  Frank Hennecke ,  Lars Nieba ,  Martin Bachmann

    Inventor： Wolfgang A. Renner ,  Frank Hennecke ,  Lars Nieba ,  Martin Bachmann

    IPC: A61K39/385

    CPC classification number: A61K39/00 ,  A61K2039/5256 ,  A61K2039/5258

    Abstract: The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the production of vaccines for the prevention of infectious diseases, the treatment of allergies and the treatment of cancers. Various embodiments of the invention provide for a virus, virus-like particle, viral capsid particle, phage or recombinant form thereof coated with any desired antigen in a highly ordered and repetitive fashion as the result of specific interactions. In one specific embodiment, a versatile new technology based on a cassette-type system (AlphaVaccine Technology) allows production of antigen coated viral particles. Other specific embodiments allow the production of antigen coated hepatitis B virus-like particles or antigen coated Measles virus-like particles.

    Abstract translation: 本发明提供用于产生有序和重复抗原或抗原决定簇的组合物和方法。 本发明的组合物可用于生产用于预防感染性疾病，过敏症的治疗和癌症治疗的疫苗。 作为特定相互作用的结果，本发明的各种实施方案提供以高度有序和重复的方式包被任何所需抗原的病毒，病毒样颗粒，病毒衣壳颗粒，噬菌体或重组形式。 在一个具体实施方案中，基于盒式系统（AlphaVaccine Technology）的多功能新技术允许产生抗原包被的病毒颗粒。 其他具体实施方案允许产生抗原包被的乙型肝炎病毒样颗粒或抗原包被的麻疹病毒样颗粒。

    Methods and compositions for modulating the interaction between adiponectin and its receptor
    44.
    发明申请
    Methods and compositions for modulating the interaction between adiponectin and its receptor 审中-公开
    调节脂联素及其受体之间相互作用的方法和组合物

    公开(公告)号：US20060286035A1

    公开(公告)日：2006-12-21

    申请号：US10555058

    申请日：2004-04-28

    Applicant: Philippe Saudan ,  Martin Bachmann

    Inventor： Philippe Saudan ,  Martin Bachmann

    IPC: A61K49/00 ,  A61K38/17 ,  C07K14/705 ,  C07H21/04 ,  C12P21/06 ,  A61K39/395

    CPC classification number: G01N33/566 ,  A61K38/00 ,  A61K38/2264 ,  A61K49/0004 ,  C07K14/47 ,  C07K14/705 ,  C07K16/28 ,  C07K2319/43 ,  G01N2333/705 ,  A61K2300/00

    Abstract: The invention is directed to methods for identifying agents that mimic or modulate the interaction between adiponectin and its receptor. In particular, the invention is directed to methods for mimicking or modulating the adiponectin-T-cadherin interaction in order to treat diseases and disorders associated with a deficiency or overabundance of adiponectin. Such diseases include, e.g., obesity, anorexia nervosa, type I and type II diabetes, coronary artery disease and atherosclerosis. The invention also provides isolated adiponectin-T-cadherin complexes and methods for identifying polypeptides that interact with adiponectin.

    Abstract translation: 本发明涉及用于鉴定模拟或调节脂联素及其受体之间相互作用的试剂的方法。 特别地，本发明涉及用于模拟或调节脂连蛋白-T-钙粘蛋白相互作用以便治疗与脂联素缺乏或过量相关的疾病和病症的方法。 这些疾病包括例如肥胖症，神经性厌食症，I型和II型糖尿病，冠状动脉疾病和动脉粥样硬化。 本发明还提供分离的脂联素-T-钙粘蛋白复合物和用于鉴定与脂连蛋白相互作用的多肽的方法。

    Gastric inhibitory polypeptide (GIP) antigen arrays and uses thereof
    46.
    发明申请
    Gastric inhibitory polypeptide (GIP) antigen arrays and uses thereof 失效
    胃抑制多肽（GIP）抗原阵列及其用途

    公开(公告)号：US20060088550A1

    公开(公告)日：2006-04-27

    申请号：US11257498

    申请日：2005-10-25

    Applicant: Martin Bachmann ,  Alma Fulurija ,  Philippe Saudan

    Inventor： Martin Bachmann ,  Alma Fulurija ,  Philippe Saudan

    IPC: A61K39/12 ,  A61K31/4439 ,  C12N7/00

    CPC classification number: C07K16/26 ,  A61K39/00 ,  A61K47/646 ,  A61K47/6901 ,  A61K2039/5258 ,  A61K2039/6075 ,  A61K2039/64 ,  C07K14/005 ,  C07K2317/34 ,  C12N7/00 ,  C12N2730/10122 ,  C12N2730/10123

    Abstract: The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The present invention provides, inter alia, a composition comprising a virus-like particle (VLP) and at least one antigen, wherein said antigen is a GIP protein or a GIP fragment linked to the VLP respectively. The invention also provides a method for producing the aforesaid composition. The compositions of this invention are useful in the production of vaccines, in particular, for the prevention and/or treatment of obesity and hereby, in particular, by inducing efficient immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context. Accordingly, the invention further provides for methods of treating and/or preventing obesity and other conditions.

    Abstract translation: 本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。 本发明尤其提供包含病毒样颗粒（VLP）和至少一种抗原的组合物，其中所述抗原是分别与VLP连接的GIP蛋白或GIP片段。 本发明还提供了一种制备上述组合物的方法。 本发明的组合物可用于疫苗的制备，特别是用于预防和/或治疗肥胖症，特别是通过诱导有效的免疫应答，特别是抗体应答。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。 因此，本发明还提供了治疗和/或预防肥胖症和其他病症的方法。

    Ghrelin-carrier conjugates
    47.
    发明申请
    Ghrelin-carrier conjugates 审中-公开
    生长素释放肽 - 载体缀合物

    公开(公告)号：US20050191317A1

    公开(公告)日：2005-09-01

    申请号：US11037396

    申请日：2005-01-19

    Applicant: Martin Bachmann ,  Alma Fulurija

    Inventor： Martin Bachmann ,  Alma Fulurija

    IPC: A61K39/00 ,  A61K39/12 ,  A61K47/48 ,  C12N7/00 ,  C12N15/86 ,  C12N15/861

    CPC classification number: B82Y5/00 ,  A01K2267/0325 ,  A61K39/0007 ,  A61K47/6901 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/6075 ,  C12N2730/10123

    Abstract: The present invention provides ordered and repetitive antigen arrays comprising, inter alia, compositions comprising a virus-like particle (VLP) to which is linked at least one antigen, wherein said antigen is grehlin or peptides or fragments thereof. The invention also provides methods for producing the aforesaid compositions. The compositions and methods of the invention are useful in the production of vaccines and to efficiently induce self-specific immune responses, in particular antibody responses. The invention also provides for compositions and methods for the prevention and/or treatment of ghrelin-related conditions, disorders or diseases. For example, the compositions of the invention are useful in the production of vaccines for the prevention or treatment of obesity and other disease associated with increased food-uptake or increased body weight.

    Abstract translation: 本发明提供了有序的和重复的抗原阵列，其特别包括包含连接至少一种抗原的病毒样颗粒（VLP）的组合物，其中所述抗原是绿色肽或肽或其片段。 本发明还提供了制备上述组合物的方法。 本发明的组合物和方法可用于疫苗的生产和有效诱导自身特异性免疫应答，特别是抗体应答。 本发明还提供了用于预防和/或治疗生长素释放肽相关病症，疾病或疾病的组合物和方法。 例如，本发明的组合物可用于生产用于预防或治疗与增加的食物吸收或增加的体重相关的肥胖症和其它疾病的疫苗。

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