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    Melan-a peptide analogue-virus-like-particle conjugates
    2.
    发明申请
    Melan-a peptide analogue-virus-like-particle conjugates 失效
    黑色素类似物 - 类似物 - 类似物 - 颗粒的共轭物

    公开(公告)号：US20060204475A1

    公开(公告)日：2006-09-14

    申请号：US10551054

    申请日：2004-03-25

    申请人： Martin Bachmann ,  Vania Manolova ,  Edwin Meijerink ,  Karl Proba ,  Katrin Schwarz

    发明人： Martin Bachmann ,  Vania Manolova ,  Edwin Meijerink ,  Karl Proba ,  Katrin Schwarz

    IPC分类号： A61K48/00 ,  C12N15/86

    CPC分类号： A61K39/39 ,  A61K2039/5258 ,  A61K2039/55561 ,  A61K2039/6075 ,  A61K2039/62 ,  A61K2039/64 ,  C07K14/005 ,  C07K14/4748 ,  C12N2710/22022 ,  C12N2730/10122 ,  C12N2730/10123 ,  C12N2760/10022 ,  Y02A50/467

    摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a modified virus-like particle (VLP) comprising a VLP which can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs), and particular peptides derived from MelanA linked thereto. Such CpGVLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against MelanA peptide analogues optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against the MelanA peptide analogues are especially directed to the Thl type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.

    摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供了包含VLP的修饰病毒样颗粒（VLP），其可加载免疫刺激物质，特别是含有非甲基化C和G（CpG）的DNA寡核苷酸，以及衍生自与其连接的MelanA的特定肽。 这样的CpGVLP比其不含CpG的对应物显着地更具免疫原性，并且诱导增强的B和T细胞应答。 与VLP本身的免疫应答相似，对于任何偶联，融合或附着于VLP的MelanA肽类似物的免疫应答也相似地增强。 此外，针对MelanA肽类似物的T细胞应答特别针对Th1型。 因此，连接到CpG负载的VLP的抗原可能是针对过敏，肿瘤和其他自身分子和慢性病毒性疾病的预防性或治疗性接种疫苗的理想疫苗。

    Vlp-Antigen Conjugates and Their Uses as Vaccines
    5.
    发明申请
    Vlp-Antigen Conjugates and Their Uses as Vaccines 失效
    Vlp抗原结合物及其用途作为疫苗

    公开(公告)号：US20080095738A1

    公开(公告)日：2008-04-24

    申请号：US11664716

    申请日：2005-10-05

    申请人： Martin Bachmann ,  Patrik Maurer ,  Edwin Meijerink ,  Katrin Schwarz ,  Karl Proba

    发明人： Martin Bachmann ,  Patrik Maurer ,  Edwin Meijerink ,  Katrin Schwarz ,  Karl Proba

    IPC分类号： A61K39/39 ,  A61K39/00 ,  A61P29/00 ,  A61P37/00 ,  A61K39/385

    CPC分类号： A61K39/0013 ,  A61K39/0005 ,  A61K39/0006 ,  A61K39/0011 ,  A61K39/39 ,  A61K2039/5258 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/55583 ,  A61K2039/57 ,  A61K2039/6075 ,  C12N2740/16211 ,  C12N2795/18123

    摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising a virus-like particle (VLP) of an RNA-bacteriophage and at least one antigen, wherein the VLP is recombinantly produced in a host, and wherein the amount of host RNA with secondary structure comprised by the VLP is at most 20% of the amount of host RNA with secondary structure originally comprised by the VLP; and wherein the VLP and the at least one antigen are linked with one another. The invention also provides methods for producing the compositions of the invention. The compositions of the invention are useful in the production of vaccines for the treatment of diseases, disorders and conditions. Furthermore, the compositions of the invention are particularly useful to efficiently induce strong antibody responses against the antigen within the indicated context while lowering or eliminating unwanted T cell responses.

    摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供了包含RNA噬菌体的病毒样颗粒（VLP）和至少一种抗原的组合物，其中VLP在宿主中重组产生，并且其中由VLP包含的具有二级结构的宿主RNA的量为 最多20％的具有二级结构的宿主RNA的量最初由VLP组成; 并且其中所述VLP和所述至少一种抗原彼此连接。 本发明还提供了制备本发明组合物的方法。 本发明的组合物可用于生产用于治疗疾病，病症和病症的疫苗。 此外，本发明的组合物特别可用于在降低或消除不想要的T细胞应答的同时在指定的上下文中有效地诱导针对抗原的强抗体应答。

    Cpg-packaged liposomes
    6.
    发明申请
    Cpg-packaged liposomes 审中-公开
    Cpg包装的脂质体

    公开(公告)号：US20060182793A1

    公开(公告)日：2006-08-17

    申请号：US10565264

    申请日：2004-07-22

    申请人： Martin Bachmann ,  Vania Manolova ,  Tazio Storni

    发明人： Martin Bachmann ,  Vania Manolova ,  Tazio Storni

    IPC分类号： A61K48/00 ,  A61K9/127

    CPC分类号： A61K39/39 ,  A61K9/127 ,  A61K2039/55555 ,  A61K2039/55561 ,  Y02A50/412

    摘要： Liposomes are known to enhance the activity of K- (B-) type CpGs which trigger the production of IL-12. In the present invention, the surprising finding was made that liposomes also enhance the activity of D- (A-) type CpGs, leading to the production of IFNα in vivo. These findings are relevant for the humans situation, since IFNα rather than IL-12 is the key cytokine for the induction of Th1 responses and anti-viral protection in humans.

    摘要翻译： 已知脂质体可增强触发IL-12产生的K-（B-）型CpG的活性。 在本发明中，令人惊奇的发现是，脂质体还增强D-（A-）型CpG的活性，导致体内IFNα的产生。 这些发现与人类情况相关，因为IFNalpha而不是IL-12是人类Th1应答诱导和抗病毒保护的关键细胞因子。

    Interleukin-1 Conjugates and Uses Thereof
    10.
    发明申请
    Interleukin-1 Conjugates and Uses Thereof 审中-公开
    白细胞介素-1共轭体及其用途

    公开(公告)号：US20110027220A1

    公开(公告)日：2011-02-03

    申请号：US11992731

    申请日：2006-09-28

    申请人： Martin Bachmann ,  Gunther Spohn ,  Alain Tissot

    发明人： Martin Bachmann ,  Gunther Spohn ,  Alain Tissot

    IPC分类号： A61K39/00 ,  C07K14/54 ,  A61P25/00 ,  A61P19/00 ,  A61P19/06 ,  A61P9/10 ,  A61P37/08 ,  A61P29/00

    CPC分类号： C07K14/545 ,  A61K38/00 ,  A61K2039/5258 ,  A61K2039/6075 ,  C07K14/005 ,  C07K2319/00 ,  C12N7/00 ,  C12N2795/18122 ,  C12N2795/18123

    摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-1 protein, an IL-1 mutein or an IL-1 fragment. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL-1 protein, IL-1 mutein or at least one IL-1 fragment linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory diseases, and chronic autoimmune diseases, genetic diseases and cardiovascular diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

    摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供了包含有序重复抗原阵列的组合物，其中抗原是IL-1蛋白，IL-1突变蛋白或IL-1片段。 更具体地，本发明提供了包含病毒样颗粒和至少一种IL-1蛋白，IL-1突变蛋白或与其连接的至少一个IL-1片段的组合物。 本发明还提供了一种制备该组合物的方法。 本发明的组合物可用于生产用于治疗炎性疾病，慢性自身免疫性疾病，遗传性疾病和心血管疾病的疫苗。 本发明的组合物有效诱导免疫应答，特别是抗体应答。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。