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公开(公告)号：US06242249B1
公开(公告)日：2001-06-05
申请号：US09414664
申请日：1999-10-07
申请人： Martin Karl Russel Burnham , Andrew Fosberry , John Edward Hodgson , Deborah Dee Jaworski , Elizabeth J Lawlor , Martin Rosenberg , Christopher Michael Traini , Min Wang , Judith Ward , Richard Warren
发明人： Martin Karl Russel Burnham , Andrew Fosberry , John Edward Hodgson , Deborah Dee Jaworski , Elizabeth J Lawlor , Martin Rosenberg , Christopher Michael Traini , Min Wang , Judith Ward , Richard Warren
IPC分类号： C07H2104
CPC分类号： C07K14/31 , A61K38/00 , A61K39/00 , A61K2039/51 , C12N9/90
摘要： The invention provides tig polypeptides and polynucleotides encoding tig polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tig polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了tig多肽和编码tig多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用tig多肽筛选抗菌化合物的方法。
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公开(公告)号：US06228617B1
公开(公告)日：2001-05-08
申请号：US09464483
申请日：1999-12-15
申请人： Martin Karl Russel Burnham , Andrew Fosberry , John Edward Hodgson , Deborah Dee Jaworski , Elizabeth J Lawlor , Martin Rosenberg , Christopher Michael Traini , Min Wang , Judith Ward , Richard Warren
发明人： Martin Karl Russel Burnham , Andrew Fosberry , John Edward Hodgson , Deborah Dee Jaworski , Elizabeth J Lawlor , Martin Rosenberg , Christopher Michael Traini , Min Wang , Judith Ward , Richard Warren
IPC分类号： C12P2106
CPC分类号： C07K14/31 , A61K38/00 , A61K39/00 , A61K2039/51 , C12N9/90
摘要： The invention provides tig polypeptides and polynucleotides encoding tig polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tig polypeptides to screen for antibacterial compounds.
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公开(公告)号：US07250285B2
公开(公告)日：2007-07-31
申请号：US11403784
申请日：2006-04-13
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , Martin Karl Russel Burnham
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , Martin Karl Russel Burnham
CPC分类号： C12N9/1077 , A61K38/00 , A61K39/00 , C07K14/3156 , C07K2319/00 , C12N9/1205 , C12N9/78 , C12N9/80 , C12Y207/01002
摘要： The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了编码这种多肽的新型多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用这些多肽筛选抗菌化合物的方法。
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44.发明授权公开(公告)号：US06346392B1
公开(公告)日：2002-02-12
申请号：US08919573
申请日：1997-07-10
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Martin Karl Russel Burnham , Robert H Reid, Jr. , Phillip N Zarfos
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Martin Karl Russel Burnham , Robert H Reid, Jr. , Phillip N Zarfos
IPC分类号： C12N1531
CPC分类号： G01N33/68 , A61K38/00 , A61K39/00 , C07K14/3156 , C07K2319/00 , G01N2333/315
摘要： The invention provides Glutamine Transport ATP-Binding Protein polypeptides and DNA (RNA) encoding Glutamine Transport ATP-Binding Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Glutamine Transport ATP-Binding Protein polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供谷氨酰胺转运ATP结合蛋白多肽和编码谷氨酰胺转运ATP结合蛋白多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还提供了利用谷氨酰胺转运ATP结合蛋白多肽筛选抗菌化合物的方法。
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公开(公告)号：US6025175A
公开(公告)日：2000-02-15
申请号：US110910
申请日：1998-07-06
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , Martin Karl Russel Burnham
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , Martin Karl Russel Burnham
IPC分类号： A61K38/00 , A61K39/00 , C07K14/315 , C12N1/21 , C12N9/12 , C12N9/78 , C12N15/54 , C07K16/00 , C12N15/00 , C12Q1/68
CPC分类号： C12N9/1205 , C07K14/3156 , C12N9/78 , C12Y207/01002 , A61K38/00 , A61K39/00
摘要： The invention provides Glucose Kinase polypeptides and DNA (RNA) encoding Glucose Kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Glucose Kinase polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了葡萄糖激酶多肽和编码葡萄糖激酶多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。 还提供了利用葡萄糖激酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US6121414A
公开(公告)日：2000-09-19
申请号：US185825
申请日：1998-11-04
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , David J Holmes
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , David J Holmes
IPC分类号： G01N33/50 , A61K31/70 , A61K35/76 , A61K38/00 , A61K38/43 , A61K39/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P11/00 , A61P27/16 , A61P29/00 , A61P31/04 , A61P43/00 , C07K14/315 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/12 , C12N9/78 , C12N9/90 , C12N15/00 , C12N15/09 , C12N15/61 , C12P21/02 , C12Q1/68 , C12R1/19 , C12R1/46 , G01N33/15 , G01N33/566 , G01N33/569 , G01N33/68 , C07K14/00
CPC分类号： C07K14/3156 , C12N9/1205 , C12N9/78 , C12N9/90 , C12Y207/01002 , A61K2039/51 , A61K38/00 , A61K39/00
摘要： The invention provides pcrA polypeptides and DNA (RNA) encoding pcrA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pcrA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了pcrA多肽和编码pcrA多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用pcrA多肽筛选抗菌化合物的方法。
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公开(公告)号：US5840560A
公开(公告)日：1998-11-24
申请号：US896083
申请日：1997-07-17
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O. Nicholas , Robert King Stodola , Martin Karl Russel Burnham
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O. Nicholas , Robert King Stodola , Martin Karl Russel Burnham
IPC分类号： A61K38/00 , A61K39/00 , C07K14/315 , C12N1/21 , C12N9/12 , C12N9/78 , C12N15/54 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C12N9/1205 , C07K14/3156 , C12N9/78 , C12Y207/01002 , A61K38/00 , A61K39/00
摘要： The invention provides Glucose Kinase polypeptides and DNA (RNA) encoding Glucose Kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Glucose Kinase polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了葡萄糖激酶多肽和编码葡萄糖激酶多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。 还提供了利用葡萄糖激酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US06310193B1
公开(公告)日：2001-10-30
申请号：US08940572
申请日：1997-09-30
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , Nicola Gail Wallis
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , Nicola Gail Wallis
IPC分类号： C07H2104
CPC分类号： C12N9/1205 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K14/3156 , C12N9/78 , C12N9/90 , C12Y207/01002
摘要： The invention provides MurC polypeptides and DNA (RNA) encoding MurC polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurC polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供MurC多肽和编码MurC多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用MurC多肽筛选抗菌化合物的方法。
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公开(公告)号：US6165989A
公开(公告)日：2000-12-26
申请号：US935307
申请日：1997-09-22
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Martin Karl Russel Burnham , Robert H Reid, Jr. , Robert King Stodola , Phillip N Zarfos
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Martin Karl Russel Burnham , Robert H Reid, Jr. , Robert King Stodola , Phillip N Zarfos
IPC分类号： C12N15/09 , A61K31/00 , A61K31/70 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K38/43 , A61K39/09 , A61K39/395 , A61K48/00 , A61P9/00 , A61P11/00 , A61P27/00 , A61P27/02 , A61P27/16 , A61P31/00 , A61P31/04 , C07K14/315 , C12N1/21 , C12N9/16 , C12N15/00 , C12N15/31 , C12N15/55 , C12P21/02 , C12R1/46 , G01N33/15 , G01N33/566 , C07H21/00 , C12N15/63
CPC分类号： C07K14/3156 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N9/16
摘要： The invention provides era polypeptides and DNA (RNA) encoding era polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing era polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了编码时代多肽的时代多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用时代多肽筛选抗菌化合物的方法。
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公开(公告)号：US5858718A
公开(公告)日：1999-01-12
申请号：US889711
申请日：1997-07-08
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , David J. Holmes
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , David J. Holmes
IPC分类号： G01N33/50 , A61K31/70 , A61K35/76 , A61K38/00 , A61K38/43 , A61K39/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P11/00 , A61P27/16 , A61P29/00 , A61P31/04 , A61P43/00 , C07K14/315 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/12 , C12N9/78 , C12N9/90 , C12N15/00 , C12N15/09 , C12N15/61 , C12P21/02 , C12Q1/68 , C12R1/19 , C12R1/46 , G01N33/15 , G01N33/566 , G01N33/569 , G01N33/68 , C12P21/06 , C07H21/04 , C12N1/00
CPC分类号： C07K14/3156 , C12N9/1205 , C12N9/78 , C12N9/90 , C12Y207/01002 , A61K2039/51 , A61K38/00 , A61K39/00
摘要： The invention provides pcrA polypeptides and DNA (RNA) encoding pcrA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pcrA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了pcrA多肽和编码pcrA多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用pcrA多肽筛选抗菌化合物的方法。
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