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49 条记录 (耗时 0.026 秒)

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF INFLUENZA
    41.
    发明申请
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF INFLUENZA 审中-公开
    用于诊断和治疗流感病毒的方法和组合物

    公开(公告)号：US20100112547A1

    公开(公告)日：2010-05-06

    申请号：US12539535

    申请日：2009-08-11

    申请人： Peter S. Lu ,  Michael Belmares ,  Dave Garman

    发明人： Peter S. Lu ,  Michael Belmares ,  Dave Garman

    IPC分类号： C12Q1/70

    CPC分类号： A61K38/07 ,  A61K38/08 ,  C07K5/1008 ,  C07K5/1013 ,  C07K5/1019 ,  C07K5/1021 ,  C07K7/06 ,  C12N2760/16111 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2500/02

    摘要： The invention provides method and compositions for determining the presence and amount of an influenza virus in a sample including high risk strains of Influenza A. Also provided are methods for determining whether a subject is infected with a influenza virus, as well as, the type and strain of the influenza virus. The methods involve contacting a sample from the subject with a PDZ polypeptides (PDZ) and/or PDZ ligands (PL) and determining whether binding interactions occur between PDZ and PL. Assays for identifying anti-viral agents are also provided, as well as, methods for using the compositions to alter PDZ binding to PL in influenza infected cells.

    摘要翻译： 本发明提供用于确定样品中流感病毒的存在和量的方法和组合物，其包括流感A的高风险菌株。还提供了确定受试者是否感染流感病毒的方法以及类型和 流感病毒株。 所述方法包括使来自受试者的样品与PDZ多肽（PDZ）和/或PDZ配体（PL）接触并确定在PDZ和PL之间是否发生结合相互作用。 还提供了用于鉴定抗病毒剂的测定法，以及使用该组合物改变流感病毒感染细胞中PDZ与PL结合的方法。

    Effective Monitoring System or Anthrax, Smallpox, or Other Pathogens
    42.
    发明申请
    Effective Monitoring System or Anthrax, Smallpox, or Other Pathogens 审中-公开
    有效的监测系统或炭疽病，天花或其他病原体

    公开(公告)号：US20090162891A1

    公开(公告)日：2009-06-25

    申请号：US11963813

    申请日：2007-12-22

    申请人： Peter S. Lu ,  Thomas M. Sherlock ,  Joseph Byerly

    发明人： Peter S. Lu ,  Thomas M. Sherlock ,  Joseph Byerly

    IPC分类号： C12Q1/04 ,  C12M1/00 ,  C12M1/34

    CPC分类号： G01N33/56911 ,  C12M23/32 ,  C12M41/36 ,  C12Q1/04 ,  G01N2001/021 ,  G01N2001/028 ,  G01N2333/32 ,  Y02A50/451 ,  Y02A50/52 ,  Y10S435/808

    摘要： A device and method for detecting anthrax or other pathogens are disclosed. Individual self-contained monitoring devices of a monitoring system can be portable or stationary (e.g. installed in air ducts or plumbing of buildings) and can be part of a network of devices. Monitoring devices may be used for the detection of a variety of airborne or surface pathogens, including but not limited to anthrax, smallpox, and Salmonella. Bioamplification-coupled proteomics assays provide rapid and reliable detection of pathogens, with self-checking capabilities reducing or eliminating false positives and false negatives. Sample preservation capability allows pathogen samples to be preserved after detection for further testing. The device of the invention can be remotely operated by minimally trained technicians or security personnel. The pathogen monitoring device of the invention provides a more compact, accurate, rapid, and cost-effective alternative to other anthrax detectors, and an effective weapon against bioterrorism.

    摘要翻译： 公开了一种用于检测炭疽病或其他病原体的装置和方法。 监控系统的各个独立的监控设备可以是便携式的或静态的（例如安装在空气管道或建筑物的管道中），并且可以是设备网络的一部分。 监测装置可用于检测各种空气传播或表面病原体，包括但不限于炭疽，天花和沙门氏菌。 生物扩增耦合蛋白质组学检测提供了快速可靠的病原体检测，具有自我检查功能，减少或消除假阳性和假阴性。 样品保存能力允许在检测后保留病原体样品进行进一步测试。 本发明的装置可由受过训练的技术人员或安全人员进行远程操作。 本发明的病原体监测装置为其他炭疽检测器提供了更紧凑，准确，快速和成本有效的替代方案，也是提供了抗生物恐怖主义的有效武器。

    Effective monitoring system for anthrax smallpox, or other pathogens
    45.
    发明授权
    Effective monitoring system for anthrax smallpox, or other pathogens 有权
    有效的监测系统为炭疽病或其他病原体

    公开(公告)号：US07312071B2

    公开(公告)日：2007-12-25

    申请号：US10313354

    申请日：2002-12-06

    申请人： Peter S. Lu ,  Thomas M. Sherlock ,  Joseph Byerly

    发明人： Peter S. Lu ,  Thomas M. Sherlock ,  Joseph Byerly

    IPC分类号： C12M1/34

    CPC分类号： G01N33/56911 ,  C12M23/32 ,  C12M41/36 ,  C12Q1/04 ,  G01N2001/021 ,  G01N2001/028 ,  G01N2333/32 ,  Y02A50/451 ,  Y02A50/52 ,  Y10S435/808

    摘要： A device and method for detecting anthrax or other pathogens are disclosed. Individual self-contained monitoring devices of a monitoring system can be portable or stationary (e.g. installed in air ducts or plumbing of buildings) and can be part of a network of devices. Monitoring devices may be used for the detection of a variety of airborne or surface pathogens, including but not limited to anthrax, smallpox, and Salmonella. Bioamplification-coupled proteomics assays provide rapid and reliable detection of pathogens, with self-checking capabilities reducing or eliminating false positives and false negatives. Sample preservation capability allows pathogen samples to be preserved after detection for further testing. The device of the invention can be remotely operated by minimally trained technicians or security personnel. The pathogen monitoring device of the invention provides a more compact, accurate, rapid, and cost-effective alternative to other anthrax detectors, and an effective weapon against bioterrorism.

    摘要翻译： 公开了一种用于检测炭疽病或其他病原体的装置和方法。 监控系统的各个独立的监控设备可以是便携式的或静态的（例如安装在空气管道或建筑物的管道中），并且可以是设备网络的一部分。 监测装置可用于检测各种空气传播或表面病原体，包括但不限于炭疽，天花和沙门氏菌。 生物扩增耦合蛋白质组学检测提供了快速可靠的病原体检测，具有自我检查功能，减少或消除假阳性和假阴性。 样品保存能力允许在检测后保留病原体样品进行进一步测试。 本发明的装置可由受过训练的技术人员或安全人员进行远程操作。 本发明的病原体监测装置为其他炭疽检测器提供了更紧凑，准确，快速和成本有效的替代方案，也是提供了抗生物恐怖主义的有效武器。

    DETECTION OF INFLUENZA VIRUS
    47.
    发明申请
    DETECTION OF INFLUENZA VIRUS 审中-公开
    检测流感病毒

    公开(公告)号：US20130266968A1

    公开(公告)日：2013-10-10

    申请号：US13598230

    申请日：2012-08-29

    申请人： Peter S. Lu ,  Michael Belmares

    发明人： Peter S. Lu ,  Michael Belmares

    IPC分类号： C07K16/10 ,  G01N33/68

    CPC分类号： C07K16/1018 ,  G01N33/56983 ,  G01N33/6854 ,  G01N2333/11 ,  G01N2500/02 ,  Y02A50/53 ,  Y02A50/60

    摘要： The present application describes methods for detecting influenza A and/or influenza B and/or distinguishing between pathogenic and seasonal influenza A subtypes. Many of these preferred formats employ pan-specific antibodies (i.e., that react with all or at least multiple strains within an influenza type) to detect presence of influenza A and/or influenza B and PDZ domains in combination with panspecific antibodies to influenza A to distinguish pathogenic and seasonal influenza A subtypes.

    摘要翻译： 本申请描述了用于检测甲型和（或）乙型流感和/或区分病原性和季节性流感A亚型的方法。 这些优选形式中的许多使用泛特异性抗体（即，与流感类型内的全部或至少多个菌株反应）以检测A型流感和/或B型流感和PDZ结构域与甲型流感病毒的特异性抗体的存在 区分致病性和季节性流感A亚型。

    Cadherin-like asymmetry protein-1, and methods for its use
    49.
    发明授权
    Cadherin-like asymmetry protein-1, and methods for its use 失效
    钙粘蛋白样不对称蛋白-1及其使用方法

    公开(公告)号：US06565848B1

    公开(公告)日：2003-05-20

    申请号：US09546934

    申请日：2000-04-11

    申请人： Peter S. Lu ,  Mark M. Davis

    发明人： Peter S. Lu ,  Mark M. Davis

    IPC分类号： A61K39395

    CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention relates to molecules involved in cell-cell interactions in the immune system. In particular, the invention relates to a cell surface protein which contains certain classical cadherin characteristics, but it exhibits an apical distribution pattern on the surface of lymphocytes. The membrane location of this molecule correlates with the contact interface between T and B cells, and antibodies against an extracellular domain of this protein disrupt T cell/B cell interactions.

    摘要翻译： 本发明涉及涉及免疫系统中的细胞 - 细胞相互作用的分子。 特别地，本发明涉及含有某些经典钙粘蛋白特征的细胞表面蛋白质，但其在淋巴细胞表面具有顶端分布模式。 该分子的膜位置与T细胞和B细胞之间的接触界面相关，并且针对该蛋白质的细胞外结构域的抗体破坏T细胞/ B细胞相互作用。