公开(公告)号：US07848788B2

公开(公告)日：2010-12-07

申请号：US10123065

申请日：2002-04-11

申请人： Steve Tulley ,  Albert C. Lardo ,  Parag Karmarkar ,  Elliot McVeigh ,  Henry R. Halperin ,  Christine Enger McNamara ,  Paul A. Bottomley ,  Ergin Atalar ,  Xiaoming Yang

发明人： Steve Tulley ,  Albert C. Lardo ,  Parag Karmarkar ,  Elliot McVeigh ,  Henry R. Halperin ,  Christine Enger McNamara ,  Paul A. Bottomley ,  Ergin Atalar ,  Xiaoming Yang

IPC分类号： A61B5/055

CPC分类号： G01R33/34084 ,  A61M25/09 ,  G01R33/287 ,  G01R33/34053 ,  G01R33/3657 ,  H01Q1/36 ,  H01Q1/362 ,  H01Q1/40 ,  H01Q1/42 ,  H01Q1/44 ,  H01Q11/08

摘要： Herein is disclosed a magnetic resonance imaging probe, having a probe shaft including a magnetic resonance antenna, and a spring tip attached to a distal end of the antenna.

摘要翻译： 本文公开了一种磁共振成像探头，其具有包括磁共振天线的探针轴以及连接到天线远端的弹簧尖端。

公开(公告)号：US07816918B2

公开(公告)日：2010-10-19

申请号：US11807108

申请日：2007-05-24

申请人： Paul A. Bottomley ,  Ananda Kumar

发明人： Paul A. Bottomley ,  Ananda Kumar

IPC分类号： G01V3/00

CPC分类号： G01R33/3415 ,  G01R33/3678

摘要： Featured is a device for NMR or MRI signals from excited nuclei as well as related apparatus, systems and methods. The device includes a strip array antenna including one or more conductor and N reactive tuning components, where N is an integer ≧1 at least one of the N reactive components is electrically coupled to each of the one or more conductors as well as to ground/virtual ground. The apparent electrical length of the conductors is tuned with the reactive tuning components so it is equal to be about nλ/4, where n is an integer ≧1 and λ is the wavelength of the signal to be detected. The length of the strip also is such as to be substantially in the approximate range of 1.3 times the depth of interest. The strip conductors are also combined with loop coils to form quadrature detectors.

摘要翻译： 特色是用于激发核的NMR或MRI信号以及相关设备，系统和方法的设备。 该装置包括带状阵列天线，其包括一个或多个导体和N个非反应调谐组件，其中N是整数≥1，N个无功分量中的至少一个电耦合到一个或多个导体中的每一个以及接地/ 虚拟地面。 导体的表观电长度用无功调谐分量进行调谐，因此等于大约nλ/ 4，其中n是整数≧1，λ是待检测信号的波长。 条的长度也基本上在感兴趣深度的1.3倍的近似范围内。 带状导体也与环形线圈组合以形成正交检测器。

公开(公告)号：US20100256480A1

公开(公告)日：2010-10-07

申请号：US12521570

申请日：2007-12-31

申请人： Paul A. Bottomley ,  Shashank Sathyanarayana

发明人： Paul A. Bottomley ,  Shashank Sathyanarayana

IPC分类号： A61B5/055 ,  G01R33/48 ,  G01R33/32 ,  H01P11/00

CPC分类号： G01R33/285 ,  G01R33/34053 ,  G01R33/34084 ,  G01R33/3685 ,  G01R33/421 ,  G01R33/422 ,  G01R33/445 ,  G01R33/4833 ,  Y10T29/49016

摘要： Featured are a device with localized sensitivity to magnetic resonance signals, an imaging system using such a device and MRI methods for performing internal MRI or MRI Endoscopy. Such an MRI method includes introducing an MRI antenna or probe into the specimen to be imaged, the antenna being configured in accordance with the devices described herein, so that the spatial coordinate frame of imaging is inherently locked or defined with respect to the introduced antenna thereby providing imaging of the specimen from the point of view of the antenna. Further such imaging is conducted so that the MRI signal is confined substantially to a volume with respect to a particular region of the antenna or probe.

摘要翻译： 特色是对磁共振信号具有局部敏感性的装置，使用这种装置的成像系统和用于执行内部MRI或MRI内窥镜检查的MRI方法。 这样的MRI方法包括将MRI天线或探针引入待成像的样本中，天线根据本文所述的装置来配置，使得成像的空间坐标系相对于引入的天线固有地被锁定或定义， 从天线的角度提供样本的成像。 进一步进行这样的成像，使得MRI信号基本上被限制在相对于天线或探针的特定区域的体积。

公开(公告)号：US5192909A

公开(公告)日：1993-03-09

申请号：US637910

申请日：1991-01-07

申请人： Christopher J. Hardy ,  Paul A. Bottomley ,  Harvey E. Cline

发明人： Christopher J. Hardy ,  Paul A. Bottomley ,  Harvey E. Cline

IPC分类号： A61B5/055 ,  G01R33/48

CPC分类号： G01R33/446

摘要： An NMR system performs in vivo localized NMR spectroscopy. A two-dimensional selective RF excitation pulse is used to localize to a cylindrical region of interest, and either phase encoding or slice selective inversion is used to localize to a disk in the cylindrical region of interest. The two-dimensional selective RF excitation is performed in a series of pulse sequences rather than a single pulse sequence, and the resulting series of acquired NMR signals are summed together to substantially cancel signal conributions from outside the cylindrical region of interest.

摘要翻译： NMR体系进行体内局部NMR光谱。 使用二维选择性RF激励脉冲来定位到感兴趣的圆柱形区域，并且使用相位编码或切片选择性反转来定位到感兴趣的圆柱形区域中的盘。 二维选择性RF激励以一系列脉冲序列而不是单个脉冲序列执行，并且所得到的一系列获取的NMR信号被相加在一起以基本上消除来自感兴趣的圆柱体区域的信号。

公开(公告)号：US4973908A

公开(公告)日：1990-11-27

申请号：US370518

申请日：1989-06-23

申请人： Paul A. Bottomley ,  Christopher J. Hardy

发明人： Paul A. Bottomley ,  Christopher J. Hardy

IPC分类号： G01R33/36 ,  A61B5/055 ,  G01R33/32 ,  G01R33/34 ,  G01R33/341

CPC分类号： G01R33/341

摘要： An NMR antenna probe has at least one substantially circular surface coil arranged in a plane and a surface coil having substantially a Figure-8 shape, substantially coplanar with the at least one circular surface coil. The Figure-8 coil has a cross-over portion which is located substantially coaxial with the axis of the at least one circular surface coil. The coil corresponding to the least-NMR-sensitive nucleus is circular, while the non-circular coil corresponds to the most-NMR-sensitive nucleus. The circular coil is positioned on the side of the NMR probe closest to the subject to be studied.

公开(公告)号：US4783641A

公开(公告)日：1988-11-08

申请号：US84774

申请日：1987-08-13

申请人： Cecil E. Hayes ,  Thomas K. F. Foo ,  William H. Perman ,  Paul R. Moran ,  Paul A. Bottomley

发明人： Cecil E. Hayes ,  Thomas K. F. Foo ,  William H. Perman ,  Paul R. Moran ,  Paul A. Bottomley

IPC分类号： G01R33/341 ,  H01P7/08 ,  H01P7/00 ,  G01R33/20

CPC分类号： H01P7/082 ,  G01R33/341

摘要： A uniform surface current density is approximated in an RF transmitting/receiving NMR coil by employing a plurality of discrete conductors having a resonantly distributed current. Inductive and capacitive lines provide a sinusoidal current distribution with various resonant modes providing different magnetic field orientations. The distributed current reduces losses. In a second order resonant mode, decoupling of the surface coil from a transmit coil is achieved without a blocking network.

摘要翻译： 通过采用具有共振分布电流的多个离散导体，在RF发射/接收NMR线圈中近似均匀的表面电流密度。 电感和电容线提供具有提供不同磁场取向的各种谐振模式的正弦电流分布。 分布式电流降低了损耗。 在二阶谐振模式中，在没有阻塞网络的情况下实现了表面线圈与发射线圈的去耦。

公开(公告)号：US4733185A

公开(公告)日：1988-03-22

申请号：US056513

申请日：1987-06-01

申请人： Paul A. Bottomley

发明人： Paul A. Bottomley

IPC分类号： A61B10/00 ,  A61B5/055 ,  G01R33/48 ,  G01R33/483 ,  G01R33/20

CPC分类号： G01R33/483

摘要： A method for acquiring an NMR spectroscopy response signal from a portion of a sample located in a voxel at the junction of three planar surfaces, each in a plane at an angle to the planes of the other two surfaces, first excites the sample with a localization subsequence which selects values for the surfaces in only two of the three dimensions, to evoke a chemical-shift spectrum from voxels substantially along a line at the junction of the two selected planes; and then provides a readout subsequence including a NMR signal portion spatially-selective in the third dimension and selected to limit the received spectroscopy response signal substantially to the voxel of interest. Any necessary cycling of sequences to improve spatial localization is provided in the two dimensions of the preliminary localization subsequence; phase cycling or alternation is not used in the selective RF pulse of the data acquisition subsequence. The methods provide improvements in immunity to localization artifacts, as may be produced physiological motion, or by NMR relaxation between the localization and read-out subsequences.

公开(公告)号：US4614195A

公开(公告)日：1986-09-30

申请号：US683071

申请日：1984-12-18

申请人： Paul A. Bottomley ,  Gary H. Glover

发明人： Paul A. Bottomley ,  Gary H. Glover

IPC分类号： A61B10/00 ,  A61B5/055 ,  G01R33/48 ,  G01R33/54 ,  G01R33/567 ,  G06T1/00 ,  A61B5/05

CPC分类号： G01R33/482 ,  G01R33/56509 ,  G01R33/5676

摘要： A reduction in motion-induced image artifact, occurring when imaging moving subjects using Fourier transform (FT) NMR techniques, is achieved by recognizing that the greatest contribution to the artifacts is simple geometric motion (such as respiration). The method relies on avoiding the synchrony between the sequence repetition time of an FT pulse sequence, such as spin warp, and the period of the motion. In one preferred embodiment, the different amplitude values of the phase-encoding gradient are selected randomly, rather than sequentially. In another preferred embodiment, gradient amplitude values are selected by alternating high and low values in the temporal implementation of the pulse sequence.

摘要翻译： 通过使用傅里叶变换（FT）NMR技术对移动物体进行成像时发生的运动诱导图像伪影的减少通过识别对人造物的最大贡献是简单的几何运动（例如呼吸）来实现。 该方法依赖于避免FT脉冲序列的序列重复时间（例如自旋扭曲）与运动周期之间的同步。 在一个优选实施例中，相位编码梯度的不同振幅值被随机地选择，而不是依次选择。 在另一个优选实施例中，通过在脉冲序列的时间实现中交替高和低值来选择梯度振幅值。

公开(公告)号：US4585993A

公开(公告)日：1986-04-29

申请号：US561381

申请日：1983-12-14

申请人： Paul A. Bottomley

发明人： Paul A. Bottomley

IPC分类号： A61B10/00 ,  A61B5/055 ,  G01N24/08 ,  G01R33/48 ,  G01R33/485 ,  G01R33/54 ,  G01R33/20

CPC分类号： G01R33/4828 ,  G01R33/485

摘要： A method for providing NMR images free of chemical shift artifacts, obtained from selected nuclei of a sample containing nuclei having chemically-shifted NMR frequencies is described. Non-selected nuclei of the sample are selectively saturated prior to applying an NMR imaging sequence by applying to the sample an RF pulse containing frequencies equal to the chemically-shifted frequencies of the non-selected nuclei and having a narrow frequency spectrum about the chemically-shifted frequencies. Alternatively, selected nuclei are directly excited during application of an NMR imaging sequence by applying to the sample an RF pulse containing frequencies equal to the chemically-shifted frequencies of the selected nuclei, and having a narrow frequency spectrum about the chemically-shifted frequencies so as to exclude signal contributions from the non-selected nuclei. These selective pulses are applied in the absence of the imaging magnetic field gradients.

摘要翻译： 描述了提供从包含具有化学位移的NMR频率的核的样品的选定核获得的没有化学位移伪影的NMR图像的方法。 在应用NMR成像序列之前，样品的未选择的核选择性饱和，通过向样品施加包含等于非选择核的化学位移频率的频率的RF脉冲，并且具有关于化学 - 移位频率。 或者，通过向样品施加包含等于所选核的化学位移频率的频率并且具有关于化学位移频率的窄频谱的RF脉冲，在NMR成像序列的应用期间直接激发所选择的核 以排除来自未选核的信号贡献。 在不存在成像磁场梯度的情况下施加这些选择脉冲。

公开(公告)号：US4480228A

公开(公告)日：1984-10-30

申请号：US434688

申请日：1982-10-15

申请人： Paul A. Bottomley

发明人： Paul A. Bottomley

IPC分类号： A61B10/00 ,  A61B5/055 ,  G01R33/48 ,  G01R33/483 ,  G01R33/485 ,  G01R33/08

CPC分类号： G01R33/4833 ,  G01R33/485

摘要： Selective irradiation is used to isolate a planar slice of nuclear spins in a nuclear magnetic resonance (NMR) sample. Selective radio frequecy pulses, applied in the presence of magnetic field gradients, are then employed to define a smaller sensitive volume in a predetermined region of the isolated planar slice. An NMR spin echo signal produced by excited nuclear spins situated in the thusly localized volume is observed in the absence of magnetic field gradients and, upon Fourier transformation, yields the desired localized chemical shift spectra.

摘要翻译： 选择性照射用于分离核磁共振（NMR）样品中核自旋的平面切片。 然后采用在存在磁场梯度的情况下应用的选择性无线电频率脉冲来在孤立平面切片的预定区域中定义较小的灵敏体积。 在没有磁场梯度的情况下观察到位于如此定位的体积中的激发的核自旋产生的NMR自旋回波信号，并且在傅里叶变换后，产生期望的局部化学位移谱。