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    Spatially-localized chemical-reaction-rate NMR spectroscopic imaging
    1.
    发明授权
    Spatially-localized chemical-reaction-rate NMR spectroscopic imaging 失效
    空间局部化学反应率NMR光谱成像

    公开(公告)号：US5201311A

    公开(公告)日：1993-04-13

    申请号：US927780

    申请日：1992-08-10

    申请人： Paul A. Bottomley ,  Christopher J. Hardy

    发明人： Paul A. Bottomley ,  Christopher J. Hardy

    IPC分类号： G01R33/483 ,  G01R33/485

    CPC分类号： G01R33/485 ,  G01R33/483

    摘要： A method for providing information about the rate of a selected chemical reaction in each of at least one selected volume elements (voxels) in a sample includes the steps of: exciting a reaction-rate-dependent chemical-shift spectrum, by a selected stimulus (such as one of saturation-transfer and inversion-transfer RF signal pulses) to label the NMR signal of a first reaction constituent; spatially localizing the NMR response signal, provided by the excited resonance, to a selected voxel within the sample; and acquiring and processing the NMR response data from the localized voxel. The excitation, localization and data acquisition subsequences are repeated to generate data substantially proportional, or equal, to the reaction rate constants in the selected voxels, and in planes and/or volumes thereof.

    摘要翻译： 提供关于样品中至少一个选定的体积元素（体素）中的每一个中选择的化学反应的速率的信息的方法包括以下步骤：通过所选择的刺激（激发反应速率依赖的化学位移谱） 例如饱和转移和反转传输RF信号脉冲之一）来标记第一反应成分的NMR信号; 将由激发谐振提供的NMR响应信号空间定位到样品内的选定体素; 并从局部体素获取和处理NMR响应数据。 重复激发，定位和数据采集子序列以产生与所选择的体素中的反应速率常数以及其平面和/或体积基本成比例或相等的数据。

    Multi-dimensional selective NMR excitation with a single RF pulse
    2.
    发明授权
    Multi-dimensional selective NMR excitation with a single RF pulse 失效
    具有单个RF脉冲的多维选择性NMR激发

    公开(公告)号：US4812760A

    公开(公告)日：1989-03-14

    申请号：US78427

    申请日：1987-07-27

    申请人： Paul A. Bottomley ,  Christopher J. Hardy ,  Matthew O'Donnell ,  Peter B. Roemer

    发明人： Paul A. Bottomley ,  Christopher J. Hardy ,  Matthew O'Donnell ,  Peter B. Roemer

    IPC分类号： A61B10/00 ,  A61B5/055 ,  G01R33/48 ,  G01R33/20

    CPC分类号： G01R33/446

    摘要： A single rotating NMR .pi. pulse provides simultaneous spatially-selective inversion or spin-echo refocussing of nuclear pins in two orthogonal dimensions. The two-dimensional spatially-selective pulse utilizes a single RF pulse, with either a square of an amplitude-modulated or a frequency-modulated envelope, and applied in the presence of an amplitude-modulated magnetic field gradient which reorients through the desired dimensions in which selection is desired while the RF pulse is present. These rotating, or ".rho.", pulses are useful for reduction of aliasing signal artifacts is restricted field-of-view high-resolution NMR imaging and, when combined with one-dimensional-localized chemical shift spectroscpoy techniques (such as those employing surface detection coils) is especially useful for the production of three-dimensionally localized NMR spectra. Substantial suppression of undesirable residual excited signals, arising from outside the desired two-dimensional spatially selected region, can be obtained by simulated annealing optimization of both the RF and magnetic field gradient amplitude portions of the .rho. pulse and/or by use of surface coil detection. The location of the selected volume is varied by frequency modulation of the RF signal pulse, or by variation of the ratio of currents in the halves of the magnetic field gradient coils.

    Spectroscopic localization using pinwheel NMR excitation pulses
    3.
    发明授权
    Spectroscopic localization using pinwheel NMR excitation pulses 失效
    使用PINHEEL NMR激发脉冲进行光谱定位

    公开(公告)号：US5192909A

    公开(公告)日：1993-03-09

    申请号：US637910

    申请日：1991-01-07

    申请人： Christopher J. Hardy ,  Paul A. Bottomley ,  Harvey E. Cline

    发明人： Christopher J. Hardy ,  Paul A. Bottomley ,  Harvey E. Cline

    IPC分类号： A61B5/055 ,  G01R33/48

    CPC分类号： G01R33/446

    摘要： An NMR system performs in vivo localized NMR spectroscopy. A two-dimensional selective RF excitation pulse is used to localize to a cylindrical region of interest, and either phase encoding or slice selective inversion is used to localize to a disk in the cylindrical region of interest. The two-dimensional selective RF excitation is performed in a series of pulse sequences rather than a single pulse sequence, and the resulting series of acquired NMR signals are summed together to substantially cancel signal conributions from outside the cylindrical region of interest.

    摘要翻译： NMR体系进行体内局部NMR光谱。 使用二维选择性RF激励脉冲来定位到感兴趣的圆柱形区域，并且使用相位编码或切片选择性反转来定位到感兴趣的圆柱形区域中的盘。 二维选择性RF激励以一系列脉冲序列而不是单个脉冲序列执行，并且所得到的一系列获取的NMR信号被相加在一起以基本上消除来自感兴趣的圆柱体区域的信号。

    NMR probe with multiple isolated coplanar surface coils
    4.
    发明授权
    NMR probe with multiple isolated coplanar surface coils 失效
    具有多个隔离的共面表面线圈的NMR探针

    公开(公告)号：US4973908A

    公开(公告)日：1990-11-27

    申请号：US370518

    申请日：1989-06-23

    申请人： Paul A. Bottomley ,  Christopher J. Hardy

    发明人： Paul A. Bottomley ,  Christopher J. Hardy

    IPC分类号： G01R33/36 ,  A61B5/055 ,  G01R33/32 ,  G01R33/34 ,  G01R33/341

    CPC分类号： G01R33/341

    摘要： An NMR antenna probe has at least one substantially circular surface coil arranged in a plane and a surface coil having substantially a Figure-8 shape, substantially coplanar with the at least one circular surface coil. The Figure-8 coil has a cross-over portion which is located substantially coaxial with the axis of the at least one circular surface coil. The coil corresponding to the least-NMR-sensitive nucleus is circular, while the non-circular coil corresponds to the most-NMR-sensitive nucleus. The circular coil is positioned on the side of the NMR probe closest to the subject to be studied.

    SAR dosimeter for RF power deposition in MRI and methods and systems related thereto
    6.
    发明授权
    SAR dosimeter for RF power deposition in MRI and methods and systems related thereto 有权
    用于MRI中RF功率沉积的SAR剂量计及与其相关的方法和系统

    公开(公告)号：US08717021B2

    公开(公告)日：2014-05-06

    申请号：US12677097

    申请日：2008-09-08

    申请人： Paul A. Bottomley ,  John P. Stralka

    发明人： Paul A. Bottomley ,  John P. Stralka

    IPC分类号： G01V3/00

    CPC分类号： G01R33/288 ,  G01R33/58

    摘要： Featured is a dosimeter device that measures SAR deposited by RF power deposition during MRI of a specimen. Such a dosimeter device includes a transducer that is configured to present a load to the MRI scanner in which the transducer is located and to provide an output representative of signals induced in the transducer. The transducer also is configured so that the presented load is substantially equivalent to another load which would be presented by the specimen during MRI of the specimen. Such a transducer also is configured so as to generate an MRI signal that is sufficient to allow the MRI scanner to adjust the RF power to a value substantially equal to that of the specimen. Also featured are methods for measuring SAR deposited by RF power deposition and apparatuses or system embodying such a dosimeter device.

    摘要翻译： 特色是一种剂量计装置，可以在样品的MRI期间测量通过RF功率沉积沉积的SAR。 这样一种剂量计装置包括一个换能器，该换能器被配置为向换能器所在的MRI扫描器提供负载，并提供代表在换能器中感应的信号的输出。 传感器还被配置成使得所呈现的负载基本上等于在样本的MRI期间由样本呈现的另一负载。 这样的换能器也被配置为产生足以使MRI扫描器将RF功率调整到基本上等于样本的值的MRI信号。 还有一些用于测量通过RF功率沉积沉积的SAR的方法以及体现这种剂量计装置的装置或系统。

    OPTIMIZED MRI STRIP ARRAY DETECTORS AND APPARATUS, SYSTEMS AND METHODS RELATED THERETO
    7.
    发明申请
    OPTIMIZED MRI STRIP ARRAY DETECTORS AND APPARATUS, SYSTEMS AND METHODS RELATED THERETO 有权
    优化的MRI条带阵列检测器及其相关的设备，系统和方法

    公开(公告)号：US20110037468A1

    公开(公告)日：2011-02-17

    申请号：US12879430

    申请日：2010-09-10

    申请人： Paul A. Bottomley ,  Ananda Kumar

    发明人： Paul A. Bottomley ,  Ananda Kumar

    IPC分类号： G01R33/44

    CPC分类号： G01R33/3415 ,  G01R33/3678

    摘要： Featured is a device for NMR or MRI signals from excited nuclei as well as related apparatus, systems and methods. The device includes a strip array antenna including one or more conductor and N reactive tuning components, where N is an integer≧1 at least one of the N reactive components is electrically coupled to each of the one or more conductors as well as to ground/virtual ground. The apparent electrical length of the conductors is tuned with the reactive tuning components so it is equal to be about nλ/4, where n is an integer≧1 and λ is the wavelength of the signal to be detected. The length of the strip also is such as to be substantially in the approximate range of 1.3 times the depth of interest. The strip conductors are also combined with loop coils to form quadrature detectors.

    摘要翻译： 特色是用于激发核的NMR或MRI信号以及相关设备，系统和方法的设备。 该装置包括带状阵列天线，其包括一个或多个导体和N个非反应调谐组件，其中N是整数≥1，N个无功分量中的至少一个电耦合到一个或多个导体中的每一个以及接地/ 虚拟地面。 导体的表观电长度用无功调谐分量进行调谐，因此等于大约nλ/ 4，其中n是整数≧1，λ是待检测信号的波长。 条的长度也基本上在感兴趣深度的1.3倍的近似范围内。 带状导体也与环形线圈组合以形成正交检测器。

    VERTEBRAL BODY REDUCTION INSTRUMENT AND METHODS RELATED THERETO
    8.
    发明申请
    VERTEBRAL BODY REDUCTION INSTRUMENT AND METHODS RELATED THERETO 有权
    VERTEBRAL身体减少仪器及其相关方法

    公开(公告)号：US20100274252A1

    公开(公告)日：2010-10-28

    申请号：US12766481

    申请日：2010-04-23

    申请人： Paul A. Bottomley ,  Shashank Sathyanarayana

    发明人： Paul A. Bottomley ,  Shashank Sathyanarayana

    IPC分类号： A61B17/60

    CPC分类号： A61B17/708

    摘要： Featured is a reduction instrument being configured and arranged to allow correction of vertebral translation and applying distraction across a segment in an independent fashion. Such a reduction instrument embodies one or more identical modules that are configured as needed for correcting the deformity. In more particular embodiments, each of the one or more modules has two degrees of freedom (DOF) with uncoupled orthogonal translations. Such a reduction instrument allows the reorientation of the vertebral segment as needed via uncoupled orthogonal translations. Such a reduction instrument also is usable in combination with a plurality of vertebral anchors, such vertebral anchors being any such vertebral anchors as are know to those skilled in the art (e.g., conventional spinal pedicle screw instrumentation) or hereinafter developed so as to form a spinal implant system. Also featured are treatment methods utilizing such a reduction instrument.

    摘要翻译： 特色是一种减少仪器，其被配置和布置成允许校正脊椎翻译并以独立方式跨越段进行牵引。 这种还原器具体现了一个或多个相同的模块，其被配置为需要校正畸形。 在更具体的实施例中，一个或多个模块中的每一个具有具有未耦合正交平移的两个自由度（DOF）。 这种减少器械允许根据需要通过非耦合的正交平移重新定向椎骨段。 这种减速器还可以与多个椎骨锚固件组合使用，这些椎骨锚固件是本领域技术人员已知的任何这样的椎骨锚固件（例如，常规的椎弓根螺钉装置）或下文开发以形成 脊柱植入系统。 还特征在于使用这种还原装置的处理方法。