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129 条记录 (耗时 0.078 秒)

    Chemiluminescent compounds and methods of use
    41.
    发明授权
    Chemiluminescent compounds and methods of use 失效
    化学发光化合物和使用方法

    公开(公告)号：US6002000A

    公开(公告)日：1999-12-14

    申请号：US661849

    申请日：1996-06-11

    申请人： Sharat Singh ,  Rajendra Singh ,  Frank Meneghini ,  Edwin F. Ullman

    发明人： Sharat Singh ,  Rajendra Singh ,  Frank Meneghini ,  Edwin F. Ullman

    IPC分类号： C07D471/10 ,  C07D491/10 ,  C07D498/10 ,  G01N33/533 ,  G01N33/58 ,  C07D513/10 ,  C09K11/06

    CPC分类号： C07D471/10 ,  C07D491/10 ,  G01N33/533 ,  G01N33/582

    摘要： Methods are disclosed for determining an analyte in a medium suspected of containing the analyte. One method comprises providing (1) combining a medium suspected of containing the analyte and a novel chemiluminescent compound, (2) combining a means for chemically activating the chemiluminescent compound; and (3) detecting the amount of luminescence generated by the chemiluminescent compound. The amount of luminescence generated is related to the amount of analyte in the medium. The chemiluminescent compound can be chemically activated by hydrogen peroxide. Compositions and kits are also disclosed.

    摘要翻译： 公开了用于确定怀疑含有分析物的介质中的分析物的方法。 一种方法包括提供（1）将怀疑含有分析物的介质与新型化学发光化合物组合，（2）组合化学发光化合物的化学活化装置; 和（3）检测由化学发光化合物产生的发光量。 产生的发光量与介质中分析物的量有关。 化学发光化合物可以被过氧化氢化学活化。 还公开了组合物和试剂盒。

    Chemiluminescent compounds and methods of use
    43.
    发明授权
    Chemiluminescent compounds and methods of use 失效
    化学发光化合物和使用方法

    公开(公告)号：US5545834A

    公开(公告)日：1996-08-13

    申请号：US373678

    申请日：1995-01-17

    申请人： Sharat Singh ,  Rajendra Singh ,  Frank Meneghini ,  Edwin F. Ullman

    发明人： Sharat Singh ,  Rajendra Singh ,  Frank Meneghini ,  Edwin F. Ullman

    IPC分类号： G01N33/532 ,  C07D471/10 ,  C07D471/20 ,  C07D491/10 ,  C07D491/113 ,  C07D498/10 ,  C07D517/10 ,  G01N21/78 ,  G01N33/533 ,  G01N33/58 ,  C07D513/10 ,  C09K11/06

    CPC分类号： C07D471/10 ,  C07D491/10 ,  G01N33/533 ,  G01N33/582 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/815 ,  Y10S435/818

    摘要： Methods are disclosed for determining an analyte in a medium suspected of containing the analyte. One method comprises providing (1) combining a medium suspected of containing the analyte and a novel chemiluminescent compound, (2) combining a means for chemically activating the chemiluminescent compound; and (3) detecting the amount of luminescence generated by the chemiluminescent compound. The amount of luminescence generated is related to the amount of analyte in the medium. The chemiluminescent compound can be chemically activated by hydrogen peroxide. Compositions and kits are also disclosed. The chemiluminescent compound is a spiro-acridan and has ##STR1## where X and Y are independently O, S, Se or NH; and Z is a chain, 1-5 atoms in length; 0 to 8 hydrogens of the compound alone or taken together, may be replaced an alkyl, alkylidine, aryl, aralkyl, or an alkyl, aryl or aralkyl substituted with one or more radicals of functional groups; 1 to 4 of the aromatic carbon atoms may be replaced by nitrogen atoms; and 0 to 1 hydrogens may be replaced by a specific binding pair member or fluorescent group.

    摘要翻译： 公开了用于确定怀疑含有分析物的介质中的分析物的方法。 一种方法包括提供（1）将怀疑含有分析物的介质与新型化学发光化合物组合，（2）组合化学发光化合物的化学活化装置; 和（3）检测由化学发光化合物产生的发光量。 产生的发光量与介质中分析物的量有关。 化学发光化合物可以被过氧化氢化学活化。 还公开了组合物和试剂盒。 化学发光化合物是螺 - 吖啶，并且其中X和Y独立地为O，S，Se或NH; Z是长度为1-5个原子的链; 可单独使用或合并在一起的化合物的0至8个氢可以被烷基，烷基锡，芳基，芳烷基或被一个或多个官能团基团取代的烷基，芳基或芳烷基取代; 1至4个芳族碳原子可被氮原子取代; 并且0至1个氢可以被特异性结合对成员或荧光基团代替。

    CITRULLINATED PEPTIDES FOR DIAGNOSING AND PROGNOSING RHEUMATOID ARTHRITIS
    47.
    发明申请
    CITRULLINATED PEPTIDES FOR DIAGNOSING AND PROGNOSING RHEUMATOID ARTHRITIS 有权
    用于诊断和预防流感嗜血杆菌的化学物质

    公开(公告)号：US20120295280A1

    公开(公告)日：2012-11-22

    申请号：US13239329

    申请日：2011-09-21

    申请人： Nicholas Chi-Kwan Ling ,  Shui Long Wang ,  Dunrui Wang ,  Sharat Singh

    发明人： Nicholas Chi-Kwan Ling ,  Shui Long Wang ,  Dunrui Wang ,  Sharat Singh

    IPC分类号： G01N33/566 ,  G01N33/573 ,  C07K14/435 ,  C07K7/06 ,  C07K7/08

    CPC分类号： G01N33/564 ,  C07K14/4713

    摘要： The present invention provides novel citrullinated peptides, their use in methods for aiding, assisting, improving, or facilitating the diagnosis or prognosis of rheumatic diseases such as rheumatoid arthritis (RA), and methods for identifying novel citrullinated peptides that are immunoreactive with anti-citrullinated protein antibodies (ACPAs). The present invention also provides methods for detecting rheumatoid factor (RF) using novel RF detection reagents as a means to aid, assist, improve, or facilitate the diagnosis or prognosis of rheumatic diseases such as RA. Kits comprising at least one of the novel citrullinated peptides and/or RF detection reagents of the present invention are also provided.

    摘要翻译： 本发明提供新颖的瓜氨酸肽，其用于帮助，协助，改善或促进风湿性疾病如类风湿性关节炎（RA）的诊断或预后的方法，以及用于鉴定与抗瓜氨酸化免疫反应的新型瓜氨酸肽 蛋白质抗体（ACPA）。 本发明还提供使用新的RF检测试剂检测类风湿因子（RF）的方法，以帮助，协助，改善或促进风湿性疾病如RA的诊断或预后。 还提供了包含本发明的新颖瓜氨酸肽和/或RF检测试剂中的至少一种的试剂盒。

    Measuring Receptor Homodimerization
    49.
    发明申请
    Measuring Receptor Homodimerization 有权
    测量受体同型二聚体

    公开(公告)号：US20090155818A1

    公开(公告)日：2009-06-18

    申请号：US12176245

    申请日：2008-07-18

    申请人： Sailaja Pidaparthi ,  Yining Shi ,  Rajiv Dua ,  Po-Ying Chan-Hui ,  Sharat Singh

    发明人： Sailaja Pidaparthi ,  Yining Shi ,  Rajiv Dua ,  Po-Ying Chan-Hui ,  Sharat Singh

    IPC分类号： G01N33/53

    CPC分类号： G01N33/566 ,  G01N33/542 ,  G01N33/74 ,  G01N2333/71 ,  G01N2333/726 ,  Y10S436/824

    摘要： The invention provides methods and kits for detecting and/or measuring receptor homodimers on a cell surface membrane. In one aspect, the methods employ pairs of probes comprising binding compounds and a cleaving probe, such that at least one binding compound binds specifically to the same epitope of a membrane-bound analyte as the cleaving probe. The binding compound includes one or more molecular tags attached through a cleavable linkage, and the cleaving probe includes a cleavage-inducing moiety that can cleave the linkage when within a defined proximity thereto. Binding of the two probes to a homodimer of a cell surface molecules results in release of molecular tags from the binding compounds, providing a measure of formation of the homodimeric complex.

    摘要翻译： 本发明提供了用于在细胞表面膜上检测和/或测量受体同二聚体的方法和试剂盒。 在一个方面，所述方法使用包含结合化合物和切割探针的探针对，使得至少一种结合化合物特异性结合作为切割探针的膜结合分析物的相同表位。 结合化合物包括通过可切割键连接的一个或多个分子标签，并且切割探针包括切割诱导部分，其在限定的接近于其内时可切割连接。 两个探针与细胞表面分子的同型二聚体的结合导致分子标签从结合化合物的释放，提供同二聚体复合物形成的量度。

    DRUG SELECTION FOR LUNG CANCER THERAPY USING ANTIBODY-BASED ARRAYS
    50.
    发明申请
    DRUG SELECTION FOR LUNG CANCER THERAPY USING ANTIBODY-BASED ARRAYS 有权
    使用基于抗体的阵列进行肺癌治疗的药物选择

    公开(公告)号：US20090035792A1

    公开(公告)日：2009-02-05

    申请号：US12172100

    申请日：2008-07-11

    申请人： Sharat Singh ,  Jeanne Harvey

    发明人： Sharat Singh ,  Jeanne Harvey

    IPC分类号： G01N33/574 ,  C12M1/34

    CPC分类号： G01N33/57423 ,  G01N33/5041 ,  G01N33/5044 ,  G01N33/5082 ,  G01N2500/10 ,  G01N2800/52

    摘要： The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.

    摘要翻译： 本发明提供用于检测肿瘤细胞中信号转导途径的组分的激活状态的组合物和方法。 关于使用本发明的信号转导途径的组分的激活状态的信息可用于癌症诊断，预后和癌症治疗的设计。