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公开(公告)号：US20070042392A1
公开(公告)日：2007-02-22
申请号：US11218141
申请日：2005-08-31
申请人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-hong Chen , Yunqing Ma , Feiyan Ren , Jian-Rui Wang , Thomas Wehrman , Chongjun Xu , Aidong Xue , Yonghong Yang , Jie Zhang , Qing Zhao , Ping Zhou , Radoje Drmanac , Yi-Cheng Cao , Dunrui Wang , Zhi Wang , Ryle Goodrich
发明人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-hong Chen , Yunqing Ma , Feiyan Ren , Jian-Rui Wang , Thomas Wehrman , Chongjun Xu , Aidong Xue , Yonghong Yang , Jie Zhang , Qing Zhao , Ping Zhou , Radoje Drmanac , Yi-Cheng Cao , Dunrui Wang , Zhi Wang , Ryle Goodrich
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/136
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
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2.发明授权公开(公告)号：US08519096B2
公开(公告)日：2013-08-27
申请号：US13239329
申请日：2011-09-21
IPC分类号： G01N33/531 , G01N33/533 , C07K17/00
CPC分类号： G01N33/564 , C07K14/4713
摘要： The present invention provides novel citrullinated peptides, their use in methods for aiding, assisting, improving, or facilitating the diagnosis or prognosis of rheumatic diseases such as rheumatoid arthritis (RA), and methods for identifying novel citrullinated peptides that are immunoreactive with anti-citrullinated protein antibodies (ACPAs). The present invention also provides methods for detecting rheumatoid factor (RF) using novel RF detection reagents as a means to aid, assist, improve, or facilitate the diagnosis or prognosis of rheumatic diseases such as RA. Kits comprising at least one of the novel citrullinated peptides and/or RF detection reagents of the present invention are also provided.
摘要翻译： 本发明提供新颖的瓜氨酸肽，其用于帮助，协助，改善或促进风湿性疾病如类风湿性关节炎（RA）的诊断或预后的方法，以及用于鉴定与抗瓜氨酸化免疫反应的新型瓜氨酸肽 蛋白质抗体（ACPA）。 本发明还提供使用新的RF检测试剂检测类风湿因子（RF）的方法，以帮助，协助，改善或促进风湿性疾病如RA的诊断或预后。 还提供了包含本发明的新颖瓜氨酸肽和/或RF检测试剂中的至少一种的试剂盒。
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3.发明申请公开(公告)号：US20120295280A1
公开(公告)日：2012-11-22
申请号：US13239329
申请日：2011-09-21
IPC分类号： G01N33/566 , G01N33/573 , C07K14/435 , C07K7/06 , C07K7/08
CPC分类号： G01N33/564 , C07K14/4713
摘要： The present invention provides novel citrullinated peptides, their use in methods for aiding, assisting, improving, or facilitating the diagnosis or prognosis of rheumatic diseases such as rheumatoid arthritis (RA), and methods for identifying novel citrullinated peptides that are immunoreactive with anti-citrullinated protein antibodies (ACPAs). The present invention also provides methods for detecting rheumatoid factor (RF) using novel RF detection reagents as a means to aid, assist, improve, or facilitate the diagnosis or prognosis of rheumatic diseases such as RA. Kits comprising at least one of the novel citrullinated peptides and/or RF detection reagents of the present invention are also provided.
摘要翻译： 本发明提供新颖的瓜氨酸肽，其用于帮助，协助，改善或促进风湿性疾病如类风湿性关节炎（RA）的诊断或预后的方法，以及用于鉴定与抗瓜氨酸化免疫反应的新型瓜氨酸肽 蛋白质抗体（ACPA）。 本发明还提供使用新的RF检测试剂检测类风湿因子（RF）的方法，以帮助，协助，改善或促进风湿性疾病如RA的诊断或预后。 还提供了包含本发明的新颖瓜氨酸肽和/或RF检测试剂中的至少一种的试剂盒。
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公开(公告)号：US20050239060A1
公开(公告)日：2005-10-27
申请号：US10122851
申请日：2002-04-12
申请人： Y. Tang , Chenghua Liu , Vinod Asundi , Jie Zhang , Feiyan Ren , Rui-hong Chen , Qing Zhao , Tom Wehrman , Aidong Xue , Yonghong Yang , Jian-Rui Wang , Ping Zhou , Yunqing Ma , Dunrui Wang , Zhiwei Wang , Radoje Drmanac
发明人： Y. Tang , Chenghua Liu , Vinod Asundi , Jie Zhang , Feiyan Ren , Rui-hong Chen , Qing Zhao , Tom Wehrman , Aidong Xue , Yonghong Yang , Jian-Rui Wang , Ping Zhou , Yunqing Ma , Dunrui Wang , Zhiwei Wang , Radoje Drmanac
CPC分类号： C07K14/47 , A61K2039/505
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
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公开(公告)号：US06743619B1
公开(公告)日：2004-06-01
申请号：US09774528
申请日：2001-01-30
申请人： Y. Tom Tang , Ping Zhou , Ryle Goodrich , Chenghua Liu , Vinod Asundi , Feiyan Ren , Jie Zhang , Qing A. Zhao , Yonghong Yang , Aidong J. Xue , Tom Wehrman , Jian-Rui Wang , Dunrui Wang , Radoje T. Drmanac
发明人： Y. Tom Tang , Ping Zhou , Ryle Goodrich , Chenghua Liu , Vinod Asundi , Feiyan Ren , Jie Zhang , Qing A. Zhao , Yonghong Yang , Aidong J. Xue , Tom Wehrman , Jian-Rui Wang , Dunrui Wang , Radoje T. Drmanac
IPC分类号： C12N990
CPC分类号： C07K14/47 , G01N2500/00
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
摘要翻译： 本发明提供了新的核酸，由这些核酸编码的新的多肽序列及其用途。
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公开(公告)号：US20050202422A1
公开(公告)日：2005-09-15
申请号：US10291128
申请日：2002-11-08
申请人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-Hong Chen , Feiyan Ren , Dunrui Wang , Jian-Rui Wang , Chongjun Xu , Aidong Xue , Yonghong Yang , Jie Zhang , Qing Zhao , Ping Zhou , Ryle Goodrich , Radoje Drmanac
发明人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-Hong Chen , Feiyan Ren , Dunrui Wang , Jian-Rui Wang , Chongjun Xu , Aidong Xue , Yonghong Yang , Jie Zhang , Qing Zhao , Ping Zhou , Ryle Goodrich , Radoje Drmanac
CPC分类号： C07K14/8107 , A61K38/00
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
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公开(公告)号：US20050175607A1
公开(公告)日：2005-08-11
申请号：US10220335
申请日：2001-02-26
申请人： Y Tang , Chenghua Liu , Vinod Asundi , Chongjun Xu , Tom Wehrman , Feiyan Ren , Yunqing Ma , Ping Zhou , Qing Zha , Yonghong Yang , Radoje Drmanac , Jie Zhang , Rui-hong Chen , Jian-Rui Wang , Dunrui Wang , Aidong Xue
发明人： Y Tang , Chenghua Liu , Vinod Asundi , Chongjun Xu , Tom Wehrman , Feiyan Ren , Yunqing Ma , Ping Zhou , Qing Zha , Yonghong Yang , Radoje Drmanac , Jie Zhang , Rui-hong Chen , Jian-Rui Wang , Dunrui Wang , Aidong Xue
CPC分类号： C07K14/47 , C12Q1/6886
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
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公开(公告)号：US06919193B2
公开(公告)日：2005-07-19
申请号：US10120988
申请日：2002-04-10
申请人： Y. Tom Tang , Ryle Goodrich , Chenghua Liu , Feiyan Ren , Dunrui Wang , Radoje T. Drmanac
发明人： Y. Tom Tang , Ryle Goodrich , Chenghua Liu , Feiyan Ren , Dunrui Wang , Radoje T. Drmanac
CPC分类号： C07K14/47 , G01N2500/00
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
摘要翻译： 本发明提供了新的核酸，由这些核酸编码的新的多肽序列及其用途。
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