公开(公告)号：US11415576B2

公开(公告)日：2022-08-16

申请号：US15614856

申请日：2017-06-06

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Elke Faatz ,  Michael Gerg ,  Hans-Peter Josel ,  Christian Vogl

IPC: G01N33/537 ,  C07K16/26 ,  G01N33/82 ,  G01N33/541

Abstract: The present invention concerns an in vitro method for measurement of 25-hydroxyvitamin D, wherein the potentially interfering compound 24,25-dihydroxyvitamin D3 is blocked by a binding agent specifically binding to 24,25-dihydroxyvitamin D3 and not binding to 25-hydroxyvitamin D.

公开(公告)号：US10718769B2

公开(公告)日：2020-07-21

申请号：US15186578

申请日：2016-06-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Hans-Peter Josel ,  Dieter Heindl ,  Thomas Froehlich ,  Stefanie Froehner

IPC: C07J17/00 ,  C07J9/00 ,  G01N33/58 ,  C07D311/04 ,  C07D311/82 ,  G01N33/569 ,  C07J51/00 ,  C12N11/06 ,  G01N33/50 ,  G01N33/543 ,  C07D495/04

Abstract: The present invention relates to novel compounds comprising one or more hydrophobic domains and a hydrophilic domain comprising PEG moieties, useful for binding cells, as well as uses and compositions related thereto. The compounds are useful for immobilizing and/or stabilizing cells.

公开(公告)号：US20190324024A1

公开(公告)日：2019-10-24

申请号：US16450176

申请日：2019-06-24

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Gerg ,  Klaus Hirzel ,  Caroline Dorothea Hojer ,  Erasmus Huber ,  Hans-Peter Josel ,  Thomas Meier ,  Michael Schraeml ,  Leopold Von Proff

IPC: G01N33/543 ,  C07K16/44

Abstract: The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as disclosed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.

公开(公告)号：US09399654B2

公开(公告)日：2016-07-26

申请号：US14609552

申请日：2015-01-30

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Frank Bergmann ,  Robert Cysewski ,  Luisa de Cola ,  Sebastian Dziadek ,  Jesus Miguel Fernandez Hernandez ,  Hans-Peter Josel ,  Christoph Seidel

IPC: C07F15/00 ,  G01N33/58 ,  C09K11/06 ,  C09K11/07

CPC classification number: C07F15/0033 ,  C09K11/06 ,  C09K11/07 ,  C09K2211/1003 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1029 ,  C09K2211/1059 ,  C09K2211/1074 ,  C09K2211/14 ,  C09K2211/185 ,  G01N33/582

Abstract: The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.

公开(公告)号：US20150147751A1

公开(公告)日：2015-05-28

申请号：US14609649

申请日：2015-01-30

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Frank Bergmann ,  Robert Cysewski ,  Luisa de Cola ,  Sebastian Dziadek ,  Jesus Miguel Fernandez Hernandez ,  Hans-Peter Josel ,  Christoph Seidel

IPC: C07F15/00 ,  C09K11/07

CPC classification number: C07F15/0033 ,  C09K11/06 ,  C09K11/07 ,  C09K2211/1007 ,  C09K2211/1029 ,  C09K2211/14 ,  C09K2211/1408 ,  C09K2211/1416 ,  C09K2211/1425 ,  C09K2211/1441 ,  C09K2211/1466 ,  C09K2211/185 ,  G01N33/582

Abstract: The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.

Abstract translation: 本发明涉及新型的基于铱的Ir（III）发光复合物，包含这些络合物作为标记的缀合物及其应用，例如， 在基于电化学发光的分析物检测中。

公开(公告)号：US20150140682A1

公开(公告)日：2015-05-21

申请号：US14610372

申请日：2015-01-30

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Frank Bergmann ,  Robert Cysewski ,  Luisa de Cola ,  Sebastian Dziadek ,  Jesus Miguel Fernandez Hernandez ,  Hans-Peter Josel ,  Christoph Seidel

IPC: G01N33/58 ,  C07F15/00

CPC classification number: C07F15/0033 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1029 ,  C09K2211/14 ,  C09K2211/1408 ,  C09K2211/1416 ,  C09K2211/1425 ,  C09K2211/1441 ,  C09K2211/1466 ,  C09K2211/185 ,  G01N33/582

Abstract: The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.

Abstract translation: 本发明涉及新型的基于铱的Ir（III）发光复合物，包含这些络合物作为标记的缀合物及其应用，例如， 在基于电化学发光的分析物检测中。

公开(公告)号：US08772486B2

公开(公告)日：2014-07-08

申请号：US13961381

申请日：2013-08-07

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Robert Cysewski ,  Luisa de Cola ,  Jesus Miguel Fernandez Hernandez ,  Hans-Peter Josel ,  Eloisa Lopez-Calle ,  Toralf Zarnt

IPC: C07F15/00

CPC classification number: G01N33/53 ,  C07F15/0033 ,  G01N33/582

Abstract: Novel iridium-based Ir (III) luminescent complexes, conjugates comprising these complexes as a label and their application, for example in electrochemiluminescence based detection of an analyte.

Abstract translation: 新型铱基Ir（III）发光复合物，包含这些络合物作为标记的共轭物及其应用，例如在基于电化学发光的检测分析物中。