利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

114 条记录 (耗时 0.041 秒)

    Barrier layer with underlying medical device and one or more reinforcing support structures
    42.
    发明申请
    Barrier layer with underlying medical device and one or more reinforcing support structures 有权
    具有底层医疗装置和一个或多个加强支撑结构的阻隔层

    公开(公告)号：US20080109017A1

    公开(公告)日：2008-05-08

    申请号：US11701799

    申请日：2007-02-02

    申请人： Steve A. Herweck ,  Joseph Ferraro ,  Paul Martakos ,  Theodore Karwoski ,  Anthony Richard Horton

    发明人： Steve A. Herweck ,  Joseph Ferraro ,  Paul Martakos ,  Theodore Karwoski ,  Anthony Richard Horton

    IPC分类号： A61F2/02

    CPC分类号： A61L31/145 ,  A61F2/0063 ,  A61F2/82 ,  A61F2002/0086 ,  A61F2002/009 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/606

    摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with anchoring reinforcements to aid with the fastening of the barrier device for implantation purposes and reinforcing truss sections or portions that prohibit or substantially reduce the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.

    摘要翻译： 阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。 如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。 底层结构可以是手术网的形式。 隔离装置还设置有锚固加强件，以帮助阻挡装置的固定用于植入目的，并且加强桁架部分或部分，其禁止或基本上减少过度拉伸和撕裂的发生。 阻挡装置可植入患者体内用于短期或长期应用，并且可包括治疗剂的受控释放。

    Application of a therapeutic substance to a tissue location using an expandable medical device
    43.
    发明申请
    Application of a therapeutic substance to a tissue location using an expandable medical device 有权
    使用可扩张医疗装置将治疗物质施用于组织位置

    公开(公告)号：US20050106206A1

    公开(公告)日：2005-05-19

    申请号：US10942764

    申请日：2004-09-15

    申请人： Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

    发明人： Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

    IPC分类号： A61K9/22 ,  A61K31/225 ,  A61L29/16 ,  A61L31/16 ,  A61M20060101 ,  A61M25/16

    CPC分类号： A61L29/16 ,  A61L31/16 ,  A61L2300/606

    摘要： A non-polymeric or biological coating applied to radially expandable interventional medical devices provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device. Thus, atraumatic local tissue transference delivery is achieved for uniform therapeutic agent distribution and controlled bio-absorption into the tissue after placement within a patient's body with a non-inflammatory coating.

    摘要翻译： 施加到可径向扩张的介入医疗装置的非聚合或生物涂层提供了涂层和与其混合的任何治疗剂的均匀的药物分布和渗透到体内的目标治疗区域。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。 因此，在用非炎性涂层放置在患者体内之后，实现了不均匀的局部组织转移递送，用于均匀的治疗剂分布和对组织的受控生物吸收。

    Application of a therapeutic substance to a tissue location using an expandable medical device
    44.
    发明申请
    Application of a therapeutic substance to a tissue location using an expandable medical device 有权
    使用可扩张医疗装置将治疗物质施用于组织位置

    公开(公告)号：US20080015500A1

    公开(公告)日：2008-01-17

    申请号：US11804478

    申请日：2007-05-18

    申请人： Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

    发明人： Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

    IPC分类号： A61M29/02

    CPC分类号： A61M25/1027 ,  A61L29/085 ,  A61L29/146 ,  A61L29/16 ,  A61L2300/22 ,  A61L2300/606 ,  A61M2025/1075 ,  A61M2025/1088 ,  C08L27/18

    摘要： A non-polymeric or biological coating applied to radially expandable medical delivery device provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The delivery device is expanded using the pressure of an inflation fluid. After expanding the delivery device to a pre-determined size and shape, the inflation fluid weeps through the porous surface of the delivery device. The coating releases the delivery device and floats on the inflation fluid until bonding to the tissue due to its affinity for the tissue. Once the coating bonds or affixes to the tissue, through an absorption mechanism by the tissue cells of the coating material, the coating and any therapeutics contained therein are delivered to the tissue. The fluid can contain a therapeutic agent, or can be otherwise biocompatible and/or inert.

    摘要翻译： 应用于可径向扩张的医疗输送装置的非聚合物或生物涂层提供了涂层和与其混合的任何治疗剂的均匀的药物分布和渗透到体内的目标治疗区域。 输送装置使用充气流体的压力膨胀。 在将输送装置膨胀至预定尺寸和形状之后，充气流体通过输送装置的多孔表面而流失。 涂层释放输送装置并漂浮在充气流体上，直到由于其对组织的亲和力而结合到组织。 一旦涂层通过涂层材料的组织细胞通过吸收机制结合或固定到组织，涂层和其中包含的任何治疗剂被递送到组织。 流体可以含有治疗剂，或者可以以其他方式生物相容和/或惰性。

    Expandable fluoropolymer device for delivery of therapeutic agents and method of making
    49.
    发明授权
    Expandable fluoropolymer device for delivery of therapeutic agents and method of making 有权
    用于递送治疗剂的可扩展含氟聚合物装置和制备方法

    公开(公告)号：US06955661B1

    公开(公告)日：2005-10-18

    申请号：US09411797

    申请日：1999-10-01

    申请人： Steve A. Herweck ,  Peter H. Gingras ,  Paul Martakos ,  Theodore Karwoski

    发明人： Steve A. Herweck ,  Peter H. Gingras ,  Paul Martakos ,  Theodore Karwoski

    IPC分类号： A61F2/958 ,  A61L29/04 ,  B29C47/00 ,  B29C55/24 ,  A61M5/00

    CPC分类号： A61M25/1029 ,  A61L29/041 ,  A61M25/10 ,  A61M2025/0057 ,  A61M2025/105 ,  A61M2025/1075 ,  B29C47/00 ,  B29C47/0023 ,  B29C55/24 ,  B29C2049/465 ,  B29K2027/18 ,  B29L2022/022 ,  B29L2031/753 ,  B32B2305/026 ,  C08L27/18

    摘要： A radially expandable fluid delivery device for delivering a fluid to a treatment site within the body is disclosed. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device. The fluid delivery device includes a tubular member defined by a wall having a thickness transverse to the longitudinal axis of the tubular member and extending between an inner and an outer surface. The wall is characterized by a microstructure of nodes interconnected by fibrils. The tubular member is deployable from a first, reduced diameter configuration to a second, increased diameter configuration upon the introduction of a pressurized fluid to the lumen. The tubular member includes at least one microporous portion having a porosity sufficient for the pressurized fluid to permeate through the wall. Substantially all of the nodes within the microporous portion are oriented such that spaces between the nodes form micro-channels extending from the inner surface-to the outer surface of the wall.

    摘要翻译： 公开了一种用于将流体输送到体内的治疗部位的可径向扩张的流体输送装置。 流体输送装置由具有微结构的微孔生物相容性含氟聚合物材料构成，微结构可以通过流体输送装置的壁提供受控的，均匀的低速流体分配，以有效地将流体输送到治疗部位，而不会损伤邻近的 设备的墙壁。 流体输送装置包括由壁限定的管状构件，其具有横向于管状构件的纵向轴线并在内表面和外表面之间延伸的厚度。 壁的特征在于通过纤维互连的节点的微结构。 当将加压流体引入内腔时，管状构件可从第一缩径直径构型展开至第二增大直径构型。 管状构件包括具有足以使加压流体渗透通过壁的孔隙的至少一个微孔部分。 基本上微孔部分内的所有节点被定向成使得节点之间的空间形成从壁的内表面延伸到外表面的微通道。

    Vascular endoprosthesis and method
    50.
    发明授权
    Vascular endoprosthesis and method 有权
    血管内假体和方法

    公开(公告)号：US06423089B1

    公开(公告)日：2002-07-23

    申请号：US09296349

    申请日：1999-04-22

    申请人： Peter Gingras ,  Paul Martakos ,  Theodore Karwoski ,  Steve A. Herweck

    发明人： Peter Gingras ,  Paul Martakos ,  Theodore Karwoski ,  Steve A. Herweck

    IPC分类号： A61F206

    CPC分类号： A61F2/82 ,  A61F2/07 ,  A61F2/90 ,  A61F2/958 ,  A61L31/048 ,  C08L27/18

    摘要： A vascular endoprosthesis is formed of a tubular liner preform with a continuous surface and having a diameter smaller than that of an intended vessel. The liner is inserted to a treatment site, and its sheet material undergoes a radially-directed expansion to a final size that fits the vessel. Insertion and in situ expansion are achieved using a catheter assembly in which either an internal stent, such as a stiff-filament helically woven tube, or an inflatable balloon urge the liner preform outwardly against the inner wall of the vessel. The stent, or one or more simple internal snap-rings anchor the expanded liner in place. The expanded liner is porous, or becomes more porous during expansion, and one or more aspects of its porosity are tailored to the intended treatment goal of immobilizing treatment material, isolating cells, or permitting controlled permeation of selected materials.

    摘要翻译： 血管内假体由具有连续表面并且直径小于预期血管的直径的管状衬垫预制件形成。 将衬垫插入到处理部位，并且其片材经历径向膨胀至适合容器的最终尺寸。 使用导管组件实现插入和原位扩张，其中内部支架例如刚性丝状螺旋编织管或可膨胀气囊将衬垫预制件向外压靠在容器的内壁上。 支架或一个或多个简单的内部卡环将扩张的衬垫固定就位。 膨胀的衬垫是多孔的，或在膨胀期间变得更多孔，并且其孔隙率的一个或多个方面是针对固定化处理材料，分离细胞或允许所选材料的受控渗透的预期治疗目标。