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公开(公告)号：US07977349B2
公开(公告)日：2011-07-12
申请号：US12188940
申请日：2008-08-08
申请人： Chantal Fuerstner , Kai Thede , Holger Zimmermann , David Brueckner , Kerstin Henninger , Dieter Lang , Rudolf Schohe-Loop
发明人： Chantal Fuerstner , Kai Thede , Holger Zimmermann , David Brueckner , Kerstin Henninger , Dieter Lang , Rudolf Schohe-Loop
IPC分类号： A61K31/4709 , A61P31/12 , C07D401/10 , C07D498/10 , C07D401/14
CPC分类号： C07D401/04 , C07D401/14 , C07D471/10
摘要： The invention relates to substituted quinolones and to methods for their preparation as well as to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.
摘要翻译： 本发明涉及取代的喹诺酮类及其制备方法，以及它们用于生产用于治疗和/或预防疾病的药物的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的药物。
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公开(公告)号：US20080261964A1
公开(公告)日：2008-10-23
申请号：US12006086
申请日：2007-12-28
申请人： Rudolf Schohe-Loop , Holger Zimmermann , Kerstin Henninger , Dieter Lang , Kai Thede , Chantal Fuerstner , David Brueckner
发明人： Rudolf Schohe-Loop , Holger Zimmermann , Kerstin Henninger , Dieter Lang , Kai Thede , Chantal Fuerstner , David Brueckner
IPC分类号： A61K31/5383 , C07D401/02 , A61K31/496 , A61P31/12 , C07D265/38
CPC分类号： C07D215/56
摘要： The invention relates to substituted quinolones of formula (I) and to methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, in particular against cytomegaloviruses.
摘要翻译： 本发明涉及式（I）的取代喹诺酮及其制备方法及其用于生产药物的用途，所述药物用于治疗和/或预防疾病，特别是用作抗病毒剂，特别是用于巨细胞病毒的疾病。
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公开(公告)号：US07320977B2
公开(公告)日：2008-01-22
申请号：US10511225
申请日：2003-04-08
申请人： Rudolf Schohe-Loop , Elmar Burchardt , Christiane Faeste , Claudia Hirth-Dietrich , Jörg Keldenich , Andreas Knorr , Thomas Lampe , Paul Naab , Delf Schmidt , Gunter Schmidt
发明人： Rudolf Schohe-Loop , Elmar Burchardt , Christiane Faeste , Claudia Hirth-Dietrich , Jörg Keldenich , Andreas Knorr , Thomas Lampe , Paul Naab , Delf Schmidt , Gunter Schmidt
IPC分类号： C07D403/04 , A61K31/501
CPC分类号： C07D231/12 , C07D233/56 , C07D237/22 , C07D249/08 , C07D401/04 , C07D401/12
摘要： The invention relates to substituted 2-Phenyl-3(2H)-Pyridazinones, to a method for the production thereof, and to their use as medicaments for the prophylaxis and/or treatment of diseases in humans and/or animals.
摘要翻译： 本发明涉及取代的2-苯基-3（2H） - 哒嗪酮，其制备方法及其用作预防和/或治疗人和/或动物疾病的药物。
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公开(公告)号：US20070191387A1
公开(公告)日：2007-08-16
申请号：US11728896
申请日：2007-03-26
申请人： Tobias Wunberg , Judith Baumeister , Ulrich Betz , Mario Jeske , Thomas Lampe , Susanne Nikolic , Jurgen Reefschlager , Rudolf Schohe-Loop , Frank Sussmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jorg Keldenich , Dieter Lang , Peter Nell
发明人： Tobias Wunberg , Judith Baumeister , Ulrich Betz , Mario Jeske , Thomas Lampe , Susanne Nikolic , Jurgen Reefschlager , Rudolf Schohe-Loop , Frank Sussmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jorg Keldenich , Dieter Lang , Peter Nell
IPC分类号： A61K31/517 , C07D403/04
CPC分类号： C07D239/84
摘要： The invention relates to substituted dihydroquinazolines and to processes for their preparation and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for use as antiviral agents, in particular against cytomegalo viruses.
摘要翻译： 本发明涉及取代的二氢喹唑啉及其制备方法，也涉及其用于制备用于治疗和/或预防疾病，特别是用作抗病毒剂，特别是针对巨细胞病毒的药物的用途。
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45.发明授权Benzisothiazolyl-substituted aminomethyl chromanes for treating diseases of the central nervous system 失效用于治疗中枢神经系统疾病的苯并异噻唑基取代的氨基甲基苯并吡喃公开(公告)号：US06919360B2
公开(公告)日：2005-07-19
申请号：US10490315
申请日：2002-09-18
申请人： Dietrich Scherling , Wolfgang Karl , Dietrich Seidel , Corinna Weinz , Rudolf Schohe-Loop , Frank Mauler
发明人： Dietrich Scherling , Wolfgang Karl , Dietrich Seidel , Corinna Weinz , Rudolf Schohe-Loop , Frank Mauler
IPC分类号： A61K31/425 , A61P9/00 , A61P17/02 , A61P25/00 , C07D417/12 , A61K31/428
CPC分类号： C07D417/12
摘要： The present invention relates to chromans, to processes for their preparation and to their use in medicaments, in particular as agents for treating disorders of the central nervous system.
摘要翻译： 本发明涉及染色剂，其制备方法及其在药物中的用途，特别是作为治疗中枢神经系统疾病的药剂。
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公开(公告)号：US5696137A
公开(公告)日：1997-12-09
申请号：US460475
申请日：1995-06-02
申请人： Hans-Georg Heine , Rudolf Schohe-Loop , Thomas Glaser , Jean Marie Viktor De Vry , Wolfgang Dompert , Henning Sommermeyer
发明人： Hans-Georg Heine , Rudolf Schohe-Loop , Thomas Glaser , Jean Marie Viktor De Vry , Wolfgang Dompert , Henning Sommermeyer
IPC分类号： A61K31/435 , A61K31/353 , A61K31/40 , A61K31/443 , A61K31/445 , A61K31/454 , A61P9/10 , A61P15/00 , A61P25/00 , A61P25/04 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P25/30 , A61P43/00 , C07D209/04 , C07D211/80 , C07D311/58 , C07D405/06 , C07D405/14 , C07D413/14 , C07D417/14 , C07D493/04 , C07D495/04 , C07D513/04 , A61K31/44 , C07D403/14
CPC分类号： C07D405/06 , C07D405/14 , C07D413/14 , C07D417/14 , C07D513/04
摘要： Azaheterocyclylmethyl-chromans of the formula: ##STR1## in which E represents an azaheterocyclyl group selected from the group consisting of: ##STR2## wherein R.sup.6 represents hydrogen, hydroxyl, halogen or phenyl; and n represents an integer 0-8; and the other substituents are as defined herein; or an optically isomeric form thereof or a salt thereof; are useful to treat anxiety, depression and psychoses.
摘要翻译： 其中E表示选自以下的氮杂杂环基团：其中R6表示氢，羟基，卤素或苯基;其中R6表示氢，羟基，卤素或苯基; n表示0〜8的整数。 并且其它取代基如本文所定义; 或其光学异构形式或其盐; 可用于治疗焦虑，抑郁和精神病。
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公开(公告)号：US5696136A
公开(公告)日：1997-12-09
申请号：US459071
申请日：1995-06-02
申请人： Hans-Georg Heine , Rudolf Schohe-Loop , Thomas Glaser , Jean Marie Viktor De Vry , Wolfgang Dompert , Henning Sommermeyer
发明人： Hans-Georg Heine , Rudolf Schohe-Loop , Thomas Glaser , Jean Marie Viktor De Vry , Wolfgang Dompert , Henning Sommermeyer
IPC分类号： A61K31/435 , A61K31/353 , A61K31/40 , A61K31/443 , A61K31/445 , A61K31/454 , A61P9/10 , A61P15/00 , A61P25/00 , A61P25/04 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P25/30 , A61P43/00 , C07D209/04 , C07D211/80 , C07D311/58 , C07D405/06 , C07D405/14 , C07D413/14 , C07D417/14 , C07D493/04 , C07D495/04 , C07D513/04 , A61K31/415
CPC分类号： C07D405/06 , C07D405/14 , C07D413/14 , C07D417/14 , C07D513/04
摘要： A method of treating psychosis by administering to a patient an azaheterocyclylmethyl-chroman of the formula: ##STR1## in which E represents an azaheterocyclyl group selected from the group consisting of: ##STR2## wherein R.sup.6 represents hydrogen, hydroxyl, halogen or phenyl; and represents an integer 0-8; and the other substituents are as defined herein; or an optically isomeric form thereof or a salt thereof.
摘要翻译： 一种治疗精神病的方法，其通过向患者施用下式的氮杂杂环甲基 - 色满酮：其中E表示选自以下的氮杂杂环基：其中R 6表示氢， 羟基，卤素或苯基; 并表示整数0-8; 并且其它取代基如本文所定义; 或其光学异构形式或其盐。
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公开(公告)号：US08324222B2
公开(公告)日：2012-12-04
申请号：US12086784
申请日：2006-12-08
申请人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop
发明人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop
IPC分类号： C07D491/04 , A61K31/519 , A61P9/00
CPC分类号： C07D491/04
摘要： The present application relates to novel, cyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.
摘要翻译： 本申请涉及新的循环取代的呋喃嘧啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于 治疗和/或预防心血管疾病。
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公开(公告)号：US08183246B2
公开(公告)日：2012-05-22
申请号：US12086783
申请日：2006-12-08
申请人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop
发明人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop
IPC分类号： A01N43/90 , A61K31/519 , C07D491/00 , C07D495/00
CPC分类号： C07D491/04
摘要： The present application relates to novel, acyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.
摘要翻译： 本申请涉及新颖的非循环取代的呋喃嘧啶衍生物，其生产方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于 治疗和/或预防心血管疾病。
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50.发明授权2-(3-phenyl-2-piperazinyl-3,4-dihydroquinazolin-4-yl)acetic acids as antiviral agents, especially against cytomegaloviruses 有权2-（3-苯基-2-哌嗪基-3,4-二氢喹唑啉-4-基）乙酸作为抗病毒剂，特别是针对巨细胞病毒公开(公告)号：US07960387B2
公开(公告)日：2011-06-14
申请号：US10545453
申请日：2004-01-29
申请人： Tobias Wunberg , Judith Baumeister , Ulrich Betz , Mario Jeske , Gerald Kleymann , Thomas Lampe , Susanne Nikolic , Jürgen Reefschläger , Rudolf Schohe-Loop , Frank Süβmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jörg Keldenich , Thomas Krämer , Peter Nell , Tse-I Lin
发明人： Tobias Wunberg , Judith Baumeister , Ulrich Betz , Mario Jeske , Gerald Kleymann , Thomas Lampe , Susanne Nikolic , Jürgen Reefschläger , Rudolf Schohe-Loop , Frank Süβmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jörg Keldenich , Thomas Krämer , Peter Nell , Tse-I Lin
IPC分类号： A61K31/497 , A61P31/12 , C07D401/04 , C07D239/84
CPC分类号： C07D239/84
摘要： The invention relates to dihydroquinazolines and methods for the production thereof, the use thereof in the treatment and/or prophylaxis of diseases, in addition to the use thereof in the production of medicaments in the treatment and/or prophylaxis of diseases, especially for use as anti-viral agents, especially against cytomegalo viruses.
摘要翻译： 本发明涉及二氢喹唑啉及其制备方法，其用于治疗和/或预防疾病的用途，除了在制备药物中用于治疗和/或预防疾病，特别是用作 抗病毒剂，特别是针对巨细胞病毒。
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