公开(公告)号：US07243367B2

公开(公告)日：2007-07-10

申请号：US10062860

申请日：2002-01-31

Applicant: James Kleinsteiber ,  Richard L. Hammons ,  Shankar Balasubramanian

Inventor： James Kleinsteiber ,  Richard L. Hammons ,  Shankar Balasubramanian

IPC: G06F7/04 ,  G06F15/16 ,  H04L9/00 ,  H04L12/00

CPC classification number: H04L63/0869 ,  H04L49/357

Abstract: A method and system for starting up a network or network device with particular discussion regarding Fibre Channel networks and switches. The method and system relate to powering on or re-starting a plurality of Fibre Channel switching devices, each of those devices having ports. The system generally calls for the selection of a priority threshold that relates to the importance of tasks in fabric formation. Some embodiments of the system exploit a port authentication procedure to separate the execution of tasks higher in priority than the threshold from tasks lower in priority than the threshold.

Abstract translation: 一种用于启动网络或网络设备的方法和系统，具体涉及光纤通道网络和交换机。 该方法和系统涉及为多个光纤通道交换设备供电或重新启动，每个设备具有端口。 系统通常要求选择与织物形成中的任务的重要性有关的优先级阈值。 该系统的一些实施例利用端口认证过程，从优先级低于阈值的任务中分离优先级高于阈值的任务的执行。

公开(公告)号：US20060064743A1

公开(公告)日：2006-03-23

申请号：US11269437

申请日：2005-11-08

Applicant: Richard Hammons ,  James Kleinsteiber ,  Hung Nguyen ,  Shankar Balasubramanian ,  Vidya Renganarayanan

Inventor： Richard Hammons ,  James Kleinsteiber ,  Hung Nguyen ,  Shankar Balasubramanian ,  Vidya Renganarayanan

IPC: H04L9/32 ,  G06F17/30 ,  G06F15/16 ,  G06F7/04 ,  G06F7/58 ,  G06K19/00 ,  G06K9/00

CPC classification number: H04L63/0823 ,  H04L63/0428 ,  H04L63/101

Abstract: A network configuration device or entity has control of defined management and security functions in the network, or in many embodiments, in a Fibre Channel fabric. The network configuration device may control many functions. Foremost, it may control the recognition, operation and succession procedure for network configuration entities. It may also control user configurable options for the network, rules for interaction between other entities in the network, rules governing management-level access to the network, and rules governing management-level access to individual devices in the network. In addition, the network configuration entity may exploit policy sets to implement its control.

公开(公告)号：US20060035233A1

公开(公告)日：2006-02-16

申请号：US10537188

申请日：2003-12-02

Applicant: Niall Gormley ,  Shankar Balasubramanian

Inventor： Niall Gormley ,  Shankar Balasubramanian

IPC: C12Q1/68 ,  C07H21/04

CPC classification number: C12Q1/6837 ,  C12Q2525/301 ,  C12Q2521/301 ,  C12Q2521/313

Abstract: The present invention relates to methods for regenerating a single-stranded nucleic acid template following its conversion to a double-stranded product, e.g., during a polymerase reaction, and also to regenerating a hairpin or anchoring sequence by removal of the template and its synthesized complement, by design of enzyme restriction sites into the hairpin or anchoring sequence.

Abstract translation: 本发明涉及在转化成双链产物之后，例如在聚合酶反应期间再生单链核酸模板的方法，还涉及通过除去模板及其合成的补体来再生发夹或锚定序列 通过将酶限制性位点设计到发夹或锚定序列中。

公开(公告)号：US06787308B2

公开(公告)日：2004-09-07

申请号：US09771708

申请日：2001-01-30

Applicant: Shankar Balasubramanian ,  David Klenerman ,  David Bentley

Inventor： Shankar Balasubramanian ,  David Klenerman ,  David Bentley

IPC: C12Q168

CPC classification number: C12Q1/6837 ,  B01J19/0046 ,  B01J2219/00274 ,  B01J2219/00317 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/0054 ,  B01J2219/00572 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00707 ,  B01J2219/00722 ,  C12Q2525/301 ,  C40B40/06 ,  C40B60/14 ,  C12Q2521/501 ,  C12Q2565/507

Abstract: A device comprising an array of molecules immobilised on a solid surface is disclosed, wherein the array has a surface density which allows each molecule to be individually resolved, e.g. by optical microscopy. Therefore, the arrays of the present invention consist of single molecules are more spatially distinct than the arrays of the prior art.

公开(公告)号：US09959278B1

公开(公告)日：2018-05-01

申请号：US13248408

申请日：2011-09-29

Applicant: Vaibhav Khanduja ,  Shankar Balasubramanian

Inventor： Vaibhav Khanduja ,  Shankar Balasubramanian

IPC: G06F17/30 ,  G06F11/14

CPC classification number: G06F17/30088 ,  G06F11/1446

Abstract: A method for performing block-level incremental backups of file system volumes using a pseudo device layer of a volume manager. A driver associated with a snapshot backup program is configured to back up the full pseudo disk upon receipt of a backup request, and not automatically performed upon startup. Incremental backups are performed thereafter using a driver that has been modified to include a monitor that tracks writes during backups. The standard I/O routine of the kernel is overwritten with an I/O routine that tracks write operations. The volume manager is called back to perform the incremental backup operations upon each write operation. The going down routine of the kernel is also overwritten to track any updates to the volume manager. If the volume manager is updated, the data structure is cleared and future backups are performed from a subsequent full backup.

公开(公告)号：US09712613B2

公开(公告)日：2017-07-18

申请号：US10425567

申请日：2003-04-29

Applicant: Shankar Balasubramanian ,  Balakumar N. Kaushik ,  Richard L. Hammons

Inventor： Shankar Balasubramanian ,  Balakumar N. Kaushik ,  Richard L. Hammons

IPC: H04L29/08 ,  H04L29/06

CPC classification number: H04L67/1095 ,  H04L29/06 ,  H04L67/1097 ,  H04L69/329

Abstract: Copy capability moved into the SAN fabric and provided as a data mover service. A well-known address is utilized to receive copy commands from the hosts. Each switch in the fabric contains a front end or service interface which receives the copy command and manages access control or zoning and LUN mapping. LUN mapping and zoning are based on shared databases. Assuming correct zoning, the service interface will perform any necessary LUN mapping on the received copy command and forward the command to a copy engine to perform the copy operation. The switch service interface also maintains copy operation status, querying the copy engine if necessary, so that any host status requests are also simply handled. Additionally, if multiple copy engines are present, the switches can communicate to perform load balancing.

公开(公告)号：US20160258014A1

公开(公告)日：2016-09-08

申请号：US15075370

申请日：2016-03-21

Applicant: Michael John Booth ,  Shankar Balasubramanian

Inventor： Michael John Booth ,  Shankar Balasubramanian

IPC: C12Q1/68 ,  C01G55/00 ,  C07H1/00 ,  C07H21/02 ,  C07H21/04

CPC classification number: C12Q1/6876 ,  C01G55/002 ,  C07H1/00 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/6806 ,  C12Q1/6827 ,  C12Q2600/154 ,  C12Q2523/115 ,  C12Q2523/125

Abstract: This invention relates to the identification of modified cytosine residues, such as 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) to be distinguished from cytosine (C) in a sample nucleotide sequence. Methods may comprise oxidising or reducing a first portion of polynucleotides which comprise the sample nucleotide sequence; treating the oxidised or reduced first portion and a second portion of polynucleotides with bisulfite; sequencing the polynucleotides in the first and second portions of the population following steps ii) and iii) to produce first and second nucleotide sequences, respectively and; identifying the residue in the first and second nucleotide sequences which corresponds to a cytosine residue in the sample nucleotide sequence. These methods may be useful, for example in the analysis of genomic DNA and/or of RNA.

Abstract translation: 本发明涉及在样本核苷酸序列中鉴定与胞嘧啶（C）不同的修饰胞嘧啶残基如5-甲基胞嘧啶（5mC），5-羟甲基胞嘧啶（5hmC）和5-甲酰胞嘧啶（5fC）。 方法可以包括氧化或还原包含样品核苷酸序列的多核苷酸的第一部分; 用亚硫酸氢盐处理氧化或还原的第一部分和第二部分多核苷酸; 在步骤ii）和iii）之后对群体的第一和第二部分中的多核苷酸进行测序以分别产生第一和第二核苷酸序列; 识别与样品核苷酸序列中的胞嘧啶残基相对应的第一和第二核苷酸序列中的残基。 这些方法可能是有用的，例如在基因组DNA和/或RNA的分析中。

公开(公告)号：US09290807B2

公开(公告)日：2016-03-22

申请号：US14235707

申请日：2012-07-27

Applicant: Michael John Booth ,  Shankar Balasubramanian

Inventor： Michael John Booth ,  Shankar Balasubramanian

IPC: C12Q1/68

CPC classification number: C12Q1/6876 ,  C01G55/002 ,  C07H1/00 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/6806 ,  C12Q1/6827 ,  C12Q2600/154 ,  C12Q2523/115 ,  C12Q2523/125

Abstract: This invention relates to the identification of modified cytosine residues, such as 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) to be distinguished from cytosine (C) in a sample nucleotide sequence. Methods may comprise oxidizing or reducing a first portion of polynucleotides which comprise the sample nucleotide sequence; treating the oxidized or reduced first portion and a second portion of polynucleotides with bisulfite; sequencing the polynucleotides in the first and second portions of the population following steps ii) and iii) to produce first and second nucleotide sequences, respectively and; identifying the residue in the first and second nucleotide sequences which corresponds to a cytosine residue in the sample nucleotide sequence. These methods may be useful, for example in the analysis of genomic DNA and/or of RNA.

Abstract translation: 本发明涉及在样本核苷酸序列中鉴定与胞嘧啶（C）不同的修饰胞嘧啶残基如5-甲基胞嘧啶（5mC），5-羟甲基胞嘧啶（5hmC）和5-甲酰胞嘧啶（5fC）。 方法可以包括氧化或还原包含样品核苷酸序列的多核苷酸的第一部分; 用亚硫酸氢盐处理氧化或还原的第一部分和第二部分多核苷酸; 在步骤ii）和iii）之后对群体的第一和第二部分中的多核苷酸进行测序以分别产生第一和第二核苷酸序列; 识别与样品核苷酸序列中的胞嘧啶残基相对应的第一和第二核苷酸序列中的残基。 这些方法可能是有用的，例如在基因组DNA和/或RNA的分析中。

公开(公告)号：US09128943B1

公开(公告)日：2015-09-08

申请号：US13248223

申请日：2011-09-29

Applicant: Vaibhav Khanduja ,  Shankar Balasubramanian ,  Sureshbabu Murugesan

Inventor： Vaibhav Khanduja ,  Shankar Balasubramanian ,  Sureshbabu Murugesan

IPC: G06F17/30

CPC classification number: G06F17/30091 ,  G06F11/1451 ,  G06F11/1458 ,  G06F2201/84

Abstract: A method for tracking resizing and recreation of volumes in a block-based snapshot backup program. In an embodiment, a record ID is associated with a major and minor number assigned to each volume to be backed up. The record ID maintains a unique reference to the bitmap corresponding to a backed up volume in case the minor number is reused by the volume manager driver during a recreate operation. The length of the volume to be maintained is maintained and compared to the length of the to track any resizing of the volume by the volume manager. In the event of any resizing or recreation, the original bitmap can be replaced with an updated bitmap to ensure proper backup of the resized or recreated volumes.

Abstract translation: 在基于块的快照备份程序中跟踪卷的大小和重建的方法。 在一个实施例中，记录ID与分配给要备份的每个卷的主号码和次号相关联。 记录ID维护对与备份卷相对应的位图的唯一引用，以防在重新创建操作期间由卷管理器驱动程序重复使用次要编号。 要维护的卷的长度被维护，并且与卷管理器跟踪卷的任何调整大小的长度进行比较。 在任何调整大小或娱乐的情况下，可以使用更新的位图替换原始位图，以确保对已调整大小或重新创建的卷的正确备份。

公开(公告)号：US08623628B2

公开(公告)日：2014-01-07

申请号：US11431939

申请日：2006-05-10

Applicant: Tobias William Barr Ost ,  Geoffrey Paul Smith ,  Shankar Balasubramanian ,  Roberto Rigatti ,  Raquel Maria Sanches

Inventor： Tobias William Barr Ost ,  Geoffrey Paul Smith ,  Shankar Balasubramanian ,  Roberto Rigatti ,  Raquel Maria Sanches

IPC: C12N9/12

CPC classification number: C12N9/1252 ,  C12Q1/686 ,  C12Y207/07007

Abstract: Modified DNA polymerases have an affinity for DNA such that the polymerase has an ability to incorporate one or more nucleotides into a plurality of separate DNA templates in each reaction cycle. The polymerases are capable of forming an increased number of productive polymerase-DNA complexes in each reaction cycle. The modified polymerases may be used in a number of DNA sequencing applications, especially in the context of clustered arrays.