公开(公告)号：US07372441B2

公开(公告)日：2008-05-13

申请号：US10868523

申请日：2004-06-15

申请人： Shawn Gallagher ,  Matthew Johnson ,  Timothy Zink

发明人： Shawn Gallagher ,  Matthew Johnson ,  Timothy Zink

IPC分类号： G09G3/10 ,  G09G3/14 ,  G09G3/32

CPC分类号： H05B33/0803 ,  H05B33/0818 ,  H05B33/0842

摘要： A circuit is provided for over-driving a super-luminescent light emitting diode having a maximum forward continuous current rating. A power supply provides a pulse width modulated signal to an analog memory connected to the power supply and a pulse generator. The pulse generator includes a window comparator engaged with the analog memory, and is responsive to a portion of the pulse width modulated signal. A power driver that is controlled by the output of the pulse generator, is operably connected with the super-luminescent light emitting diode and with the power supply so as to energize the super-luminescent light emitting diode with a current that is above the maximum forward continuous current rating by between two and ten times that rated current. A signal is also provided along with a method of over-driving a super-luminescent light emitting diode. An inverter and timer are coupled to the pulse generator and an array of light emitting diodes that operate at time intervals determined by the timer that are wholly distinct from time intervals when the at least one super-luminescent light emitting diode is over-driven.

摘要翻译： 提供一种用于过驱动具有最大正向连续电流额定值的超发光发光二极管的电路。 电源向连接到电源的模拟存储器和脉冲发生器提供脉宽调制信号。 脉冲发生器包括与模拟存储器接合的窗口比较器，并且响应脉冲宽度调制信号的一部分。 由脉冲发生器的输出控制的功率驱动器与超发光发光二极管和电源可操作地连接，以便以超过最大向前的电流激励超发光发光二极管 连续额定电流为额定电流的两倍和十倍。 还提供了一种过驱动超发光发光二极管的方法。 反相器和定时器耦合到脉冲发生器和发光二极管阵列，其在由定时器确定的时间间隔上工作，当至少一个超发光发光二极管被过驱动时，它们完全不同于时间间隔。

公开(公告)号：US07125706B2

公开(公告)日：2006-10-24

申请号：US09880609

申请日：2001-06-12

申请人： Shuyuan Zhang ,  Capucine Thwin ,  Zheng Wu ,  Toohyon Cho ,  Shawn Gallagher

发明人： Shuyuan Zhang ,  Capucine Thwin ,  Zheng Wu ,  Toohyon Cho ,  Shawn Gallagher

IPC分类号： C12N7/01 ,  C12N15/861 ,  A61K39/235

CPC分类号： C07K14/4746 ,  A61K35/761 ,  A61K38/00 ,  A61K48/00 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/10351 ,  C12N2710/10352 ,  C12N2750/14143

摘要： The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have shown that there is improved Ad-p53 production cells grown in serum-free conditions, and in particular in serum-free suspension culture. Also important to the increase of yields is the use of detergent lysis. Combination of these aspects of the invention permits purification of virus by a single chromatography step that results in purified virus of the same quality as preparations from double CsCl banding using an ultracentrifuge.

摘要翻译： 本发明解决了在细胞培养系统中生长时提高病毒载体产量的需要。 特别地，已经证明，对于腺病毒，在附着的细胞培养系统中使用低中等灌注速率提供了提高的产量。 在其它实施方案中，发明人已经表明，在无血清条件下，特别是在无血清悬浮培养物中生长的Ad-p53生产细胞有改善。 提高产量也很重要的是使用洗涤剂溶解。 本发明的这些方面的组合允许通过单个色谱步骤纯化病毒，其导致与使用超速离心机的双CsCl条带制备相同质量的纯化病毒。

公开(公告)号：US07073481B2

公开(公告)日：2006-07-11

申请号：US10249874

申请日：2003-05-14

申请人： W. Douglas Glenn ,  Eric Dillen ,  Shawn Gallagher ,  Prakash Bedapudi

发明人： W. Douglas Glenn ,  Eric Dillen ,  Shawn Gallagher ,  Prakash Bedapudi

IPC分类号： F02D31/00 ,  F02M37/04

CPC分类号： F02D41/401 ,  F02B3/06 ,  F02B2275/14 ,  F02D29/02 ,  F02D2200/0414 ,  F02D2200/703 ,  F02M59/00 ,  F02M61/18 ,  Y02T10/123 ,  Y02T10/42 ,  Y02T10/44

摘要： A diesel engine (E) has a combustion chamber (C), a piston (T) movable in the chamber, air intake and exhaust valves (IV, EV), and a nozzle (N) injecting fuel into the combustion chamber. By controlling characteristics of an air-fuel mixture, emissions produced by combustion of the air-fuel mixture in the chamber are reduced to levels which satisfy the Tier 2 requirements established by the Environmental Protection Agency (EPA) for the engine. This may include controlling hydraulic flow characteristics through the nozzle, increasing the compression ratio within the combustion chamber, lowering the manifold air temperature (MAT), and retarding the start of fuel injection (SOI) within the chamber.

摘要翻译： 柴油发动机（E）具有燃烧室（C），可在室内移动的活塞（T），进气和排气阀（IV，EV）以及向燃烧室喷射燃料的喷嘴（N）。 通过控制空气 - 燃料混合物的特性，室内空气燃料混合物的燃烧产生的排放减少到满足环境保护局（EPA）为发动机确定的方法2要求的水平。 这可以包括控制通过喷嘴的液压流动特性，增加燃烧室内的压缩比，降低歧管空气温度（MAT），以及延迟室内燃料喷射（SOI）的开始。

公开(公告)号：US07071633B2

公开(公告)日：2006-07-04

申请号：US10617280

申请日：2003-07-10

申请人： Shawn Gallagher ,  Matthew Johnson ,  Timothy Zink

发明人： Shawn Gallagher ,  Matthew Johnson ,  Timothy Zink

IPC分类号： H05B37/00

CPC分类号： H05B33/0842 ,  H05B33/0803 ,  H05B33/0818

摘要： A circuit is provided for over-driving a super-luminescent light emitting diode having a maximum forward continuous current rating. A power supply provides a pulse width modulated signal to an analog memory connected to the power supply and a pulse generator. The pulse generator includes a window comparator engaged with the analog memory, and is responsive to a portion of the pulse width modulated signal. A power driver that is controlled by the output of the pulse generator, is operably connected with the super-luminescent light emitting diode and with the power supply so as to energize the super-luminescent light emitting diode with a current that is above the maximum forward continuous current rating by between two and ten times that rated current. A signal is also provided along with a method of over-driving a super-luminescent light emitting diode.

公开(公告)号：US20060132064A1

公开(公告)日：2006-06-22

申请号：US11343645

申请日：2006-01-30

申请人： Shawn Gallagher ,  Matthew Johnson ,  Timothy Zink

发明人： Shawn Gallagher ,  Matthew Johnson ,  Timothy Zink

IPC分类号： H05B37/02

CPC分类号： H05B33/0842 ,  H05B33/0803 ,  H05B33/0818

摘要： A circuit is provided for over-driving a super-luminescent light emitting diode having a maximum forward continuous current rating. A power supply provides a pulse width modulated signal to an analog memory connected to the power supply and a pulse generator. The pulse generator includes a window comparator engaged with the analog memory, and is responsive to a portion of the pulse width modulated signal. A power driver that is controlled by the output of the pulse generator, is operably connected with the super-luminescent light emitting diode and with the power supply so as to energize the super-luminescent light emitting diode with a current that is above the maximum forward continuous current rating by between two and ten times that rated current. A signal is also provided along with a method of over-driving a super-luminescent light emitting diode.