BIOLOGIC DEVICE FOR REGULATION OF GENE EXPRESSION AND METHOD THEREFOR
    41.
    发明申请
    BIOLOGIC DEVICE FOR REGULATION OF GENE EXPRESSION AND METHOD THEREFOR 审中-公开
    用于调节基因表达的生物学设备及其方法

    公开(公告)号:US20070036771A1

    公开(公告)日:2007-02-15

    申请号:US11277552

    申请日:2006-03-27

    IPC分类号: A61K48/00 G06F19/00 A61N1/00

    摘要: A system and device are provided which include a gene regulatory system controlling expression of one or more expression cassettes present in or released by the device, by emitting one or more stimulations. An expression cassette includes a regulatable transcription control element that is responsive to the emitted stimulations linked to an open reading frame of interest. The system optionally includes a sensor to sense a parameter indicative of a need, a telemetry module to receive an external command, or a programmable device, for regulating gene expression of the open reading frame.

    摘要翻译: 提供了一种系统和装置,其包括通过发射一种或多种刺激来控制存在于或释放的装置中的一种或多种表达盒的表达的基因调控系统。 表达盒包括可调节的转录控制元件,其响应于与感兴趣的开放阅读框架相关联的发射刺激。 该系统可选地包括用于感测指示需要的参数的传感器,用于接收外部命令的遥测模块或用于调节开放阅读框的基因表达的可编程设备。

    Epicardial patch including isolated extracellular matrix with pacing electrodes
    42.
    发明申请
    Epicardial patch including isolated extracellular matrix with pacing electrodes 失效
    心外膜包括分离的细胞外基质与起搏电极

    公开(公告)号:US20060136028A1

    公开(公告)日:2006-06-22

    申请号:US11017627

    申请日:2004-12-20

    IPC分类号: A61N1/05

    摘要: An epicardial patch includes an extracellular matrix (ECM) and a plurality of electrodes. The isolated ECM is configured for epicardial attachment over a myocardial region including an injured area to control post-injury remodeling of the myocardial region. The plurality of electrodes is configured for delivering electrical stimulation to enhance the effect of the isolated ECM in remodeling control by altering workload and stress on the myocardial region.

    摘要翻译: 心外膜贴片包括细胞外基质(ECM)和多个电极。 分离的ECM被配置用于在包括受伤区域的心肌区域上的心外膜附着以控制心肌区域的损伤后重建。 多个电极被配置为通过改变心肌区域上的工作负荷和压力来传递电刺激以增强孤立的ECM在重塑控制中的作用。

    Method and apparatus for minimizing post-infarct ventricular remodeling
    45.
    发明申请
    Method and apparatus for minimizing post-infarct ventricular remodeling 失效
    用于最小化梗死后心室重塑的方法和装置

    公开(公告)号:US20050288720A1

    公开(公告)日:2005-12-29

    申请号:US10862011

    申请日:2004-06-04

    IPC分类号: A61N1/362

    CPC分类号: A61N1/3627

    摘要: A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. The pre-excitation pacing in conjunction with counterpulsation therapy serves to either prevent or minimize post-infarct remodeling.

    摘要翻译: 心律管理装置被配置为将预激励起搏递送到心室心肌梗塞区域附近的一个或多个部位。 预激励起搏结合反搏疗法可预防或最小化梗死后重塑。

    Servo drive bag machine
    47.
    发明授权
    Servo drive bag machine 失效
    伺服驱动袋机

    公开(公告)号:US5094656A

    公开(公告)日:1992-03-10

    申请号:US269820

    申请日:1988-11-10

    IPC分类号: B31B1/10 B31B19/10

    CPC分类号: B31B19/00 B31B2219/022

    摘要: A machine for the continuous production of plastic bags utilizes a servo drive motor to drive the machines film web draw roll assembly and through a seal roll index gear also to drive a seal roll of the machine in coordination with the servo driven draw roll.

    摘要翻译: 用于连续生产塑料袋的机器利用伺服驱动电机来驱动机器薄膜卷筒纸组件并通过密封辊分度齿轮,以与伺服驱动牵引辊协调地驱动机器的密封辊。

    Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure
    50.
    发明申请
    Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure 有权
    在缺血后或心力衰竭期间调节细胞代谢的方法和装置

    公开(公告)号:US20080091138A1

    公开(公告)日:2008-04-17

    申请号:US11998969

    申请日:2007-12-03

    IPC分类号: A61M31/00

    摘要: A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid to glucose. One example of such a system includes an implantable device detecting an ischemia and a transdermal drug delivery device delivering a drug when an ischemic condition is detected. Another example of such a system includes one or more implantable devices detecting a predefined change in cardiac metabolic level and delivering a drug when the change is detected. Such systems are applied to treat, for example, patients suffering ischemia and/or heart failure and patients having suffered myocardial infarction.

    摘要翻译: 药物递送系统检测指示需要增加心脏代谢水平的心脏状况,并且作为响应将药物释放到组织或血液中以将促进心脏收缩的代谢合成能量的来源从脂肪酸转移到葡萄糖。 这种系统的一个实例包括检测缺血的可植入装置和当检测到缺血状况时递送药物的透皮药物递送装置。 这种系统的另一个例子包括一个或多个可植入装置,用于检测心脏代谢水平的预定变化并在检测到变化时递送药物。 这种系统被应用于治疗例如患有缺血和/或心力衰竭的患者和患有心肌梗塞的患者。