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    COMPOSITIONS AND METHODS FOR SYSTEMIC DELIVERY OF Bcl-2 AND Bcl-xL ANTAGONISTS
    43.
    发明申请
    COMPOSITIONS AND METHODS FOR SYSTEMIC DELIVERY OF Bcl-2 AND Bcl-xL ANTAGONISTS 有权

    公开(公告)号：US20230025865A1

    公开(公告)日：2023-01-26

    申请号：US17784404

    申请日：2020-12-11

    Applicant: The Regents of the University of Michigan

    Inventor： Duxin Sun ,  Wei Gao ,  Hongxiang Hu

    IPC: C07D401/14 ,  A61K9/14 ,  A61P35/00

    Abstract: This disclosure provides compositions and methods for albumin nanoformulation of Bcl-2 and Bcl-xL inhibitor APG-1252 to suppress and/or inhibit growth of cancer cells (e.g., tumor cells). In particular, the present invention is directed to compositions comprising nanoparticles associated with (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) APG-1252, methods for synthesizing such nanoparticles, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings). Such nanoparticle formulations of APG-1252 are capable of increasing solubility, protecting against its degradation, reducing platelet toxicity, and expanding (improving) different indications to improve anticancer efficacy in various cancers and cancer metastasis in lymph nodes.

    Conjugated gold nanoparticles
    46.
    发明授权
    Conjugated gold nanoparticles 有权
    共轭金纳米颗粒

    公开(公告)号：US09587071B2

    公开(公告)日：2017-03-07

    申请号：US14962619

    申请日：2015-12-08

    Applicant: The Regents of the University of Michigan ,  IMRA of America, Inc.

    Inventor： Duxin Sun ,  Hongwei Chen ,  Wei Qian ,  Yong Che ,  Masayuki Ito ,  Hayley Paholak ,  Kanokwan Sansanaphongpricha

    IPC: C08G65/48 ,  A61K47/48 ,  C08G65/334 ,  A61K41/00 ,  A61K49/00

    CPC classification number: C08G65/48 ,  A61K41/0052 ,  A61K47/50 ,  A61K47/60 ,  A61K49/0065 ,  C08G65/3344

    Abstract: The present invention relates to methods, compositions, and kits for generating conjugated gold nanoparticles. In certain embodiments, the present invention provides methods of generating unsaturated conjugated gold nanoparticles by mixing naked gold nanoparticles with a first type of attachment molecules at a molar ratio such that the attachment molecules attach to the naked gold particles at a density level below the saturation level of the naked gold particles (e.g., at a saturation level of 1-99%). In some embodiments, a second type of attachment molecules (e.g., with the opposite charge as the first type of attachment molecules) are mixed with the unsaturated conjugated gold nanoparticles to generate double-conjugated gold nanoparticles (e.g., that are zwitterionic).

    Abstract translation: 本发明涉及用于产生共轭金纳米颗粒的方法，组合物和试剂盒。 在某些实施方案中，本发明提供了通过将裸金纳米颗粒与第一类型附着分子以摩尔比混合以使得附着分子以低于饱和水平的密度水平附着于裸金颗粒的方式来产生不饱和共轭金纳米颗粒的方法 的裸金粒子（例如，在1-99％的饱和度水平）。 在一些实施方案中，将第二类型的附着分子（例如，具有相反电荷作为第一类型的附着分子）与不饱和共轭金纳米颗粒混合以产生双共轭金纳米颗粒（例如，两性离子）。

    CONJUGATED GOLD NANOPARTICLES
    47.
    发明申请
    CONJUGATED GOLD NANOPARTICLES 有权
    结合金纳米粒子

    公开(公告)号：US20160090446A1

    公开(公告)日：2016-03-31

    申请号：US14962619

    申请日：2015-12-08

    Applicant: IMRA of America, Inc. ,  The Regents of the University of Michigan

    Inventor： Duxin Sun ,  Hongwei Chen ,  Wei Qian ,  Yong Che ,  Masayuki Ito ,  Hayley Paholak ,  Kanokwan Sansanaphongpricha

    IPC: C08G65/48

    CPC classification number: C08G65/48 ,  A61K41/0052 ,  A61K47/50 ,  A61K47/60 ,  A61K49/0065 ,  C08G65/3344

    Abstract: The present invention relates to methods, compositions, and kits for generating conjugated gold nanoparticles. In certain embodiments, the present invention provides methods of generating unsaturated conjugated gold nanoparticles by mixing naked gold nanoparticles with a first type of attachment molecules at a molar ratio such that the attachment molecules attach to the naked gold particles at a density level below the saturation level of the naked gold particles (e.g., at a saturation level of 1-99%). In some embodiments, a second type of attachment molecules (e.g., with the opposite charge as the first type of attachment molecules) are mixed with the unsaturated conjugated gold nanoparticles to generate double-conjugated gold nanoparticles (e.g., that are zwitterionic).

    Abstract translation: 本发明涉及用于产生共轭金纳米颗粒的方法，组合物和试剂盒。 在某些实施方案中，本发明提供了通过将裸金纳米颗粒与第一类型附着分子以摩尔比混合以使得附着分子以低于饱和水平的密度水平附着于裸金颗粒的方式来产生不饱和共轭金纳米颗粒的方法 的裸金粒子（例如，在1-99％的饱和度水平）。 在一些实施方案中，将第二类型的附着分子（例如，具有相反电荷作为第一类型的附着分子）与不饱和共轭金纳米颗粒混合以产生双共轭金纳米颗粒（例如，两性离子）。

    CLEAVABLE POLYMERIC MICELLES
    48.
    发明申请
    CLEAVABLE POLYMERIC MICELLES 审中-公开
    可溶性聚合物

    公开(公告)号：US20160058702A1

    公开(公告)日：2016-03-03

    申请号：US14838618

    申请日：2015-08-28

    Applicant: The Regents of the University of Michigan

    Inventor： Kanokwan Sansanaphongpricha ,  Hongwei Chen ,  Duxin Sun

    IPC: A61K9/107 ,  A61K47/34 ,  A61K31/704

    CPC classification number: A61K9/107 ,  A61K9/0019 ,  A61K9/5138 ,  A61K9/5146 ,  A61K31/00 ,  A61K31/704 ,  A61K47/34

    Abstract: The present invention provides compositions, systems, and methods employing cleavable polymeric micelles. For example, provided herein are compositions comprising micelles that contain a hydrophobic agent (e.g., metal nanoparticles and/or therapeutic agent), where the micelles are formed from a plurality of amphiphilic polymer molecules that comprise a hydrophilic polymer and a hydrophobic polymer, where the hydrophobic polymer comprises a cleavable Furan-Maleimide adduct. Also provided herein are methods of administering such compositions to a subject and treating a localized area of the subject with a device that emits heat, NIR light, and/or alternating magnetic current such that at least some of the micelles inside the subject near the localized area are disrupted (e.g., releasing a therapeutic agent).

    Abstract translation: 本发明提供了使用可切割聚合胶束的组合物，体系和方法。 例如，本文提供了包含含有疏水剂（例如，金属纳米颗粒和/或治疗剂）的胶束的组合物，其中胶束由包含亲水性聚合物和疏水性聚合物的多个两亲聚合物分子形成，其中 疏水性聚合物包含可切割的呋喃 - 马来酰亚胺加合物。 本文还提供了将这种组合物施用于受试者并用发射热，NIR光和/或交替磁流的装置治疗受试者的局部区域的方法，使得受试者内的至少一些胶束接近局部 区域被破坏（例如释放治疗剂）。

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