公开(公告)号：US20050228168A1

公开(公告)日：2005-10-13

申请号：US10992133

申请日：2004-11-19

申请人： Koichi Kinoshita ,  Fumio Osakada ,  Yasuyoshi Ueda ,  Karunakaran Narasimhan ,  Angella Cearley ,  Kenneth Yee ,  Isao Noda

发明人： Koichi Kinoshita ,  Fumio Osakada ,  Yasuyoshi Ueda ,  Karunakaran Narasimhan ,  Angella Cearley ,  Kenneth Yee ,  Isao Noda

IPC分类号： C08F6/00 ,  C08G63/06 ,  C08G63/90 ,  C12P7/62

CPC分类号： C12P7/625 ,  C08G63/06 ,  C08G63/90

摘要： The present invention provides a method for conveniently obtaining a biodegradable polyhydroxyalkanoate by a solvent extraction method. A method for producing a polyhydroxyalkanoate crystal comprises precipitating a polyhydroxyalkanoate crystal using a monohydric alcohol having 4 to 10 carbon atoms as a extraction solvent, keeping a polyhydroxyalkanoate solution containing 0.1 to 10% by weight of water relative to the total amount of the solution warm at 70° C. or higher, and cooling the solution to below 70° C.

摘要翻译： 本发明提供一种通过溶剂萃取方法方便地获得生物可降解的聚羟基链烷酸酯的方法。 聚羟基链烷酸酯晶体的制造方法包括使用具有4〜10个碳原子的一元醇作为提取溶剂使聚羟基链烷酸酯晶体析出，保持含有0.1〜10重量％的水的聚羟基链烷酸酯溶液相对于温度为 70℃以上，将溶液冷却至70℃以下。

公开(公告)号：US20050226858A1

公开(公告)日：2005-10-13

申请号：US11101437

申请日：2005-04-08

申请人： Shiro Kitamura ,  Takahiro Ueda ,  Kenji Fujii ,  Yasuyoshi Ueda

发明人： Shiro Kitamura ,  Takahiro Ueda ,  Kenji Fujii ,  Yasuyoshi Ueda

IPC分类号： A61K31/015 ,  A61K31/07 ,  A61K38/43

CPC分类号： A61K31/015 ,  A61K31/07 ,  A61K2300/00

摘要： A composition having an antioxidative activity, especially, having a sufficient activity for removing active oxygen and/or free radicals is provided. The composition includes both reduced coenzyme Q10 and a carotenoid, and the activity for removing active oxygen and/or free radicals is synergistically enhanced. A method for removing active oxygen and/or free radicals by using the composition containing both reduced coenzyme Q10 and a carotenoid is also provided.

摘要翻译： 提供具有抗氧化活性的组合物，特别是具有足够的活性氧和/或自由基活性的活性。 该组合物包括还原型辅酶Q 10和类胡萝卜素，并且促进除去活性氧和/或自由基的活性协同增强。 还提供了通过使用含有还原型辅酶Q 10和类胡萝卜素的组合物除去活性氧和/或自由基的方法。

公开(公告)号：US20050176999A1

公开(公告)日：2005-08-11

申请号：US10503264

申请日：2003-02-04

申请人： Koki Yamashita ,  Toshihiro Takeda ,  Yasuyoshi Ueda

发明人： Koki Yamashita ,  Toshihiro Takeda ,  Yasuyoshi Ueda

IPC分类号： C07C51/363 ,  C07C51/41 ,  C07C51/43 ,  C07C53/15 ,  C07C53/16

CPC分类号： C07C51/412 ,  C07C51/363 ,  C07C51/43 ,  C07C53/19

摘要： The invention provides processes for producing efficiently optically active 2-halogenocarboxylic acids useful in the preparation of drugs or the like and salts thereof with amines. Specifically an optically active 2-halogenocarboxylic acid is produced by halogenating an optically active amino acid in water in the presence of a hydrophobic organic solvent and nitrous acid with the configuration retained and with the racemization inhibited through the removal of 2-hydroxy-bromocarboxylic acid formed as a by-product; the obtained optically active 2-halogenocarboxylic acid is transferred to an aqueous phase by converting it into a salt thereof with a base, followed by the removal of the organic phase; and the optically active 2-halogenocarboxylic acid is transferred again to an organic solvent phase, followed by the removal of the aqueous phase, whereby an optically active 2-halogenocarboxylic acid is obtained through the removal of a halogen component. Further, a high-quality salt of an optically active 2-halogenocarboxylic acid with an amine can be obtained by a crystallization method wherein the amine is added over the period of ½ hour or longer either continuously or in portions and/or wherein the crystallization solvent consists of a hydrophobic organic solvent and a hydrophilic organic solvent.

摘要翻译： 本发明提供了可用于制备药物等的有效光学活性2-卤代羧酸的方法及其与胺的盐。 具体地说，光学活性的2-卤代羧酸是通过在疏水性有机溶剂和亚硝酸存在下在水中卤化光学活性氨基酸而形成的，其中保留了结构，并且通过除去形成的2-羟基 - 溴代羧酸来抑制外消旋化 作为副产品; 将得到的光学活性2-卤代羧酸通过将其转化为其盐与碱反应，然后除去有机相，转移到水相中。 并将光学活性2-卤代羧酸再次转移到有机溶剂相中，然后除去水相，由此通过除去卤素组分获得光学活性的2-卤代羧酸。 此外，光学活性2-卤代羧酸与胺的高品质盐可以通过结晶方法获得，其中胺在连续或部分加入0.5小时或更久的时间内和/或其中结晶溶剂 由疏水性有机溶剂和亲水性有机溶剂构成。

公开(公告)号：US06713628B2

公开(公告)日：2004-03-30

申请号：US10295897

申请日：2002-11-18

申请人： Yasuyoshi Ueda ,  Koichi Kinoshita ,  Tadashi Moroshima ,  Yoshifumi Yanagida ,  Yoshihide Fuse

发明人： Yasuyoshi Ueda ,  Koichi Kinoshita ,  Tadashi Moroshima ,  Yoshifumi Yanagida ,  Yoshihide Fuse

IPC分类号： C07D20704

CPC分类号： C07K5/0222 ,  C07K5/06026

摘要： There is provided a process for preparing a pharmacologically acceptable salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid which comprises condensing an amino acid and N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine.N-carboxyanhydride under basic condition, carrying out decarboxylation under between neutral and acidic condition to obtain N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid, and forming a pharmacologically acceptable salt thereof, wherein the production of a by-product (3): is suppressed by carrying out in an aqueous liquid a series of operations till formation of the pharmacologically acceptable salt or till isolation of the pharmacologically acceptable salt. The present invention enables to prepare the pharmacologically acceptable salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid having high quality, in a commercial scale with high yield and economical efficiency.

摘要翻译： 提供了制备N-（1（S） - 乙氧基羰基-3-苯基丙基）-L-丙氨酰 - 氨基酸的药学上可接受的盐的方法，其包括将氨基酸和N-（1（S） - 乙氧基羰基 - 3-苯基丙基）-L-丙氨酸N-羧酸酐，在中性和酸性条件下进行脱羧，得到N-（1（S） - 乙氧基羰基-3-苯基丙基）-L-丙氨酰 - 氨基酸，和 形成其药理学上可接受的盐，其中通过在含水液体中进行一系列操作直到形成药理学上可接受的盐或直到药理学上可接受的盐的分离来抑制副产物（3）的产生。 本发明能够以高产率和经济效益以商业规模制备质量高的N-（1（S） - 乙氧基羰基-3-苯基丙基）-L-丙氨酰 - 氨基酸的药理学上可接受的盐。

公开(公告)号：US06359155B1

公开(公告)日：2002-03-19

申请号：US09719686

申请日：2001-02-15

申请人： Koichi Kinoshita ,  Tadashi Moroshima ,  Yoshifumi Yanagida ,  Nobuo Nagashima ,  Yasuhiro Saka ,  Tatsuya Honda ,  Yoshihide Fuse ,  Yasuyoshi Ueda

发明人： Koichi Kinoshita ,  Tadashi Moroshima ,  Yoshifumi Yanagida ,  Nobuo Nagashima ,  Yasuhiro Saka ,  Tatsuya Honda ,  Yoshihide Fuse ,  Yasuyoshi Ueda

IPC分类号： C07D30720

CPC分类号： C07C29/147 ,  C07B2200/07 ,  C07D307/20 ,  Y02P20/55 ,  C07C31/42

摘要： An industrial advantage process for producing high-purity 3-hydroxytetrahydrofuran easily and simply, which comprises reducing a 4-halo-3-hydroxybutyric acid ester (1) with a boron hydride compound and/or an aluminum hydride compound as a reducing agent in an organic solvent immiscible with water; treating the reaction mixture with an acid and water to thereby effect conversion to the corresponding 4-halo-1,3-butanediol and at the same time giving an aqueous solution containing said compound; carrying out the cyclization reaction of the 4-halo-1,3-butanediol in said aqueous solution; extracting the resulting 3-hydroxytetrahydrofuran from the 3-hydroxytetrahydrofuran-containing aqueous solution using an organic solvent immiscible with water; and isolating the 3-hydroxytetrahydrofuran by concentration and/or distillation of the solution obtained.

摘要翻译： 用于容易且简单地生产高纯度3-羟基四氢呋喃的工业优势方法，其包括用硼氢化合物和/或氢化铝化合物作为还原剂还原4-卤代-3-羟基丁酸酯（1） 与水不混溶的有机溶剂;用酸和水处理反应混合物，从而转化为相应的4-卤代-1,3-丁二醇，同时得到含有所述化合物的水溶液;进行环化反应 所述水溶液中的4-卤代-1,3-丁二醇;使用与水不混溶的有机溶剂从含3-羟基四氢呋喃的水溶液中萃取所得3-羟基四氢呋喃; 通过所得溶液的浓缩和/或蒸馏来使3-羟基四氢呋喃分离。

公开(公告)号：US06218552B1

公开(公告)日：2001-04-17

申请号：US08229671

申请日：1994-04-19

申请人： Junichi Sekihachi ,  Jun Yamamoto ,  Yasuyoshi Ueda

发明人： Junichi Sekihachi ,  Jun Yamamoto ,  Yasuyoshi Ueda

IPC分类号： C07D30777

CPC分类号： C09B67/0025 ,  C09B57/00 ,  Y10T428/2913 ,  Y10T428/2915

摘要： A compound, 3-phenyl-7-[4-(tetrahydrofurfuryloxy)phenyl]-1,5-dioxa-s-indacene-2,6-dione, which has a structure of crystals exhibiting the strongest peak at an angle of diffraction, 2&thgr;, of 4.7°, among peaks appearing within the range of not smaller than 3° of 2&thgr;, in an X-ray diffraction using a Cu-K&agr;-ray. The compound gives dyed or printed products having deep and brilliant tint of colors with excellent fastnesses, when applied to hydrophobic fiber materials, particularly, polyester fiber materials.

摘要翻译： 具有在衍射角呈现最强峰的结晶结构的化合物3-苯基-7- [4-（四氢呋喃氧基）苯基] -1,5-二氧杂-s-引丙烯-2,6-二酮， 在使用Cu-Kalpha射线的X射线衍射中，出现在不大于3θ的范围内的峰之间的4.7°的2θ。 当应用于疏水性纤维材料，特别是聚酯纤维材料时，该化合物产生具有优异坚牢度的深色和辉煌色彩的染色或印刷产品。

公开(公告)号：US5831041A

公开(公告)日：1998-11-03

申请号：US954518

申请日：1997-10-20

申请人： Nobutaka Kunimi ,  Toshiyuki Araki ,  Yasuyoshi Ueda

发明人： Nobutaka Kunimi ,  Toshiyuki Araki ,  Yasuyoshi Ueda

IPC分类号： C07D251/70 ,  C09B62/085 ,  C09B62/45 ,  C09B62/51 ,  D06P1/04 ,  D06P1/38 ,  D06P1/384

CPC分类号： D06P1/384 ,  C07D251/70 ,  C09B62/45 ,  C09B62/51 ,  D06P1/38 ,  D06P1/04

摘要： A monoazo compound represented by the general formula (I): ##STR1## wherein A represents alkylene which may be substituted or a group: --(CH.sub.2)m--Q.sup.1 --(CH.sub.2)n-- wherein Q.sup.1 is --O--, --S-- or --NR.sup.3 --, m and n are, independently with each other, 2, 3 or 4 and R.sup.3 is hydrogen, alkyl which may be substituted or phenyl which may be substituted; B represents .beta.-carboxyvinyl, alkyl which may be substituted or phenyl which may be substituted; D represents phenylene which may be substituted; X represents aliphatic, aromatic, alicyclic, cyclic or unsubstituted amino; R.sup.1 and R.sup.2 represent, independently with each other, hydrogen or alkyl which may be substituted; and SO.sub.2 Y is a reactive vinyl sulfone group; or a salt thereof, and a process for dyeing or printing fiber materials using said compound. Said process enables red dyeing or printing of hydroxyl group and/or amido group containing organic materials with excellent fixing in deep dyeing.

摘要翻译： 式（I）表示的单偶氮化合物：其中A表示可被取代的亚烷基或基团： - （CH 2）m -Q 1 - （CH 2）n - ，其中Q 1 是-O-，-S-或-NR 3 - ，m和n彼此独立地为2,3或4，R 3为氢，可被取代的烷基或可被取代的苯基; B代表β-羧基乙烯基，可被取代的烷基或可被取代的苯基; D表示可被取代的亚苯基; X代表脂族，芳族，脂环族，环状或未取代的氨基; R1和R2彼此独立地表示氢或可被取代的烷基; SO2Y为反应性乙烯基砜基; 或其盐，以及使用所述化合物染色或印刷纤维材料的方法。 所述方法能够在深染色中具有优异的固色性，可以对含有羟基和/或含氨基的有机材料进行染色或印刷。

公开(公告)号：US5012015A

公开(公告)日：1991-04-30

申请号：US319718

申请日：1989-03-07

申请人： Masanobu Terao ,  Yuzo Maegawa ,  Yasuyoshi Ueda ,  Kiyoyasu Hashimoto ,  Takashi Omura

发明人： Masanobu Terao ,  Yuzo Maegawa ,  Yasuyoshi Ueda ,  Kiyoyasu Hashimoto ,  Takashi Omura

IPC分类号： C07C201/10 ,  C07C205/12 ,  C07C205/26 ,  C07C309/39

CPC分类号： C07C201/10

摘要： 2,4-Dichloro-3-alkyl-6-nitrophenol, which is a precursor of 2,4-dichloro-3-alkyl-6-aminophenol useful for the production of a cyan coupler to be used with a sensitive material in the field of a photography in color, is industrially advantageously produced by (a) nitration of 2,4,5-trichloro-3-alkylbenzene, followed by hydrolysis of the resulting 2,4,5-trichloro-3-alkyl-6-nitrobenzene, or (b) hydrolysis of 2,4,5-trichloro-3-alkylbenzene-6-sulfonic acid or a salt thereof, followed by nitration of the resulting 2,4-dichloro-3-alkylphenol-6-sulfonic acid or a salt thereof, the starting material usable for these processes being 4-alkylbenzenesulfonic acid or a salt thereof, which is easily available.

摘要翻译： 2,4-二氯-3-烷基-6-硝基苯酚，它是2,4-二氯-3-烷基-6-氨基苯酚的前体，可用于生产与现场敏感材料一起使用的青色成色剂 在工业上有利地通过（a）2,4-二氯-3-烷基苯的硝化，然后水解所得的2,4,5-三氯-3-烷基-6-硝基苯， 或（b）2,4,5-三氯-3-烷基苯-6-磺酸或其盐的水解，然后硝化得到的2,4-二氯-3-烷基苯酚-6-磺酸或盐 可用于这些方法的原料是4-烷基苯磺酸或其盐，其容易获得。

公开(公告)号：US08853464B2

公开(公告)日：2014-10-07

申请号：US13176479

申请日：2011-07-05

申请人： Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

发明人： Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

IPC分类号： C07C41/40

CPC分类号： C07C41/40 ,  C07C43/23

摘要： The present invention provides a method of producing reduced coenzyme Q10 crystals suitable for commercial scale production thereof.According to a method of the present invention of producing a reduced coenzyme Q10 crystal which comprises a crystallization of reduced coenzyme Q10 in a solution of alcohols and/or ketones, reduced coenzyme Q10 crystal excellent in slurry properties and crystalline properties maybe obtained. Moreover, an isolation process including a crystal separation or the whole process including the isolation process maybe minimized and simplified. Thus, highly pure reduced coenzyme Q10 may be obtained in a high yield.

摘要翻译： 本发明提供了适合于商业规模生产的还原型辅酶Q10晶体的制造方法。 根据本发明的制备还原型辅酶Q10晶体的方法，所述还原型辅酶Q10晶体包括在醇和/或酮溶液中结晶还原型辅酶Q10，可得到浆料性能和结晶性能优异的还原型辅酶Q10晶体。 此外，包括晶体分离的分离过程或包括隔离过程的整个过程可以被最小化和简化。 因此，可以高产率获得高纯度还原型辅酶Q10。

公开(公告)号：US20130142767A1

公开(公告)日：2013-06-06

申请号：US13642375

申请日：2011-04-20

申请人： Takao Yamaguchi ,  Shiro Kitamura ,  Yasuyoshi Ueda

发明人： Takao Yamaguchi ,  Shiro Kitamura ,  Yasuyoshi Ueda

IPC分类号： A61K31/122 ,  A23L1/29 ,  A61K8/35

CPC分类号： A61K31/122 ,  A23K20/111 ,  A23L33/00 ,  A23L33/10 ,  A23P10/30 ,  A61K8/347 ,  A61K8/355 ,  A61K9/4858 ,  A61K47/10 ,  A61K2800/92 ,  A61Q19/00

摘要： The present invention relates to a method of producing reduced coenzyme Q10, including reducing oxidized coenzyme Q10 using a reducing agent in terpenes that can highly dissolve oxidized coenzyme Q10 and reduced coenzyme Q10 in the co-existence of at least one kind of additive selected from the group consisting of alcohols, water, a surfactant and diacylglycerol. In addition, the present invention relates to a composition comprising terpenes, a reducing agent, reduced coenzyme Q10 and at least one kind selected from the group consisting of alcohols, water, a surfactant and diacylglycerol, and a method of stabilizing reduced coenzyme Q10 comprising preparing the composition.

摘要翻译： 本发明涉及一种还原型辅酶Q10的制造方法，其包括使用萜烯中的还原剂还原氧化型辅酶Q10，所述还原型辅酶Q10可以在选自以下的至少一种添加剂的共存中高度溶解氧化型辅酶Q10和还原型辅酶Q10 由醇，水，表面活性剂和二酰基甘油组成的组。 此外，本发明涉及包含萜烯，还原剂，还原型辅酶Q10和选自醇，水，表面活性剂和二酰基甘油中的至少一种的组合物，以及稳定还原型辅酶Q10的方法，包括制备 组成。