利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

69 条记录 (耗时 0.029 秒)

    Rhodium-phosphine complex
    41.
    发明授权
    Rhodium-phosphine complex 失效
    铑膦络合物

    公开(公告)号：US4605750A

    公开(公告)日：1986-08-12

    申请号：US651123

    申请日：1984-09-17

    申请人： Hidenori Kumobayashi ,  Susumu Akutagawa

    发明人： Hidenori Kumobayashi ,  Susumu Akutagawa

    IPC分类号： C07B53/00 ,  B01J31/00 ,  B01J31/24 ,  C07B31/00 ,  C07B61/00 ,  C07C67/00 ,  C07C209/68 ,  C07F15/00

    CPC分类号： B01J31/2452 ,  C07C209/68 ,  C07F15/008 ,  B01J2231/645 ,  B01J2531/0266 ,  B01J2531/52 ,  B01J2531/822

    摘要： A novel rhodium-phosphine complex represented by the formula (I):[Rh(BINAP).sub.2 ].sup.+ Y.sup.-wherein BINAP represents 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl, and Y represents ClO.sub.4, PF.sub.6, BF.sub.4, PCl.sub.6 or B(C.sub.6 H.sub.4) is described. This complex can be used as a catalyst for various organic syntheses and also for asymmetric syntheses such as an asymmetric isomerization reaction and an asymmetric hydrogenation reaction. Due to its high activity, the complex is very useful as a catalyst.

    摘要翻译： 由式（I）表示的新型铑 - 膦配合物：[Rh（BINAP）2] + Y-，其中BINAP表示2,2'-双（二苯基膦基）-1,1'-联萘，Y表示ClO4，PF6 ，BF4，PC16或B（C6H4）。 该络合物可用作各种有机合成的催化剂，也可用作不对称异构化反应和不对称氢化反应的不对称合成。 由于其活性高，络合物作为催化剂是非常有用的。

    Ru catalyzed acyloxylation process for preparing 4-acyloxyazetidinone derivatives
    45.
    发明授权
    Ru catalyzed acyloxylation process for preparing 4-acyloxyazetidinone derivatives 失效
    Ru催化酰氧化方法制备4-酰氧基氮杂环丁酮衍生物

    公开(公告)号：US5440030A

    公开(公告)日：1995-08-08

    申请号：US167201

    申请日：1993-12-16

    申请人： Takao Saito ,  Hidenori Kumobayashi ,  Shunichi Murahashi

    发明人： Takao Saito ,  Hidenori Kumobayashi ,  Shunichi Murahashi

    IPC分类号： B01J27/128 ,  B01J31/12 ,  B01J31/30 ,  C07B61/00 ,  C07D205/08 ,  C07F7/18 ,  C07B41/12

    CPC分类号： C07F7/186 ,  C07D205/08 ,  C07F7/1892

    摘要： A process for preparing a 4-acyloxyazetidinone or a derivative thereof represented by formula (IV): ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group, a hydroxyethyl group, or a protected hydroxyethyl group; R.sup.3 represents an alkyl group having from 1 to 10 carbon atoms which may be substituted with a halogen atom, a cyano group, a lower alkoxy group or a phenyl group, or a substituted or unsubstituted phenyl group, provided that the .alpha.-positioned carbon atom of said alkyl group should not have more than two halogen atoms; and R.sup.4 represents a hydrogen atom, a lower alkyl group, or a lower alkoxycarbonyl group,which is useful as an intermediate for penera antibiotics is disclosed, comprising reacting azetidinone or a derivative thereof represented by formula (II): ##STR2## wherein R.sup.1 is as defined above, and R.sup.2 represents a hydrogen atom, a lower alkyl group, a lower alkoxycarbonyl group, or a carboxyl group,with a carboxylic acid represented by formula (III):R.sup.3 COOH (III)wherein R.sup.3 is as defined above,in the presence of (1) a transition metal compound selected from a ruthenium compound, an osmium compound, and a cobalt compound, (2) an aldehyde having 2 or more carbon atoms, provided that the carbon atom at the .alpha.-position thereof should not have two or more halogen atoms, and (3) oxygen. The compound (IV) can be prepared with safety through simple and easy operations.

    摘要翻译： 制备由式（IV）表示的4-酰氧基氮杂环丁酮或其衍生物的方法：n原子，低级烷基，羟乙基或被保护的羟乙基; R3表示可以被卤素原子，氰基，低级烷氧基或苯基取代的具有1至10个碳原子的烷基或取代或未取代的苯基，条件是α-位置的碳原子 的所述烷基不应具有多于两个的卤素原子; 其中R 4表示氢原子，低级烷基或低级烷氧基羰基，其可用作倍他安抗生素的中间体，包括使由式（II）表示的氮杂环丁酮或其衍生物： 其中R 1如上所定义，R 2表示氢原子，低级烷基，低级烷氧基羰基或羧基，与式（III）表示的羧酸：R3COOH（III）其中R3如上定义 在（1）选自钌化合物，锇化合物和钴化合物的过渡金属化合物的存在下，（2）具有2个或更多个碳原子的醛，条件是其α位上的碳原子 不应该有两个或更多的卤素原子，和（3）氧。 化合物（IV）可以通过简单和容易的操作安全地制备。

    Acetyloxylation process for producing 4-acetoxyazetidinones with osmium catalyst
    47.
    发明授权
    Acetyloxylation process for producing 4-acetoxyazetidinones with osmium catalyst 失效
    用羧酸催化剂生产4-乙酰氧基苯乙酮的乙酰氧化方法

    公开(公告)号：US5191076A

    公开(公告)日：1993-03-02

    申请号：US799150

    申请日：1991-11-26

    申请人： Takao Saito ,  Hidenori Kumobayashi ,  Shunichi Murahashi

    发明人： Takao Saito ,  Hidenori Kumobayashi ,  Shunichi Murahashi

    IPC分类号： C07D205/08 ,  B01J23/46 ,  B01J27/08 ,  C07B61/00 ,  C07D205/085

    CPC分类号： C07D205/085

    摘要： A process for producing a 4-acetoxyazetidinone represented by formula (I): ##STR1## wherein Z represents a hydrogen atom, a lower alkyl group, or a protected or unprotected hydroxyethyl group; and W represents a hydrogen atom, a lower alkyl group, or a group of --COOR.sup.1, wherein R.sup.1 represents a lower alkyl group, is disclosed, which comprises reacting an azetidinone represented by formula (II): ##STR2## wherein Z is as defined above; and Y represents a hydrogen atom, carboxyl group, a lower alkyl group, or a group of --COOR.sup.1, wherein R.sup.1 represents a lower alkyl group, with acetic acid and an oxidizing agent in the presence of, as a catalyst, an anhydrous or hydrous osmium compound represented by OsX.sub.3, wherein X represents a chlorine atom, a bromine atom, or an iodine atom.

    Substituted acetoxyazetidinone derivatives and process for preparing 4-acyloxyazetidinone derivatives
    50.
    发明授权
    Substituted acetoxyazetidinone derivatives and process for preparing 4-acyloxyazetidinone derivatives 失效
    取代的乙酰氧基氮杂环丁酮衍生物和制备4-酰氧基氮杂环丁酮衍生物的方法

    公开(公告)号：US5629420A

    公开(公告)日：1997-05-13

    申请号：US436810

    申请日：1995-05-08

    申请人： Takao Saito ,  Hidenori Kumobayashi ,  Shunichi Murahashi

    发明人： Takao Saito ,  Hidenori Kumobayashi ,  Shunichi Murahashi

    IPC分类号： B01J27/128 ,  B01J31/12 ,  B01J31/30 ,  C07B61/00 ,  C07D205/08 ,  C07F7/18 ,  C07B41/12

    CPC分类号： C07F7/186 ,  C07D205/08 ,  C07F7/1892

    摘要： A process for preparing a 4-acyloxyazetidinone or a derivative thereof represented by formula (IV): ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group, a hydroxyethyl group, or a protected hydroxyethyl group; R.sup.3 represents an alkyl group having from 1 to 10 carbon atoms which may be substituted with a halogen atom, a cyano group, a lower alkoxy group or a phenyl group, or a substituted or unsubstituted phenyl group, provided that the .alpha.-positioned carbon atom of said alkyl group should not have more than two halogen atoms; and R.sup.4 represents a hydrogen atom, a lower alkyl group, or a lower alkoxycarbonyl group, which is useful as an intermediate for penem antibiotics is disclosed, comprising reacting azetidinone or a derivative thereof represented by formula (II): ##STR2## wherein R.sup.1 is as defined above, and R.sup.2 represents a hydrogen atom, a lower alkyl group, a lower alkoxycarbonyl group, or a carboxyl group, with a carboxylic acid represented by formula (III):R.sup.3 COOH (III)wherein R.sup.3 is as defined above, in the presence of (1) a transition metal compound selected from a ruthenium compound, an osmium compound, and a cobalt compound, (2) an aldehyde having 2 or more carbon atoms, provided that the carbon atom at the .alpha.-position thereof should not have two or more halogen atoms, and (3) oxygen. The compound (IV) can be prepared with safety through simple and easy operations.

    摘要翻译： 制备由式（Ⅳ）表示的4-酰氧基氮杂环丁酮或其衍生物的方法：原子，低级烷基，羟乙基或被保护的羟乙基; R3表示可以被卤素原子，氰基，低级烷氧基或苯基取代的具有1至10个碳原子的烷基或取代或未取代的苯基，条件是α-位置的碳原子 的所述烷基不应具有多于两个的卤素原子; 其中R 4表示可用作Penem抗生素中间体的氢原子，低级烷基或低级烷氧基羰基，包括使由式（II）表示的氮杂环丁酮或其衍生物： 其中R 1如上所定义，R 2表示氢原子，低级烷基，低级烷氧基羰基或羧基，与式（III）表示的羧酸：R3COOH（III）其中R3如上定义 在（1）选自钌化合物，锇化合物和钴化合物的过渡金属化合物的存在下，（2）具有2个或更多个碳原子的醛，条件是其α位上的碳原子 不应该有两个或更多的卤素原子，和（3）氧。 化合物（IV）可以通过简单和容易的操作安全地制备。