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公开(公告)号：US06613017B1
公开(公告)日：2003-09-02
申请号：US09633924
申请日：2000-08-08
申请人： Timothy J. Mickley
发明人： Timothy J. Mickley
IPC分类号： A61M500
CPC分类号： A61M25/0084 , A61M25/0069 , A61M2025/0089
摘要： A catheter adapted to deliver therapeutic or diagnostic agents to a target tissue of a human body is disclosed. A catheter in accordance with the present invention comprises a first elongate shaft having a proximal end, a distal end, and a lumen extending therethrough, a second elongate shaft disposed within the lumen of the first elongate shaft, the first elongate shaft including a first helical member comprising a plurality of turns, the second elongate shaft including a second helical member comprising a plurality of turns.
摘要翻译： 公开了适于将治疗剂或诊断剂递送到人体的靶组织的导管。 根据本发明的导管包括具有近端，远端和延伸通过其的内腔的第一细长轴，设置在第一细长轴的内腔内的第二细长轴，第一细长轴包括第一螺旋 构件包括多个匝，所述第二细长轴包括包括多个匝的第二螺旋构件。
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42.发明授权
公开(公告)号：US6045565A
公开(公告)日：2000-04-04
申请号：US184220
申请日：1998-11-02
CPC分类号： A61B17/32002 , A61B17/3468 , A61B17/3478 , A61F2/2493 , A61B17/320758 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2017/320084 , A61B2018/00208 , A61B2018/00392 , A61B2018/1425 , A61B2018/1861 , A61B90/39 , A61M2025/0089
摘要： Devices and methods for increasing blood perfusion within the myocardium of the heart by wounding the myocardium and applying growth factors to promote vascularization. One method includes driving spikes into the myocardium from within the heart, with the spikes being formed of biodegradable material, containing releasable growth factors, and having lumens and side holes. An alternative method utilizes non-biodegradable spikes with lumens and side holes. Another method promotes vascularization by injecting angiogenic material into holes bored into the myocardium, leaving a patent hole. Another method includes injecting angiogenic material into the myocardium without boring, leaving no patent hole. The angiogenic material can be carried in a biodegradable adhesive. Revascularization of the myocardium is promoted in one method by externally wounding the heart and applying a patch including growth factors.
摘要翻译： 通过伤害心肌并应用生长因子促进血管形成来增加心脏心肌内的血液灌注的装置和方法。 一种方法包括从心脏内将尖峰驱动到心肌中，其中尖峰由可生物降解的材料形成，包含可释放的生长因子，并且具有腔和侧孔。 一种替代方法是利用不可生物降解的钉与流明和侧孔。 另一种方法通过将血管生成材料注入穿入心肌的孔中来促进血管形成，留下专利孔。 另一种方法包括将血管生成物质注入到心肌中而无需镗孔，没有留下专利孔。 血管生成物质可以携带在可生物降解的粘合剂中。 通过外部伤心并施用包括生长因子的贴片在一种方法中促进心肌的血运重建。
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公开(公告)号：US08790388B2
公开(公告)日：2014-07-29
申请号：US13410543
申请日：2012-03-02
申请人： Timothy J. Mickley
发明人： Timothy J. Mickley
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2002/9583 , A61F2250/0039 , A61M2025/1004
摘要： Medical devices, systems, and techniques are described for reducing the profile of a stent. In one example, a stent having a reduced state and an expanded state includes a plurality of interconnected annular rings arranged about a longitudinal axis, each of the plurality of annular bands comprising a plurality of peaks and a plurality of troughs, wherein in the reduced state, at least one of the plurality of peaks of at least one of the plurality of rings is positioned a first distance from the longitudinal axis, another one of the plurality of peaks being positioned a second distance from the longitudinal axis, the first distance being less than the second distance, and wherein in the expanded state, the plurality of peaks of the stent being positioned at substantially the same distance from the longitudinal axis.
摘要翻译： 描述了用于减小支架轮廓的医疗装置，系统和技术。 在一个示例中，具有减小状态和扩张状态的支架包括围绕纵向轴线布置的多个互连的环形圈，所述多个环形带中的每一个包括多个峰和多个槽，其中处于还原状态 所述多个环中的至少一个环中的至少一个的至少一个峰中的至少一个与所述纵向轴线定位成第一距离，所述多个峰中的另一个位于距所述纵向轴线的第二距离处，所述第一距离较小 并且其中在展开状态下，支架的多个峰位于与纵向轴线基本相同的距离处。
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公开(公告)号：US08292873B2
公开(公告)日：2012-10-23
申请号：US12187439
申请日：2008-08-07
申请人： Timothy J. Mickley , Erik Sperry , Stephanie Webber , Chad Harris , Samuel J. Epstein , Grace Kim
发明人： Timothy J. Mickley , Erik Sperry , Stephanie Webber , Chad Harris , Samuel J. Epstein , Grace Kim
IPC分类号： A61M25/00
CPC分类号： A61M25/0084 , A61B2017/00247 , A61B2017/22077 , A61B2018/00392
摘要： A catheter device includes an elongate tubular housing, a cannula, and a flexible proboscis. The cannula defines a cannula lumen which is in fluid communication with a cannula exit port located adjacent the distal end of the elongate housing. The distal tip of the cannula is disposed within the cannula lumen. The cannula defines a proboscis lumen and the cannula has a proboscis exit port in fluid communication with the proboscis lumen. The proboscis exit port is located at the distal tip of the cannula. The flexible proboscis has a distal tip and is disposed within the proboscis lumen.
摘要翻译： 导管装置包括细长管状外壳，套管和柔性长鼻子。 套管限定套管腔，其与位于细长壳体的远端附近的套管出口相流体连通。 套管的远端设置在套管腔内。 套管限定了长鼻腔，并且套管具有与长鼻腔流体连通的长鼻出口。 长鼻子出口位于套管的远端。 柔性长鼻具有远端尖端并且设置在长鼻腔内。
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公开(公告)号：US20120239128A1
公开(公告)日：2012-09-20
申请号：US13240678
申请日：2011-09-22
申请人： Brian Tischler , James F. Hemerick , Daniel Gregorich , Michael P. Meyer , Timothy J. Mickley , Jan Weber , Dennis A. Boismier
发明人： Brian Tischler , James F. Hemerick , Daniel Gregorich , Michael P. Meyer , Timothy J. Mickley , Jan Weber , Dennis A. Boismier
CPC分类号： A61F2/91 , A61F2/844 , A61F2/958 , A61F2002/9583 , A61F2220/0075 , A61F2220/0091 , A61F2230/006
摘要： Techniques are disclosed that allow a stent to be folded within a balloon of a stent delivery system. In one example, a stent has first and second columns that extend from a proximal end to a distal end along a longitudinal axis. Each of the first columns extend substantially parallel to the longitudinal axis and comprise a plurality of elements that each have a substantially polygonal shape. Each of the second columns extend substantially parallel to the longitudinal axis and are between adjacent first columns. Each of the respective second columns include a plurality of first connectors that have a curvilinear shape and that extend in a substantially circumferential direction to connect adjacent first columns. The stent also has a plurality of second connectors, wherein at least one of the second connectors extends between a first element and a second element.
摘要翻译： 公开了允许支架在支架输送系统的球囊内折叠的技术。 在一个示例中，支架具有沿着纵向轴线从近端延伸到远端的第一和第二柱。 每个第一列基本上平行于纵向轴线延伸并且包括多个元件，每个元件具有基本上多边形的形状。 每个第二列基本上平行于纵向轴线延伸并且在相邻的第一列之间。 每个相应的第二列包括多个第一连接器，其具有曲线形状并且沿大致圆周方向延伸以连接相邻的第一列。 支架还具有多个第二连接器，其中至少一个第二连接器在第一元件和第二元件之间延伸。
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公开(公告)号：US20120226342A1
公开(公告)日：2012-09-06
申请号：US13410543
申请日：2012-03-02
申请人： Timothy J. Mickley
发明人： Timothy J. Mickley
CPC分类号： A61F2/958 , A61F2002/9583 , A61F2250/0039 , A61M2025/1004
摘要： Medical devices, systems, and techniques are described for reducing the profile of a stent. In one example, a stent having a reduced state and an expanded state includes a plurality of interconnected annular rings arranged about a longitudinal axis, each of the plurality of annular bands comprising a plurality of peaks and a plurality of troughs, wherein in the reduced state, at least one of the plurality of peaks of at least one of the plurality of rings is positioned a first distance from the longitudinal axis, another one of the plurality of peaks being positioned a second distance from the longitudinal axis, the first distance being less than the second distance, and wherein in the expanded state, the plurality of peaks of the stent being positioned at substantially the same distance from the longitudinal axis.
摘要翻译： 描述了用于减小支架外形的医疗装置，系统和技术。 在一个示例中，具有减小状态和扩张状态的支架包括围绕纵向轴线布置的多个互连的环形圈，所述多个环形带中的每一个包括多个峰和多个槽，其中处于还原状态 所述多个环中的至少一个环中的至少一个的至少一个峰中的至少一个与所述纵向轴线定位成第一距离，所述多个峰中的另一个位于距所述纵向轴线的第二距离处，所述第一距离较小 并且其中在展开状态下，支架的多个峰位于与纵向轴线基本相同的距离处。
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公开(公告)号：US08038709B2
公开(公告)日：2011-10-18
申请号：US12022413
申请日：2008-01-30
申请人： Maria Palasis , Timothy J. Mickley , Toby Freyman , Wendy Naimark
发明人： Maria Palasis , Timothy J. Mickley , Toby Freyman , Wendy Naimark
CPC分类号： A61M31/002 , A61F2/24 , A61F2250/0067
摘要： The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device is provided comprising a body. The body may have a portion thereof including therapeutic agent and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.
摘要翻译： 本发明涉及使用这些医疗装置来治疗心脏瓣膜的可植入医疗装置和方法。 在一个实施例中，提供了包括身体的医疗装置。 身体可以具有其一部分，包括治疗剂，并且可被构造成在靠近心脏瓣膜的位置支撑装置。 根据本发明的实施例的方法还可以包括提供具有身体的医疗装置，其中至少一部分包括治疗剂。 这些方法还可以包括将医疗装置定位在靠近心脏瓣膜的下游表面的位置并固定装置。 然后释放的治疗剂可以被递送到心脏瓣膜。
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公开(公告)号：US20110160840A1
公开(公告)日：2011-06-30
申请号：US12964175
申请日：2010-12-09
IPC分类号： A61F2/82
摘要： A stent comprises at least one closed pathway that defines a single cell. In some embodiments, the closed pathway includes a plurality of petals constructed and arranged to extend away from the tubular wall of the stent. In one embodiment, some of the petals of the closed pathway overlap other of the petals of the closed pathway when the stent is in a reduced state. In at least one embodiment, the stent comprises a plurality of closed pathways. In one embodiment, the closed pathways are arranged in bands that extend either along the length of the stent or about the circumference of the stent.
摘要翻译： 支架包括限定单个电池的至少一个闭合通路。 在一些实施例中，封闭通路包括构造和布置为远离支架的管状壁延伸的多个花瓣。 在一个实施例中，当支架处于减小状态时，闭合通道的一些花瓣与闭合通路的其他花瓣重叠。 在至少一个实施例中，支架包括多个闭合通路。 在一个实施例中，闭合通道被布置成沿着支架的长度或者围绕支架的圆周延伸的带。
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公开(公告)号：US20080027528A1
公开(公告)日：2008-01-31
申请号：US11496249
申请日：2006-07-31
申请人： Karl Jagger , Tracee Eidenschink , Derek Sutermeister , Daniel Gregorich , Yousef Alkhatib , Matt Heidner , Adam Jennings , Richard C. Gunderson , John Blix , Timothy J. Mickley , Richard Olson , Jan Weber , Dominick Godin
发明人： Karl Jagger , Tracee Eidenschink , Derek Sutermeister , Daniel Gregorich , Yousef Alkhatib , Matt Heidner , Adam Jennings , Richard C. Gunderson , John Blix , Timothy J. Mickley , Richard Olson , Jan Weber , Dominick Godin
IPC分类号： A61F2/06
CPC分类号： A61F2/966 , A61F2/95 , A61F2/97 , A61F2002/9583 , A61F2002/9665 , A61F2250/0059
摘要： A catheter system comprises a catheter comprising a distal portion, a proximal portion and an inner shaft. The inner shaft comprises a medical device receiving region for receiving and carrying a medical device. The retaining device is at least partially constructed of an electroactive polymer. The retaining device is located on or adjacent to the medical device receiving region. The electroactive polymer of the retaining device has an activated state and an inactivated state. The retaining device is capable of retaining a medical device to the catheter and releasing the medical device from the catheter by transitioning between the activated state and the inactivated state.
摘要翻译： 导管系统包括导管，其包括远侧部分，近端部分和内部轴。 内轴包括用于接收和携带医疗装置的医疗装置接收区域。 保持装置至少部分地由电活性聚合物构成。 保持装置位于或邻近医疗装置接收区域。 保持装置的电活性聚合物具有活化状态和失活状态。 保持装置能够将医疗装置保持在导管上，并且通过在激活状态和非活动状态之间转换而将医疗装置从导管释放。
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公开(公告)号：US06939322B2
公开(公告)日：2005-09-06
申请号：US10621378
申请日：2003-07-18
申请人： Justin Crank , Scott Larson , Timothy J. Mickley
发明人： Justin Crank , Scott Larson , Timothy J. Mickley
CPC分类号： A61M25/0068 , A61J1/1406 , A61M5/46 , A61M25/0074 , A61M25/0084 , A61M25/0108 , A61M25/0662 , A61M2025/0008 , A61M2025/0081 , A61M2025/0085 , A61M2025/0086 , A61M2025/0091 , A61M2205/19 , A61M2210/125
摘要： Myocardial revascularization catheters and methods are provided herein. Catheters in accord with the present invention may include an outer shaft and an inner shaft where the inner shaft may be slidably and rotatably disposed in the outer shaft and the distal movement of the inner shaft may be arrested by the engagement of stops and catches located within the inner and outer shaft Methods in accord with the current invention may include providing a therapeutic, providing a radiopaque contrast media, injecting the therapeutic through a lumen into the myocardium of the heart, and injecting the radiopaque contrast media through a lumen into myocardium of the heart. In this example, the location of the injection the radiopaque material may be chosen to indicate the injection point of the injection of the therapeutic.
摘要翻译： 本文提供了心肌血运重建导管和方法。 根据本发明的导管可以包括外轴和内轴，其中内轴可以可滑动地和可旋转地设置在外轴中，并且内轴的远端运动可以通过位于内部的止动件和卡扣的接合来阻止 根据本发明的内外轴方法可以包括提供治疗剂，提供不透射线的造影剂，通过内腔将治疗剂注射到心脏的心肌中，以及将不透射线的造影剂通过内腔注射到心脏的心肌中 心。 在该示例中，可以选择注射不透射线材料的位置以指示治疗剂的注射的注射点。
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