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    STEM CELL SOURCE FOR PROMOTING NEOVASCULARISATION
    42.
    发明申请
    STEM CELL SOURCE FOR PROMOTING NEOVASCULARISATION 有权
    用于促进新生血管的干细胞来源

    公开(公告)号：US20100028401A1

    公开(公告)日：2010-02-04

    申请号：US12183992

    申请日：2008-07-31

    申请人： Garry Paul Duffy ,  Frank Barry ,  Timothy O'Brien

    发明人： Garry Paul Duffy ,  Frank Barry ,  Timothy O'Brien

    IPC分类号： A61F2/00 ,  C12N5/06 ,  A61K35/12 ,  A61K31/7088 ,  A61P9/00 ,  A61L15/00 ,  A61K38/00 ,  C12Q1/02

    CPC分类号： G01N33/5023 ,  A61K31/7088 ,  A61K35/12 ,  A61K38/19 ,  A61L15/44 ,  A61L17/005 ,  A61L27/3834 ,  A61L31/16 ,  A61L2300/64 ,  C12N5/0663 ,  C12N2501/998

    摘要： The Eph (erythropoietin-producing hepatocellular carcinoma) receptors and their cell surface anchored ligands, the Ephrins, comprise the largest of the receptor tyrosine kinases families with 14 receptors and 8 ligands. The receptors are subdivided into Eph-A and Eph-B categories and have known actions in the development of the vascular and nervous system. The present invention relates to an isolated mesenchymal stem cell selected from the group consisting of an isolated mesenchymal stem cell that expresses Ephrin-B2, an isolated mesenchymal stem cell that over-expresses Ephrin-B2, and an isolated mesenchymal stem cell that is genetically modified to increase Ephrin-B2 expression. The invention further relates to the various applications of the isolated mesenchymal stem cells of the present invention.

    摘要翻译： Eph（促红细胞生成素产生肝细胞癌）受体及其细胞表面锚定配体，Ephrins包含具有14个受体和8个配体的最大的受体酪氨酸激酶家族。 受体被细分为Eph-A和Eph-B类别，并且在血管和神经系统的发育中具有已知的作用。 本发明涉及分离的间充质干细胞，其选自表达Ephrin-B2的分离的间充质干细胞，过表达Ephrin-B2的分离的间充质干细胞和经遗传修饰的分离的间充质干细胞 以增加Ephrin-B2表达。 本发明进一步涉及本发明的分离的间充质干细胞的各种应用。

    Integrated multi-function showerhead
    43.
    发明申请
    Integrated multi-function showerhead 有权
    集成多功能花洒

    公开(公告)号：US20070246578A1

    公开(公告)日：2007-10-25

    申请号：US11788086

    申请日：2007-04-19

    申请人： Jamy Bulan ,  James Dempsey ,  Timothy O'Brien ,  Harshil Parikh

    发明人： Jamy Bulan ,  James Dempsey ,  Timothy O'Brien ,  Harshil Parikh

    IPC分类号： B05B1/14 ,  A62C31/02 ,  A62C2/08

    CPC分类号： B05B1/18 ,  B05B1/16

    摘要： A showerhead has at least a first set of nozzles and a second set of nozzles for discharging water. The showerhead discharges water according to one of multiple water delivery functions, where a first water delivery function corresponds to water being discharged through only the first set of nozzles, a second water delivery function corresponds to water being discharged through only the second set of nozzles and a third water delivery function corresponds to water being discharged through the first and second sets of nozzles simultaneously. The spacing between the first set of nozzles and the second set of nozzles is carefully selected so that the third water delivery function corresponds to the integrated nozzles of the first and second sets of nozzles. As a result, the third water delivery function provides a coherent and balanced water flow resulting in a more pleasant feel.

    摘要翻译： 喷头具有至少第一组喷嘴和用于排放水的第二组喷嘴。 淋浴器根据多个输水功能之一排出水，其中第一输水功能对应于仅通过第一组喷嘴排出的水，第二输水功能对应于仅通过第二组喷嘴排出的水，以及 第三输水功能对应于同时通过第一组和第二组喷嘴排出的水。 仔细选择第一组喷嘴和第二组喷嘴之间的间隔，使得第三输水功能对应于第一组和第二组喷嘴的集成喷嘴。 结果，第三次输水功能提供了一致和平衡的水流，从而产生更舒适的感觉。

    Vehicle instrument panel with seamless airbag cover
    48.
    发明授权
    Vehicle instrument panel with seamless airbag cover 失效
    汽车仪表板带无缝安全气囊盖

    公开(公告)号：US5997030A

    公开(公告)日：1999-12-07

    申请号：US816791

    申请日：1997-03-19

    申请人： Lynn F. Hannert ,  Timothy O'Brien

    发明人： Lynn F. Hannert ,  Timothy O'Brien

    IPC分类号： B60K37/00 ,  B60R21/2165 ,  B60R21/20

    CPC分类号： B60R21/2165

    摘要： An improved instrument panel includes an airbag cover defined by a tear strip on an inner face of the airbag cover. The outer face of the instrument panel does not include any indication of the tear strip, and thus has a seamless appearance. A hinge is preferably provided to secure the airbag cover to the remainder of the instrument panel when the airbag deploys.

    摘要翻译： 改进的仪表板包括由安全气囊盖的内表面上的撕裂条限定的安全气囊盖。 仪表板的外表面不包括撕裂条的任何指示，因此具有无缝的外观。 优选地设置铰链以在气囊展开时将气囊盖固定到仪表板的其余部分。

    CA125 gene and its use for diagnostic and therapeutic interventions
    50.
    发明授权
    CA125 gene and its use for diagnostic and therapeutic interventions 有权
    CA125基因及其在诊断和治疗干预中的应用

    公开(公告)号：US09556245B2

    公开(公告)日：2017-01-31

    申请号：US12455366

    申请日：2009-06-01

    申请人： Timothy O'Brien ,  John Beard ,  Lowell Underwood

    发明人： Timothy O'Brien ,  John Beard ,  Lowell Underwood

    IPC分类号： C12Q1/68 ,  C07K14/47 ,  C07H21/00 ,  A61K38/00

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. An amino terminal extension is presented, which comprises four genomic exons. The molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. More specifically, this invention is directed to a CA125 cDNA sequence which can be introduced into animal or human cells to achieve transcription or expression of the cDNA.

    摘要翻译： 已经克隆了CA125基因，并且已经鉴定了多个重复序列以及羧基末端。 CA125分子包含三个主要的结构域：细胞外氨基末端结构域（Domain 1）; 一个大的多重重复域（域2）; 和包含具有短细胞质结构域的跨膜锚的羧基末端结构域（结构域3）。 氨基末端结构域以其O-糖基化的能力为主，其结果是丝氨酸和苏氨酸残基的丰富度。 提供氨基末端延伸，其包含四个基因组外显子。 分子结构由包含156个氨基酸重复单元的重复结构域所支配，其包含表位结合位点。 已经确定，排序和连续地排列在CA125领域结构中的60多个重复单位。 更具体地，本发明涉及可以引入动物或人类细胞以实现cDNA转录或表达的CA125 cDNA序列。