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    STEM CELL SOURCE FOR PROMOTING NEOVASCULARISATION
    1.
    发明申请
    STEM CELL SOURCE FOR PROMOTING NEOVASCULARISATION 有权
    用于促进新生血管的干细胞来源

    公开(公告)号：US20100028401A1

    公开(公告)日：2010-02-04

    申请号：US12183992

    申请日：2008-07-31

    申请人： Garry Paul Duffy ,  Frank Barry ,  Timothy O'Brien

    发明人： Garry Paul Duffy ,  Frank Barry ,  Timothy O'Brien

    IPC分类号： A61F2/00 ,  C12N5/06 ,  A61K35/12 ,  A61K31/7088 ,  A61P9/00 ,  A61L15/00 ,  A61K38/00 ,  C12Q1/02

    CPC分类号： G01N33/5023 ,  A61K31/7088 ,  A61K35/12 ,  A61K38/19 ,  A61L15/44 ,  A61L17/005 ,  A61L27/3834 ,  A61L31/16 ,  A61L2300/64 ,  C12N5/0663 ,  C12N2501/998

    摘要： The Eph (erythropoietin-producing hepatocellular carcinoma) receptors and their cell surface anchored ligands, the Ephrins, comprise the largest of the receptor tyrosine kinases families with 14 receptors and 8 ligands. The receptors are subdivided into Eph-A and Eph-B categories and have known actions in the development of the vascular and nervous system. The present invention relates to an isolated mesenchymal stem cell selected from the group consisting of an isolated mesenchymal stem cell that expresses Ephrin-B2, an isolated mesenchymal stem cell that over-expresses Ephrin-B2, and an isolated mesenchymal stem cell that is genetically modified to increase Ephrin-B2 expression. The invention further relates to the various applications of the isolated mesenchymal stem cells of the present invention.

    摘要翻译： Eph（促红细胞生成素产生肝细胞癌）受体及其细胞表面锚定配体，Ephrins包含具有14个受体和8个配体的最大的受体酪氨酸激酶家族。 受体被细分为Eph-A和Eph-B类别，并且在血管和神经系统的发育中具有已知的作用。 本发明涉及分离的间充质干细胞，其选自表达Ephrin-B2的分离的间充质干细胞，过表达Ephrin-B2的分离的间充质干细胞和经遗传修饰的分离的间充质干细胞 以增加Ephrin-B2表达。 本发明进一步涉及本发明的分离的间充质干细胞的各种应用。

    Mesenchymal stem cell for promoting neovascularisation
    2.
    发明授权
    Mesenchymal stem cell for promoting neovascularisation 有权
    用于促进新生血管形成的间充质干细胞

    公开(公告)号：US08617883B2

    公开(公告)日：2013-12-31

    申请号：US12183992

    申请日：2008-07-31

    申请人： Garry Paul Duffy ,  Frank Barry ,  Timothy O'Brien

    发明人： Garry Paul Duffy ,  Frank Barry ,  Timothy O'Brien

    IPC分类号： C12N5/08

    CPC分类号： G01N33/5023 ,  A61K31/7088 ,  A61K35/12 ,  A61K38/19 ,  A61L15/44 ,  A61L17/005 ,  A61L27/3834 ,  A61L31/16 ,  A61L2300/64 ,  C12N5/0663 ,  C12N2501/998

    摘要： The Eph (erythropoietin-producing hepatocellular carcinoma) receptors and their cell surface anchored ligands, the Ephrins, comprise the largest of the receptor tyrosine kinases families with 14 receptors and 8 ligands. The receptors are subdivided into Eph-A and Eph-B categories and have known actions in the development of the vascular and nervous system. The present invention relates to an isolated mesenchymal stem cell selected from the group consisting of an isolated mesenchymal stem cell that expresses Ephrin-B2, an isolated mesenchymal stem cell that over-expresses Ephrin-B2, and an isolated mesenchymal stem cell that is genetically modified to increase Ephrin-B2 expression. The invention further relates to the various applications of the isolated mesenchymal stem cells of the present invention.

    摘要翻译： Eph（促红细胞生成素产生肝细胞癌）受体及其细胞表面锚定配体，Ephrins包含具有14个受体和8个配体的最大的受体酪氨酸激酶家族。 受体被细分为Eph-A和Eph-B类别，并且在血管和神经系统的发育中具有已知的作用。 本发明涉及分离的间充质干细胞，其选自表达Ephrin-B2的分离的间充质干细胞，过表达Ephrin-B2的分离的间充质干细胞和经遗传修饰的分离的间充质干细胞 以增加Ephrin-B2表达。 本发明还涉及本发明的分离的间充质干细胞的各种应用。

    Markers, Antibodies and Recombinant scFvs for Mesenchymal Stem Cell Sub-populations and Osteoclasts
    5.
    发明申请
    Markers, Antibodies and Recombinant scFvs for Mesenchymal Stem Cell Sub-populations and Osteoclasts 审中-公开
    标记，抗体和重组scFv用于间充质干细胞亚群和破骨细胞

    公开(公告)号：US20100062038A1

    公开(公告)日：2010-03-11

    申请号：US12529789

    申请日：2008-03-12

    申请人： Tyrone Villalard Bowes ,  Udo Greiser ,  William James Johnathan Finlay ,  Timothy O'Brien ,  Frank Barry

    发明人： Tyrone Villalard Bowes ,  Udo Greiser ,  William James Johnathan Finlay ,  Timothy O'Brien ,  Frank Barry

    IPC分类号： A61F2/00 ,  C07K7/06 ,  C07H21/04 ,  C07K16/00 ,  C12N15/63 ,  G01N33/566 ,  C12N5/00 ,  A61K35/12

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： Abstract Markers, antibodies and recombinant scFvs for Mesenchymal Stem Cell sub-populations and osteoclasts. The present invention relates to specific epitopes of surface membrane bound glycoproteins expressed by mesenchymal stem cells and pre-osteoclasts and relates to antibodies such as monoclonal antibodies and recombinant scFv or fragments thereof, raised to the particular epitope and their use in identifying, isolating, and characterization of mesenchymal stem cell sub-populations such as that termed “Stromal Progenitor Cells” (SPCs) in bone marrow and identifying, isolating, and characterization of pre-osteoclasts in peripheral blood. By binding to a specific epitope on the cell surface, limbin/EVC-2 detection and separation by conventional cell sorting methodologies are facilitated.

    摘要翻译： 摘要标记，抗体和重组scFvs用于间充质干细胞亚群和破骨细胞。 本发明涉及由间充质干细胞和破骨细胞表达的表面膜结合的糖蛋白的特异性表位，涉及产生特定表位的抗体如单克隆抗体和重组scFv或其片段，以及它们在鉴定，分离和 间质干细胞亚群的表征，如骨髓中称为“间质祖细胞”（SPCs），并鉴定，分离和表征外周血中破骨细胞。 通过结合细胞表面上的特异性表位，促进了常规细胞分选方法的limbin / EVC-2检测和分离。

    Autonomous Filter Element
    8.
    发明申请
    Autonomous Filter Element 审中-公开

    公开(公告)号：US20130008838A1

    公开(公告)日：2013-01-10

    申请号：US13584023

    申请日：2012-08-13

    申请人： Aaron Burke ,  Anthony DiLeo ,  Timothy O'Brien

    发明人： Aaron Burke ,  Anthony DiLeo ,  Timothy O'Brien

    IPC分类号： B01D35/14

    CPC分类号： B01D53/22 ,  B01D61/22 ,  B01D63/08 ,  B01D65/02 ,  B01D65/08 ,  B01D2311/103 ,  B01D2311/16 ,  B01D2313/22 ,  B01D2321/40 ,  G01F1/6888 ,  G01F1/69 ,  G01F15/125

    摘要： An autonomous filter device and a method for improving the filter life and performance is disclosed. The filter element is equipped with one or more sensors, adapted to measure one or more characteristics. In response to the measured characteristic, the control logic within the filter element is able to determine an appropriate response. For example, the control logic may determine that a sudden, but temporary, blockage has occurred in the filter membrane. In response, the control logic may initiate a specific response designed to alleviate the blockage. The control logic will then determine the success of the response, based monitoring any change in the fluid characteristics. Based thereon, the control logic may alert the operator that the filter element must be replaced. Alternatively, if the response was successful in correcting the blockage, the control logic need not notify the operator, as the filter element is back to normal operating operation.

    Autonomous Filter Element
    9.
    发明申请
    Autonomous Filter Element 审中-公开
    自动过滤元件

    公开(公告)号：US20120318738A1

    公开(公告)日：2012-12-20

    申请号：US13584032

    申请日：2012-08-13

    申请人： Aaron Burke ,  Anthony DiLeo ,  Timothy O'Brien

    发明人： Aaron Burke ,  Anthony DiLeo ,  Timothy O'Brien

    IPC分类号： B01D65/08 ,  B01D35/18 ,  G08B21/00 ,  B01D35/14

    CPC分类号： B01D53/22 ,  B01D61/22 ,  B01D63/08 ,  B01D65/02 ,  B01D65/08 ,  B01D2311/103 ,  B01D2311/16 ,  B01D2313/22 ,  B01D2321/40 ,  G01F1/6888 ,  G01F1/69 ,  G01F15/125

    摘要： An autonomous filter device and a method for improving the filter life and performance is disclosed. The filter element is equipped with one or more sensors, adapted to measure one or more characteristics. In response to the measured characteristic, the control logic within the filter element is able to determine an appropriate response. For example, the control logic may determine that a sudden, but temporary, blockage has occurred in the filter membrane. In response, the control logic may initiate a specific response designed to alleviate the blockage. The control logic will then determine the success of the response, based monitoring any change in the fluid characteristics. Based thereon, the control logic may alert the operator that the filter element must be replaced. Alternatively, if the response was successful in correcting the blockage, the control logic need not notify the operator, as the filter element is back to normal operating operation.

    摘要翻译： 公开了一种自主的过滤装置和改善过滤器寿命和性能的方法。 过滤器元件配备有适于测量一个或多个特性的一个或多个传感器。 响应于测量的特性，滤波器元件内的控制逻辑能够确定适当的响应。 例如，控制逻辑可以确定在过滤膜中已经发生突然而暂时的堵塞。 作为响应，控制逻辑可以启动旨在减轻阻塞的特定响应。 然后，控制逻辑将确定响应的成功，基于监测流体特性的任何变化。 基于此，控制逻辑可以警告操作者必须更换过滤元件。 或者，如果响应成功地纠正堵塞，则控制逻辑不需要通知操作者，因为过滤器元件已经回到正常的操作操作。