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公开(公告)号：US20060205054A1
公开(公告)日：2006-09-14
申请号：US10652846
申请日：2003-08-29
IPC分类号： C12Q1/68 , G01N33/574 , C12P21/06 , C12N9/48
CPC分类号： C07K14/4748 , C12N9/6424 , G01N33/57407 , G01N2333/96433 , G01N2500/00
摘要： The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.
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公开(公告)号：US08216794B2
公开(公告)日：2012-07-10
申请号：US12802335
申请日：2010-06-04
CPC分类号： C07K14/4748 , C12N9/6424 , G01N33/57407 , G01N2333/96433 , G01N2500/00
摘要： The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.
摘要翻译： 本发明提供编码在卵巢，乳腺和结肠癌样品中过表达的称为肿瘤抗原衍生基因-14（TADG-14）的新型细胞外丝氨酸蛋白酶的DNA。 还提供了能够表达本发明的DNA的载体和宿主细胞以及本发明的DNA和蛋白质的用途。 还提供了TADG-14蛋白质变体，其具有检测和靶向卵巢癌的潜在作用。
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公开(公告)号：US20120264123A1
公开(公告)日：2012-10-18
申请号：US13486011
申请日：2012-06-01
CPC分类号： C07K14/4748 , C12N9/6424 , G01N33/57407 , G01N2333/96433 , G01N2500/00
摘要： The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.
摘要翻译： 本发明提供编码在卵巢，乳腺和结肠癌样品中过表达的称为肿瘤抗原衍生基因-14（TADG-14）的新型细胞外丝氨酸蛋白酶的DNA。 还提供了能够表达本发明的DNA的载体和宿主细胞以及本发明的DNA和蛋白质的用途。 还提供了TADG-14蛋白质变体，其具有检测和靶向卵巢癌的潜在作用。
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公开(公告)号：US20110086056A1
公开(公告)日：2011-04-14
申请号：US12807390
申请日：2010-09-03
CPC分类号： C07K14/435 , A61K39/00 , A61K2039/5154 , C12N9/6424 , C12Q1/37 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/573 , G01N33/57449 , G01N33/57492 , G01N2333/96433 , G01N2500/20
摘要： The present invention discloses the protease hepsin is specifically over-expressed in ovarian and other malignancies. A number of hepsin peptides can induce immune responses to hepsin, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies. There is also provided a hepsin protein variant that is useful as a marker for ovarian cancer cells, prostate cancer cells or kidney cancer cells.
摘要翻译： 本发明公开了蛋白酶hepsin在卵巢和其他恶性肿瘤中特异性过度表达。 许多hepsin肽可诱导对hepsin的免疫应答，从而证明这些肽在监测和发展卵巢癌和其他恶性肿瘤的免疫治疗方面的潜力。 还提供了可用作卵巢癌细胞，前列腺癌细胞或肾癌细胞的标志物的hepsin蛋白质变体。
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公开(公告)号：US07795211B2
公开(公告)日：2010-09-14
申请号：US10652993
申请日：2003-08-29
IPC分类号： G01N33/574 , C12Q1/68 , A61K39/00 , C07K14/435 , C12Q1/37
CPC分类号： C07K14/435 , A61K39/00 , A61K2039/5154 , C12N9/6424 , C12Q1/37 , C12Q1/686 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/573 , G01N33/57449 , G01N33/57492 , G01N2333/96433 , G01N2500/20
摘要： The present invention discloses the protease hepsin is specifically over-expressed in ovarian and other malignancies. A number of hepsin peptides can induce immune responses to hepsin, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies. There is also provided a hepsin protein variant that is useful as a marker for ovarian cancer cells, prostate cancer cells or kidney cancer cells.
摘要翻译： 本发明公开了蛋白酶hepsin在卵巢和其他恶性肿瘤中特异性过度表达。 许多hepsin肽可诱导对hepsin的免疫应答，从而证明这些肽在监测和发展卵巢癌和其他恶性肿瘤的免疫治疗方面的潜力。 还提供了可用作卵巢癌细胞，前列腺癌细胞或肾癌细胞的标志物的hepsin蛋白质变体。
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公开(公告)号：US08609819B2
公开(公告)日：2013-12-17
申请号：US13486011
申请日：2012-06-01
CPC分类号： C07K14/4748 , C12N9/6424 , G01N33/57407 , G01N2333/96433 , G01N2500/00
摘要： The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.
摘要翻译： 本发明提供编码在卵巢，乳腺和结肠癌样品中过表达的称为肿瘤抗原衍生基因-14（TADG-14）的新型细胞外丝氨酸蛋白酶的DNA。 还提供了能够表达本发明的DNA的载体和宿主细胞以及本发明的DNA和蛋白质的用途。 还提供了TADG-14蛋白质变体，其具有检测和靶向卵巢癌的潜在作用。
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公开(公告)号：US20100291124A1
公开(公告)日：2010-11-18
申请号：US12802335
申请日：2010-06-04
IPC分类号： A61K39/00 , G01N33/53 , C07K14/47 , C40B30/04 , C12Q1/68 , C12N5/071 , C07H21/04 , A61P35/00
CPC分类号： C07K14/4748 , C12N9/6424 , G01N33/57407 , G01N2333/96433 , G01N2500/00
摘要： The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.
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公开(公告)号：US07732163B2
公开(公告)日：2010-06-08
申请号：US10652846
申请日：2003-08-29
CPC分类号： C07K14/4748 , C12N9/6424 , G01N33/57407 , G01N2333/96433 , G01N2500/00
摘要： The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.
摘要翻译： 本发明提供编码在卵巢，乳腺和结肠癌样品中过表达的称为肿瘤抗原衍生基因-14（TADG-14）的新型细胞外丝氨酸蛋白酶的DNA。 还提供了能够表达本发明的DNA的载体和宿主细胞以及本发明的DNA和蛋白质的用途。 还提供了TADG-14蛋白质变体，其具有检测和靶向卵巢癌的潜在作用。
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公开(公告)号：US06602674B1
公开(公告)日：2003-08-05
申请号：US09692820
申请日：2000-10-18
IPC分类号： G01N33574
CPC分类号： A61K38/57 , C12Q1/37 , G01N33/57449
摘要： The present invention provides a method of detecting/monitoring tumor growth and progression in a tissue by measuring the level of antileukoprotease. Also provided is a method of treating an individual having a tumor by administering antileukoprotease to inhibit the activity of stratum corneum chymotryptic enzyme. Specifically, the tumor is an ovarian carcinoma.
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公开(公告)号：US20090142328A1
公开(公告)日：2009-06-04
申请号：US11906596
申请日：2007-10-03
IPC分类号： A61K38/48
CPC分类号： A61K38/57 , C12Q1/37 , G01N33/57449
摘要： The present invention provides a method of detecting/monitoring tumor growth and progression in a tissue by measuring the level of antileukoprotease. Also provided is a method of treating an individual having a tumor by administering antileukoprotease to inhibit the activity of stratum corneum chymotryptic enzyme. Specifically, the tumor is an ovarian carcinoma.
摘要翻译： 本发明提供了通过测定抗白蛋白酶水平来检测/监测组织中肿瘤生长和进展的方法。 还提供了通过施用抗白蛋白酶来抑制角质层糜蛋白酶的活性来治疗患有肿瘤的个体的方法。 具体来说，肿瘤是卵巢癌。
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