公开(公告)号：US5466853A

公开(公告)日：1995-11-14

申请号：US94293

申请日：1993-07-19

申请人： Yasumi Koinuma ,  Takeo Matsumoto ,  Nobuharu Nakada ,  Nobuo Nakabayashi ,  Kazuhiko Ishihara

发明人： Yasumi Koinuma ,  Takeo Matsumoto ,  Nobuharu Nakada ,  Nobuo Nakabayashi ,  Kazuhiko Ishihara

IPC分类号： C07F9/09 ,  C08F30/02 ,  G02B1/04 ,  C07F9/10

CPC分类号： C07F9/091 ,  C08F30/02 ,  G02B1/043

摘要： A diester monomer is represented by the formula (I) ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 represent a hadrogen atom, an alkoxy, alkenyloxy or hydroxyalkyloxy carbonyl group having 1 to 20 carbon atoms, or a phosphorylcholine derivative ##STR2## where Y denotes --(CH.sub.2)n, --(CH.sub.2 CH.sub.2 O).sub.n CH.sub.2 CH.sub.2 -- ##STR3## n denotes 1 to 8, m is an integer of 0 or 1, R.sub.4, R.sub.5 and R.sub.6 denote an alkyl or aryl group having 1 to 8 carbon atoms, or a hydroxyalkyl group having 2 to 20 carbon atoms; on the proviso that if R.sub.1 is a hydrogen atom, neither R.sub.2 nor R.sub.3 is a hydrogen atom and at least one of R.sub.2 and R.sub.3 denotes the aforesaid phosphorylcholine derivative group, and that if R.sub.2 is a hydrogen atom, neither R.sub.1 nor R.sub.3 is a hydrogen atom and at least one of R.sub.1 and R.sub.3 denotes the aforesaid phosphorycholine derivative group. A polymer and a water-containing contact lens are obtained by polymerizing a starting component material including the above-mentioned diester monomer of the formula (I). A contact lens processing solution includes the polymer and a solvent for dissolving the polymer.

摘要翻译： 二酯单体由式（I）表示：其中R 1，R 2和R 3表示氢原子，具有1至20个碳原子的烷氧基，烯氧基或羟基烷氧基羰基，或磷酸胆碱衍生物 其中Y表示 - （CH 2）n， - （CH 2 CH 2 O）n CH 2 CH 2 - ，n表示1至8，m表示0或1的整数，R 4，R 5和R 6表示具有1至8个碳原子的烷基或芳基 ，或具有2〜20个碳原子的羟烷基; 条件是如果R1是氢原子，R2和R3都不是氢原子，R2和R3中的至少一个表示前述的磷酸胆碱衍生物，如果R2是氢原子，则R1和R3都不是氢 原子，R1和R3中的至少一个表示前述的磷酸胆碱衍生物基团。 通过聚合包含上述式（I）的二酯单体的起始组分材料，获得聚合物和含水接触透镜。 隐形眼镜处理溶液包括聚合物和用于溶解聚合物的溶剂。

公开(公告)号：US5264215A

公开(公告)日：1993-11-23

申请号：US599827

申请日：1990-10-19

申请人： Nobuo Nakabayashi ,  Kazuhiko Ishihara ,  Takashi Yamamoto

发明人： Nobuo Nakabayashi ,  Kazuhiko Ishihara ,  Takashi Yamamoto

IPC分类号： A61K6/033 ,  A61L24/00 ,  A61L27/34 ,  A61F2/02 ,  A61C13/10 ,  A61F2/28 ,  C08L33/12

CPC分类号： A61L24/0084 ,  A61L27/34 ,  A61L2430/02

摘要： Disclosed is a bone cement composition comprising polyalkyl methacrylate derived from methacrylate having an alkyl group of 1-4 carbon atoms, hydroxyapatite, alkyl methacrylate having an alkyl group of 1-4 carbon atoms, 4-(2-methacryloyloxyethyl)trimellitic acid or anhydride thereof, and a polymerization initiator. Also disclosed are a cured product of the composition, an implant material using the composition and a process for the preparation of the implant material.

公开(公告)号：US5243006A

公开(公告)日：1993-09-07

申请号：US689940

申请日：1991-05-31

申请人： Nobuo Nakabayashi ,  Kazuhiko Ishihara ,  Takashi Yamamoto ,  Toru Kinoshita

发明人： Nobuo Nakabayashi ,  Kazuhiko Ishihara ,  Takashi Yamamoto ,  Toru Kinoshita

IPC分类号： A61K6/00 ,  A61K6/083 ,  C08F20/38 ,  C08F212/00 ,  C08F212/14 ,  C08F220/06 ,  C08F220/10 ,  C08F220/12 ,  C08F220/38 ,  C08F290/04 ,  C09D4/06 ,  C09D155/00 ,  C09J133/04 ,  C09J155/00

CPC分类号： C08F220/38 ,  A61K6/0029 ,  C08F212/14 ,  C08F220/12

摘要： The acrylic copolymer of the present invention is an acrylic copolymer comprising recurring units derived from a (meth)acrylic ester compound and recurring units derived from a vinyl compound having --SO.sub.3 R (wherein R represents a hydrogen atom or a lower alkyl group) or having an acceptable salt thereof, wherein at least a part of ester groups of the (meth)acrylic ester compound is substituted by a group having recurring units derived from a (meth)acrylic ester. The present invention further provides a process for the preparation of the acrylic copolymer and use application of the acrylic copolymer utilizing its adhesion properties.

摘要翻译： PCT No.PCT / JP90 / 01266 Sec。 371日期1991年5月31日 102（e）日期1991年5月31日PCT提交1990年10月2日PCT公布。 出版物WO91 / 04994 日本1991年4月18日。本发明的丙烯酸共聚物是包含衍生自（甲基）丙烯酸酯化合物的重复单元和衍生自具有-SO 3 R的乙烯基化合物的重复单元的丙烯酸共聚物（其中R表示氢原子或 低级烷基）或其可接受的盐，其中（甲基）丙烯酸酯化合物的酯基的至少一部分被来自（甲基）丙烯酸酯的重复单元的基团取代。 本发明还提供了制备丙烯酸共聚物的方法，并利用其粘合性能来应用丙烯酸共聚物。

公开(公告)号：US20150005180A9

公开(公告)日：2015-01-01

申请号：US10572332

申请日：2004-09-17

申请人： Kazuhiko Ishihara ,  Sohei Funaoka ,  Kanehisa Yokoyama

发明人： Kazuhiko Ishihara ,  Sohei Funaoka ,  Kanehisa Yokoyama

IPC分类号： C40B30/04 ,  C40B60/12 ,  C40B40/08 ,  C40B40/12 ,  C40B50/18 ,  C40B99/00 ,  C40B40/10

CPC分类号： C12Q1/003

摘要： A biochip is provided that suppresses nonspecific adsorption or bonding of a detection target substance without coating with an adsorption inhibitor and that has excellent detection sensitivity. The constitution is such that it has a macromolecular substance containing a phosphorylcholine group and an active ester group on a substrate surface of a biochip substrate.

摘要翻译： 提供一种生物芯片，其抑制检测对象物质的非特异性吸附或结合而不用吸附抑制剂涂覆并且具有优异的检测灵敏度。 其结构是在生物芯片基板的基板表面上具有含有磷酰胆碱基和活性酯基的大分子物质。

公开(公告)号：US08575229B2

公开(公告)日：2013-11-05

申请号：US13120507

申请日：2008-11-07

申请人： Hyung Il Kim ,  Kazuhiko Ishihara

发明人： Hyung Il Kim ,  Kazuhiko Ishihara

IPC分类号： C08F230/02 ,  A61F2/02 ,  A61F2/82 ,  C08G79/04 ,  C08L85/02

CPC分类号： A61L31/041 ,  A61F2/82 ,  A61F2210/0004 ,  A61L27/14 ,  A61L27/26 ,  A61L27/507 ,  A61L31/148 ,  A61L2300/80 ,  C08L101/02 ,  C08L67/04

摘要： A bioabsorbable blend comprising poly(L-lactide) (PLLA) and a phosphorylcholine group-containing copolymer (PPCP) capable of enduring the mechanical strength of blood vessel walls and applicable for fabricating cardiovascular devices was developed. The blend acts as a scaffold to support blood vessel walls during vascular healing and undergoes biodegradation in vivo after vascular healing is complete. Furthermore, the blend can prevent the formation and adsorption of thrombi.

公开(公告)号：US20120164210A1

公开(公告)日：2012-06-28

申请号：US12998931

申请日：2009-12-17

申请人： Masakazu Ueda ,  Kayoko Ueda ,  Tsunenori Arai ,  Sachiko Matsuda ,  Kazuhiko Ishihara

发明人： Masakazu Ueda ,  Kayoko Ueda ,  Tsunenori Arai ,  Sachiko Matsuda ,  Kazuhiko Ishihara

IPC分类号： A61K31/80 ,  A61P35/00 ,  A61K9/127

CPC分类号： A61K41/0071 ,  A61K9/127 ,  A61K31/409 ,  A61K31/78 ,  A61K47/6849 ,  A61K47/6933 ,  C08F20/34 ,  C08F30/02

摘要： The present invention relates to a cancer-cell-specific polymer compound containing a photosensitizer for photodynamic therapy and having a surface to which an antibody against a cancer-cell-specific antigen binds. An object of the present invention is to provide a photodynamic therapeutic agent that can reach the cancer tissue at a low concentration via active targeting and makes complications (e.g., sunlight hypersensitivity) associated with photodynamic therapy unlikely to occur.

摘要翻译： 本发明涉及含有用于光动力学治疗的光敏剂并具有针对癌细胞特异性抗原的抗体结合的表面的癌细胞特异性聚合物化合物。 本发明的目的是提供一种能够通过活性靶向以低浓度达到癌组织的光动力治疗剂，并且与光动力学治疗相关的并发症（例如，阳光超敏反应）不太可能发生。

公开(公告)号：US08063238B2

公开(公告)日：2011-11-22

申请号：US12439192

申请日：2007-08-31

申请人： Yu Nagase ,  Naoya Shimoyamada ,  Yasuhiko Iwasaki ,  Kazuhiko Ishihara

发明人： Yu Nagase ,  Naoya Shimoyamada ,  Yasuhiko Iwasaki ,  Kazuhiko Ishihara

IPC分类号： C07F9/02 ,  C08G18/70

CPC分类号： C08G73/1046 ,  C07F9/091 ,  C08G18/10 ,  C08G18/3206 ,  C08G69/26 ,  C08G73/105 ,  C08G18/4854 ,  C08G18/3889

摘要： Highly polymerizable diamine compounds having a phosphorylcholine group are disclosed. High-molecular weight polymers are obtained from the highly polymerizable diamine compound having a phosphorylcholine group as a monomer, and the polymers have improved mechanical strength, water resistance and heat resistance while maintaining excellent biocompatibility and processability of MPC polymers. Processes for producing the polymers are disclosed. The diamine compounds having a phosphorylcholine group are represented by Formula (I). The polymers contain at least 1 mol % of a specific structural unit with a phosphorylcholine group represented by Formula (II) and have a number average molecular weight of not less than 5,000. In the processes, the diamine compound is used as a monomer.

摘要翻译： 公开了具有磷酸胆碱基团的高度可聚合的二胺化合物。 从具有磷酸胆碱基团的高度可聚合的二胺化合物作为单体获得高分子量聚合物，并且聚合物具有改善的机械强度，耐水性和耐热性，同时保持MPC聚合物优异的生物相容性和加工性。 公开了制备聚合物的方法。 具有磷酸胆碱基团的二胺化合物由式（I）表示。 聚合物含有至少1摩尔％的具有由式（II）表示的磷酸胆碱基团并且数均分子量不小于5,000的特定结构单元。 在该方法中，二胺化合物用作单体。

公开(公告)号：US20100222226A1

公开(公告)日：2010-09-02

申请号：US10572332

申请日：2004-09-17

申请人： Kazuhiko Ishihara ,  Sohei Funaoka ,  Kanehisa Yokoyama

发明人： Kazuhiko Ishihara ,  Sohei Funaoka ,  Kanehisa Yokoyama

IPC分类号： C40B30/04 ,  C40B99/00 ,  C40B60/12 ,  C40B40/08 ,  C40B40/10 ,  C40B40/12 ,  C40B50/18

CPC分类号： C12Q1/003

摘要： To provide an electronic component mounting system and an electronic component mounting method which can prevent a mounting failure due to positional error in a height direction of a substrate and ensure mounting quality. The electronic component mounting system includes a plurality of electronic component mounting devices connected to one another and mounts an electronic component on a substrate to manufacture a mounting substrate. A print test device for testing the substrate after solder printing measures a height position of a height measurement point set on the upper surface of the substrate 4 by a height measuring machine 22 and outputs a measurement result as substrate height data. In a component placing step using an electronic component placing device, a control parameter for controlling a component placing operation of the placing head 32 is updated. Accordingly, it is possible to correct a variation of the height position of an individual substrate and to prevent a mounting failure due to positional error in the height direction of the substrate.

摘要翻译： 提供一种能够防止由于基板的高度方向上的位置误差引起的安装故障并确保安装质量的电子部件安装系统和电子部件安装方法。 电子部件安装系统包括彼此连接的多个电子部件安装装置，并将电子部件安装在基板上以制造安装基板。 用于在焊接印刷之后测试基板的印刷测试装置通过高度测量机22测量设置在基板4的上表面上的高度测量点的高度位置，并输出测量结果作为基板高度数据。 在使用电子部件放置装置的部件放置步骤中，更新用于控制放置头32的部件放置操作的控制参数。 因此，可以校正单个基板的高度位置的变化，并且可以防止由于基板的高度方向上的位置误差引起的安装故障。

公开(公告)号：US20100210458A1

公开(公告)日：2010-08-19

申请号：US12702046

申请日：2010-02-08

申请人： Tomoko Katsuhara ,  Masahiro Matsumoto ,  Kazuhiko Ishihara

发明人： Tomoko Katsuhara ,  Masahiro Matsumoto ,  Kazuhiko Ishihara

IPC分类号： B01J20/26

CPC分类号： B01J20/286 ,  B01J20/28042 ,  B01J20/28097 ,  B01J20/3204 ,  B01J20/327 ,  B01J20/328 ,  B01J2220/52 ,  B01J2220/54 ,  B01J2220/58 ,  B01J2220/82

摘要： A biomicromolecule-separating, monolithic silica column having a silica matrix and pores formed in the silica matrix, the silica matrix and pores have been modified at surfaces thereof with a polymer, which is obtainable by polymerization of a monomer composition including a phosphorylcholine-analogous-group-containing monomer represented by the following formula (1): R1, R2 and R3 are the same or different and each represent a hydrogen atom, C1-6 alkyl group or C1-6 hydroxyalkyl group, R4 represents a C1-6 alkylene group, R5 represents a hydrogen atom or methyl group, and n stands for an integer of from 1 to 4, such that the surface-modified pores are provided with a pore size comparable to a molecular size of biomicromolecules to be separated.

摘要翻译： 具有二氧化硅基质和在二氧化硅基质中形成的孔，二氧化硅基质和孔的生物分子分离的整体硅石柱已经在其表面上用聚合物改性，聚合物可通过聚合包含磷酸胆碱类似物的单体组合物获得， 由下式（1）表示的含有基团的单体：R1，R2和R3相同或不同，各自表示氢原子，C1-6烷基或C1-6羟烷基，R4表示C1-6亚烷基 R 5表示氢原子或甲基，n表示1〜4的整数，使得表面改性孔的孔径与分离的生物分子的分子大小相当。

公开(公告)号：US20080300375A1

公开(公告)日：2008-12-04

申请号：US10592774

申请日：2005-05-18

申请人： Yukimitsu Suda ,  Kazuyuki Miyazawa ,  Kazuhiko Ishihara

发明人： Yukimitsu Suda ,  Kazuyuki Miyazawa ,  Kazuhiko Ishihara

IPC分类号： C08G77/22

CPC分类号： G02B1/043 ,  C08J7/12

摘要： The present invention is an eye lens material wherein phosphorylcholine groups of a specific structure are covalently bonded onto the material surface by means of an after-treatment in which a phosphorylcholine-containing chemical compound is reacted with an eye lens material.The object of the present invention is to provide a contact lens that prevents protein adsorption and a method of manufacturing thereof.

摘要翻译： 本发明是一种眼透镜材料，其中特定结构的磷酸胆碱基通过其中含磷酰胆碱的化合物与眼睛透镜材料反应的后处理共价键合到材料表面上。 本发明的目的是提供一种防止蛋白质吸附的隐形眼镜及其制造方法。