公开(公告)号：US08090252B1

公开(公告)日：2012-01-03

申请号：US12848834

申请日：2010-08-02

申请人： Tony K. Tang ,  Jing Xu ,  Roman C. Gutierrez

发明人： Tony K. Tang ,  Jing Xu ,  Roman C. Gutierrez

IPC分类号： G03B3/00 ,  G03B13/18

CPC分类号： G03B5/00 ,  G02B13/009 ,  G02B15/10 ,  G03B3/00 ,  G03B17/04 ,  Y10T29/49117

摘要： A lens barrel assembly for a camera is disclosed. The lens barrel assembly comprises a lens barrel, at least one optical element disposed within the lens barrel, and an actuator configured to move the optical element. The actuator can be disposed entirely or partially within the lens barrel. The actuator can be a MEMS actuator, such as a MEMS actuator that is formed at least partially of silicon. The optical element can be a lens.

公开(公告)号：US08067548B2

公开(公告)日：2011-11-29

申请号：US12180455

申请日：2008-07-25

申请人： Haitao Wang ,  Yong Du ,  Rui Zhang ,  Jing Xu ,  Longbin Liu

发明人： Haitao Wang ,  Yong Du ,  Rui Zhang ,  Jing Xu ,  Longbin Liu

IPC分类号： C12P21/08 ,  A61K39/00

CPC分类号： C12N15/62 ,  A61K47/6811 ,  A61K47/6835 ,  C07K2317/53 ,  C07K2319/30

摘要： A fusion protein having a non-immunoglobulin polypeptide having a cysteine residue proximal to the C terminal thereof, and an immunoglobulin component with a mutated hinge region is provided. The mutation comprises a point mutated site corresponding in position to the position in a native hinge region of the cysteine residue located nearest the cysteine residue of the non-Ig component. The distance from the cysteine residue of the non-immunoglobulin polypeptide and any remaining cysteine residues of the mutated hinge region is sufficient to prevent the formation of a disulphide bond therebetween.

摘要翻译： 提供了具有非免疫球蛋白多肽的融合蛋白，其具有接近其C末端的半胱氨酸残基和具有突变的铰链区的免疫球蛋白组分。 该突变包括位于位于最接近非Ig组分的半胱氨酸残基的半胱氨酸残基的天然铰链区的位置的点突变位点。 与非免疫球蛋白多肽的半胱氨酸残基和突变的铰链区的任何剩余半胱氨酸残基的距离足以防止其间形成二硫键。

公开(公告)号：US20110170642A1

公开(公告)日：2011-07-14

申请号：US13120147

申请日：2008-09-19

申请人： Haifeng Wang ,  Jiang Wang ,  Jing Xu ,  Bin Zhou

发明人： Haifeng Wang ,  Jiang Wang ,  Jing Xu ,  Bin Zhou

IPC分类号： H03D1/04

CPC分类号： H04W72/1231 ,  H04L1/0026 ,  H04L1/0029 ,  H04L2001/0097

摘要： The invention is related to an apparatus comprising: a receiver configured to receive a channel quality indication matrix; a processor configured to repeat, until the channel quality indication matrix is empty except for selected scheduling results, the following procedure: selecting a column of the channel quality indication matrix having the smallest number of non-zero channel quality indicators; searching for a largest channel quality indicator in the selected column of the channel quality indication matrix; selecting the searched largest channel quality indicator as a scheduling result, and emptying the column and row of the channel quality indication matrix corresponding to the selected scheduling result except for the selected scheduling result.

摘要翻译： 本发明涉及一种装置，包括：接收机，被配置为接收信道质量指示矩阵; 处理器，被配置为重复，除了所选择的调度结果之外，直到信道质量指示矩阵为空，以下过程：选择具有最小数量的非零信道质量指示符的信道质量指示矩阵的列; 在通道质量指示矩阵的选定列中搜索最大信道质量指标; 选择搜索到的最大信道质量指示符作为调度结果，并且排除与所选择的调度结果相对应的所选择的调度结果之外的信道质量指示矩阵的列和行。

公开(公告)号：US20100303759A1

公开(公告)日：2010-12-02

申请号：US12665682

申请日：2007-06-22

申请人： Haitao Wang ,  Chunsheng Mao ,  Jizhi Li ,  Ling Wang ,  Yong Du ,  Longbin Liu ,  Jing Xu ,  Rui Zhang

发明人： Haitao Wang ,  Chunsheng Mao ,  Jizhi Li ,  Ling Wang ,  Yong Du ,  Longbin Liu ,  Jing Xu ,  Rui Zhang

IPC分类号： A61K38/21 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  C07K14/555 ,  A61P35/04 ,  A61P31/12

CPC分类号： C07K14/56 ,  A61K38/00 ,  C07K14/555

摘要： This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human interferon alpha 2b (HuIFN-α2b). The invention encompasses a polynucleotide encoding the protein and recombinant vectors and host cells comprising the polynucleotide. Preferably the polynucleotide is selected from the group of polynucleotides each having a sequence at least 93% identical to SEQ ID: No. 1 and the protein is selected from the group of proteins each having an amino acid sequence at least 85% identical to SEQ ID No: 2. The proteins and compositions comprising the proteins can be used for treatment of conditions responsive to interferon therapy, such as viral diseases and cancer.

公开(公告)号：US20090305986A1

公开(公告)日：2009-12-10

申请号：US12455610

申请日：2009-06-03

申请人： Edward John Belouski ,  Murielle Marie Ellison ,  Agnes Eva Hamburger ,  Randy Ira Hecht ,  Yue-Sheng Li ,  Mark Leo Michaels ,  Jeonghoon Sun ,  Jing Xu

发明人： Edward John Belouski ,  Murielle Marie Ellison ,  Agnes Eva Hamburger ,  Randy Ira Hecht ,  Yue-Sheng Li ,  Mark Leo Michaels ,  Jeonghoon Sun ,  Jing Xu

IPC分类号： C07K14/00 ,  C07K17/14 ,  A61K38/18 ,  C12N15/11 ,  C12N15/12 ,  C12N15/85 ,  C12N5/06

CPC分类号： C07K14/50 ,  A61K38/00 ,  A61K38/1825 ,  A61K2039/505 ,  C07K16/18 ,  C07K2319/30

摘要： The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.

摘要翻译： 本发明提供编码FGF21突变体多肽，FGF21突变体多肽，包含FGF21突变体多肽的药物组合物的核酸分子，以及使用此类核酸，多肽或药物组合物治疗代谢紊乱的方法。

公开(公告)号：US20090297522A1

公开(公告)日：2009-12-03

申请号：US12162320

申请日：2007-01-27

申请人： Haitao Wang ,  Yong Du ,  Rui Zhang ,  Jing Xu ,  Longbin Liu

发明人： Haitao Wang ,  Yong Du ,  Rui Zhang ,  Jing Xu ,  Longbin Liu

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C12P21/02

CPC分类号： C07K14/505 ,  A61K9/0019 ,  A61K38/00 ,  A61K47/6811 ,  C07K2317/53 ,  C07K2319/30

摘要： A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo in comparison to naturally occurring or recombinant native human erythropoietin. In one embodiment of the invention the protein has a half-life in vivo at least three fold higher than native human erythropoietin. The fusion protein also exhibits enhanced erythropoietic bioactivity in comparison to native human erythropoietin. In one embodiment, the fusion protein comprises the complete peptide sequence of a human erythropoietin (EPO) molecule and the peptide sequence of an Fc fragment of human immunoglobulin IgG1. The Fc fragment in the fusion protein includes the hinge region, CH2 and CH3 domains of human immunoglobulin IgG1. The EPO molecule may be linked directly to the Fc fragment to avoid extraneous peptide linkers and lessen the risk of an immunogenic response when administered in vivo. In one embodiment the hinge region is a human Fc fragment variant having a non-cysteine residue at amino acid 6. The invention also relates to nucleic acid and amino acid sequences encoding the fusion protein and transfected cell lines and methods for producing the fusion protein. The invention further includes pharmaceutical compositions comprising the fusion protein and methods of using the fusion protein and/or the pharmaceutical compositions, for example to stimulate erythropoiesis in subjects in need of therapy.

摘要翻译： 描述了包含与免疫球蛋白肽部分连接的人促红细胞生成素肽部分的重组融合蛋白。 与天然存在的或重组的天然人促红细胞生成素相比，融合蛋白在体内具有延长的半衰期。 在本发明的一个实施方案中，蛋白质的体内半衰期比天然人促红细胞生成素高至少三倍。 与天然人促红细胞生成素相比，融合蛋白也表现出增强的红细胞生物活性。 在一个实施方案中，融合蛋白包含人促红细胞生成素（EPO）分子的完整肽序列和人免疫球蛋白IgG1的Fc片段的肽序列。 融合蛋白中的Fc片段包括人免疫球蛋白IgG1的铰链区，CH2和CH3结构域。 EPO分子可以直接连接到Fc片段，以避免外来的肽接头并且当在体内施用时减轻免疫原性应答的风险。 在一个实施方案中，铰链区是在氨基酸6具有非半胱氨酸残基的人Fc片段变体。本发明还涉及编码融合蛋白和转染细胞系的核酸和氨基酸序列以及用于产生融合蛋白的方法。 本发明还包括包含融合蛋白的药物组合物和使用融合蛋白和/或药物组合物的方法，例如刺激需要治疗的受试者的红细胞生成。

公开(公告)号：US20060194815A1

公开(公告)日：2006-08-31

申请号：US11293866

申请日：2005-12-02

申请人： Laurent Lecanu ,  Janet Greeson ,  Vassilios Papadopoulos ,  Jing Xu

发明人： Laurent Lecanu ,  Janet Greeson ,  Vassilios Papadopoulos ,  Jing Xu

IPC分类号： A61K31/496

CPC分类号： A61K31/497 ,  A61K31/33 ,  A61K31/496

摘要： The present invention relates to cortisol-modulating compounds, including but not limited to benzamide and benzoic acid derivatives such as procaine and procaine derivatives, utilized in compositions and methods for treating cortisol-mediated disorders, including but not limited to age-related depression, hypertension, Alzheimer's disease, and acquired immunodeficiency syndrome.

摘要翻译： 本发明涉及皮质醇调节化合物，包括但不限于苯甲酰胺和苯甲酸衍生物如普鲁卡因和普鲁卡因衍生物，用于治疗皮质醇介导的病症的组合物和方法，包括但不限于与年龄有关的抑郁症，高血压 ，阿尔茨海默病和获得性免疫缺陷综合征。

公开(公告)号：US09844060B2

公开(公告)日：2017-12-12

申请号：US14111229

申请日：2011-04-15

申请人： Yong Teng ,  Yuanyong Yin ,  Lingfeng Wang ,  Jiang Wang ,  Jing Xu ,  Kari Veikko Horneman

发明人： Yong Teng ,  Yuanyong Yin ,  Lingfeng Wang ,  Jiang Wang ,  Jing Xu ,  Kari Veikko Horneman

IPC分类号： H04W72/10 ,  H04W72/08 ,  H04W52/28 ,  H04W84/18 ,  H04W24/02 ,  H04W28/02 ,  H04W16/10 ,  H04W84/04

CPC分类号： H04W72/082 ,  H04W16/10 ,  H04W24/02 ,  H04W28/021 ,  H04W52/28 ,  H04W72/10 ,  H04W84/045 ,  H04W84/18

摘要： It is provided an apparatus, including base station means to provide a base station functionality using component carriers; neighbor detecting means to detect a neighboring base station; informing means to inform a coordinating device about the neighboring base station; willingness setting means to set a willingness to perform self-tuning based on a respective long-term priority for each component carrier, wherein the long-term priorities are received from the coordinating device, and the willingness is only set if the long-term priorities are not in contradiction to an actual requirement, willingness providing means to provide an indication of the willingness to the coordinating device; and self-tuning means to perform self-tuning if an agreement statement is received from the coordinating device, wherein, as a result of the self-tuning, a usage of each component carrier by the base station means is based on the received long-term information and the actual requirement.

公开(公告)号：US09622132B2

公开(公告)日：2017-04-11

申请号：US14235241

申请日：2011-07-28

申请人： Haifeng Wang ,  Jing Xu ,  Ting Zhou ,  Zhenhong Li ,  Wei Zou ,  Jinling Du

发明人： Haifeng Wang ,  Jing Xu ,  Ting Zhou ,  Zhenhong Li ,  Wei Zou ,  Jinling Du

IPC分类号： H04W36/00 ,  H04W36/16 ,  H04W36/06 ,  H04W36/14 ,  H04W76/02

CPC分类号： H04W36/165 ,  H04W36/0055 ,  H04W36/06 ,  H04W36/14 ,  H04W76/14

摘要： A method and an apparatus for switching D2D data communications between a licensed and a license-exempt band are disclosed. A D2D device receives from a cellular network a pre-switch notification to prepare for a switch of its D2D communications, and in response adopts a temporary strategy for conducting its D2D transmissions prior to the switch. After the switch the D2D device discontinues the temporary strategy. In one embodiment the temporary strategy and its duration are indicated in the pre-switch notification. Two example temporary strategies are presented: ‘no-new-data’ where new data transmissions are suspended and data re-transmissions are sent with high reliability; and ‘no-feedback’ where new data is sent with high reliability and data re-transmissions are suspended. Different embodiments have the cellular network access node or D2D device contending for the radio resource in the license-exempt frequency band.

公开(公告)号：US09332533B2

公开(公告)日：2016-05-03

申请号：US14234072

申请日：2012-07-04

申请人： Jing Xu ,  Xueming Pan ,  Zukang Shen ,  Yanan Lin

发明人： Jing Xu ,  Xueming Pan ,  Zukang Shen ,  Yanan Lin

IPC分类号： H04W72/04 ,  H04L1/18 ,  H04L5/00

CPC分类号： H04W72/0406 ,  H04L1/18 ,  H04L1/1861 ,  H04L1/1893 ,  H04L1/1896 ,  H04L5/0055 ,  H04L5/0064

摘要： Examples of the present disclosure provide an ACK/NACK/SR resource mapping method and an apparatus. According to the technical solution provided by the examples of the present disclosure, in a system including a terminal utilizing a first type protocol and a terminal utilizing a second type protocol, the base station allocates the ACK/NACK/SR resources corresponding to the second type protocol in an area outside of the ACK/NACK/SR resource area reserved for the terminal utilizing the first type protocol, and informs the terminal utilizing the second type protocol of the allocation information of the corresponding ACK/NACK/SR resources. Thus, the terminal utilizing the second type protocol may transmit feedback information via the corresponding ACK/NACK/SR resources.

摘要翻译： 本公开的示例提供了ACK / NACK / SR资源映射方法和装置。 根据本公开的示例提供的技术方案，在包括使用第一类型协议的终端的系统和使用第二类型协议的终端的系统中，基站分配与第二类型相对应的ACK / NACK / SR资源 在为使用第一类型协议的终端预留的ACK / NACK / SR资源区域之外的区域中的协议，并且利用第二类型协议通知相应ACK / NACK / SR资源的分配信息的终端。 因此，利用第二类型协议的终端可以经由相应的ACK / NACK / SR资源发送反馈信息。