摘要:
This invention relates to novel compounds having the formula (I): and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
摘要:
This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence:
摘要:
A thread scheduler may be used in a chip multiprocessor or symmetric multiprocessor system to schedule threads to processors. The scheduler may determine the bandwidth utilization of the two threads in combination and whether that utilization exceeds the threshold value. If so, the threads may be scheduled on different processor clusters that do not have the same paths between the common memory and the processors. If not, then the threads may be allocated on the same processor cluster that shares cache among processors.
摘要:
A self-collimator concave spectral shaping device for chirped-pulse-amplification (CPA): uses a spectrum decomposing system with CTSI construction, a spectrum synthesizing system with CTSI structure that is symmetrical to the decomposing structure, and a spectrum shaping system including an aperture and a planar reflector for spectrum shaping function design. The device accomplishes the following functions: firstly decomposing the spectrum of a chirped temporal pulse laser to a spectral domain; then shaping the spectrum in the spectral domain; finally synthesizing un-shiftily this shaped spectrum in the spectral domain into a temporal chirped pulse with a designed shape. The device has the feature of requiring less optical components, compacting the structure, requiring less space, cheap in cost, and running stability, for its small size of concave reflector, and its self-collimation and its symmetrical distribution, which it can be not only utilized in a general laser spectrum shaping and spectrum modulation, but also can be utilized for a high energy and ultra-high peak-power laser system in chirped pulse amplification with a large caliber and with a chirped pulse bandwidth of a few nanometers.
摘要:
An audio and video (AV) apparatus includes a player module for playing audio and video files, generating audio and video signals, and an internal display and an internal speaker. The AV apparatus further includes: a first switch for generating first instructions; an output module for being externally connected to output the audio and video signals; and a control module connected to the first switch. The control module being configured for disabling the internal display and internal speaker at receiving the first instructions at a situation that the output module is externally connected to output the audio and video signals, and disabling the internal display while keeping the internal speaker enabled at receiving the first instruction at a situation that the output module is not externally connected. A method for controlling the audio and video apparatus is provided as well.
摘要:
An aqueous antibacterial polymer emulsion and coating compositions are provided. The aqueous antibacterial polymer emulsion comprising a polymer A, an oxidant and a metal complexed with a copolymer B comprising heterocyclic containing monomers; wherein the metal is selected from copper, silver, gold, tin, zinc and combinations thereof; and wherein the emulsion is heat stable. The coating compositions made therefrom provide persistent, broad spectrum antibacterial activity without discoloration problem upon exposure to heat and/or sun light.
摘要:
A hybrid vehicle has a power system with a torsional coupling. The power system includes a battery system for receiving, storing and providing electrical power, an internal combustion engine configured to provide rotational power through a flywheel, a first motor-generator, a second motor-generator, a control system, and a torsional coupling. The torsional coupling may absorb rotational shock caused by angular or rotational speed differences between the engine and the first motor-generator. The torsional coupling includes a driven plate assembly, a cover assembly and an interconnecting plate assembly. The interconnecting plate assembly may include a plurality of shock absorbing elements that absorb shock and vibration between the engine and the motor-generator.
摘要:
A method for screening for risk of cancer in a subject is carried out by detecting the presence or absence of at least one mutation in the delta-catenin gene promoter or 5′ untranslated region in a biological sample from said subject, the presence of such mutation or an increased frequency of mutation indicating said subject is afflicted with or at least at risk of developing cancer.
摘要:
A hybrid vehicle includes two front wheels, two rear wheels, an internal combustion engine, a first motor/generator, and a second motor/generator. The first motor/generator may be rotatably coupled to the internal combustion engine, and the second motor/generator may be rotatably coupled to at least one wheel of the hybrid vehicle. The first motor/generator, the second motor/generator and a gear transmission are housed within the engine compartment and are located between two front wheels and arranged in a substantially linear manner. The first motor/generator, the second motor/generator, and the gear transmission are located substantially above a centerline of the front wheels of the vehicle.