公开(公告)号：US20220119467A1

公开(公告)日：2022-04-21

申请号：US17419236

申请日：2020-01-06

Applicant: The Regents of the University of California ,  University of Washington

Inventor： David Baker ,  Scott Boyken ,  Hana El-Samad ,  Marc Lajoie ,  Robert Langan ,  Andrew Ng

IPC: C07K14/47 ,  A61K35/17

Abstract: Provided are molecular feedback circuits employing caged-degrons. Aspects of such circuits include the use of a caged-degron to modulate the output of a signaling pathway in a feedback-controlled manner. Also provided are nucleic acids encoding molecular circuits and cells containing such nucleic acids. Methods of using caged-degron-based molecular feedback circuits are also provided, including e.g., methods of modulating a signaling pathway of a cell that include genetically modifying the cell with a caged-degron-based molecular feedback circuit.

公开(公告)号：US11192926B2

公开(公告)日：2021-12-07

申请号：US16500331

申请日：2018-04-03

Applicant: UNIVERSITY OF WASHINGTON ,  INSTITUTE FOR RESEARCH IN BIOMEDICINE

Inventor： Neil P. King ,  David Baker ,  Brooke Nickerson ,  Lance Joseph Stewart ,  Laurent Perez ,  Antonio Lanzavecchia ,  Jessica Marcandalli

IPC: A61K39/00 ,  A61K39/12 ,  A61K39/155 ,  C07K14/005 ,  A61K39/385 ,  A61P31/14 ,  B82Y5/00 ,  C12N7/00

Abstract: Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.

公开(公告)号：US20210317413A1

公开(公告)日：2021-10-14

申请号：US17259508

申请日：2019-07-15

Applicant: The Board of Trustees of the Leland Stanford Junior University ,  UNIVERSITY OF WASHINGTON

Inventor： Kenan Christopher Garcia ,  Yi Miao ,  David Baker ,  Keunwan Park ,  Luke Dang

IPC: C12N5/0775 ,  C07K14/47 ,  C12N5/071

Abstract: Wnt signaling antagonist and agonist compositions and methods for their use are provided.

公开(公告)号：US20200317744A1

公开(公告)日：2020-10-08

申请号：US16909185

申请日：2020-06-23

Applicant: UNIVERSITY OF WASHINGTON ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： Daniel Adriano Silva Manzano ,  Shawn Yu ,  Umut Ulge ,  David Baker ,  Kenan Christopher Garcia ,  Jamie Spangler ,  Carl WALKEY

IPC: C07K14/55 ,  C07K14/54

Abstract: De novo designed polypeptides that bind to IL-2 receptor βγc heterodimer (IL-2Rβγc), IL-4 receptor αγc heterodimer (IL-4Rαγc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.

公开(公告)号：US20190183933A1

公开(公告)日：2019-06-20

申请号：US16289274

申请日：2019-02-28

Applicant: The Board of Trustees of the Leland Stanford Junior University ,  UNIVERSITY OF WASHINGTON

Inventor： Kenan Christopher Garcia ,  Jonathan Sockolosky ,  David Baker ,  Chris King

IPC: A61K35/17 ,  A61K38/20 ,  C07K14/55 ,  C12N5/0783 ,  A61K38/17 ,  C12N15/10

CPC classification number: A61K35/17 ,  A61K38/1793 ,  A61K38/2013 ,  A61K2039/5156 ,  A61K2300/00 ,  C07K14/55 ,  C12N5/0638 ,  C12N15/1034 ,  C12N2740/10043

Abstract: Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided.

公开(公告)号：US20190083585A1

公开(公告)日：2019-03-21

申请号：US16203109

申请日：2018-11-28

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Justin Siegel ,  David Baker ,  Sydney Rin Anna Gordon ,  Ingrid Swanson Pultz ,  Elizabeth Joy Stanley ,  Sarah Jane Wolf

IPC: A61K38/48 ,  C12N9/50 ,  C12N9/52

Abstract: Disclosed herein are compositions and methods for treating celiac sprue.

公开(公告)号：US20170363648A1

公开(公告)日：2017-12-21

申请号：US15692211

申请日：2017-08-31

Applicant: President and Fellows of Harvard College ,  University of Washington

Inventor： George M. Church ,  Justin Feng ,  Daniel J. Mandell ,  David Baker ,  Stanley Fields ,  Benjamin Ward Jester ,  Christine Elaine Tinberg

IPC: G01N33/74

CPC classification number: G01N33/743 ,  G01N2500/10

Abstract: Disclosed is a biosensor engineered to conditionally respond to the presence of specific small molecules, the biosensors including conditionally stable ligand-binding domains (LBDs) which respond to the presence of specific small molecules, wherein readout of binding is provided by reporter genes or transcription factors (TFs) fused to the LBDs.

公开(公告)号：US09840539B2

公开(公告)日：2017-12-12

申请号：US14766259

申请日：2014-03-13

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： David Baker ,  Christine E. Tinberg ,  Sagar D. Khare ,  Jiayi Dou

IPC: A61K38/16 ,  C07K1/00 ,  C07K14/435 ,  G01N33/74 ,  C12N15/10 ,  A61K38/00

CPC classification number: C07K14/435 ,  A61K38/005 ,  C12N15/1034 ,  G01N33/743

Abstract: Isolated polypeptides with steroid binding activity and methods for their use as therapeutics and detection agents are disclosed herein.

公开(公告)号：US09778261B2

公开(公告)日：2017-10-03

申请号：US15272650

申请日：2016-09-22

Applicant: University of Washington

Inventor： Paul Yager ,  Caitlin Anderson ,  David Baker ,  Yu-Ru Lin ,  Carly Holstein

IPC: A61K39/395 ,  A61K39/00 ,  C07K16/28 ,  C07H21/04 ,  C12N15/10 ,  G01N33/569 ,  C07K14/00

CPC classification number: G01N33/56983 ,  C07K14/00 ,  C07K14/001 ,  C07K2319/43 ,  C07K2319/70 ,  G01N2333/11

Abstract: The present invention provides porous membrane-binding polypeptides, fusion proteins thereof, and methods for use of the polypeptides and fusion proteins in binding assays.

公开(公告)号：US09766255B2

公开(公告)日：2017-09-19

申请号：US14993509

申请日：2016-01-12

Applicant: President and Fellows of Harvard College ,  University of Washington

Inventor： George M. Church ,  Justin Feng ,  Daniel J. Mandell ,  David Baker ,  Stanley Fields ,  Benjamin Ward Jester ,  Christine Elaine Tinberg

IPC: C12N7/00 ,  G01N33/74

CPC classification number: G01N33/743 ,  G01N2500/10

Abstract: Disclosed is a biosensor engineered to conditionally respond to the presence of specific small molecules, the biosensors including conditionally stable ligand-binding domains (LBDs) which respond to the presence of specific small molecules, wherein readout of binding is provided by reporter genes or transcription factors (TFs) fused to the LBDs.