公开(公告)号：US11032125B2

公开(公告)日：2021-06-08

申请号：US16123619

申请日：2018-09-06

申请人： Board of Regents of the University of Nebraska

发明人： Shane Farritor ,  Tyler Wortman ,  Kyle Strabala ,  Ryan McCormick ,  Amy Lehman ,  Dmitry Oleynikov ,  Eric Markvicka

IPC分类号： A61B34/30 ,  H04L12/24 ,  A61B90/30 ,  B25J9/00 ,  B25J9/06 ,  H04L12/26 ,  A61B90/00

摘要： Various medical devices and related systems, including robotic and/or in vivo medical devices, and various robotic surgical devices for in vivo medical procedures. Included herein, for example, is a robotic surgical system having a support beam positionable through an incision, and a robotic device having a device body, first and second rotating shoulder components coupled to the device body, and first and second robotic arms coupled to the first and second shoulder components, respectively.

公开(公告)号：US11028444B2

公开(公告)日：2021-06-08

申请号：US15965510

申请日：2018-04-27

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services ,  Arizona Board of Regents on Behalf of the University of Arizona ,  Queen Mary University of London ,  Board of Regents of the University of Nebraska ,  Oslo University Hospital HF ,  Oregon Health & Science University ,  University of Rochester ,  Hospital Clinic de Barcelona ,  Universitat de Barcelona ,  British Columbia Cancer Agency Branch ,  Julius-Maximilians-University of Würzburg

发明人： Lisa M. Rimsza ,  Andrew T. Lister ,  Wing C. Chan ,  Dennis Weisenburger ,  Jan Delabie ,  Erlend B. Smeland ,  Harald Holte ,  Stein Kvaløy ,  Rita M. Braziel ,  Richard I. Fisher ,  Pedro Jares ,  Armando Lopez-Guillermo ,  Elias Campo Guerri ,  Elaine S. Jaffe ,  Georg Lenz ,  Wyndham H. Wilson ,  George W. Wright ,  Sandeep S. Dave ,  Louis M. Staudt ,  Randy D. Gascoyne ,  Joseph M. Connors ,  Hans-Konrad Muller-Hermelink ,  Andreas Rosenwald ,  German Ott

IPC分类号： G01N33/48 ,  C12Q1/6886 ,  G01N33/574

摘要： The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients.

公开(公告)号：US20210150935A1

公开(公告)日：2021-05-20

申请号：US16616599

申请日：2018-06-07

申请人： Board of Regents of the University of Nebraska

发明人： Nicholas Markin

IPC分类号： G09B23/28

摘要： A simulator system can be used to train personnel regarding transesophageal echocardiography (TEE) performance techniques. TEE is an ultrasonic imaging modality that can be used to capture images of a subject's heart. An imaging probe is inserted into the esophagus of the subject and positioned/aimed toward the subject's heart to capture the images. The TEE training system described is a system for ultrasonic diagnosis training (e.g., targeting the heart) which can be operated using an actual echocardiography machine used in clinic setting, and allows the practice of both acquisition and manipulation of images by the user so as to provide multiple aspects of learning 3D TEE.

公开(公告)号：US20210113558A1

公开(公告)日：2021-04-22

申请号：US16981325

申请日：2019-04-09

申请人： BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

发明人： Howard E. GENDELMAN ,  Benson EDAGWA

IPC分类号： A61K31/505 ,  A61K31/551 ,  A61K31/536 ,  A61K31/496 ,  A61K31/4439 ,  A61K9/51 ,  A61K47/69 ,  A61P31/14

摘要： The present invention provides prodrugs and methods of use thereof.

公开(公告)号：US10960069B2

公开(公告)日：2021-03-30

申请号：US16353626

申请日：2019-03-14

申请人： The Board of Regents of the University of Nebraska

发明人： Qingsheng Li ,  Yanmin Wan ,  Feng Li

IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  C07K14/00 ,  A61K38/16 ,  A61K39/145 ,  A61K9/00 ,  A61P31/16 ,  C12N9/18 ,  C12N7/00

摘要： The present disclosure provides a DNA vaccine or immunogenic composition expressing consensus hemagglutinin-esterase-fusion (HEF) protein (FluD-Vax) and a protein-based vaccine utilizing the HEF consensus protein. Methods of making and using the compositions are also provided herein.

公开(公告)号：US20210002258A1

公开(公告)日：2021-01-07

申请号：US16766762

申请日：2018-12-03

申请人： BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

发明人： Amarnath Natarajan

IPC分类号： C07D403/04 ,  A61P35/04

摘要： Provided herein are compounds having a structure of formula (I) and methods of using the disclosed compounds to inhibit IKKβ activity.

公开(公告)号：US10799620B2

公开(公告)日：2020-10-13

申请号：US16307711

申请日：2017-07-21

申请人： BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

发明人： Jingwei Xie ,  Shixuan Chen ,  Bernard Timothy Baxter

IPC分类号： A61L27/54 ,  A61L27/18 ,  A61K31/7068 ,  A61K9/00 ,  A61K9/70

摘要： Nanofiber structures are provided along with methods of production and methods of use.

公开(公告)号：US20200085842A1

公开(公告)日：2020-03-19

申请号：US16694722

申请日：2019-11-25

申请人： Board of Regents of the University of Nebraska

发明人： Dong Wang ,  Fang Yuan ,  Zhenshan Jia ,  Xiaobei Wang

IPC分类号： A61K31/57 ,  C07J41/00 ,  A61K9/107 ,  A61K47/10 ,  A61K47/34

摘要： Polyethylene glycol (PEG)-conjugated glucocorticoid prodrugs, methods of preparation, and use for the treatment of diseases and disorders are disclosed. In particular, PEG-conjugated dexamethasone compounds and methods of using them for treating inflammatory and autoimmune diseases, including but not limited to lupus, are disclosed.

公开(公告)号：US10591468B2

公开(公告)日：2020-03-17

申请号：US15900680

申请日：2018-02-20

申请人： Board of Regents of the University of Nebraska

发明人： Geoffrey M. Thiele ,  Daniel R. Anderson ,  Michael J. Duryee

IPC分类号： A61P9/10 ,  G01N33/68 ,  G01N33/564 ,  G01N33/53 ,  A61K49/00 ,  C07K16/06 ,  C07K16/18 ,  C07K16/42

摘要： In various embodiments methods are provided for identifying a mammal having an elevated risk for an adverse cardiac event (e.g. an MI) and/or determining the prognosis for the mammal. In certain embodiments the methods comprise determining, or causing to be determined, the presence and/or level of antibodies that bind a malondialdehyde-acetaldheyde adduct (MAA adduct) in a biological sample from the mammal, where an elevated level of anti-MAA adduct antibodies, as compared to the level found in a normal healthy mammal is an indicator that that said mammal has one or more atherosclerotic lesions and/or is at elevated risk for a myocardial infarction.

公开(公告)号：US10577617B2

公开(公告)日：2020-03-03

申请号：US14995109

申请日：2016-01-13

申请人： The Board of Trustees of the University of Illinois ,  The United States of America, as represented by the Secretary of Agriculture ,  The Board of Regents of the University of Nebraska ,  The University of Florida Research Foundation, Incorporated

发明人： Aleel K. Grennan ,  Donald R. Ort ,  Stephen Patrick Moose ,  Damla D. Bilgin ,  Thomas Clemente ,  Fredy Altpeter ,  Stephen P. Long

IPC分类号： C12N15/82

摘要： The impact of plastid size change in both monocot and dicot plants has been examined. In both, when plastid size is increased there is an increase in biomass relative to the parental lines. Thus, provided herein are methods for increasing the biomass of a plant, comprising decreasing the expression of at least one plastid division protein in a plant. Optionally, the level of chlorophyll in the plant is also reduced.