公开(公告)号：US11338016B2

公开(公告)日：2022-05-24

申请号：US16878809

申请日：2020-05-20

Applicant: Howard University

Inventor： Yousef Tizabi

IPC: A61K38/16 ,  A61K9/00

Abstract: C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) provides therapeutic effects in motor impairments associated with Parkinson disease (PD), and provides long lasting antidepressant effects, thus useful in treating and mitigating depression, particularly PD-depression co-morbid condition. A method for treating or mitigating depression, including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof. A method for treating or mitigating motor impairments associated with Parkinson's disease (PD), including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof.

公开(公告)号：US11319273B2

公开(公告)日：2022-05-03

申请号：US14689827

申请日：2015-04-17

Applicant: Howard University

Inventor： Evaristus A. Nwulia ,  Amol Kulkarni

IPC: C07C49/255 ,  A61K31/12 ,  C07D207/36 ,  A61K31/40 ,  C07D307/60 ,  A61K31/341 ,  C07D333/32 ,  A61K31/381 ,  C07C323/22 ,  A61K45/06 ,  A61M31/00 ,  A61K31/122 ,  A61K31/4025 ,  A61K9/00 ,  C07D237/14 ,  C07D265/02 ,  C07D279/02

Abstract: Compounds having formulas (I) to (VIII), salts thereof, or combinations thereof and pharmaceutical compositions comprising one or more these compounds are described herein for the treatment of HIV and neurodegenerative effects caused by HIV. Also provided herein are methods and a kit for inhibiting HIV-1, treating latent HIV in the brain, and preventing HIV-mediated cognitive decline and HIV dementia comprising administering the compounds having the formulas (I) to (VIII) and pharmaceutical compositions comprising the compounds having these formulas. The compounds having formulas I through VIII are curcumin analogs which are advantageously characterized as having anti-retroviral, neuroprotective, anti-glucosidase, and anti-HIV integrase properties. In one aspect, the pharmaceutical composition is delivered intranasally.

公开(公告)号：US20210405105A1

公开(公告)日：2021-12-30

申请号：US17364061

申请日：2021-06-30

Applicant: Howard University

Inventor： Charles J. KIM

IPC: G01R31/08 ,  G06F17/17 ,  G01R31/52 ,  G01R31/58

Abstract: A method, computer program, and computer system is provided for fault detection in an electrical network. An inductance between a reference point and a fault is determined at a first time based on measuring a fault current. A resistance between the reference point and the fault may be determined at a second time based on measuring a differential of the fault current as zero. A location of the fault may be identified based on the inductance and the resistance.

公开(公告)号：US20210361739A1

公开(公告)日：2021-11-25

申请号：US16878809

申请日：2020-05-20

Applicant: Howard University

Inventor： Yousef TIZABI

IPC: A61K38/16

Abstract: C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) provides therapeutic effects in motor impairments associated with Parkinson disease (PD), and provides long lasting antidepressant effects, thus useful in treating and mitigating depression, particularly PD-depression co-morbid condition. A method for treating or mitigating depression, including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof. A method for treating or mitigating motor impairments associated with Parkinson's disease (PD), including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof.

公开(公告)号：US20210038638A1

公开(公告)日：2021-02-11

申请号：US17077950

申请日：2020-10-22

Applicant: HOWARD UNIVERSITY

Inventor： James W MITCHELL ,  Dazhi YANG

IPC: A61K31/785 ,  A61K31/738 ,  B01J20/26 ,  B01J20/28 ,  B01J20/30 ,  A61P7/08 ,  C08B15/06 ,  C08G81/00 ,  C08G83/00 ,  C08J9/16 ,  A61K9/14 ,  C08F251/02 ,  C08G73/02 ,  C08L1/08 ,  C08L3/20 ,  C08L5/02 ,  C08L5/08

Abstract: Covalently cross-linked copolymers are described herein. More specifically, polysaccharide-polyamine copolymeric matrices or structures and cationic copolymeric matrices are described herein. The polysaccharide-polyamine copolymers, when protonated, can form cationic copolymeric matrices having exceptionally high densities of cationic sites. In one form, the covalently cross-linked copolymers provide a three-dimensional structure, especially when hydrated.

公开(公告)号：US10400083B2

公开(公告)日：2019-09-03

申请号：US14391044

申请日：2013-03-08

Applicant: Tongxin Wang ,  James W. Mitchell

Inventor： Tongxin Wang ,  James W. Mitchell

IPC: C08K3/32 ,  A61L27/12 ,  A61L27/18 ,  A61L27/58

Abstract: A method is provided for synthesizing PLA/apatite composites with improved mechanical strength. In one aspect, a calcium-phosphate/phosphonate hybrid shell is developed to incorporate more reactive hydroxyl groups onto hydroxyapatite (HA) particles. PLA is covalently bonded to HA calcium phosphate hybrid shell, creating a strong interphase between HA and PLA, thus significantly improve the mechanical strength in comparison to that of non-modified HA.

公开(公告)号：US10016473B2

公开(公告)日：2018-07-10

申请号：US14591780

申请日：2015-01-07

Applicant: Howard University

Inventor： Evaristus A. Nwulia

IPC: A61K36/00 ,  A61K36/53 ,  A61K9/00 ,  A61K36/752 ,  A61M16/12 ,  A61K36/54 ,  A61M15/00 ,  A61M16/16 ,  A61M16/06 ,  A61M16/20 ,  A61M21/00 ,  A61M16/00

CPC classification number: A61K36/53 ,  A61K9/0043 ,  A61K9/007 ,  A61K36/54 ,  A61K36/752 ,  A61M15/0085 ,  A61M16/0666 ,  A61M16/0672 ,  A61M16/12 ,  A61M16/122 ,  A61M16/16 ,  A61M16/162 ,  A61M16/208 ,  A61M21/00 ,  A61M2016/003 ,  A61M2021/0016 ,  A61M2202/0208 ,  A61M2205/8206 ,  A61M2205/8237

Abstract: A method, apparatus and kit have been discovered which utilize pulsed odorants, drugs, medicaments, and combinations thereof to treat diseases, symptoms of diseases and the like. In one form, the pulsed odorants, drugs, medicaments, and combinations thereof can be used to regenerate the connections of the neurons of the brain and central nervous system in the treatment of symptoms of such person afflicted with neuro-disorders, such as caused by disease or trauma.

公开(公告)号：US09870641B2

公开(公告)日：2018-01-16

申请号：US14184446

申请日：2014-02-19

Applicant: Howard University

Inventor： John M. M. Anderson ,  Mandoye Ndoye

IPC: G06T15/00 ,  G06T15/08 ,  G01S7/295 ,  G01S13/00 ,  G01S13/88 ,  G01S13/90 ,  G01S7/04

CPC classification number: G06T15/08 ,  G01S7/046 ,  G01S7/295 ,  G01S13/003 ,  G01S13/885 ,  G01S13/90

Abstract: A majorize-minimize (MM) mathematical principle is applied to least squares regularization estimation problems to effect efficient processing of image data sets to provide good quality images. In a ground penetrating radar application, these approaches can reduce processing time and memory use by accounting for a symmetric nature of a given radar pulse, accounting for similar discrete time delays between transmission of a given radar pulse and reception of reflections from the given radar pulse, and accounting for a short duration of the given radar pulse.

公开(公告)号：US09675556B2

公开(公告)日：2017-06-13

申请号：US14575517

申请日：2014-12-18

Applicant: Howard University

Inventor： Emmanuel Oyekanmi Akala ,  Simeon Kolawole Adesina

IPC: B01J13/06 ,  B01J13/16 ,  A61K9/16 ,  A61K31/337 ,  A61K31/704 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00 ,  A61K9/51 ,  C08G63/85

CPC classification number: C08G63/78 ,  A61K9/1635 ,  A61K9/5153 ,  A61K31/337 ,  A61K31/7034 ,  A61K31/704 ,  B01J13/06 ,  B01J13/16 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00 ,  C08F299/024 ,  C08G63/06 ,  C08G63/82 ,  C08G63/85 ,  C08G63/912 ,  Y10S977/773 ,  Y10T428/2982

Abstract: The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alklyene glycol-graft-lactate) that is crosslinked by at least one hydrolysable monomer. Another embodiment of the present invention is a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent. Another embodiment of the present invention is a polymer particle comprising, a crosslinked copolymer comprises structures represented by Formulas (I), (II), and (III), where Formulas (I), (II) and (III) are defined in the specification. Yet other embodiments of the present invention include a method of preparing a methacrylate terminated macromonomer, a method of preparing a crosslinking agent, and a method of preparing a therapeutic agent loaded nanosphere by dispersion polymerization.

公开(公告)号：US09511343B2

公开(公告)日：2016-12-06

申请号：US14006080

申请日：2012-03-22

Applicant: Reginald B. Little ,  James W. Mitchell

Inventor： Reginald B. Little ,  James W. Mitchell

IPC: B01J19/08 ,  C01B31/04 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: B01J19/087 ,  B01J2219/089 ,  B01J2219/0892 ,  B82Y30/00 ,  B82Y40/00 ,  C01B31/043 ,  C01B31/0484 ,  C01B32/194 ,  C01B32/23

Abstract: Methods and apparatus to control reaction rates of chemical reactions. Methods can include mixing chemical reactants to provide a reaction mixture, at least one chemical reactant being magnetic; and applying a magnetic field to the reaction mixture, the magnetic field being applied to effect a control of the rate of a chemical reaction between the reactants in the reaction mixture, the magnetic field being effective to change the reaction rate over a chemical reaction between the same reactants at the same pressure and temperature where the reaction mixture is not exposed to the magnetic field.

Abstract translation: 控制化学反应速率的方法和装置。 方法可以包括混合化学反应物以提供反应混合物，至少一种化学反应物是磁性的; 并且向反应混合物施加磁场，施加磁场以控制反应混合物中反应物之间的化学反应速率，该磁场有效地改变反应速率之间的化学反应 相同的反应物在相同的压力和温度下反应混合物不暴露于磁场。