公开(公告)号：US10774109B2

公开(公告)日：2020-09-15

申请号：US16083483

申请日：2017-03-10

申请人： KYOWA HAKKO BIO CO., LTD.

发明人： Kazunari Fukumoto ,  Maya Iguchi ,  Hiroshi Nagano

IPC分类号： C07K5/037 ,  A61K38/06 ,  A61P1/16 ,  A61P39/02 ,  C30B7/08 ,  C30B29/58 ,  C07K5/02

摘要： The present invention provides a crystal of reduced glutathione having excellent powder properties and a method for producing the same. The present invention relates to a crystal of reduced glutathione, wherein the average crystal thickness is 10 μm or more.

公开(公告)号：US10369186B2

公开(公告)日：2019-08-06

申请号：US14435679

申请日：2013-10-30

申请人： KYOWA HAKKO BIO CO., LTD.

发明人： Kota Kumagai ,  Masahiko Morita ,  Takahiro Hara ,  Kohji Fukunaga

IPC分类号： A61K38/06 ,  A61K31/198

摘要： An objection of the present invention is to provide an agent for preventing or improving decline in brain function such as decreased perception ability, decreased memory learning ability, decreased thinking ability, decreased concentration, decreased attention, decreased judgment ability, depression, and decreased exercise performance caused thereby. According to the present invention, an agent for protecting brain neuronal cells, comprising citrulline or a salt thereof and glutathione or a salt thereof as active ingredients as well as an agent for preventing or improving decline in brain function, comprising citrulline or a salt thereof and glutathione or a salt thereof as active ingredients is provided.

公开(公告)号：US10369185B2

公开(公告)日：2019-08-06

申请号：US15312882

申请日：2015-05-22

申请人： KYOWA HAKKO BIO CO., LTD.

发明人： Yukihiro Hishida ,  Takeshi Ikeda ,  Ryusuke Nakagiri ,  Ayako Kamimura

IPC分类号： A61K38/00 ,  A61K39/38 ,  A61K38/05 ,  A23L2/52 ,  A61K9/00

摘要： A composition for enhancement of ability to concentrate and method of improving ability to concentrate using alanylglutamine or a salt of alanylglutamine as an active ingredient.

公开(公告)号：US20190225642A1

公开(公告)日：2019-07-25

申请号：US16339301

申请日：2017-10-06

申请人： KYOWA HAKKO BIO CO., LTD.

发明人： Kazunari FUKUMOTO

IPC分类号： C07H19/10 ,  C07H1/06

摘要： An object of the present invention is to provide a crystal of cytidine diphosphate choline which contains no methanol and has improved powder properties, and a production method thereof. According to the present invention, the crystal of cytidine diphosphate choline which contains no methanol and has improved powder properties can be obtained by precipitating the crystal of cytidine diphosphate choline in an aqueous solution in which cytidine diphosphate choline is dissolved, collecting the precipitated crystal of cytidine diphosphate choline, and washing the collected crystal of cytidine diphosphate choline with an aqueous solution containing an organic solvent other than methanol in which a water content is 5% to 50% by volume.

公开(公告)号：US10329250B2

公开(公告)日：2019-06-25

申请号：US15515142

申请日：2015-10-08

申请人： KYOWA HAKKO BIO CO., LTD.

发明人： Tetsuro Ujihara ,  Satoshi Mitsuhashi

IPC分类号： C12N9/10 ,  C07C401/00 ,  C12P33/00 ,  B01J19/12 ,  C12P7/22 ,  C12N15/09

摘要： According to the present invention, there can be provided a process for producing 7-dehydrocholesterol (7DHC), comprising culturing, in a medium, a 7DHC-producing Labyrinthulea microorganism in which sterol 24-C-methyltransferase activity is reduced or lost as compared to a parent strain, allowing 7DHC to be produced and accumulated in the culture, and collecting the 7DHC from the culture; and a process for producing vitamin D3, comprising irradiating, with ultraviolet light, 7-dehydrocholesterol produced by the production process.

公开(公告)号：US10005808B2

公开(公告)日：2018-06-26

申请号：US15500020

申请日：2015-07-29

申请人： KYOWA HAKKO BIO CO., LTD.

发明人： Kazunari Fukumoto ,  Masahiro Abe

IPC分类号： C07H7/02

CPC分类号： C07H7/02 ,  C07B2200/13 ,  C07H13/04

摘要： According to the present invention, a crystal of an alkali metal N-acetylneuraminate anhydrate, and a process for producing a crystal of an alkali metal N-acetylneuraminate anhydrate, comprising adding or adding dropwise a solvent selected from the group consisting of alcohols and ketones to an aqueous N-acetylneuraminic acid solution containing an alkali metal-containing compound and having a pH of 3.0 to 9.0 to precipitate a crystal of an alkali metal N-acetylneuraminate anhydrate, and collecting the crystal of an alkali metal N-acetylneuraminate anhydrate from the aqueous solution, can be provided.

公开(公告)号：US09918951B2

公开(公告)日：2018-03-20

申请号：US12866001

申请日：2009-02-05

申请人： Yasushi Sakai ,  Shun Kayahashi

发明人： Yasushi Sakai ,  Shun Kayahashi

IPC分类号： A61K9/00 ,  A61K31/198 ,  A61K9/14 ,  A61K47/12 ,  A61K47/18 ,  A23L33/10 ,  A23L33/175

CPC分类号： A61K31/198 ,  A23L33/10 ,  A23L33/175 ,  A23V2002/00 ,  A61K9/145 ,  A61K47/12 ,  A61K47/183 ,  A23V2200/02 ,  A23V2250/31 ,  A23V2250/0606 ,  A23V2250/063 ,  A23V2250/032 ,  A23V2250/056 ,  A23V2250/044 ,  A23V2250/708

摘要： The invention provides a method of improving the preservation stability of glutathione in a solid composition containing glutathione and arginine. In particular, glutathione and arginine are made to be coexistent with an organic acid such as citric acid, tartaric acid, ascorbic acid, malic acid, malonic acid, succinic acid, fumaric acid, maleic acid and the like. The amount of the organic acid to coexistent with glutathione and arginine is generally 0.1-2 parts by weight relative to 1 part by weight of arginine.

公开(公告)号：US20180002364A1

公开(公告)日：2018-01-04

申请号：US15545881

申请日：2016-01-27

申请人： KYOWA HAKKO BIO CO., LTD.

发明人： Kazunari FUKUMOTO

IPC分类号： C07H5/06

CPC分类号： C07H5/06 ,  C07B2200/13 ,  C07H1/00 ,  C07H7/027

摘要： According to the present invention, a crystal of ammonium N-acetylneuraminate anhydrate, and a process for producing a crystal of ammonium N-acetylneuraminate anhydrate, comprising adding or adding dropwise a solvent selected from the group consisting of alcohols and ketones to an aqueous N-acetylneuraminic acid solution containing an ammonium-containing compound and having a pH of 3.0 to 9.0 to precipitate a crystal of ammonium N-acetylneuraminate anhydrate, and collecting the crystal of ammonium N-acetylneuraminate anhydrate from the aqueous solution, can be provided.

公开(公告)号：US20170253627A1

公开(公告)日：2017-09-07

申请号：US15500020

申请日：2015-07-29

申请人： KYOWA HAKKO BIO CO., LTD.

发明人： Kazunari FUKUMOTO ,  Masahiro ABE

IPC分类号： C07H7/02

CPC分类号： C07H7/02 ,  C07B2200/13 ,  C07H13/04

摘要： According to the present invention, a crystal of an alkali metal N-acetylneuraminate anhydrate, and a process for producing a crystal of an alkali metal N-acetylneuraminate anhydrate, comprising adding or adding dropwise a solvent selected from the group consisting of alcohols and ketones to an aqueous N-acetylneuraminic acid solution containing an alkali metal-containing compound and having a pH of 3.0 to 9.0 to precipitate a crystal of an alkali metal N-acetylneuraminate anhydrate, and collecting the crystal of an alkali metal N-acetylneuraminate anhydrate from the aqueous solution, can be provided.

公开(公告)号：US20170172962A1

公开(公告)日：2017-06-22

申请号：US15454325

申请日：2017-03-09

申请人： Kyowa Hakko Bio Co., Ltd. ,  National University Corporation Nagoya University

发明人： Masayuki OCHIAI ,  Koji MORISHITA ,  Toshio HAYASHI

IPC分类号： A61K31/198

CPC分类号： A61K31/198 ,  A23L2/52 ,  A23L33/175 ,  A23V2002/00 ,  A61K9/205 ,  A61K9/2054 ,  A61K31/155 ,  A61K36/00 ,  A61K2300/00 ,  A23V2250/0614 ,  A23V2250/0606

摘要： The invention provides a method of increasing blood flow in a subject in need of increased blood flow by administering citrulline or a salt thereof and arginine or a salt thereof to the subject.