公开(公告)号：US20230323466A1

公开(公告)日：2023-10-12

申请号：US18016021

申请日：2021-07-15

Applicant: Queensland University of Technology

Inventor： Mark ADAMS ,  Derek RICHARD ,  Kenneth O'BYRNE

IPC: C12Q1/6886 ,  A61K33/243 ,  A61K45/06 ,  A61K35/00

CPC classification number: C12Q1/6886 ,  A61K33/243 ,  A61K45/06 ,  A61K35/00 ,  C12Q2600/106 ,  C12Q2600/158

Abstract: The present disclosure relates to cancer and more particularly, methods of treating and/or determining the responsiveness to treatment and/or prognosis of cancers, such as lung cancer and breast cancer.

公开(公告)号：US20230227657A1

公开(公告)日：2023-07-20

申请号：US17996191

申请日：2021-04-15

Applicant: QUEENSLAND UNIVERSITY OF TECHNOLOGY

Inventor： Christopher Winfried Barner-Kowollik ,  Florian Feist ,  James Peter Blinco ,  Anja Sabrina Goldmann

IPC: C09B69/10 ,  C09K11/06 ,  G01N21/64

CPC classification number: C09B69/109 ,  C09K11/06 ,  G01N21/64 ,  C09K2211/1416 ,  C09K2211/1425 ,  C09K2211/1466 ,  C09K2211/1483 ,  G01N2021/6421

Abstract: A fluorescent macromolecule comprising: a linear sequence-defined backbone; and a plurality of fluorophores attached to the backbone in a pre-determined order to form a fluorophore sequence, wherein the fluorophores in the fluorophore sequence are separated from one another by a distance permitting interaction between adjacent fluorophores such that the macromolecule emits fluorescence at a plurality of wavelengths when irradiated by light to form a fluorescence emission spectrum, and wherein the fluorescence emission spectrum has a profile that is determined by the fluorophore sequence.

公开(公告)号：US11540994B2

公开(公告)日：2023-01-03

申请号：US16753126

申请日：2018-06-25

Applicant: Meat & Livestock Australia Ltd ,  Queensland University of Technology

Inventor： Robert Speight ,  Laura Navone

IPC: A61Q19/10 ,  A61K8/66 ,  A61K8/39 ,  A61K8/49 ,  A61K8/86 ,  C12N9/50

Abstract: Provided herein is a method of at least partly removing a biological deposit, such as a dag, from the skin of an animal. The method includes administering to the biological deposit an effective amount of a composition containing a keratinase, and optionally one or both of a reducing agent and a surfactant. Also provided is a composition for use in the aforementioned method as well as a method of making same.

公开(公告)号：US20210400858P1

公开(公告)日：2021-12-23

申请号：US16873740

申请日：2020-06-19

Applicant: Queensland University of Technology

Inventor： James Dale ,  Robert Harding ,  Harjeet Khanna ,  Anthony James ,  Jennifer Kleidon ,  Mark Smith ,  Upendra Shekhawat

IPC: A01H6/00

Abstract: A new banana cultivar ‘QCAV-4’ is provided that, when under significant disease pressure, remains largely free from infection by Fusarium wilt tropical race 4 (TR4). In the absence of such significant disease pressure, ‘QCAV-4’ appears to be essentially phenotypically identical to the wild type parent Cavendish Grand Nain. This includes in relation to immature and mature plant characteristics, fruit characteristics, and yield.

公开(公告)号：US20210364519A1

公开(公告)日：2021-11-25

申请号：US17053707

申请日：2018-12-21

Applicant: Queensland University of Technology

Inventor： Joshua T. Burgess ,  Emma Bolderson ,  Derek J. Richard ,  Kenneth J. O'Byrne

IPC: G01N33/574 ,  G01N33/50 ,  A61K45/06

Abstract: Provided herein are methods of treating a cancer with or predicting the responsiveness of a cancer to an anti-cancer agent which is capable of inhibiting an enzyme that mediates repair of DNA strand breaks, such as PARP, said method including the step of determining an expression level of SASH1. A method of treating a cancer that includes administering a therapeutically effective amount of an agent that increases the expression and/or an activity of SASH1 is also provided. Further provided herein are methods for identifying an agent that modulates the expression and/or an activity of SASH1 for use in the treatment of cancer.

公开(公告)号：US09441234B2

公开(公告)日：2016-09-13

申请号：US14364184

申请日：2012-12-07

Applicant: Mark D. Kinkema ,  Stacy Miles

Inventor： Mark D. Kinkema ,  Stacy Miles

IPC: C12N15/82

CPC classification number: C12N15/8245 ,  C12N15/8216

Abstract: A sugar cane plant cell comprising a recombinant nucleic acid molecule is provided, the recombinant nucleic acid molecule comprising a nucleotide sequence of interest, a promoter and the nucleotide sequence of SEQ ID NO:1, wherein the promoter is downstream of and in operative association with the nucleotide sequence of SEQ ID NO:1 and upstream of and in operative association with the nucleotide sequence of interest, and the nucleotide sequence of interest is expressed at a level at least about 6 times greater than the level of expression of said nucleotide sequence of interest in a control. Additionally, a method of increasing the expression of a nucleotide sequence of interest in a sugar cane plant cell using the recombinant nucleic acid molecule of the invention is provided.

Abstract translation: 提供了包含重组核酸分子的甘蔗植物细胞，所述重组核酸分子包含目的核苷酸序列，启动子和SEQ ID NO：1的核苷酸序列，其中所述启动子位于SEQ ID NO：1的下游且与 SEQ ID NO：1的核苷酸序列并与感兴趣的核苷酸序列上游并且与目标核苷酸序列有效结合，并且感兴趣的核苷酸序列的表达水平比所述核苷酸序列的表达水平至少大约6倍 控制权益。 另外，提供了使用本发明的重组核酸分子增加甘蔗植物细胞中目的核苷酸序列的表达的方法。

公开(公告)号：US08911997B2

公开(公告)日：2014-12-16

申请号：US10565616

申请日：2004-07-28

Applicant: Zee Upton ,  Damien Harkin ,  David Leavesley

Inventor： Zee Upton ,  Damien Harkin ,  David Leavesley

IPC: C12N5/00 ,  C12N5/071 ,  A61K35/12

CPC classification number: C12N5/0629 ,  A61K35/12 ,  C12N2501/105

Abstract: A cell culture medium and system are provided which eliminate or at least reduce the requirement for exogenous components such as serum and feeder cells. The cell culture medium comprises an IGF and vitronectin or fibronectin and, optionally an IGFBP, and is particularly suitable for propagating keratinocytes for subsequent use in skin growth and regeneration. This invention also relates to compositions and methods for skin growth and regeneration in situ, which utilize aerosol delivery of cultured keratinocytes.

Abstract translation: 提供了消除或至少减少对外源成分如血清和饲养细胞的需求的细胞培养基和系统。 细胞培养基包含IGF和玻连蛋白或纤连蛋白和任选的IGFBP，并且特别适用于增殖角质形成细胞，用于随后用于皮肤生长和再生。 本发明还涉及用于原位皮肤生长和再生的组合物和方法，其利用培养的角化细胞的气雾剂递送。

公开(公告)号：US08747830B2

公开(公告)日：2014-06-10

申请号：US12663438

申请日：2008-06-10

Applicant: Erin A. Rayment ,  Tim Dargaville ,  Zee Upton

Inventor： Erin A. Rayment ,  Tim Dargaville ,  Zee Upton

IPC: A61K31/74

CPC classification number: C07F9/3873 ,  A61K47/58 ,  A61K47/6955 ,  A61L15/44 ,  A61L2300/112 ,  A61L2300/434

Abstract: The invention provides a dressing composition comprising a bisphosphonate matrix metalloproteinase (MMP) inhibitor covalently bound to a polymer wherein, when the dressing is contacted with a wound, substantially all of the bisphosphonate remains with the dressing composition and is unable to enter the wound tissue. The invention also provides for a method of treatment of a wound by contacting a dressing composition comprising a covalently bound MMP inhibitor with the wound fluid to thereby selectively inhibit one or more MMP's in the wound fluid without inhibiting those in the wound tissue.

Abstract translation: 本发明提供一种敷料组合物，其包含与聚合物共价结合的二膦酸酯基质金属蛋白酶（MMP）抑制剂，其中当敷料与伤口接触时，基本上所有的双膦酸盐都与敷料组合物保持不动，并且不能进入伤口组织。 本发明还提供了通过使包含共价结合的MMP抑制剂的敷料组合物与伤口液接触从而选择性地抑制伤口液中的一种或多种MMP而不抑制伤口组织中的那些的方法来治疗伤口。

公开(公告)号：US20140093918A1

公开(公告)日：2014-04-03

申请号：US14100510

申请日：2013-12-09

Applicant: Queensland University of Technology ,  Syngenta Participations AG

Inventor： Zhanying Zhang ,  Ian Mark O'Hara ,  William Orlando Sinclair Doherty ,  Darryn Rackemann

IPC: C13K1/02 ,  C12P19/02 ,  C12P19/14

CPC classification number: D21B1/021 ,  C08B37/0006 ,  C08B37/0057 ,  C08H6/00 ,  C08H8/00 ,  C12P7/10 ,  C12P19/02 ,  C12P19/14 ,  C12P2201/00 ,  C12P2203/00 ,  C13K1/02 ,  C13K13/002 ,  Y02E50/16

Abstract: The present invention provides compositions and methods for the pretreatment of lignocellulosic material. The present invention further provides for pretreated lignocellulosic material that can be used to produce useful products, such as fermentable sugars.

Abstract translation: 本发明提供了用于预处理木质纤维素材料的组合物和方法。 本发明进一步提供可用于生产有用产物如可发酵糖的预处理木质纤维素材料。

公开(公告)号：US20130291233A1

公开(公告)日：2013-10-31

申请号：US13978133

申请日：2011-12-15

Applicant: Manuel Benito Sainz ,  Mark David Kinkema

Inventor： Manuel Benito Sainz ,  Mark David Kinkema

IPC: C12N15/82

CPC classification number: C12N15/8238 ,  C12N15/113 ,  C12N15/8241

Abstract: The present invention provides nucleic acid molecules comprising one or more nucleotide sequences selected from the group consisting of the nucleotide sequence of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, and/or SEQ ID NO:10 that can be operably linked to a promoter, thereby making the promoter inducible by a chemical compound that can induce the expression of the alcohol dehydrogenase system of Aspergillus nidulans. Methods for making an inducible promoter and for making the expression of a nucleotide sequence of interest inducible are also provided. Further provided are plants, plant parts, and plant cells, comprising the compositions of the present invention.

Abstract translation: 本发明提供了包含一个或多个选自下组的核酸序列的核酸分子：SEQ ID NO：1，SEQ ID NO：3，SEQ ID NO：4，SEQ ID NO：5，SEQ ID NO： ：6，SEQ ID NO：7，SEQ ID NO：8和/或SEQ ID NO：10，其可以可操作地连接到启动子，从而使启动子可诱导可诱导醇脱氢酶表达的化学化合物 构巢曲霉系统。 还提供了制备诱导型启动子和用于诱导感兴趣的核苷酸序列的表达的方法。 还提供植物，植物部分和植物细胞，其包含本发明的组合物。