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197 条记录 (耗时 0.018 秒)

    Preparation of tri-cyclo nitriles
    43.
    发明授权
    Preparation of tri-cyclo nitriles 失效
    三环腈的制备

    公开(公告)号：US4591461A

    公开(公告)日：1986-05-27

    申请号：US791773

    申请日：1985-10-28

    申请人： Alain Jouquey ,  Peter F. Hunt

    发明人： Alain Jouquey ,  Peter F. Hunt

    IPC分类号： C07J1/00 ,  C07C67/00 ,  C07C239/00 ,  C07C253/00 ,  C07C255/31 ,  C07C255/47 ,  C07C271/00 ,  C07J41/00 ,  C07J73/00 ,  C07J75/00 ,  C07C121/46 ,  C07C121/47

    CPC分类号： C07J41/0016 ,  C07J73/005 ,  C07C2103/26

    摘要： A novel process for the preparation of a 16-imino-17-aza-steroid of the formula ##STR1## wherein A is selected from the group consisting of hydrogen and tritium comprising reacting a compound of the formula ##STR2## wherein A has the above definition and R is an acyl of an organic carboxylic acid of 1 to 8 carbon atoms with an oximation agent to obtain a compound of the formula ##STR3## reacting the latter with an agent to form an acid chloride to obtain a compound of the formula ##STR4## reacting the latter with ammonia to obtain a compound of the formula ##STR5## reacting the latter with an alkali metal hypohalite in the presence of a base to obtain a compound of the formula ##STR6## wherein X is a halogen and reacting the latter with a base to obtain the desired compound and the novel compound of formula I wherein A is tritium and the novel intermediates of formulae III, IV, V and VI.

    摘要翻译： 一种用于制备式I的16亚氨基-17-氮杂类固醇的新方法，其中A选自氢和氚，包括使下式化合物II与式 上述定义，R为具有1至8个碳原子的有机羧酸的酰基与肟化剂反应，得到下式化合物，其中后者与试剂反应形成酰氯，得到化合物 IV使后者与氨反应，得到下式的化合物，其中R 1在碱的存在下与碱金属次卤酸盐反应，得到式VI的化合物，其中X为 卤素并使其与碱反应以获得所需化合物和式I的新型化合物，其中A是氚，以及式III，IV，V和VI的新型中间体。

    Catalytic production of octahydrophenanthrene-enriched solvent
    45.
    发明授权
    Catalytic production of octahydrophenanthrene-enriched solvent 失效
    催化生产富含八氢菲的溶剂

    公开(公告)号：US4312746A

    公开(公告)日：1982-01-26

    申请号：US118762

    申请日：1980-02-05

    申请人： Shirley C. Tsai ,  Howard G. McIlvried, III

    发明人： Shirley C. Tsai ,  Howard G. McIlvried, III

    IPC分类号： C10G1/06 ,  C10G1/04 ,  C10G45/44 ,  C10G45/50 ,  C10G45/00 ,  C07C5/10

    CPC分类号： C10G45/44 ,  C10G1/042 ,  C10G45/50 ,  C07C2103/26

    摘要： The OHP content of an OHP- and THP-containing solvent is enriched by contacting the solvent with hydrogen in the presence of a supported catalyst comprising Group VIB and Group VIII metals under conditions to increase the OHP/THP ratio in the solvent to a level greater than 0.4 and preferably greater than 1. The preferred catalyst contains tungsten where it is desired to provide an OHP/THP ratio greater than 1 in the OHP-enriched solvent, and also contains titanium to improve the hydrogen selectivity of the catalyst so as to enhance the preservation of aromatics in the hydrogenated solvent. The OHP-enriched solvent provides increased solvation of coal and improved yields of liquid fuel product in a coal liquefaction process which utilizes the solvent.

    摘要翻译： 在包含VIB族和VIII族金属的负载型催化剂存在下，通过使溶剂与氢气接触，使OHP和THP的溶剂的OHP含量在使溶剂中的OHP / THP比增加至更高的条件下得到富集 优选大于1.优选的催化剂含有钨，其中希望在富含OHP的溶剂中提供大于1的OHP / THP比，并且还含有钛以改善催化剂的氢选择性以增强 芳烃在氢化溶剂中的保存。 富含OHP的溶剂在利用溶剂的煤液化过程中提供了煤的溶剂化提高和液体燃料产物的提高。

    1,9-Dihydroxyoctahydrophenanthrenes and intermediates therefor
    46.
    发明授权
    1,9-Dihydroxyoctahydrophenanthrenes and intermediates therefor 失效
    1,9-二羟基八氢菲和其中间体

    公开(公告)号：US4268523A

    公开(公告)日：1981-05-19

    申请号：US78476

    申请日：1979-09-24

    申请人： Thomas H. Althuis ,  Charles A. Harbert ,  Michael R. Johnson ,  Lawrence S. Melvin, Jr.

    发明人： Thomas H. Althuis ,  Charles A. Harbert ,  Michael R. Johnson ,  Lawrence S. Melvin, Jr.

    IPC分类号： C07C41/22 ,  C07C41/26 ,  C07C43/225 ,  C07C43/23 ,  C07C45/45 ,  C07C45/46 ,  C07C45/54 ,  C07C45/61 ,  C07C45/67 ,  C07C45/68 ,  C07C45/71 ,  C07C45/73 ,  C07C49/747 ,  C07C49/755 ,  C07C49/83 ,  C07D211/32 ,  C07D213/30 ,  C07D213/50 ,  C07D317/22 ,  C07D317/72 ,  A01N35/00 ,  C07C49/788

    CPC分类号： C07D213/30 ,  C07C41/01 ,  C07C41/22 ,  C07C41/26 ,  C07C45/45 ,  C07C45/46 ,  C07C45/54 ,  C07C45/61 ,  C07C45/67 ,  C07C45/68 ,  C07C45/71 ,  C07C45/73 ,  C07C49/747 ,  C07C49/755 ,  C07C49/83 ,  C07D211/32 ,  C07D213/50 ,  C07D317/22 ,  C07D317/72 ,  C07C2101/14 ,  C07C2103/26

    摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, benzyl, benzoyl, alkanoyl of 1 to 5 carbon atoms or --CO--(CH.sub.2).sub.p --NR'R" wherein p is 0 or an integer from 1 to 4; each of R' and R" when taken individually is hydrogen or alkyl of 1 to 4 carbon atoms; R' and R" when taken together with the nitrogen to which they are attached form a 5- or 6-membered heterocyclic ring selected from piperidino, pyrollo, pyrrolidino, morpholino and N-alkylpiperazino having from 1 to 4 carbon atoms in the alkyl group;R.sub.2 is selected from hydrogen, alkanoyl of 1 to 6 carbon atoms and benzoyl;R.sub.3 is selected from hydrogen, methyl and ethyl;R.sub.4 is selected from hydrogen, alkyl of 1 to 6 carbon atoms and benzyl;Z is selected from:(a) alkylene having from one to nine carbon atoms;(b) -(alk.sub.1).sub.m -X-(alk.sub.2).sub.n - wherein each of (alk.sub.1) and (alk.sub.2) is alkylene having from 1 to 9 carbon atoms, with the proviso that the summation of carbon atoms in (alk.sub.1) plus (alk.sub.2) is not greater than 9;m and n are each 0 or 1;X is selected from O, S, SO and SO.sub.2 ; andW is selected from hydrogen, methyl, pyridyl, piperidyl, phenyl, monochlorophenyl, monofluorophenyl and ##STR2## wherein W.sub.1 is selected from hydrogen, phenyl, monochlorophenyl and monofluorophenyl; a is an integer from 1 to 5 and b is 0 or an integer from 1 to 4, with the proviso that the sum of a and b is not greater than 5.Compounds I and II are useful as analgesics. Compound III is useful as an intermediate for the preparation of Compounds I and II. Intermediates for the preparation of I, II and III are disclosed. A process for the use of compounds I and II to produce analgesia is also described.

    摘要翻译： 其中R1是氢，苄基，苯甲酰基，1至5个碳原子的烷酰基或-CO-（CH2）p-NR'R“，其中p是0或 1到4的整数; 当单独使用时，R'和R“各自为氢或1至4个碳原子的烷基; 当与它们所连接的氮一起取代时，R'和R“与烷基中具有1至4个碳原子的5-或6-元杂环选自哌啶子基，吡咯烷基，吡咯烷子基，吗啉代和N-烷基哌嗪基 组; R 2选自氢，1至6个碳原子的烷酰基和苯甲酰基; R3选自氢，甲基和乙基; R4选自氢，1至6个碳原子的烷基和苄基; Z选自：（a）具有1至9个碳原子的亚烷基; （b） - （alk1）mX-（alk2）n-其中（alk1）和（alk2）各自为具有1至9个碳原子的亚烷基，条件是（alk1）加（alk2） ）不大于9; m和n分别为0或1; X选自O，S，SO和SO2; W选自氢，甲基，吡啶基，哌啶基，苯基，一氯苯基，一氟苯基和其中W1选自氢，苯基，一氯苯基和单氟苯基; a为1至5的整数，b为0或1至4的整数，条件是a和b之和不大于5.化合物I和II可用作止痛剂。 化合物III可用作制备化合物I和II的中间体。 公开了制备I，II和III的中间体。 还描述了使用化合物I和II产生止痛的方法。

    Production of aromatic compounds containing ethylene double bonds
    47.
    发明授权
    Production of aromatic compounds containing ethylene double bonds 失效
    生产含乙烯双键的芳香族化合物

    公开(公告)号：US4158099A

    公开(公告)日：1979-06-12

    申请号：US673317

    申请日：1976-04-05

    申请人： Adolf E. Siegrist ,  Peter Liechti ,  Hans R. Meyer ,  Kurt Weber

    发明人： Adolf E. Siegrist ,  Peter Liechti ,  Hans R. Meyer ,  Kurt Weber

    IPC分类号： C07C2/86 ,  C07C17/26 ,  C07C41/30 ,  C07C43/215 ,  C07D213/06 ,  C07D213/16 ,  C07D213/30 ,  C07D317/50 ,  C07D317/54 ,  C07D333/08 ,  C07D333/16 ,  C07C41/06

    CPC分类号： C07D213/16 ,  C07C17/263 ,  C07C2/86 ,  C07C41/30 ,  C07D213/06 ,  C07D213/30 ,  C07D317/50 ,  C07D317/54 ,  C07D333/08 ,  C07D333/16 ,  C07C2103/24 ,  C07C2103/26 ,  C07C2103/50

    摘要： The invention provides a new process for the manufacture of aromatic compounds which at least once contain a benzene ring of an aromatic carbocyclic ring system bonded by an ethylene double bond in conjugation with a further aromatic ring system, i.e. contain the stilbene skeleton or stilbene analogon as central structural element, as well as certain classes of new compounds of this type. The process is characterized by the reaction of a Schiff base of an aromatic aldehyde with an aromatic carbocyclic six-membered ring compound which contains one to four methyl groups bonded to ring carbon atoms of a benzene ring, which furthermore contains aromatic rings which are exclusively six-membered carbocyclic rings, and wherein those benzene rings whose methyl groups are to be caused to react are free of other substituents which contain atoms wich are replaceable by alkali metal. The reaction is carried out in the presence of (a) a strongly basic alkali compound and (b) an N-dialkyl-acylamide as solvent. The compounds obtainable according to this process show a marked fluorescence emission and therefore are suitable for all purposes where fluorescence properties are used, as for instance optical brighteners, scintillators fluorescence dyes, etc.

    摘要翻译： 本发明提供了一种制备芳族化合物的新方法，所述芳族化合物至少一次含有通过乙烯双键与另外的芳族环系统共轭的芳族碳环系统的苯环，即含有二苯乙烯骨架或1,2-二苯乙烯类似物作为 中心结构元素，以及某些类型的这类新化合物。 该方法的特征在于芳族醛的席夫碱与芳族碳环六元环化合物的反应，所述芳族碳环六元环化合物含有与苯环的环碳原子键合的一至四个甲基，其还包含仅六个芳环的芳环 并且其中将要使甲基反应的那些苯环不含可被碱金属替代的原子的其它取代基。 反应在（a）强碱性碱性化合物和（b）N-二烷基 - 酰基酰胺作为溶剂的存在下进行。 根据该方法可获得的化合物显示出显着的荧光发射，因此适用于所有使用荧光性质的目的，例如荧光增白剂，闪烁体荧光染料等。

    15-Oxasteroids
    49.
    发明授权
    15-Oxasteroids 失效
    15-OXASTEROIDS

    公开(公告)号：US4066666A

    公开(公告)日：1978-01-03

    申请号：US702243

    申请日：1976-07-02

    申请人： Perry Rosen

    发明人： Perry Rosen

    IPC分类号： C07D307/77 ,  C07D317/72 ,  C07D319/04

    CPC分类号： C07D307/77 ,  C07C2103/26

    摘要： 15-Oxasteroids of the androstane, pregnane, estrane, and 19-norpregnane series are useful as hormonal agents.

    摘要翻译： 雄甾烷，孕烷，雌激素和19-去甲孕烷系列的甾体化合物可用作激素剂。