公开(公告)号：US20040245457A1

公开(公告)日：2004-12-09

申请号：US10849098

申请日：2004-05-19

申请人： ESA, Inc.

发明人： Michael C. Granger ,  Gary J. Van Berkel

IPC分类号： H01J049/10

CPC分类号： H01J49/165 ,  H01J49/0436

摘要： Disclosed are systems and methods that include a flow-cell that includes porous conductive material(s) that provides a working electrode(s), an inlet connected to the flow-cell to deliver a solution containing an analyte(s), an outlet connected to the flow-cell to allow the solution to exit the flow-cell, a counter electrode positioned proximate to the outlet, and a voltage source(s) coupled to the working electrode(s) and the counter electrode. The methods can include delivering a solution containing an analyte(s) through an inlet to a flow-cell that includes porous conductive material(s) that provides a working electrode(s), connecting the flow-cell to an outlet for allowing the solution to exit the flow-cell, placing a counter-electrode proximate the outlet, and supplying a voltage from a voltage source(s) to the working electrode(s) and/or the counter-electrode.

摘要翻译： 公开了包括流动池的系统和方法，流动池包括提供工作电极的多孔导电材料，连接到流动池以输送含有分析物的溶液的入口，连接的出口 流动池以允许溶液离开流动池，靠近出口定位的对电极和耦合到工作电极和对电极的电压源。 所述方法可以包括将含有分析物的溶液通过入口输送到流动池，该流动池包括提供工作电极的多孔导电材料，将流动池连接到出口以允许溶液 离开流通池，将反电极放置在靠近出口处，并将电压从电压源提供给工作电极和/或对电极。

公开(公告)号：US20020055184A1

公开(公告)日：2002-05-09

申请号：US09391432

申请日：1999-09-08

发明人： STEPHEN NAYLOR ,  JOHN F. O'BRIEN ,  H. ROBERT BERGEN III

IPC分类号： G01N033/558

CPC分类号： H01J49/0436 ,  G01N1/405 ,  G01N33/6887 ,  G01N2333/79

摘要： Systems for detecting analytes that include an immunoaffinity cartridge, a preconcentrator cartridge, and a mass spectrometer are described. The systems also can include a membrane cartridge. Methods for detecting the presence or absence of an analyte in a biological sample are described.

摘要翻译： 描述了用于检测包括免疫亲和柱，预浓缩器盒和质谱仪的分析物的系统。 该系统还可以包括膜盒。 描述了用于检测生物样品中分析物的存在或不存在的方法。

公开(公告)号：US06360588B1

公开(公告)日：2002-03-26

申请号：US09448634

申请日：1999-11-24

申请人： Edward Allan Ross ,  Ian R. Tebbett ,  Charles J. Schmidt ,  Timothy Patrick Griffin ,  Margaret Wheland Couch

发明人： Edward Allan Ross ,  Ian R. Tebbett ,  Charles J. Schmidt ,  Timothy Patrick Griffin ,  Margaret Wheland Couch

IPC分类号： G01N1508

CPC分类号： H01J49/0436 ,  G01N13/04 ,  G01N15/0826 ,  G01N30/7233 ,  G01N2015/084 ,  G01N2030/027

摘要： The subject invention pertains to the efficient and accurate detection and analysis of materials passing through a membrane. In a specific example the transport of materials through skin is analyzed. The subject method can allow accurate, precise, and specific real time measurements of compounds crossing a membrane. Accordingly, the subject method can save time in product development of pharmaceuticals, cosmetics, and protective clothing products, and can also reduce the need for animal and human testing.

摘要翻译： 本发明涉及通过膜的材料的有效和准确的检测和分析。 在具体实例中分析材料通过皮肤的运输。 主题方法可以准确，精确和具体地实时测量跨越膜的化合物。 因此，本发明方法可以节省药物，化妆品和防护服产品的产品开发时间，并且还可以减少动物和人体测试的需要。

公开(公告)号：US5703359A

公开(公告)日：1997-12-30

申请号：US681945

申请日：1996-07-29

申请人： Francis M. Wampler, III

发明人： Francis M. Wampler, III

IPC分类号： B01D63/06 ,  B01D63/08 ,  B01D69/10 ,  B01D71/70 ,  B01L3/00 ,  G01N1/34 ,  H01J49/04

CPC分类号： B01D63/087 ,  B01D63/063 ,  B01D69/10 ,  G01N1/34 ,  H01J49/0427 ,  H01J49/0436 ,  G01N2001/4016

摘要： For treating a fluid sample for introduction to a mass spectrometer or other appropriate use, a composite membrane and support assembly allows analytes from a sample flow to permeate through a membrane free from the undesired background matrix. The composite membrane and support assembly comprises a semipermeable membrane, a fiber member for supporting the membrane, and a rigid perforated member for supporting the membrane and the fiber support.

摘要翻译： 为了处理用于引入质谱仪或其他合适用途的流体样品，复合膜和支持组件允许来自样品流的分析物渗透通过不需要的背景基质的膜。 复合膜和支撑组件包括半透膜，用于支撑膜的纤维构件和用于支撑膜和纤维支撑体的刚性穿孔构件。

公开(公告)号：US5131261A

公开(公告)日：1992-07-21

申请号：US545294

申请日：1990-06-28

申请人： James C. Tou ,  Donald C. Rulf

发明人： James C. Tou ,  Donald C. Rulf

IPC分类号： G01N15/08

CPC分类号： H01J49/0436 ,  G01N15/08

摘要： A system for measuring the permeation rate of organic molecules across a polymer film, which includes a membrane chamber, an electron impact mass spectrometer and a flow-through hollow fiber probe for providing an interface between the membrane chamber and the mass spectrometer. The membrane chamber supports the polymer film sample to be tested, and permits one side of the sample to be exposed to a vapor containing a known concentration of organic molecules under substantially atmospheric pressure and controlled environmental conditions on both the upstream and downstream sides of the sample. The membrane chamber features a unique permeation cell and sample holder arrangement which employs a pair of adhesive backed cards to sandwich the sample and maintain a permanent desirable alignment of the sample.

摘要翻译： 一种用于测量聚合物膜上的有机分子的渗透速率的系统，其包括膜室，电子轰击质谱仪和用于在膜室和质谱仪之间提供界面的流通中空纤维探针。 膜室支持要测试的聚合物膜样品，并且允许样品的一侧在基本上大气压下和在样品的上游侧和下游侧的受控环境条件下暴露于含有已知浓度的有机分子的蒸汽 。 膜室具有独特的渗透池和样品保持器装置，其采用一对粘性支持的卡夹住样品并保持样品的永久期望的对准。

公开(公告)号：US5019139A

公开(公告)日：1991-05-28

申请号：US455472

申请日：1989-12-22

申请人： Mark A. LaPack ,  James C. Tou

发明人： Mark A. LaPack ,  James C. Tou

IPC分类号： B01D53/22 ,  B01D63/06 ,  B01D63/08 ,  G01N1/00 ,  G01N1/22 ,  H01J37/20 ,  H01J49/04

CPC分类号： G01N35/1097 ,  H01J37/20 ,  H01J49/0436

摘要： A combination of a membrane, such as a silicone rubber membrane, and a valve having a chamber within it, such as a solenoid valve. The present invention is suitable, for example, for use with a mass spectrometer. The membrane partitions the chamber into a first chamber portion and a second chamber portion. The valve has at least three passageways into it. The first two passageways lead to the first chamber portion. The third passageway leads to the second chamber portion. A solenoid plunger is used to close off the third passageway when desired. When used with a mass spectrometer, the third passageway is connected to the vacuum inlet of the mass spectrometer and a sample is flowed into and out of the first chamber portion via the first two passaageways. A component of interest in the sample can permeate across the membrane into the second chamber portion and can flow via the third passageway to the mass spectrometer. When desired, the plunger can be used to close the third passageway.