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公开(公告)号：US06211246B1
公开(公告)日：2001-04-03
申请号：US09329900
申请日：1999-06-10
IPC分类号： A61K31135
CPC分类号： A61K31/137 , A61K9/10 , A61K31/19 , Y10S514/849 , Y10S514/853 , A61K31/135 , A61K2300/00
摘要： The present invention provides a method which provides for a faster absorption of pharmaceutically acceptable amines. The method provides a pharmaceutically acceptable amine in combination with a non-steroidal anti-inflammatory drug in a liquid form. A preferred embodiment employs pseudoephedrine and ibuprofen.
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公开(公告)号：US5837286A
公开(公告)日：1998-11-17
申请号：US782433
申请日：1997-01-15
IPC分类号： A61K9/46 , A61K31/167 , A61K45/08 , A61K47/02 , A61K47/44
CPC分类号： A61K47/44 , A61K9/0007 , Y10S514/849 , Y10S514/853
摘要： This invention provides a taste masking composition composed of clove oil and either supportive flavor components or calcium carbonate. This taste masking composition has been found to be particularly useful to mask unpalatable medicinals in formulations which are intended to be chewed, dissolve in the mouth prior to ingestion or ingested in solution.
摘要翻译： 本发明提供由丁香油和支持性风味成分或碳酸钙组成的掩味组合物。 已经发现，这种掩味组合物特别有用于掩盖拟制成咀嚼，在摄取或摄入溶液之前在口中溶解的制剂中的不可食用药物。
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公开(公告)号：US5560913A
公开(公告)日：1996-10-01
申请号：US379407
申请日：1995-01-27
申请人： Philip L. Kupper
发明人： Philip L. Kupper
IPC分类号： A61K9/00 , A61K36/45 , A61K36/736 , A61K36/752 , A61K36/886 , A61K47/36 , A61K47/46 , A61K35/78 , A61K31/19 , A61K31/44
CPC分类号： A61K9/0095 , A61K47/36 , A61K47/46 , Y10S514/819 , Y10S514/82 , Y10S514/825 , Y10S514/849 , Y10S514/853 , Y10S514/855 , Y10S514/858 , Y10S514/859 , Y10S514/861 , Y10S514/893 , Y10S514/895
摘要： The present invention relates to orally ingestible, pharmaceutical compositions containing at least one pharmaceutical active and a taste masking component.
摘要翻译： 本发明涉及含有至少一种药物活性和味道掩蔽组分的口服可摄取的药物组合物。
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44.发明授权Substituted naphthalenes, indoles, benzofurans, and benzothiophenes as lipoxygenase inhibitors 失效取代的萘，吲哚，苯并呋喃和苯并噻吩作为脂氧合酶抑制剂
公开(公告)号：US4737519A
公开(公告)日：1988-04-12
申请号：US878115
申请日：1986-06-25
IPC分类号： C07C11/00 , C07D209/08 , C07D307/86 , C07D333/54 , C07C69/94 , C07C101/04 , C07D333/52
CPC分类号： C07D333/54 , C07C11/00 , C07D209/08 , C07D307/86 , Y10S514/822 , Y10S514/826 , Y10S514/851 , Y10S514/853 , Y10S514/854 , Y10S514/855 , Y10S514/906
摘要： The present invention provides certain novel substituted naphthalenes, indoles, benzofurans, and benzothiophenes of Formula I which are useful as inhibitors of leukotriene biosynthesis and as inhibitors of lipoxygenase. They are thus employed wherever it is medically necessary or desirable to inhibit these systems. ##STR1##
摘要翻译： 本发明提供了可用作白细胞三烯生物合成抑制剂和脂氧合酶抑制剂的某些新颖的式I的取代萘，吲哚，苯并呋喃和苯并噻吩。 因此，它们被用于禁止这些系统的任何医学上必需或可取的地方。
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45.发明授权Pharmaceutical compositions and method of use for prostaglandin 1,11- and 1,15-lactones 失效前列腺素1,11-和1,15-内酯的药物组合物和用途方法
公开(公告)号：US4067991A
公开(公告)日：1978-01-10
申请号：US692439
申请日：1976-06-03
申请人： Gordon L. Bundy
发明人： Gordon L. Bundy
IPC分类号： C07C405/00 , C07D309/12 , C07D313/00 , C07D321/00 , A61K31/365
CPC分类号： C07C405/00 , C07D309/12 , C07D313/00 , C07D321/00 , Y10S514/822 , Y10S514/826 , Y10S514/853
摘要： There are described pharmaceutical compositions comprising a lactone which is the 1,9-lactone, the 1,11-lactone, or the 1,15-lactone of a prostaglandin or prostaglandin analog in combination with a pharmaceutical carrier and formulated to deliver said prostaglandin or prostaglandin analog to an esterase-containing tissue area of a mammal. Also disclosed are methods for administering said compositions to a mammal.
摘要翻译： 描述了药物组合物，其包含内酯，其是与药物载体组合的前列腺素或前列腺素类似物的1,9-内酯，1,11-内酯或1,15-内酯，并配制成输送所述前列腺素或 前列腺素类似物与哺乳动物的含酯酶组织区域。 还公开了将哺乳动物施用所述组合物的方法。
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公开(公告)号：US4032543A
公开(公告)日：1977-06-28
申请号：US670523
申请日：1976-03-29
申请人： Gordon L. Bundy
发明人： Gordon L. Bundy
IPC分类号： C07C405/00 , C07D309/12 , C07D313/00 , C07D321/00 , A01N9/28
CPC分类号： C07C405/00 , C07D309/12 , C07D313/00 , C07D321/00 , Y10S514/822 , Y10S514/826 , Y10S514/853
摘要： The present invention provides novel lactones of prostaglandin-type free acids and a process for their preparation. These lactones are useful for the same pharmacological purposes as the corresponding prostaglandin-type free acids.
摘要翻译： 本发明提供了前列腺素型游离酸的新型1,15内酯及其制备方法。 这些内酯可用于与相应的前列腺素型游离酸相同的药理学目的。
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公开(公告)号：US3965167A
公开(公告)日：1976-06-22
申请号：US223352
申请日：1972-02-03
IPC分类号： A61K31/195 , C07C101/04
CPC分类号： A61K31/195 , Y10S514/853
摘要： The ammonium salt of N-acetyl-L-cysteine is a relatively non-hygroscopic crystalline solid which renders it particularly useful for administration by insufflation in the treatment of bronchopulmonary disease. It is of use in a mucolytic process wherein bronchopulmonary mucus is contacted with solid ammonium N-acetyl-L-cysteinate utilizing only the energy of the inspiratory action of the inhaler.
摘要翻译： N-乙酰基-L-半胱氨酸的铵盐是相对非吸湿性的结晶固体，其特别可用于通过吹入在治疗支气管肺疾病中施用。 它在粘液溶解过程中有用，其中支气管肺粘液仅利用吸入器吸气作用的能量与N-乙酰基-L-半胱氨酸固体铵接触。
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公开(公告)号：US08992916B2
公开(公告)日：2015-03-31
申请号：US14044314
申请日：2013-10-02
IPC分类号： A61K39/395 , C07K16/24 , A61K39/00
CPC分类号： C07K16/244 , A61K38/012 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/76 , C07K2317/92 , C12N15/81 , C12P21/02 , Y10S514/853
摘要： The present invention relates to human anti-IL-13 binding molecules, particularly antibodies, and to methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, such as asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.
摘要翻译： 本发明涉及人抗IL-13结合分子，特别是抗体，以及在诊断或治疗IL-13相关疾病如哮喘，特应性皮炎，过敏性鼻炎， 纤维化，炎性肠病和霍奇金淋巴瘤。
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公开(公告)号：US20140023660A1
公开(公告)日：2014-01-23
申请号：US14044314
申请日：2013-10-02
IPC分类号： C07K16/24
CPC分类号： C07K16/244 , A61K38/012 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/76 , C07K2317/92 , C12N15/81 , C12P21/02 , Y10S514/853
摘要： The present invention relates to human anti-IL-13 binding molecules, particularly antibodies, and to methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, such as asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.
摘要翻译： 本发明涉及人抗IL-13结合分子，特别是抗体，以及在诊断或治疗IL-13相关疾病如哮喘，特应性皮炎，过敏性鼻炎， 纤维化，炎性肠病和霍奇金淋巴瘤。
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公开(公告)号：US20110091458A1
公开(公告)日：2011-04-21
申请号：US12975667
申请日：2010-12-22
申请人： Emma CAMPBELL , Sofia Parveen , Joe Buechler , Gunars Valkirs
发明人： Emma CAMPBELL , Sofia Parveen , Joe Buechler , Gunars Valkirs
CPC分类号： C07K16/244 , A61K38/012 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/76 , C07K2317/92 , C12N15/81 , C12P21/02 , Y10S514/853
摘要： The present invention relates to human anti-IL-13 binding molecules, particularly antibodies, and to methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, such as asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.
摘要翻译： 本发明涉及人抗IL-13结合分子，特别是抗体，以及在诊断或治疗IL-13相关疾病如哮喘，特应性皮炎，过敏性鼻炎， 纤维化，炎性肠病和霍奇金淋巴瘤。
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