公开(公告)号：US06818745B1

公开(公告)日：2004-11-16

申请号：US09700696

申请日：2001-06-12

申请人： Peter Stanley Rowe

发明人： Peter Stanley Rowe

IPC分类号： C07K14435

CPC分类号： C07K14/575 ,  A61K38/00 ,  C07K14/4748

摘要： The present invention relates to a novel human protein called phosphatonin, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.

摘要翻译： 本发明涉及一种称为磷酸肌钙蛋白的新型人蛋白质，以及编码该蛋白质的分离的多核苷酸。 还提供了用于产生该人蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该新型人蛋白相关的疾病的诊断和治疗方法。

公开(公告)号：US06762165B2

公开(公告)日：2004-07-13

申请号：US09749637

申请日：2000-12-28

申请人： Baldomero M. Olivera ,  G. Edward Cartier ,  Maren Watkins ,  David R. Hillyard ,  J. Michael McIntosh ,  Richard T. Layer ,  Robert M. Jones

发明人： Baldomero M. Olivera ,  G. Edward Cartier ,  Maren Watkins ,  David R. Hillyard ,  J. Michael McIntosh ,  Richard T. Layer ,  Robert M. Jones

IPC分类号： C07K14435

CPC分类号： C07K14/43504 ,  A61K38/00

摘要： The invention relates to relatively short peptides (termed O-Superfamily conotoxins herein), about 20-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.

摘要翻译： 本发明涉及相对较短的肽（本文中称为O超家族芋螺毒素），长度约20-40个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且其优选包括 两个二硫键。

公开(公告)号：US06759512B1

公开(公告)日：2004-07-06

申请号：US09170042

申请日：1998-10-13

申请人： Gregg Hastings ,  Patrick J. Dillon

发明人： Gregg Hastings ,  Patrick J. Dillon

IPC分类号： C07K14435

CPC分类号： C07K14/47 ,  A61K38/00 ,  Y02A50/411

摘要： A human F-spondin-like protein and DNA (RNA) encoding such protein and a procedure for producing such protein by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating spinal cord injuries and damage to peripheral nerves by promoting neural-cell adhesion and neurite extension, inhibiting tumor metastases and tumor angiogenesis, and stimulating wound repair. Antagonists are also disclosed which may be utilized to prevent malaria. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

摘要翻译： 公开了一种编码这种蛋白质的人类F-脊椎样蛋白样蛋白和DNA（RNA）以及通过重组技术产生这种蛋白质的方法。 还公开了通过促进神经细胞粘附和神经突延伸，抑制肿瘤转移和肿瘤血管发生以及刺激伤口修复来利用这种多肽来治疗脊髓损伤和损伤周围神经的方法。 还公开了可用于预防疟疾的拮抗剂。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

公开(公告)号：US06759508B2

公开(公告)日：2004-07-06

申请号：US09854133

申请日：2001-05-11

申请人： Michael J. Lodes ,  Raodoh Mohamath ,  Robert A. Henderson ,  Darin R. Benson ,  Heather Secrist

发明人： Michael J. Lodes ,  Raodoh Mohamath ,  Robert A. Henderson ,  Darin R. Benson ,  Heather Secrist

IPC分类号： C07K14435

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4748 ,  C07K2319/00 ,  Y02A50/396

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

公开(公告)号：US06750027B2

公开(公告)日：2004-06-15

申请号：US09930026

申请日：2001-08-14

申请人： Preeti Lal ,  Jennifer L. Hillman ,  Karl J. Guegler ,  Neil C. Corley ,  Yalda Azimzai

发明人： Preeti Lal ,  Jennifer L. Hillman ,  Karl J. Guegler ,  Neil C. Corley ,  Yalda Azimzai

IPC分类号： C07K14435

CPC分类号： C12N9/93

摘要： The invention provides human ubiquitin-conjugating enzyme homologs (UCEH) and polynucleotides which identify and encode UCEH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of UCEH.

摘要翻译： 本发明提供了人泛素缀合酶同源物（UCEH）和识别和编码UCEH的多核苷酸。 本发明还提供了表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与UCEH表达相关的障碍的方法。

公开(公告)号：US06635480B1

公开(公告)日：2003-10-21

申请号：US09463932

申请日：2000-04-14

申请人： Se-Jin Lee ,  Thanh Huynh ,  Suzanne Sebald

发明人： Se-Jin Lee ,  Thanh Huynh ,  Suzanne Sebald

IPC分类号： C07K14435

CPC分类号： G01N33/74 ,  A61K38/00 ,  A61K48/00 ,  C07K14/475 ,  C12N2799/027 ,  G01N2333/475 ,  G01N2333/50 ,  G01N2500/00

摘要： Growth differentiation factor, Lefty-2, is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the Lefty-2 polypeptide and polynucleotide sequences.

摘要翻译： 公开了生长分化因子Lefty-2及其多核苷酸序列和氨基酸序列。 还公开了使用Lef-2多肽和多核苷酸序列的诊断和治疗方法。

公开(公告)号：US06602984B1

公开(公告)日：2003-08-05

申请号：US09613822

申请日：2000-07-11

申请人： John M. Greene ,  Mark D. Adams

发明人： John M. Greene ,  Mark D. Adams

IPC分类号： C07K14435

CPC分类号： C12N9/6424 ,  A61K38/00

摘要： Human elastase IV polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, restoration of elasticity of arterial walls, improvement of serum lipid abnormality and improvement of serum lipoprotein metabolism are disclosed. Also disclosed are antagonist/inhibitors against such polypeptides and their use in treating inflammation, arthritis, e.g. rheumatoid arthritis and osteoarthritis, septic shock, pancreatitis and limiting tissue damage in ulceration. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.

摘要翻译： 人弹性蛋白酶IV多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法，并且用于治疗目的，例如恢复动脉壁的弹性，改善血清脂质异常和改善血清脂蛋白 公开了代谢。 还公开了针对这种多肽的拮抗剂/抑制剂及其在治疗炎症，关节炎等中的用途。 类风湿关节炎和骨关节炎，脓毒性休克，胰腺炎和限制溃疡组织损伤。 还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。

公开(公告)号：US06444793B1

公开(公告)日：2002-09-03

申请号：US09325256

申请日：1999-06-03

申请人： R. Blake Pepinsky ,  Darren P. Baker ,  Dingyi Wen ,  Kevin P. Williams ,  Ellen A. Garber ,  Frederick R. Taylor ,  Alphonse Galdes ,  Jeffrey Porter

发明人： R. Blake Pepinsky ,  Darren P. Baker ,  Dingyi Wen ,  Kevin P. Williams ,  Ellen A. Garber ,  Frederick R. Taylor ,  Alphonse Galdes ,  Jeffrey Porter

IPC分类号： C07K14435

CPC分类号： A61K38/1709 ,  C07K1/1077 ,  C07K14/46 ,  C07K2319/00

摘要： Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle.

摘要翻译： 描述了疏水性修饰的蛋白质及其制备方法。 疏水部分连接到蛋白质的表面氨基酸残基。 疏水部分可以是脂质或肽。 或者，蛋白质可以通过向蛋白质附加疏水结构的各种化学反应衍生化。 优选的蛋白质是哺乳动物来源的，并且选自Sonic，Indian和Desert hedgehog。 疏水部分用作方便的系链，其可以连接囊泡，例如细胞膜，脂质体或胶束。

公开(公告)号：US06395510B1

公开(公告)日：2002-05-28

申请号：US09271014

申请日：1999-03-17

申请人： Craig B. Thompson ,  Lawrence H. Boise ,  Gabriel Nuñez

发明人： Craig B. Thompson ,  Lawrence H. Boise ,  Gabriel Nuñez

IPC分类号： C07K14435

CPC分类号： C07K14/4747 ,  C07K14/465

摘要： The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering programmed cell death for use in diagnostic, drug design and therapeutic applications.

摘要翻译： 本发明一般涉及获得和使用影响程序性脊椎动物细胞死亡的BCL-2以外的多肽的组合物和方法。 本发明还涉及编码那些多肽的多核苷酸，携带那些序列的重组载体，包含序列或载体的重组宿主细胞和重组多肽。 本发明还提供了在分析设计用于选择和改善能够改变程序性细胞死亡的物质用于诊断，药物设计和治疗应用的测定中使用分离的重组多肽的方法。

公开(公告)号：US06365715B1

公开(公告)日：2002-04-02

申请号：US09432473

申请日：1999-11-01

申请人： Anthony J Arleth ,  Nabil A Elshourbagy ,  Xiaotong Li ,  Robert N Willette

发明人： Anthony J Arleth ,  Nabil A Elshourbagy ,  Xiaotong Li ,  Robert N Willette

IPC分类号： C07K14435

CPC分类号： C12N9/6489 ,  A61K38/00 ,  A61K39/00 ,  C07K14/51

摘要： HC/BTLP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hC/BTLP polypeptides and polynucleotides in the design of protocols for the treatment of restenosis, atherosclerosis, congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), benign prostatic hypertrophy (BPH), nephritis, fibrosis, glomerulonephritis, gliosis, cirrhosis and anomalies of wound healing, such as keloids among others, and diagnostic assays for such conditions.

摘要翻译： 公开了通过重组技术制备此类多肽的HC / BTLP多肽和多核苷酸和方法。 还公开了在设计用于治疗再狭窄，动脉粥样硬化，充血性心力衰竭（CHF），慢性阻塞性肺病（COPD），良性前列腺肥大（BPH），肾炎，纤维化）的方案中使用hC / BTLP多肽和多核苷酸的方法 ，肾小球性肾炎，神经胶质增生，肝硬化和伤口愈合的异常，例如瘢痕疙瘩等，以及这些病症的诊断测定。