公开(公告)号：US20190240249A1

公开(公告)日：2019-08-08

申请号：US16266170

申请日：2019-02-04

申请人： BC3 Technologies

发明人： Thomas Freier ,  Rivelino Montenegro ,  Wayne Grube, JR.

IPC分类号： A61K31/722 ,  A61K9/12 ,  A61K9/14

CPC分类号： A61K31/722 ,  A61K9/124 ,  A61K9/146

摘要： A hemostatic material and a method of treating a bleeding wound of a human or an animal include a hemostatic powder for application to the wound. The hemostatic powder comprises a first part consisting of a native chitosan base and a second part consisting of a chitosan salt, where the first and the second parts form the main component of the hemostatic powder, or at least 50% of a total weight of the hemostatic powder, and the second part forms a layer that at least partially coats the first part. The hemostatic powder may be provided in a hemostatic spray formulation that comprises a mixture of the hemostatic powder dispersed in a liquefied gas for release from a cannister onto the wound. A treatment method involves applying the hemostatic spray formulation directly to the wound. Other embodiments are also disclosed.

公开(公告)号：US20190231869A1

公开(公告)日：2019-08-01

申请号：US16379535

申请日：2019-04-09

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS

发明人： Billy M. Hargis ,  Neil R. Pumford ,  Marion Morgan ,  Srichaitanya Shivaramaiah ,  Guillermo Tellez-Isaias ,  Amanda Wolfenden

IPC分类号： A61K39/39 ,  C08L5/08 ,  A61K39/02 ,  A61K39/145 ,  A61K39/155 ,  A61K31/7004 ,  A61K39/08 ,  C08B37/08 ,  A61K31/722 ,  A61K39/12 ,  A61K39/112 ,  C12N7/00

摘要： Adjuvants comprising chitosan cross-linked with an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of combining or linking the adjuvants with antigens are also provided. The adjuvant-antigen combinations can be used in vaccine formulations and the vaccine formulations can be used in methods to vaccinate animals against the source of the antigen or to enhance the immune response in a subject.

公开(公告)号：US10308725B2

公开(公告)日：2019-06-04

申请号：US15324904

申请日：2015-09-29

申请人： DISEASE ADSORPTION SYSTEM TECHNOLOGIES CO., LTD.

发明人： Yuzo Nishida

IPC分类号： C08B37/08 ,  C07H15/18 ,  A61K31/722 ,  G01N33/20 ,  B01D21/01 ,  A61K9/00 ,  A61K9/06

摘要： A chelate compound wherein a chelate-forming moiety is attached to a base compound having an amino group and at least a part of the amino group is in the form of a halide salt. A specific example of the halide salt is hydrochloride. As the base compound, a chitosan having a glucosamine skeleton is preferred. Also, chitosan beads are usable. The chelate compound is produced by reacting the base compound having an amino group with an aldehyde group of an aromatic cyclic compound, aromatic cyclic compound having at least a functional group capable of forming a chelate and the aldehyde group, to form a Schiff base, reducing the Schiff base with a reducing agent and then treating with a hydrohalogenic acid (hydrochloric acid).

公开(公告)号：US10258688B2

公开(公告)日：2019-04-16

申请号：US15363281

申请日：2016-11-29

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS

发明人： Billy M. Hargis ,  Neil R. Pumford ,  Marion Morgan ,  Srichaitanya Shivaramaiah ,  Guillermo Tellez-Isaias ,  Amanda Wolfenden

IPC分类号： A61K39/39 ,  A61K39/08 ,  A61K39/085 ,  A61K39/112 ,  C08B37/08 ,  C08L5/08 ,  A61K39/02 ,  A61K39/145 ,  C12N7/00 ,  A61K31/722 ,  A61K31/7004 ,  A61K39/00 ,  A61K39/12 ,  A61K39/155

摘要： Adjuvants comprising chitosan cross-linked with an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of combining or linking the adjuvants with antigens are also provided. The adjuvant-antigen combinations can be used in vaccine formulations and the vaccine formulations can be used in methods to vaccinate animals against the source of the antigen or to enhance the immune response in a subject.

公开(公告)号：US10149895B2

公开(公告)日：2018-12-11

申请号：US14900986

申请日：2014-06-26

申请人： VIRBAC

发明人： Natalia Bernachon ,  Patricia Monginoux

IPC分类号： A61K33/06 ,  A61K38/55 ,  A61K45/06 ,  A61K31/122 ,  A61K31/202 ,  A61K31/352 ,  A61K31/375 ,  A61K31/59 ,  A61K31/715 ,  A61K31/722 ,  A61K9/00 ,  A61K35/20 ,  A61K35/60 ,  A61K36/185 ,  A61K36/481 ,  A61K36/708 ,  A61K47/36

摘要： Described herein is an association of at least one phosphate binder, at least one uremic toxin binder, at least one vasoactive antihypertensive agent and at least one antifibrotic agent for the management of progressive renal diseases including chronic kidney diseases (CKD) in domestic carnivores. Specifically, the application describes veterinarian compositions comprising such an association and the use thereof for the treatment of CKD conditions.

公开(公告)号：US20180296589A1

公开(公告)日：2018-10-18

申请号：US15769477

申请日：2016-10-27

申请人： CROMA-PHARMA GESELLSCHAFT M.B.H.

发明人： Martin Prinz ,  Sonja Höller

IPC分类号： A61K31/722 ,  A61K9/00 ,  A61K9/08 ,  A61P27/04

摘要： The present invention relates to a sterile aqueous ophthalmic solution comprising N-(N-acetylcysteinyl-)chitosan or a pharmaceutically acceptable salt thereof in a carrier solution, wherein the N-(N-acetylcysteinyl-)chitosan has a content of free thiol groups in an amount of from 80 μmol/g polymer to 280 μmol/g polymer, for the specific use in the prevention or treatment of dry eye syndrome or dry eye signs and/or symptoms wherein said solution is applied prior to sleep.

公开(公告)号：US20180289609A1

公开(公告)日：2018-10-11

申请号：US15948446

申请日：2018-04-09

申请人： SYNEDGEN, INC.

发明人： Stacy M. Townsend ,  Shenda M. Baker ,  William P. Wiesmann

IPC分类号： A61K8/73 ,  A61K8/92 ,  A61C17/20 ,  A61K8/368 ,  A61K8/49 ,  A61Q17/00 ,  A61K31/047 ,  A61K31/722 ,  A61K45/06 ,  A61Q11/00 ,  A61K31/726 ,  A61K31/4164 ,  A61K31/155 ,  A61K8/34

摘要： Described herein are methods and compositions that contain a soluble polyglucosamine or polyglucosamine derivative for use in oral health. The compositions are useful for, e.g., reducing bacteria (e.g., by clumping and removing) or disrupting a biofilm in the mouth of a subject, reducing dry mouth, and reducing oral inflammation.

公开(公告)号：US10064832B2

公开(公告)日：2018-09-04

申请号：US15505980

申请日：2015-08-11

申请人： DONGGUK UNIVERSITY INDUSTRY-ACADEMY COOPERATION FOUNDATION

发明人： Gun Il Im ,  Mi Lan Kang

IPC分类号： A61K31/167 ,  A61K9/00 ,  A61K47/48 ,  A61K31/722 ,  C08B37/08 ,  C08L5/08 ,  A61K47/69

摘要： The present invention relates to kartogenin-conjugated chitosan particles with an improved sustained release property and biocompatibility. Effects of increases in biocompatibility, chondrogenic differentiation efficiency and retention time in the joints were confirmed by using kartogenin-chitosan microparticles or kartogenin-chitosan nanoparticles of the present invention, and thus targeted treatment, in the prevention or treatment of bone diseases, is enabled through a more fundamental approach.

公开(公告)号：US20180201694A1

公开(公告)日：2018-07-19

申请号：US15105153

申请日：2014-12-16

申请人： JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH (JNCASR)

发明人： Jayanta Haldar ,  Jiaul Hoque ,  Goutham Belagula Manjunath ,  Padma Akkapeddi

IPC分类号： C08B37/08 ,  A01N43/16 ,  C09D5/14 ,  C09D105/08 ,  A61K31/722 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A01N59/16 ,  A61L15/28 ,  A61L15/44 ,  A61L26/00 ,  A61L27/20 ,  A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L31/04 ,  A61L29/16 ,  A61L29/08 ,  A61L29/04

CPC分类号： C08B37/003 ,  A01N33/12 ,  A01N43/16 ,  A01N59/16 ,  A61K31/722 ,  A61L15/28 ,  A61L15/44 ,  A61L17/005 ,  A61L17/145 ,  A61L26/0023 ,  A61L26/0066 ,  A61L27/20 ,  A61L27/34 ,  A61L27/54 ,  A61L29/043 ,  A61L29/085 ,  A61L29/16 ,  A61L31/042 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/606 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  C08L5/08 ,  C09D5/14 ,  C09D105/08 ,  Y02A50/473 ,  A01N43/40 ,  A01N43/42 ,  A01N43/90 ,  A01N45/00

摘要： The present disclosure relates to chitin derivatives of Formula (I), its isomers, prodrugs and pharmaceutically acceptable salts thereof. The present disclosure further relates to a process of preparing the chitin derivatives, its isomers, prodrugs and pharmaceutically acceptable salts thereof. The compounds of the present disclosure are useful in antimicrobial coatings. The present disclosure further relates to an antibacterial polymeric nanocomposite and a process for preparing the antibacterial polymeric nanocomposites.

公开(公告)号：US20180200286A1

公开(公告)日：2018-07-19

申请号：US15923696

申请日：2018-03-16

申请人： SYNEDGEN, INC.

发明人： Shenda M. Baker ,  William P. Wiesmann ,  Ruth Baxter

IPC分类号： A61K31/722 ,  A61L26/00 ,  C08L5/08 ,  A61K47/61

摘要： Described herein are methods of treating wounds, the method comprising administering to a subject an effective amount of a composition comprising a soluble or derivatized chitosan wherein the soluble or derivatized chitosan when administered contacts the wound, thereby treating the wound.