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    Mitotic Kinesin Inhibitors
    45.
    发明申请
    Mitotic Kinesin Inhibitors 失效
    有丝分裂驱动蛋白抑制剂

    公开(公告)号：US20090042966A1

    公开(公告)日：2009-02-12

    申请号：US11887800

    申请日：2006-04-03

    申请人： Paul J. Coleman ,  Christopher D. Cox

    发明人： Paul J. Coleman ,  Christopher D. Cox

    IPC分类号： A61K31/415 ,  C07D231/06 ,  A61P35/00

    CPC分类号： C07D231/06

    摘要： The present invention relates to fluorinated dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

    摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的疾病和用于抑制KSP驱动蛋白的氟化二氢吡唑化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。

    Fungicidal 5-Hydroxypyrazolines, Processes for their Preparation and Comprising Them
    50.
    发明申请
    Fungicidal 5-Hydroxypyrazolines, Processes for their Preparation and Comprising Them 审中-公开
    杀真菌剂5-羟基吡唑啉，其制备方法及其组成

    公开(公告)号：US20080182886A1

    公开(公告)日：2008-07-31

    申请号：US11915779

    申请日：2006-05-24

    申请人： Markus Gewehr ,  Jochen Dietz ,  Thomas Grote ,  Andreas Gypser ,  Matthias Niedenbruck

    发明人： Markus Gewehr ,  Jochen Dietz ,  Thomas Grote ,  Andreas Gypser ,  Matthias Niedenbruck

    IPC分类号： A01N43/56 ,  C07D231/06 ,  A01P3/00 ,  A01N25/26

    CPC分类号： A01N43/56 ,  C07D231/06

    摘要： Novel 5-hydroxypyrazolines of the formula I in which the substituents are as defined below: B is phenyl, naphthyl or 5- or 6-membered hetaryl which contains one to four heteroatoms from the group consisting of O, N and S; A is C═O, C═S or SO2; W is CX1X2; X1, X2 are hydrogen, fluorine, chlorine or bromine; R1 is alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, phenyl, 5- or 6-membered heterocyclyl or hetaryl which contains one to four heteroatoms from the group consisting of O, N and S; R2 is hydrogen or alkyl; R3 is hydrogen, nitro, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, haloalkenyl, alkynyl, haloalkynyl or NR′2, where R′ independently of one another are hydrogen or alkyl; R4 is hydrogen, halogen, nitro, cyano, NR′2, alkyl, haloalkyl, COOR′ or 5- or 6-membered hetaryl or heterocyclyl; where the variables mentioned above may be substituted according to the description; processes for their preparation, their use for controlling harmful fungi and compositions comprising them.

    摘要翻译： 式I的新型5-羟基吡唑啉，其中取代基如下所定义：B是苯基，萘基或含有一至四个由O，N和S组成的组的杂原子的5-或6-元杂芳基; A是C-O，C-S或SO 2。 W是CX 1，X 2， X 1，X 2是氢，氟，氯或溴; R 1是烷基，卤代烷基，烯基，卤代烯基，炔基或卤代炔基，环烷基，环烯基，环炔基，苯基，5-或6-元杂环基或杂芳基，其含有一至四个 O，N和S; R 2是氢或烷基; R 3是氢，硝基，氰基，烷基，卤代烷基，烷氧基，卤代烷氧基，烯基，卤代烯基，炔基，卤代炔基或NR'2，其中R'彼此独立地 是氢或烷基; R 4是氢，卤素，硝基，氰基，NR'2，烷基，卤代烷基，COOR'或5-或6-元杂芳基或杂环基; 其中上述变量可以根据描述被替代; 其制备方法，它们用于控制有害真菌的用途和包含它们的组合物。