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    NOVEL METHOD FOR DOWN-REGULATION OF AMYLOID
    41.
    发明申请
    NOVEL METHOD FOR DOWN-REGULATION OF AMYLOID 审中-公开
    用于下调AMYLOID的新方法

    公开(公告)号：US20090092579A1

    公开(公告)日：2009-04-09

    申请号：US12108478

    申请日：2008-04-23

    申请人： Martin Roland Jensen ,  Peter Birk ,  Klaus Gregorius Nielsen

    发明人： Martin Roland Jensen ,  Peter Birk ,  Klaus Gregorius Nielsen

    IPC分类号： A61K38/20 ,  A61K39/00 ,  C07K14/00 ,  C12N15/11 ,  C12N15/00 ,  C12N1/21 ,  A61K38/21 ,  C07K16/18 ,  C12N1/19 ,  C12N1/10 ,  C12N5/06 ,  A61K38/16 ,  C12N15/87

    CPC分类号： A61K39/385 ,  A61K38/00 ,  A61K38/1709 ,  A61K39/0007 ,  A61K47/646 ,  A61K2039/53 ,  A61K2039/6037 ,  A61K2039/6087 ,  A61K2039/64 ,  C07K14/4711 ,  C07K2319/00 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2500/04

    摘要： Disclosed are novel methods for combating diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloidogenic proteins (proteins contributing to formation of amyloid) such as beta amyloid (Aβ). Immunization is preferably effected by administration of analogues of autologous amyloidogenic polypeptides, said analogues being capable of inducing antibody production against the autologous amyloidogenic polypeptides. Especially preferred as an immunogen is autologous Aβ which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes while substantially preserving the majority of Aβ's B-cell epitopes. Also disclosed are nucleic acid vaccination against amyloidogenic polypeptides and vaccination using live vaccines as well as methods and means useful for the vaccination. Such methods and means include methods for identification of useful immunogenic analogues of the amyloidogenic proteins, methods for the preparation of analogues and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.

    摘要翻译： 公开了用于对抗以沉淀淀粉样蛋白为特征的疾病的新方法。 所述方法通常依赖于抗淀粉样变蛋白（有助于形成淀粉样蛋白的蛋白质）如β淀粉样蛋白（Abeta）的免疫。 免疫优选通过施用自体淀粉样蛋白多肽的类似物来实现，所述类似物能够诱导针对自体淀粉样蛋白多肽的抗体产生。 作为免疫原特别优选的是通过引入一个或几个外来的免疫显性和混杂的T细胞表位而修饰的自体Abeta，同时基本上保留了大部分的Abeta的B细胞表位。 还公开了针对淀粉样变性多肽的核酸接种和使用活疫苗的疫苗接种以及可用于疫苗接种的方法和装置。 这样的方法和手段包括用于鉴定淀粉样蛋白形成蛋白质的有用的免疫原性类似物的方法，用于制备类似物和药物制剂的方法，以及核酸片段，载体，转化细胞，多肽和药物制剂。

    Recombinant viral-based malaria vaccines
    44.
    发明授权
    Recombinant viral-based malaria vaccines 有权
    重组病毒基疟疾疫苗

    公开(公告)号：US07387894B2

    公开(公告)日：2008-06-17

    申请号：US11607366

    申请日：2006-12-01

    申请人： Maria G. Pau ,  Lennart Holterman ,  Jorn Kaspers ,  Antonius J. H. Stegmann

    发明人： Maria G. Pau ,  Lennart Holterman ,  Jorn Kaspers ,  Antonius J. H. Stegmann

    IPC分类号： C12N15/00 ,  C12N1/10 ,  C07H21/04 ,  C07H21/00 ,  A61K45/00 ,  A01N63/00 ,  A01N65/00

    CPC分类号： C12N15/86 ,  A61K39/015 ,  A61K2039/5256 ,  C07K14/445 ,  C12N7/00 ,  C12N2710/10343 ,  Y02A50/412

    摘要： The present invention relates to novel vaccines against malaria infections, based on recombinant viral vectors, such as alpha viruses, adenoviruses or vaccinia viruses. The recombinant viral-based vaccines can be used to immunize against different Plasmodium infections, such as infections by P. falciparum or P. yoelii. Novel codon-optimized circumsporozoite genes are disclosed. Preferably, replication-defective adenoviruses are used, derived from serotypes that encounter low titers of neutralizing antibodies. The invention, therefore, also relates to the use of different adenoviral serotypes that are administered to elicit a strong immune response, either in single vaccination set-ups or in prime-boost set-ups in which compositions based on different serotypes can be applied.

    摘要翻译： 本发明涉及基于重组病毒载体，例如α病毒，腺病毒或牛痘病毒的抗疟疾感染的新型疫苗。 基于重组病毒的疫苗可用于免疫不同的疟原虫感染，例如恶性疟原虫或约氏疟原虫的感染。 公开了新的密码子优化的环子孢子基因。 优选使用衍生自遇到低滴度中和抗体的血清型的复制缺陷型腺病毒。 因此，本发明还涉及使用不同的腺病毒血清型，其被施用以引发强免疫应答，在单次疫苗接种装置中或在其中可以应用基于不同血清型的组合物的初始 - 加强装置中。

    METHODS AND MEDIUMS FOR CULTIVATING DINOPHYSIS ACUMINATA
    45.
    发明申请
    METHODS AND MEDIUMS FOR CULTIVATING DINOPHYSIS ACUMINATA 有权
    用于培养食品的方法和药物

    公开(公告)号：US20080102513A1

    公开(公告)日：2008-05-01

    申请号：US11849973

    申请日：2007-09-04

    申请人： Won Ho YIH ,  Hyung Seop KIM ,  Myung Gil PARK ,  Jung-rae RHO

    发明人： Won Ho YIH ,  Hyung Seop KIM ,  Myung Gil PARK ,  Jung-rae RHO

    IPC分类号： C12N1/10

    CPC分类号： C12N1/10 ,  Y10S435/947

    摘要： Disclosed are a method and a medium for cultivating the marine dinoflagellate Dinophysis acuminata. The laboratory culture of D. acuminata causing diarrhetic shellfish poisoning, whose cultivation was known difficult, has been first established, thereby contributing to a better understanding of ecophysiology, biology and toxicology of Dinophysis species, as well as the evolution of dinoflagellate plastids.

    摘要翻译： 公开了用于培养海洋鞭毛藻Dinophion acuminata的方法和培养基。 首先建立了引起腹泻贝类中毒的腹泻贝类中毒的实验室培养，从而有助于更好地了解Dinophysis物种的生态生物学，生物学和毒理学，以及鞭毛藻质体的演化。

    METHODS FOR THE IN VITRO CULTURE OF SPOROZOEA SP. AND USES THEREOF
    46.
    发明申请
    METHODS FOR THE IN VITRO CULTURE OF SPOROZOEA SP. AND USES THEREOF 有权
    SPOROZOEA SP的体外培养方法。 并使用它

    公开(公告)号：US20070224223A1

    公开(公告)日：2007-09-27

    申请号：US11754498

    申请日：2007-05-29

    申请人： Siobhan Ellison

    发明人： Siobhan Ellison

    IPC分类号： A61K39/002 ,  C12N1/10 ,  C12N5/06

    CPC分类号： C12N1/10 ,  A61K39/012 ,  A61K2039/52 ,  Y02A50/489

    摘要： The invention relates to a method of excysting and growing protozoal oocysts by in vitro tissue culture resulting in production of a continuous culture of merozoites. The invention also provides an economical and reliable supply of cultured Eimeria sp. for vaccine production, assays and research. Domesticated avians that have been vaccinated using the provied Eimeria sp. are also provided.

    摘要翻译： 本发明涉及通过体外组织培养来解除和生长原生动物卵囊的方法，导致产生裂殖子的连续培养。 本发明还提供经济和可靠的培养的艾美球虫的供应。 用于疫苗生产，测定和研究。 已使用已证明的艾美球虫疫苗接种的驯养禽鸟 也提供。

    Apparatuses and methods for the production of haematophagous organisms and parasites suitable for vaccine production
    49.
    发明申请
    Apparatuses and methods for the production of haematophagous organisms and parasites suitable for vaccine production 有权
    用于生产适合疫苗生产的血液生物和寄生虫的装置和方法

    公开(公告)号：US20070169209A1

    公开(公告)日：2007-07-19

    申请号：US11726622

    申请日：2007-03-21

    申请人： Stephen Hoffman ,  Thomas Luke

    发明人： Stephen Hoffman ,  Thomas Luke

    IPC分类号： A01K67/033 ,  C12N1/10

    CPC分类号： A01K67/033

    摘要： Disclosed are apparatuses and methods for the production of attenuated aseptic parasites in haematophagous insects generally, and production of Plasmodium species sporozoites in Anopheles species mosquitoes specifically; apparatuses and methods for the production of strains of haematophagous insects with desired properties such as hypoallergenicity or hyperinfectivity; methods of producing a parasite strain that is capable of withstanding cyropreservation at temperatures close to freezing; apparatuses and methods for the injection of an attenuated parasite vaccine; production of parasites and haematophagous insects that are free from contamination by unwanted biological agents; apparatuses for the reconstruction of complex parasitic life cycles aseptically to avoid the contamination of the parasite or the insect vector host with unwanted biological agents.

    摘要翻译： 公开了通常在血虫中生产减毒无菌寄生虫的装置和方法，特别是在按蚊种中产生疟原虫种子孢子; 用于生产具有所需性质如低致敏性或超感染性的血液昆虫菌株的装置和方法; 生产能够在接近冷冻的温度下耐受静脉保存的寄生虫菌株的方法; 用于注射减毒寄生虫疫苗的装置和方法; 生产不受不需要的生物制剂污染的寄生虫和血液昆虫; 用于无菌地重建复杂寄生生命周期的装置，以避免寄生虫或昆虫载体宿主与不想要的生物制剂的污染。