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511.
公开(公告)号:US10288622B2
公开(公告)日:2019-05-14
申请号:US14883685
申请日:2015-10-15
Inventor: Eran Ovadia , Irun R. Cohen , Johannes Herkel , Raanan Margalit , Meirav Pevsner-Fischer
IPC: G01N33/53 , C12Q1/64 , G01N33/68 , A61K38/08 , A61K38/18 , A61K38/30 , A61K45/06 , A61K31/343 , C07K7/06 , G01N33/543
Abstract: The present invention relates to uses of a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, analogs and derivatives thereof, for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). The present invention further provides a method for assessing responsiveness to treatment with the peptide of the invention. In addition, the present invention relates to prognosis of ALS progression, using Akt and phosphorylated Akt as biomarkers.
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公开(公告)号:US20190102512A1
公开(公告)日:2019-04-04
申请号:US15525093
申请日:2015-11-17
Applicant: Yeda Research and Development Co., Ltd.
Inventor: Eran SEGAL , Eran ELINAV
IPC: C12Q1/6888 , G06F17/18
Abstract: A method of assessing the growth dynamics of a bacterium in a microbiome is disclosed.
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公开(公告)号:US10238113B2
公开(公告)日:2019-03-26
申请号:US14656693
申请日:2015-03-12
Applicant: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY , YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor: Robert Fluhr , Moshe Sagi
Abstract: The present invention relates to regulation of ureide levels for optimal plant survival during nutrient remobilization such as occurs during normal growth, dark stress and senescence. Plants can be genetically engineered or selected using a suitable gene marker to have enhanced ureide accumulation. The present invention further provides methods of protecting plants, or extending the shelf life of fresh plant produce by application of exogenous ureides.
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公开(公告)号:US20190085350A1
公开(公告)日:2019-03-21
申请号:US16208640
申请日:2018-12-04
Applicant: Yeda Research and Development Co. Ltd.
Inventor: Mark SAFRO , Liron KLIPCAN , Inbar MAYMON , Igal FINAROV
Abstract: Transgenic plants resistant to bio-herbicides, particularly to phytotoxic non-protein amino acids including the meta-tyrosine (m-tyrosine) amino acid analog and salts thereof, means and methods for producing the transgenic plants.
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公开(公告)号:US20190059314A1
公开(公告)日:2019-02-28
申请号:US16123248
申请日:2018-09-06
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor: Asaph AHARONI , Prashant Sonawane , Maxim Itkin
CPC classification number: A01H6/82 , A01H5/10 , C12N9/1059 , C12N15/8218 , C12N15/8243 , C12N15/8247
Abstract: The present invention relates to key genes in the biosynthesis of steroidal alkaloids and saponins, including regulatory genes and enzyme-encoding genes, and to use thereof for altering the content of steroidal (glyco)alkaloids or phytosterols in plants. The present invention provides genetically modified plants or gene edited plants with altered content of steroidal (glyco)alkaloids, particularly to Solanaceous crop plants with reduced content of antinutritional steroidal glycoalkaloids and to the increase in phytosterols, including cholesterol or cholestanol in these plants. The present invention also provides methods of altering gene expression.
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公开(公告)号:US20190055561A1
公开(公告)日:2019-02-21
申请号:US16180083
申请日:2018-11-05
Applicant: Yeda Research and Development Co. Ltd.
Inventor: Alon CHEN , Orna ISSLER
IPC: C12N15/113 , C12Q1/6883 , C12N15/11
Abstract: A method of treating a bipolar disorder in a subject in need thereof is disclosed. The method comprising administering to the subject sa therapeutically effective amount of a miR-135, a precursor thereof or a nucleic acid molecule encoding said miR-135 or said precursor thereof, thereby treating the bipolar disorder. Methods of diagnosing a mood disorder in a human subject and of monitoring treatment of an anti-depressant drug or a medicament for the treatment of a mood disorder are also disclosed.
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公开(公告)号:US20190018041A1
公开(公告)日:2019-01-17
申请号:US16120375
申请日:2018-09-03
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor: Shahal ILANI , Sharon Pecker , Avishai Benyamini , Jonah Waissman , Assaf Hamo , Maayan Honig , Joseph Sulpizio , Lior Ella
Abstract: A method for use in construction of an electronic device and a transistor structure are presented. The method comprising: providing one or more nanotubes grown on a surface of a first substrate; providing a desired electrode arrangement fabricated on a surface of a second substrate. The electrode arrangement comprises at least two elevated source and drain electrodes and one or more gate electrodes located in between said elevated source and drain electrodes. The method also comprises bringing the electrode arrangement on the second substrate to close proximity with the first substrate such that surfaces of the first and second substrates face each other; scanning said first substrate with said electrode arrangement and determining contact of electrodes of the electrode arrangement with a nanotube located on the first substrate; and detaching said nanotube from the first substrate to provide a transistor structure comprising an isolated nanotube between the source and drain electrodes. The invention further provides systems comprising electronic devices and transistor structures of the invention. The invention further provides methods of use, the methods utilize electronic devices and transistor structures of the invention.
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公开(公告)号:US10174343B2
公开(公告)日:2019-01-08
申请号:US15108389
申请日:2013-12-26
Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) , Yeda Research and Development Co. Ltd. , Ramot at Tel-Aviv University Ltd.
Inventor: Itzhak Mizrahi , Naama Shterzer , Raphael Lamed , Inna Rozman Grinberg , Edward A. Bayer , Sarah Morais , Etai Landou
IPC: C12P19/14 , C12P7/14 , C12N1/22 , C12P39/00 , C12N9/42 , C12N9/24 , C12P7/06 , C12N9/04 , C12N9/88 , C12P7/10 , C12Q1/6888
Abstract: Lactic acid bacterial cultures, cell populations and articles of manufacture comprising same are disclosed for generating ethanol from lignocellulose.
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公开(公告)号:US10125365B2
公开(公告)日:2018-11-13
申请号:US15111539
申请日:2015-02-05
Applicant: Yeda Research and Development Co. Ltd.
Inventor: Alon Chen , Orna Issler
IPC: C07H21/02 , C07H21/04 , A61K31/70 , C12N15/113 , C12N15/11 , C12Q1/6883 , C12N5/00
Abstract: A method of treating a bipolar disorder in a subject in need thereof is disclosed. The method comprising administering to the subject sa therapeutically effective amount of a miR-135, a precursor thereof or a nucleic acid molecule encoding said miR-135 or said precursor thereof, thereby treating the bipolar disorder. Methods of diagnosing a mood disorder in a human subject and of monitoring treatment of an anti-depressant drug or a medicament for the treatment of a mood disorder are also disclosed.
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公开(公告)号:US20180273639A1
公开(公告)日:2018-09-27
申请号:US15961928
申请日:2018-04-25
Applicant: Yeda Research and Development Co. Ltd.
Inventor: Deborah FASS , Iris Grossman , Tal Ilani
IPC: C07K16/40 , C07K16/18 , A61K39/395
CPC classification number: C07K16/40 , A01K2227/105 , A01K2267/0306 , A61K39/395 , A61K2039/505 , A61P35/00 , C07K16/18 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: An antibody comprising an antigen recognition domain exhibiting species cross reactivity to human QSOX1 and murine QSOX1 is disclosed. Methods of producing the antibody, pharmaceutical compositions comprising the antibody and methods of using the antibody for treating medical conditions are also disclosed.
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